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Glia, ISSN 0894-1491, 04/2010, Volume 58, Issue 5, pp. 588 - 598
Neural injury leads to inflammation and activation of microglia that in turn may participate in progression of neurodegeneration. The mechanisms involved in... 
neurodegenerative diseases | heme oxygenase‐1 | innate immune system | Neurodegenerative diseases | Innate immune system | Heme oxygenase-1 | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Dopamine Plasma Membrane Transport Proteins - metabolism | Tyrosine 3-Monooxygenase - metabolism | Flow Cytometry - methods | Leukocyte Common Antigens - metabolism | Reactive Oxygen Species - metabolism | Culture Media, Conditioned - pharmacology | Male | Glial Fibrillary Acidic Protein - metabolism | Brain - metabolism | MPTP Poisoning - complications | Inflammation - metabolism | Microglia - physiology | MPTP Poisoning - pathology | Antigens, Differentiation - metabolism | Neurons - metabolism | Neurons - drug effects | Dopamine - metabolism | Gliosis - etiology | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Cytokines - metabolism | Neurons - chemistry | Mice, Inbred C57BL | Gene Expression Regulation - physiology | NF-E2-Related Factor 2 - deficiency | Inflammation - etiology | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Analysis of Variance | Microfilament Proteins | NF-E2-Related Factor 2 - metabolism | Cyclooxygenase 2 - metabolism | Brain - pathology | Mice | CD11b Antigen - metabolism | Cell Line, Transformed | Nitric Oxide Synthase Type II - metabolism | Index Medicus
Journal Article
The Journal of neuroscience, ISSN 1529-2401, 01/2011, Volume 31, Issue 1, pp. 157 - 163
Mutations in parkin, an E3 ubiquitin ligase, are the most common cause of autosomal-recessive Parkinson's disease (PD). Here, we show that the stress-signaling... 
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Free Radical Scavengers - pharmacology | Phosphorylation - physiology | Peptide Elongation Factors - metabolism | Humans | Oxidative Stress - physiology | Male | Piperazines - toxicity | Green Fluorescent Proteins - genetics | Metalloporphyrins - pharmacology | Case-Control Studies | Brain - metabolism | Pyrimidines - toxicity | Transfection - methods | Ubiquitination - drug effects | Tumor Suppressor Proteins - genetics | Statistics, Nonparametric | MPTP Poisoning - pathology | Phosphorylation - drug effects | Peptide Elongation Factors - genetics | Disease Models, Animal | Polyethylene Glycols - pharmacology | Cell Line | Proto-Oncogene Proteins c-abl - genetics | Tumor Suppressor Proteins - metabolism | Drug Administration Schedule | Immunoprecipitation - methods | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Dopamine - pharmacology | Ubiquitin-Protein Ligases - metabolism | Gene Expression Regulation - physiology | MPTP Poisoning - drug therapy | Imatinib Mesylate | Brain - drug effects | Gene Expression Regulation - drug effects | Tyrosine - metabolism | Animals | MPTP Poisoning - metabolism | Acetylcysteine - pharmacology | Brain - pathology | Protein Kinase Inhibitors - toxicity | Proto-Oncogene Proteins c-abl - metabolism | Mice | Benzamides | Oxidative Stress - drug effects | MPTP Poisoning - chemically induced | Ubiquitin-Protein Ligases - genetics | Index Medicus | Brief Communications
Journal Article
Journal of neuropathology and experimental neurology, ISSN 0022-3069, 08/2011, Volume 70, Issue 8, pp. 686 - 697
Loss-of-function mutations in the ubiquitin ligase parkin are the major cause of recessively inherited early-onset Parkinson disease (PD). Impairment of parkin... 
α-Synuclein | Neuroprotection | Adeno-associated virus | Osmotic minipump | Parkinson disease | MPTP | Parkin | Pathology | Neurosciences | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Chromatography, High Pressure Liquid - methods | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - administration & dosage | Humans | Microinjections - methods | Motor Activity - drug effects | Male | Green Fluorescent Proteins - genetics | Statistics as Topic | Corpus Striatum - metabolism | MPTP Poisoning - complications | Nerve Degeneration - prevention & control | Neurons - physiology | MPTP Poisoning - pathology | Oncogene Protein v-akt - metabolism | Corpus Striatum - pathology | Neurotoxins - administration & dosage | Transduction, Genetic - methods | Dopamine - metabolism | Disease Models, Animal | Mesencephalon - pathology | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | bcl-2-Associated X Protein - metabolism | Nerve Degeneration - pathology | Gene Expression Regulation - drug effects | Rotarod Performance Test | Animals | Cell Count - methods | Analysis of Variance | MPTP Poisoning - metabolism | Signal Transduction - drug effects | Genetic Vectors - physiology | Mice | MPTP Poisoning - chemically induced | Nerve Degeneration - etiology | Ubiquitin-Protein Ligases - genetics | alpha-Synuclein - metabolism | Ubiquitin-Protein Ligases - therapeutic use | Index Medicus
Journal Article
The Journal of neuroscience, ISSN 0270-6474, 02/2012, Volume 32, Issue 6, pp. 2062 - 2085
Journal Article
BMC neuroscience, ISSN 1471-2202, 2012, Volume 13, Issue 1, pp. 132 - 132
Background: Parkinson's disease is characterized by a continuous loss of neurons within the substantia nigra (SN) leading to a depletion of dopamine. Within... 
NG2 | Dopamine | Physical activity | Environmental enrichment | Substantia nigra | Oligodendrocytes | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Adult Stem Cells - physiology | Motor Activity - physiology | Tyrosine 3-Monooxygenase - metabolism | Nestin | MPTP Poisoning - physiopathology | Green Fluorescent Proteins - genetics | Dopamine Agents - therapeutic use | Substantia Nigra - cytology | MPTP Poisoning - rehabilitation | Dopamine Agents - pharmacology | Intermediate Filament Proteins - genetics | MPTP Poisoning - pathology | Female | Microfilament Proteins - metabolism | Bromodeoxyuridine - metabolism | Dopamine - metabolism | Disease Models, Animal | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | Calcium-Binding Proteins - metabolism | Green Fluorescent Proteins - metabolism | Levodopa - pharmacology | Levodopa - therapeutic use | Mice, Inbred C57BL | Cells, Cultured | Proteoglycans - metabolism | Mice, Transgenic | Antigens - metabolism | 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism | MPTP Poisoning - drug therapy | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Analysis of Variance | Environment | Mice | Physical fitness | Exercise | Neurons | Analysis | Phenols | Dopa | Confidence intervals | Brain | Neurodegeneration | Rodents | Parkinsons disease | Manuscripts | Index Medicus | Adults
Journal Article
Antioxidants & redox signaling, ISSN 1523-0864, 05/2012, Volume 16, Issue 9, pp. 855 - 868
Aims: Mitochondrial damage due to Ca 2+ overload-induced opening of permeability transition pores (PTP) is believed to play a role in selective degeneration of... 
Forum Original Research Communication | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Tyrosine 3-Monooxygenase - metabolism | Substantia Nigra - pathology | Apoptosis - drug effects | Calcium - metabolism | Humans | Basal Ganglia - metabolism | Apoptosis - genetics | Mitochondrial Membrane Transport Proteins - genetics | MPTP Poisoning - genetics | Cell Death - genetics | Dopaminergic Neurons - metabolism | Dopaminergic Neurons - drug effects | MPTP Poisoning - pathology | 1-Methyl-4-phenylpyridinium - metabolism | Disease Models, Animal | Astrocytes - drug effects | Microglia - drug effects | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - metabolism | Cyclophilins - genetics | Mitochondria - metabolism | Mice, Knockout | Animals | MPTP Poisoning - metabolism | Mice | alpha-Synuclein - metabolism | Mitochondria | Parkinson's disease | Cyclophilin | Physiological aspects | Causes of | Chemical properties | Research | Enzyme activation | Calcium ions | Neurotoxicity syndromes | Animal models | Peptidylprolyl isomerase | Dopamine | Free radicals | Calcium | Mesencephalon | Neurodegenerative diseases | Mitochondrial permeability transition pore | Membrane permeability | Antioxidants | Depolarization | Neurotoxicity | Neurodegeneration | MPTP | Electron transport | Genotypes | Movement disorders | Apoptosis | Index Medicus
Journal Article
Journal of neuroinflammation, ISSN 1742-2094, 09/2018, Volume 15, Issue 1, pp. 258 - 258
Background: alpha-Synuclein (alpha-Syn)-induced neuroinflammation plays a crucial role in the pathogenesis of Parkinson's disease (PD). Dopamine D2 receptor... 
α-Synuclein | Inflammation | Dopamine D2 receptor | Astrocyte | β-Arrestin2 | Parkinson’s disease | Neurosciences | Immunology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Tyrosine 3-Monooxygenase - metabolism | Protein Binding - genetics | Embryo, Mammalian | beta-Arrestin 2 - metabolism | Receptors, Dopamine D2 - metabolism | Protein Binding - drug effects | MPTP Poisoning - pathology | Neurons - metabolism | alpha-Synuclein - genetics | Disease Models, Animal | Animals, Newborn | Dopamine Agonists - pharmacology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | beta-Arrestin 2 - genetics | Mice, Transgenic | Signal Transduction - genetics | Mutation - genetics | Receptors, Dopamine D2 - genetics | Gene Expression Regulation - drug effects | Animals | MPTP Poisoning - metabolism | Signal Transduction - drug effects | Adaptor Proteins, Signal Transducing - genetics | Mice | Quinpirole - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | MPTP Poisoning - chemically induced | alpha-Synuclein - metabolism | Astrocytes - metabolism | Parkinson's disease | Disease | Mesencephalon | Pathogenesis | Schizophrenia | Kinases | Synuclein | Western blotting | Lipopolysaccharides | Proteins | Signal transduction | Rodents | Tumor necrosis factor-TNF | Dopamine D2 receptors | Growth factors | Enzyme-linked immunosorbent assay | Movement disorders | Dopamine | Cytokines | Neurodegenerative diseases | Neurons | TAK1 protein | Astrocytes | Transgenic mice | Quinpirole | Protein interaction | Immunofluorescence | Psychiatry | Index Medicus
Journal Article