X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (1335) 1335
humans (920) 920
dna repair (692) 692
dna-binding proteins - metabolism (628) 628
dna damage (613) 613
mre11 homologue protein (592) 592
biochemistry & molecular biology (559) 559
cell biology (505) 505
mre11 complex (449) 449
double-strand breaks (448) 448
dna-binding proteins - genetics (435) 435
animals (422) 422
homologous recombination (419) 419
cell cycle proteins - metabolism (386) 386
mre11 (378) 378
nuclear proteins - metabolism (349) 349
dna (345) 345
saccharomyces-cerevisiae (342) 342
repair (334) 334
dna breaks, double-stranded (332) 332
mutation (327) 327
proteins (318) 318
enzymes and coenzymes (307) 307
phosphorylation (293) 293
genetics & heredity (290) 290
cell cycle proteins - genetics (265) 265
nuclear proteins - genetics (259) 259
dna repair enzymes - metabolism (243) 243
article (229) 229
research (227) 227
cancer (226) 226
mre11 protein (221) 221
ataxia-telangiectasia (216) 216
mice (213) 213
ataxia telangiectasia mutated proteins (207) 207
protein-serine-threonine kinases - metabolism (207) 207
deoxyribonucleic acid--dna (204) 204
cell line (203) 203
oncology (195) 195
genetic aspects (178) 178
protein (172) 172
dna-damage response (166) 166
protein binding (162) 162
exodeoxyribonucleases - metabolism (159) 159
cell cycle (157) 157
complex (157) 157
cell line, tumor (156) 156
dna replication (154) 154
recombination (152) 152
dna repair enzymes - genetics (151) 151
female (151) 151
atm (150) 150
saccharomyces cerevisiae - genetics (149) 149
atm activation (148) 148
tumor suppressor proteins - metabolism (147) 147
ionizing-radiation (143) 143
strand break repair (142) 142
recombination, genetic (138) 138
genomic instability (137) 137
damage response (136) 136
dna repair - genetics (135) 135
biology (134) 134
multidisciplinary sciences (134) 134
signal transduction (133) 133
cell-cycle (130) 130
genetics (128) 128
rad50 (128) 128
dna - metabolism (126) 126
yeast (126) 126
molecular sequence data (123) 123
physiological aspects (123) 123
saccharomyces cerevisiae proteins - metabolism (123) 123
cells (120) 120
biological phenomena, cell phenomena, and immunity (119) 119
dna-damage (119) 119
nbs1 (117) 117
nijmegen breakage syndrome (117) 117
endodeoxyribonucleases - metabolism (115) 115
replication (113) 113
analysis (112) 112
exodeoxyribonucleases - genetics (111) 111
protein-serine-threonine kinases - genetics (111) 111
genes (109) 109
male (109) 109
molecular biology (109) 109
hela cells (108) 108
saccharomyces cerevisiae proteins - genetics (108) 108
amino acid sequence (103) 103
chromosomes (101) 101
dna-binding proteins - physiology (100) 100
toxicology (100) 100
apoptosis (99) 99
research article (97) 97
mammalian-cells (96) 96
gene expression (95) 95
saccharomyces cerevisiae - metabolism (95) 95
dna repair - physiology (94) 94
mrn complex (94) 94
damage (93) 93
genetic research (93) 93
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature, ISSN 0028-0836, 03/2005, Volume 434, Issue 7033, pp. 605 - 611
Journal Article
Cell, ISSN 0092-8674, 04/2011, Volume 145, Issue 1, pp. 54 - 66
Journal Article
Journal Article
Science, ISSN 0036-8075, 4/2005, Volume 308, Issue 5721, pp. 551 - 554
Journal Article
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 07/2005, Volume 25, Issue 13, pp. 5363 - 5379
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
REPAIR PROTEINS | FISSION YEAST | MRE11 COMPLEX | NIJMEGEN BREAKAGE SYNDROME | IMPORTIN-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | PROTEIN-PROTEIN INTERACTIONS | DISTINCT FUNCTIONAL DOMAINS | ATAXIA-TELANGIECTASIA | SCHIZOSACCHAROMYCES-POMBE | CELL BIOLOGY | Fungal Proteins - chemistry | Xenopus | Schizosaccharomyces pombe Proteins - chemistry | Phosphorylation | Humans | Molecular Sequence Data | Oocytes | Cell Cycle Proteins - chemistry | DNA-Binding Proteins - metabolism | Tumor Suppressor Proteins - chemistry | Schizosaccharomyces pombe Proteins - metabolism | Conserved Sequence | Female | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Tumor Suppressor Proteins - metabolism | Schizosaccharomyces pombe Proteins - genetics | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | Models, Molecular | Ataxia Telangiectasia Mutated Proteins | Xenopus Proteins | DNA-Binding Proteins - chemistry | Amino Acid Motifs | Chromosomal Proteins, Non-Histone - genetics | Two-Hybrid System Techniques | Animals | Models, Biological | Cell Extracts | Protein Conformation | Protein-Serine-Threonine Kinases - chemistry | Mutation | Chromosomal Proteins, Non-Histone - chemistry | DNA Damage - radiation effects | Fungal Proteins - metabolism | Index Medicus | Chromosome Structure and Dynamics
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2010, Volume 29, Issue 3, pp. 574 - 585
The Mre11/Rad50/Nbs1 (MRN) complex has a central function in facilitating activation of the ATM protein kinase at sites of DNA double‐strand breaks (DSBs).... 
MRN | checkpoints | ATM | DNA repair | 53BP1 | Checkpoints | DEPENDENT PHOSPHORYLATION | MRE11 COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | TELANGIECTASIA-LIKE DISORDER | S-PHASE CHECKPOINT | CELL BIOLOGY | BRCT PROTEIN 53BP1 | CLASS-SWITCH RECOMBINATION | DNA-DAMAGE-RESPONSE | ATAXIA-TELANGIECTASIA | IONIZING IRRADIATION | Phosphorylation | Protein Binding - genetics | Humans | Recombinant Fusion Proteins - physiology | Multiprotein Complexes - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Recombinant Fusion Proteins - metabolism | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Multiprotein Complexes - metabolism | BRCA1 Protein - metabolism | DNA Repair Enzymes - metabolism | Protein Multimerization - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - physiology | Tumor Suppressor Proteins - metabolism | Protein-Serine-Threonine Kinases - physiology | Cell Cycle Proteins - metabolism | Cells, Cultured | Nuclear Proteins - metabolism | Protein Structure, Tertiary - genetics | Ataxia Telangiectasia Mutated Proteins | Multiprotein Complexes - physiology | Tumor Suppressor Proteins - physiology | Animals | Recombinant Fusion Proteins - genetics | Mice | Tumor Suppressor p53-Binding Protein 1 | Enzyme Activation - genetics | Intracellular Signaling Peptides and Proteins - physiology | Cell Cycle Proteins - physiology | Protein Structure, Tertiary - physiology | Signal transduction | Kinases | Molecular biology | Substrates | Index Medicus
Journal Article
Nature Structural & Molecular Biology, ISSN 1545-9993, 08/2009, Volume 16, Issue 8, pp. 819 - 824
Here we have used an intrachromosomal substrate to monitor the end joining of distant ends, which leads to DNA rearrangements in mammalian cells. We show that... 
NUCLEASE ACTIVITY | MRE11/RAD50/NBS1 COMPLEX | REPAIR PATHWAY | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | DNA-DAMAGE CHECKPOINT | GENOMIC STABILITY | BIOPHYSICS | GENE CONVERSION | HOMOLOGOUS RECOMBINATION | RNA, Small Interfering - genetics | Cricetulus | Humans | DNA Repair Enzymes - genetics | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Flow Cytometry | Transfection | Base Sequence | Tumor Suppressor Proteins - genetics | DNA Repair Enzymes - metabolism | Cell Cycle Proteins - genetics | Pyrimidinones - pharmacology | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | CHO Cells | Cell Line | Cricetinae | Tumor Suppressor Proteins - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Blotting, Western | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | DNA Repair | Protein Binding | Mutation | Thiones - pharmacology | Microscopy, Fluorescence | Recombination, Genetic - drug effects | Control | Gene mutations | DNA damage | Causes of | Ataxia telangiectasia | Genetic aspects | Research | Health aspects | Cellular biology | Molecular biology | Mammals | Chromosomes | Index Medicus
Journal Article
Journal Article
The FEBS Journal, ISSN 1742-464X, 08/2017, Volume 284, Issue 15, pp. 2378 - 2395
The molecular chaperone heat shock protein 90 (Hsp90α) regulates cell proteostasis and mitigates the harmful effects of endogenous and exogenous stressors on... 
Hsp90α | double‐strand break | 17 | DNA | AAG | damage response | ATM | NBN | ionizing radiation | H2AX | DNA damage response | 17-AAG | DNA double-strand break | CANCER-CELLS | DEPENDENT PHOSPHORYLATION | GENOTOXIC STRESS | MRE11 COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | Hsp90 alpha | HISTONE H2AX | HEAT-SHOCK-PROTEIN | HSP90 INHIBITORS | DAMAGE RESPONSE | CELL-CYCLE | IONIZING-RADIATION | Nijmegen Breakage Syndrome - pathology | Ataxia Telangiectasia Mutated Proteins - metabolism | Checkpoint Kinase 2 - chemistry | Humans | Checkpoint Kinase 1 - chemistry | DNA Breaks, Double-Stranded | Cell Cycle Proteins - chemistry | Checkpoint Kinase 2 - metabolism | Proteasome Endopeptidase Complex - drug effects | Ubiquitination - drug effects | Protein Processing, Post-Translational - drug effects | RNA Interference | Gene Deletion | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Cell Cycle Proteins - genetics | HSP90 Heat-Shock Proteins - chemistry | Phosphorylation - drug effects | Nuclear Proteins - genetics | DNA Repair - drug effects | Ataxia Telangiectasia Mutated Proteins - chemistry | Nijmegen Breakage Syndrome - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Nuclear Proteins - metabolism | Lactams, Macrocyclic - pharmacology | Nuclear Proteins - chemistry | Nijmegen Breakage Syndrome - genetics | Benzoquinones - pharmacology | Checkpoint Kinase 1 - metabolism | Point Mutation | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Models, Biological | Protein Stability - drug effects | HSP90 Heat-Shock Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins - genetics | Cell Line, Transformed | Protein Multimerization - drug effects | Amino Acid Substitution | Biotechnology | Hsp90 protein | Phosphorylation | DNA damage | Irradiated | Kinases | DNA repair | Degradation | Proteins | Ionizing radiation | MRE11 protein | Fibroblasts | Ataxia | Inhibition | Localization | Repair | Deoxyribonucleic acid--DNA | CHK2 protein | BRCA1 protein | Alpha rays | Lymphoblastoid cell lines | Heat shock proteins | I.R. radiation | Breast cancer | Clients | Damage localization | DNA-dependent protein kinase | Ataxia telangiectasia | Ataxia telangiectasia mutated protein | Control stability | Iridium | Position (location) | Radiation damage | Adenosine triphosphatase | Heat shock | Index Medicus
Journal Article