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1. Extrinsic Substrate Stiffness Regulates Chondrocyte Phenotype through Actin Remodeling and MRTF Mechanotransduction Pathway
by Nabavi Niaki, Mortah
06/2014
To obtain a cell source for cartilage tissue engineering primary cells are passaged on polystyrene dishes to increase cell number however, this stiff... 
Cartilage | MRTF | 0541 | Actin | dedifferentiation | Tissue Engineering
Dissertation
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2. Full Text RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance
by Lionarons, Daniël A and Hancock, David C and Rana, Sareena and East, Philip and Moore, Christopher and Murillo, Miguel M and Carvalho, Joana and Spencer-Dene, Bradley and Herbert, Eleanor and Stamp, Gordon and Damry, Djamil and Calado, Dinis P and Rosewell, Ian and Fritsch, Ralph and Neubig, Richard R and Molina-Arcas, Miriam and Downward, Julian
Cancer Cell, ISSN 1535-6108, 07/2019, Volume 36, Issue 1, pp. 68 - 83.e9
P29 is the third most commonly mutated codon in human cutaneous melanoma, after V600 and Q61. Here, we study the role of RAC1 in melanoma development and... 
MRTF | SRF | NF1 | PTEN | melanoma | BRAF | RAC1 | EMT | p53
Journal Article
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3. Full Text Pharmacokinetic Optimization of CCG-203971: Novel Inhibitors of the Rho/MRTF/SRF Transcriptional Pathway as Potential Antifibrotic Therapeutics for Systemic Scleroderma
by Hutchings, Kim M and Lisabeth, Erika M and Rajeswaran, Walajapet and Wilson, Michael W and Sorenson, Roderick J and Campbell, Phillip L and Ruth, Jeffrey H and Amin, Asif and Tsou, Pei-Suen and Leipprandt, Jeffrey R and Olson, Samuel R and Wen, Bo and Zhao, Ting and Sun, Duxin and Khanna, Dinesh and Fox, David A and Neubig, Richard R and Larsen, Scott D
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 4/2017, Volume 27, Issue 8, pp. 1744 - 1749
We recently reported the development of a novel inhibitor of Rho-mediated gene transcription ( 1 , CCG-203971) that is efficacious in multiple animal models of... 
Rho | fibrosis | MRTF | Scleroderma | myofibroblast | antifibrotic
Journal Article
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4. Full Text Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels
by Hadden, William J and Young, Jennifer L and Holle, Andrew W and McFetridge, Meg L and Kim, Du Yong and Wijesinghe, Philip and Taylor-Weiner, Hermes and Wen, Jessica H and Lee, Andrew R and Bieback, Karen and Vo, Ba-Ngu and Sampson, David D and Kennedy, Brendan F and Spatz, Joachim P and Engler, Adam J and Cho, Yu Suk
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 22, pp. 5647 - 5652
The spatial presentation of mechanical information is a key parameter for cell behavior. We have developed a method of polymerization control in which the... 
Extracellular matrix | Stem cell differentiation | Stem cell migration | Stiffness | Mechanobiology | mechanobiology | COACTIVATOR | CYTOSKELETON | MULTIDISCIPLINARY SCIENCES | MECHANICAL REGULATION | stiffness | SOFT | stem cell differentiation | MRTF | MYOTUBES | SUBSTRATE STIFFNESS | DIFFERENTIATION | DUROTAXIS DEPENDS | stem cell migration | extracellular matrix | Biological Sciences
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5. Full Text Mechanical strain induces a pro-fibrotic phenotype in human mitral valvular interstitial cells through RhoC/ROCK/MRTF-A and Erk1/2 signaling pathways
by Blomme, Benoit and Deroanne, Christophe and Hulin, Alexia and Lambert, Charles and Defraigne, Jean-Olivier and Nusgens, Betty and Radermecker, Marc and Colige, Alain
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 10/2019, Volume 135, pp. 149 - 159
The mitral valve is a complex multilayered structure populated by fibroblast-like cells, valvular interstitial cells (VIC) which are embedded in an... 
Heart valve disease | MRTF-A | CTGF/CCN2 | Mechanical strain | RhoGTPases | MMV
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6. Full Text When Hippo meets actin in the nucleus
by Chatzifrangkeskou, Maria and O'Neill, Eric
Molecular & Cellular Oncology, ISSN 2372-3556, 09/2019, Volume 6, Issue 5, p. e1638728
Nuclear actin is exported from the nucleus via the Exportin-6 (XPO6)/RAN GTPase complex. We recently identified that RASSF1A and the hippo pathway kinase... 
Exportin-6 | cancer | MRTF-A | RASSF1A | Nuclear actin
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7. Full Text MRTF-A Regulates the Proliferation and Migration of Non-small Cell Lung Cancer Cells of A549 through HOTAIR
by Zhang, Kun and Zhou, Yubin and Feng, Gang and Zeng, Fuchun
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 02/2019, Volume 22, Issue 2, pp. 82 - 89
HOTAIR | MRTF-A | Migration | A549 | Proliferation | Lung neoplasms
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8. Full Text Transcriptional regulation of endothelial-to-mesenchymal transition in cardiac fibrosis: role of myocardin-related transcription factor A and activating transcription factor 31
by Dogra, Nilambra and Saikia, Uma Nahar and Sharma, Vibhuti and Khullar, Madhu
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 2017, Volume 95, Issue 10, pp. 1263 - 1270
The etiology of cardiac fibrogenesis is quite diverse, but a common feature is the presence of activated fibroblasts. Experimental evidence suggests that a... 
diabète | ATF-3 | fibrose cardiaque | MRTF-A | cardiac fibrosis | TEndM | diabetes | EndMT
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9. MRTF induces BEL-7404 hepatocellular carcinoma cell migration
by Jiang, Yong and Jiang, Zhibin and Shao, Guojie and Tian, Yu
Advanced Science Letters, ISSN 1936-6612, 07/2013, Volume 19, Issue 7, pp. 1969 - 1973
Hepatocellular carcinoma | MRTF | AQP1
Journal Article
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10. Full Text RASSF1A is required for the maintenance of nuclear actin levels
by Chatzifrangkeskou, Maria and Pefani, Dafni-Eleftheria and Eyres, Michael and Vendrell, Iolanda and Fischer, Roman and Pankova, Daniela and O'Neill, Eric
The EMBO journal, ISSN 0261-4189, 08/2019, Volume 38, Issue 16, p. e101168
Nuclear actin participates in many essential cellular processes including gene transcription, chromatin remodelling and mRNA processing. Actin shuttles into... 
Signal Transduction | RASSF1A | nuclear envelope | Cell Adhesion, Polarity & Cytoskeleton | Membrane & Intracellular Transport | exportin‐6 | MRTF‐A | nuclear actin
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11. Full Text Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility
by Nikhil Jain and K. Venkatesan Iyer and Abhishek Kumar and G. V. Shivashankar
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2013, Volume 110, Issue 28, pp. 11349 - 11354
Physical forces in the form of substrate rigidity or geometrical constraints have been shown to alter gene expression profile and differentiation programs.... 
Chromatin | 3T3 cells | Cell nucleus | Genes | Actins | Histones | Gene expression regulation | Acetylation | Endothelial cells | Mesenchymal stem cells | MRTF-A signaling | Cell matrix interaction | Chromatin remodelling | Substrate geometry | Transcription control | cell matrix interaction | CHROMATIN-STRUCTURE | MULTIDISCIPLINARY SCIENCES | chromatin remodelling | TRANSCRIPTION | ACTIN DYNAMICS | HISTONE ACETYLATION | transcription control | STRESS FIBERS | SHAPE | NUCLEUS | substrate geometry | MUTANT ACTINS | DIFFERENTIATION | TRICHOSTATIN | Animals | Actomyosin - physiology | Gene Expression Regulation | Histone Deacetylases - metabolism | Transcription, Genetic | Mice | Histones - metabolism | 3T3 Cells | Substrates (Biochemistry) | Myosin | Physiological aspects | Cytogenetics | Genetic aspects | Research | Gene expression | Biological Sciences
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12. Full Text MKL1 overexpression predicts poor prognosis in patients with papillary thyroid cancer and promotes nodal metastasis
by Cheng, X and Xu, SC and Pan, J and Zheng, JX and Wang, XW and Yu, HX and Bao, JD and Xu, Y and Guan, HX and Zhang, L
JOURNAL OF CELL SCIENCE, ISSN 0021-9533, 08/2019, Volume 132, Issue 16, p. jcs231399
Papillary thyroid cancer (PTC), the most common thyroid malignancy, has a strong propensity for cervical lymph node metastasis (LNM), which increases the risk... 
MANAGEMENT | Papillary thyroid cancer | MRTF-A | MMP2 | MKL1 | INDUCTION | COMPARTMENT | CELL BIOLOGY | Lymph node metastasis | TGF-beta | Smad3 | INHIBITS METASTASIS | DISSECTION | PRO-INFLAMMATORY TRANSCRIPTION | EXPRESSION | CARCINOMA
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13. Full Text Sphingosine 1-phosphate signaling induces SNAI2 expression to promote cell invasion in breast cancer cells
by Wang, W and Hind, T and Lam, BWS and Herr, DR
FASEB JOURNAL, ISSN 0892-6638, 06/2019, Volume 33, Issue 6, pp. 7180 - 7191
Epithelial-mesenchymal transition (EMT) is a critical process implicated in the initial stage of cancer metastasis, which is the major cause of tumor... 
TRANSCRIPTION FACTORS | MRTF-A | SPHK1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE 1 | YAP | PROLIFERATION | INDUCTION | EMT | SLUG | RHOA | CELL BIOLOGY | PROTEIN-COUPLED RECEPTOR | SPHINGOSINE-1-PHOSPHATE | BIOLOGY | epithelial-mesenchymal transition
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14. Full Text Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts
by Esnault, Cyril and Stewart, Aengus and Gualdrini, Francesco and East, Phil and Horswell, Stuart and Matthews, Nik and Treisman, Richard
Genes and Development, ISSN 0890-9369, 05/2014, Volume 28, Issue 9, pp. 943 - 958
The transcription factor SRF (serum response factor) recruits two families of coactivators, the MRTFs (myocardin-related transcription factors) and the TCFs... 
Rho | Signal transduction | Chromatin | MRTF | SRF | TCF | MYOCARDIN | ACTIVATION | signal transduction | CHROMATIN LANDSCAPE | SRF ACTIVITY | DEVELOPMENTAL BIOLOGY | chromatin | CELL BIOLOGY | CIRCADIAN CLOCK | HUMAN GENOME | IN-VIVO | GENETICS & HEREDITY | GENE-EXPRESSION | DYNAMICS | KINASE CASCADE | Serum - metabolism | Signal Transduction | Fibroblasts - physiology | Serum Response Factor - metabolism | Actins - metabolism | CLOCK Proteins - genetics | Circadian Clocks - genetics | Animals | Period Circadian Proteins - metabolism | Period Circadian Proteins - genetics | Mice | Transcription, Genetic - genetics | Mitogen-Activated Protein Kinases - metabolism | Influence | Transcription factors | Cellular signal transduction | Research | Genetic transcription | Rho(D) immune globulin | Research Paper
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15. Full Text p75 neurotrophin receptor regulates NGF-induced myofibroblast differentiation and collagen synthesis through MRTF-A
by Liu, Guijun and Liu, Zhenxing and Liu, Jian and Cao, Yongqian and Yin, Siyuan and Ma, Jiaxu and Zhang, Min and Wang, Yibing
Experimental Cell Research, ISSN 0014-4827, 10/2019, Volume 383, Issue 1, p. 111504
Myofibroblasts are characterized by de novo expression of α-smooth muscle actin (α-SMA) and play a key role in tissue repair and remodeling. In addition to... 
p75NTR | MRTF-A | NGF | Differentiation | Myofibroblast | CELLS | CYTOKINES | FACTOR PROMOTES ANGIOGENESIS | TISSUE | TRANSCRIPTION | FIBROBLASTS | NERVE GROWTH-FACTOR | CELL BIOLOGY | INHIBITION | p75(NTR) | ONCOLOGY | SKIN | EXPRESSION
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16. Full Text Epigenetic activation of PERP transcription by MKL1 contributes to ROS-induced apoptosis in skeletal muscle cells
by Li, Zilong and Chen, Baoyu and Dong, Wenhui and Xu, Wenping and Xu, Yong and Song, Mingzi and Fang, Mingming and Guo, Junli
BBA - Gene Regulatory Mechanisms, ISSN 1874-9399, 09/2018, Volume 1861, Issue 9, pp. 905 - 915
Excessive reactive oxygen species (ROS) causes irreparable damages to cells and commit cells to programmed cell death or apoptosis. A panel of well-documented... 
Epigenetics | Transcriptional regulation | ROS | Apoptosis | COMPLEX | MRTF-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | MODEL | HISTONE | FAMILY | P53 | PATHOPHYSIOLOGY | BIOPHYSICS | GENE-EXPRESSION | PRO-INFLAMMATORY TRANSCRIPTION | INDUCED CARDIAC-HYPERTROPHY
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17. Full Text Hypoxia suppresses myofibroblast differentiation by changing RhoA activity
by Leinhos, Lisa and Peters, Johannes and Krull, Sabine and Helbig, Lena and Vogler, Melanie and Levay, Magdolna and Van Belle, Gijsbert J and Ridley, Anne J and Lutz, Susanne and Katschinski, Dörthe M and Zieseniss, Anke
Journal of Cell Science, ISSN 0021-9533, 03/2019, Volume 132, Issue 5, p. jcs223230
Fibroblasts show a high range of phenotypic plasticity, including transdifferentiation into myofibroblasts. Myofibroblasts are responsible for generation of... 
ARHGAP29 | Hypoxia | MRTF-A | Hypoxia-inducible-factor | Myofibroblast | RhoA | SMOOTH MUSCLE ACTIN | INDUCIBLE FACTOR | ACTIVATION | PULMONARY-ARTERY | CELL BIOLOGY | GTPASES | HIF-1-ALPHA | HIF-ALPHA | PROMOTES | EXPRESSION | GENOME-WIDE ASSOCIATION
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18. Full Text The Wnt-β-catenin signaling regulated MRTF-A transcription to activate migration-related genes in human breast cancer cells
by He, Hongpeng and Du, Fu and He, Yongping and Wei, Zhaoqiang and Meng, Chao and Xu, Yuexin and Zhou, Hao and Wang, Nan and Luo, Xue-Gang and Ma, Wenjian and Zhang, Tong-Cun
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 20, pp. 15239 - 15251
MRTF-A is a transcriptional co-activator being critical for multiple processes including tissue fibrosis and cancer metastasis. The Rho-actin signaling... 
Breast cancer | Rho-actin | Metastasis | MRTF-A | Wnt-β-catenin
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19. Full Text Tumor Progression is Mediated by Thymosin-beta 4 through a TGF beta/MRTF Signaling Axis
by Morita, T and Hayashi, K
MOLECULAR CANCER RESEARCH, ISSN 1541-7786, 05/2018, Volume 16, Issue 5, pp. 880 - 893
Although enhanced thymosin beta 4 (TMSB4X/T beta 4) expression is associated with tumor progression and metastasis, its tumor-promoting functions remain... 
TRANSCRIPTION FACTORS | MIGRATION | MYOCARDIN | GROWTH-FACTOR-BETA | ACTIVATION | METASTASIS | MRTF-A | ONCOLOGY | SMOOTH-MUSCLE-CELLS | ACTIN-BINDING | INDUCED RHOA | CELL BIOLOGY
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20. Full Text Steerable Induction of the Thymosin β4/MRTF-A Pathway via AAV-Based Overexpression Induces Therapeutic Neovascularization
by Ziegler, Tilman and Kraus, Markus and Husada, Wira and Gesenhues, Florian and Jiang, Qui and Pinkenburg, Olaf and Trenkwalder, Teresa and Laugwitz, Karl-Ludwig and le Noble, Ferdinand and Weber, Christian and Kupatt, Christian and Hinkel, Rabea
Human Gene Therapy, ISSN 1043-0342, 12/2018, Volume 29, Issue 12, pp. 147 - 1415
Viral vectors have been frequently used in a variety of preclinical animal models to deliver genetic constructs into tissues. Among the vectors used,... 
Research Articles | thymosin b4 | MRTF-A | vessel maturation | AAV | neovascularization | Cytomegalovirus | Animal models | Angiopoietin | Myocardial ischemia | Gene expression | Tissues | Vectors (Biology) | Density | Promoters | Vascularization | Ischemia | Immunogenicity | Perfusion
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