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Nature structural & molecular biology, ISSN 1545-9985, 2011, Volume 19, Issue 1, pp. 17 - 24
Journal Article
Molecular cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, pp. 405 - 415
The Mre11-Rad50-Xrs2/Nbs1 (MRX/N) complex orchestrates the cellular response to DSBs through its structural, enzymatic, and signaling roles... 
Xrs2 | Rad50 | Mre11 | homologous recombination | end resection | Sae2 | DNA repair | REPAIR | PROTEIN | MRE11 COMPLEX | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CYCLE | END RESECTION | YEAST XRS2 | SACCHAROMYCES-CEREVISIAE | SAE2 | DOUBLE-STRAND-BREAK | CELL BIOLOGY | Endonucleases - deficiency | Endonucleases - genetics | DNA, Fungal - genetics | Saccharomyces cerevisiae - genetics | Saccharomyces cerevisiae - drug effects | Intracellular Signaling Peptides and Proteins - metabolism | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Cell Nucleus - metabolism | ATP-Binding Cassette Transporters - genetics | DNA Breaks, Double-Stranded - drug effects | DNA End-Joining Repair | Endodeoxyribonucleases - metabolism | ATP-Binding Cassette Transporters - metabolism | Exodeoxyribonucleases - genetics | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Gene Expression Regulation, Fungal | Chromosomal Proteins, Non-Histone - metabolism | Signal Transduction | Protein-Serine-Threonine Kinases - genetics | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Protein Transport | Endodeoxyribonucleases - genetics | DNA, Fungal - metabolism | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Cell Nucleus - drug effects | Camptothecin - pharmacology | Methyl Methanesulfonate - pharmacology | Enzymes
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 4/2015, Volume 112, Issue 15, pp. E1880 - E1887
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2005, Volume 308, Issue 5721, pp. 551 - 554
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2010, Volume 285, Issue 2, pp. 1097 - 1104
.... We demonstrate that the MRE11-RAD50-NBS1 (MRN) complex acts to promote DNA end resection and the generation of single-stranded DNA, which is critically important for HR repair... 
EARLY EMBRYONIC LETHALITY | TARGETED DISRUPTION | DAMAGE-RESPONSE PATHWAYS | GENOMIC STABILITY | MRE11 COMPLEX | CHROMOSOMAL FRAGMENTATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HUMAN RAD50/MRE11 | DOUBLE-STRAND BREAKS | HISTONE H2AX | S-PHASE CHECKPOINT | Recombination, Genetic - physiology | Humans | DNA Repair - physiology | DNA Repair Enzymes - genetics | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | DNA Breaks, Double-Stranded | DNA, Single-Stranded - genetics | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Multiprotein Complexes - metabolism | ATP-Binding Cassette Transporters - genetics | BRCA1 Protein - metabolism | DNA Repair Enzymes - metabolism | ATP-Binding Cassette Transporters - metabolism | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Cell Line | DNA, Single-Stranded - metabolism | Cell Cycle Proteins - metabolism | Chromosomal Proteins, Non-Histone | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | BRCA1 Protein - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Histones - genetics | Signal Transduction - physiology | Mice | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1 | Protein Translocation | DNA | DNA Repair | Repair, Recombination, and Chromosome Dynamics | DNA Damage | DNA Recombination | Protein-Protein Interactions | Tumor Suppressor
Journal Article