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The Journal of Immunology, ISSN 0022-1767, 03/2010, Volume 184, Issue 5, pp. 2261 - 2271
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2012, Volume 122, Issue 11, pp. 3955 - 3959
Progranulin (PGRN) is a widely expressed secreted protein that is linked to inflammation. In humans, PGRN haploinsufficiency is a major inherited cause of... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | TNF RECEPTORS | INHIBITION | TDP-43 | HOST-DEFENSE | NECROSIS-FACTOR-ALPHA | NEUROPATHOLOGY | FRONTOTEMPORAL LOBAR DEGENERATION | EXPRESSION | PARKINSONS-DISEASE | Inflammation - chemically induced | Inflammation - pathology | Microglia - metabolism | Neurons - pathology | Humans | Cerebral Cortex - pathology | Cerebral Cortex - metabolism | Frontotemporal Dementia - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Inflammation - metabolism | MPTP Poisoning - genetics | Cell Death - genetics | MPTP Poisoning - pathology | Microglia - pathology | Neurons - metabolism | Cell Death - drug effects | Frontotemporal Dementia - pathology | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | Frontotemporal Dementia - genetics | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - adverse effects | Neurotoxins - adverse effects | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Neurotoxins - pharmacology | Animals | MPTP Poisoning - metabolism | Lipopolysaccharides - pharmacology | Inflammation - genetics | Mice | Interferon-gamma - pharmacology | Care and treatment | Neurons | Development and progression | Genetic aspects | Research | Gene expression | Dementia | Brief Report
Journal Article
Journal Article
European Journal of Neuroscience, ISSN 0953-816X, 03/2009, Volume 29, Issue 5, pp. 954 - 963
Rosiglitazone is a commonly prescribed insulin-sensitizing drug with a selective agonistic activity on the peroxisome proliferator-activated receptor-gamma... 
Inflammation | Tyrosine hydroxylase | Dopamine | Glia | MPP | Motor behaviour | MICROGLIAL ACTIVATION | MPTP MODEL | ALZHEIMERS-DISEASE | glia | SUBSTANTIA-NIGRA | NEUROSCIENCES | tyrosine hydroxylase | inflammation | ALPHA-SYNUCLEIN AGGREGATION | ACTIVATED-RECEPTOR-GAMMA | REACTIVE ASTROCYTES | motor behaviour | NEUROBLASTOMA SH-SY5Y CELLS | NIGROSTRIATAL SYSTEM | dopamine | NIGRA PARS COMPACTA | Tyrosine 3-Monooxygenase - metabolism | Chromatography, High Pressure Liquid - methods | Dynorphins - genetics | Catalepsy | Motor Activity - drug effects | Male | Glial Fibrillary Acidic Protein - metabolism | PPAR gamma - metabolism | RNA, Messenger - metabolism | Smell - drug effects | Globus Pallidus - metabolism | Thiazolidinediones - therapeutic use | Drug Interactions | MPTP Poisoning - pathology | Dynorphins - metabolism | Tandem Mass Spectrometry - methods | Dopamine - metabolism | Disease Models, Animal | Locomotion - drug effects | 3,4-Dihydroxyphenylacetic Acid - metabolism | Mice, Inbred C57BL | Psychomotor Performance - drug effects | MPTP Poisoning - prevention & control | Gene Expression Regulation - drug effects | Globus Pallidus - drug effects | Animals | MPTP Poisoning - metabolism | PPAR gamma - agonists | Mice | CD11b Antigen - metabolism | MPTP Poisoning - chemically induced | Chronic Disease | Tyrosine | Parkinson's disease | RNA | Intermediate filament proteins | Probenecid | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 04/2017, Volume 116, pp. 412 - 420
Paeoniflorin (PF) is a major bioactive ingredient in roots that has low toxicity and has been shown to have neuroprotective effects. Our in vitro experiments... 
Paeoniflorin | Neuroprotective effect | Parkinson's disease | Phosphatidylinositol 3-kinase (PI3K)/Akt | OXIDATIVE STRESS | TYROSINE-HYDROXYLASE | SIGNAL PATHWAY | C57BL/6 MICE | KINASE | DEATH | DOPAMINERGIC NEUROTOXICITY | NEUROSCIENCES | ADENOSINE A RECEPTOR | PHARMACOLOGY & PHARMACY | GROWTH-FACTOR | PC12 CELLS | Dopamine Plasma Membrane Transport Proteins - metabolism | Motor Activity - physiology | Tyrosine 3-Monooxygenase - metabolism | Caspase 9 - metabolism | Substantia Nigra - pathology | Dopaminergic Neurons - pathology | Caspase 3 - metabolism | Motor Activity - drug effects | Male | Phosphatidylinositol 3-Kinases - metabolism | Substantia Nigra - metabolism | Corpus Striatum - metabolism | Monoterpenes - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Neuroprotective Agents - pharmacology | Dopaminergic Neurons - metabolism | Dopaminergic Neurons - drug effects | MPTP Poisoning - pathology | bcl-Associated Death Protein - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Corpus Striatum - pathology | Cell Survival - physiology | Dopamine - metabolism | Cell Survival - drug effects | Monoamine Oxidase Inhibitors - pharmacology | Glucosides - pharmacology | Mice, Inbred C57BL | MPTP Poisoning - drug therapy | Substantia Nigra - drug effects | Animals | MPTP Poisoning - metabolism | Corpus Striatum - drug effects | Monoamine Oxidase - metabolism | Tyrosine | Analysis | Monoamine oxidase
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 02/2014, Volume 67, pp. 10 - 18
Endoplasmic reticulum (ER) stress has been implicated in Parkinson disease. We previously reported that thioredoxin 1 (Trx-1) suppressed the ER stress caused... 
MPP+/MPTP | Parkinson disease | ER stress | Free radicals | Thioredoxin-1 | MPTP | MPP | APOPTOSIS | ACTIVATION | UNFOLDED-PROTEIN RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | NEUROTOXICITY | P38 MAP KINASE | IRE1 | ENDOCRINOLOGY & METABOLISM | PC12 CELLS | TRANSCRIPTION FACTOR | Transcription Factor CHOP - genetics | Endoribonucleases - genetics | TNF Receptor-Associated Factor 2 - genetics | MPTP Poisoning - physiopathology | Endoplasmic Reticulum Stress - genetics | PC12 Cells | Heat-Shock Proteins - genetics | MPTP Poisoning - genetics | MAP Kinase Kinase 4 - metabolism | Thioredoxins - genetics | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - analogs & derivatives | Thioredoxins - metabolism | Protein-Serine-Threonine Kinases - metabolism | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - pharmacology | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Signal Transduction | Caspase 12 - genetics | 1-Methyl-4-phenylpyridinium - pharmacology | Heat-Shock Proteins - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Rats | TNF Receptor-Associated Factor 2 - metabolism | Mice, Transgenic | Caspase 12 - metabolism | Animals | MPTP Poisoning - metabolism | MAP Kinase Kinase 4 - genetics | Mice | MPTP Poisoning - chemically induced | Transcription Factor CHOP - metabolism | Glucose metabolism | Enzymes | Inositol | Parkinson's disease | Genetic engineering | Stress (Physiology) | Glucose | Thioredoxin | Dextrose
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2011, Volume 108, Issue 16, pp. 6632 - 6637
Journal Article
Neuropharmacology, ISSN 0028-3908, 10/2017, Volume 125, pp. 396 - 407
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2017, Volume 12, Issue 4, pp. e0174470 - e0174470
Journal Article
Journal of Pineal Research, ISSN 0742-3098, 08/2016, Volume 61, Issue 1, pp. 96 - 107
Journal Article
Journal Article