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06/2014
To obtain a cell source for cartilage tissue engineering primary cells are passaged on polystyrene dishes to increase cell number however, this stiff... 
Cartilage | MRTF | 0541 | Actin | dedifferentiation | Tissue Engineering
Dissertation
Cancer Cell, ISSN 1535-6108, 07/2019, Volume 36, Issue 1, pp. 68 - 83.e9
P29 is the third most commonly mutated codon in human cutaneous melanoma, after V600 and Q61. Here, we study the role of RAC1 in melanoma development and... 
MRTF | SRF | NF1 | PTEN | melanoma | BRAF | RAC1 | EMT | p53
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 4/2017, Volume 27, Issue 8, pp. 1744 - 1749
We recently reported the development of a novel inhibitor of Rho-mediated gene transcription ( 1 , CCG-203971) that is efficacious in multiple animal models of... 
Rho | fibrosis | MRTF | Scleroderma | myofibroblast | antifibrotic
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 22, pp. 5647 - 5652
The spatial presentation of mechanical information is a key parameter for cell behavior. We have developed a method of polymerization control in which the... 
Extracellular matrix | Stem cell differentiation | Stem cell migration | Stiffness | Mechanobiology | mechanobiology | COACTIVATOR | CYTOSKELETON | MULTIDISCIPLINARY SCIENCES | MECHANICAL REGULATION | stiffness | SOFT | stem cell differentiation | MRTF | MYOTUBES | SUBSTRATE STIFFNESS | DIFFERENTIATION | DUROTAXIS DEPENDS | stem cell migration | extracellular matrix | Biological Sciences
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 10/2019, Volume 135, pp. 149 - 159
The mitral valve is a complex multilayered structure populated by fibroblast-like cells, valvular interstitial cells (VIC) which are embedded in an... 
Heart valve disease | MRTF-A | CTGF/CCN2 | Mechanical strain | RhoGTPases | MMV
Journal Article
Molecular & Cellular Oncology, ISSN 2372-3556, 09/2019, Volume 6, Issue 5, p. e1638728
Nuclear actin is exported from the nucleus via the Exportin-6 (XPO6)/RAN GTPase complex. We recently identified that RASSF1A and the hippo pathway kinase... 
Exportin-6 | cancer | MRTF-A | RASSF1A | Nuclear actin
Journal Article
Zhongguo fei ai za zhi = Chinese journal of lung cancer, 02/2019, Volume 22, Issue 2, pp. 82 - 89
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 2017, Volume 95, Issue 10, pp. 1263 - 1270
The etiology of cardiac fibrogenesis is quite diverse, but a common feature is the presence of activated fibroblasts. Experimental evidence suggests that a... 
diabète | ATF-3 | fibrose cardiaque | MRTF-A | cardiac fibrosis | TEndM | diabetes | EndMT
Journal Article
Advanced Science Letters, ISSN 1936-6612, 07/2013, Volume 19, Issue 7, pp. 1969 - 1973
Journal Article
The EMBO journal, ISSN 0261-4189, 08/2019, Volume 38, Issue 16, p. e101168
Nuclear actin participates in many essential cellular processes including gene transcription, chromatin remodelling and mRNA processing. Actin shuttles into... 
Signal Transduction | RASSF1A | nuclear envelope | Cell Adhesion, Polarity & Cytoskeleton | Membrane & Intracellular Transport | exportin‐6 | MRTF‐A | nuclear actin
Journal Article
by Cheng, X and Xu, SC and Pan, J and Zheng, JX and Wang, XW and Yu, HX and Bao, JD and Xu, Y and Guan, HX and Zhang, L
JOURNAL OF CELL SCIENCE, ISSN 0021-9533, 08/2019, Volume 132, Issue 16, p. jcs231399
Papillary thyroid cancer (PTC), the most common thyroid malignancy, has a strong propensity for cervical lymph node metastasis (LNM), which increases the risk... 
MANAGEMENT | Papillary thyroid cancer | MRTF-A | MMP2 | MKL1 | INDUCTION | COMPARTMENT | CELL BIOLOGY | Lymph node metastasis | TGF-beta | Smad3 | INHIBITS METASTASIS | DISSECTION | PRO-INFLAMMATORY TRANSCRIPTION | EXPRESSION | CARCINOMA
Journal Article
by Wang, W and Hind, T and Lam, BWS and Herr, DR
FASEB JOURNAL, ISSN 0892-6638, 06/2019, Volume 33, Issue 6, pp. 7180 - 7191
Epithelial-mesenchymal transition (EMT) is a critical process implicated in the initial stage of cancer metastasis, which is the major cause of tumor... 
TRANSCRIPTION FACTORS | MRTF-A | SPHK1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE 1 | YAP | PROLIFERATION | INDUCTION | EMT | SLUG | RHOA | CELL BIOLOGY | PROTEIN-COUPLED RECEPTOR | SPHINGOSINE-1-PHOSPHATE | BIOLOGY | epithelial-mesenchymal transition
Journal Article
Experimental Cell Research, ISSN 0014-4827, 10/2019, Volume 383, Issue 1, p. 111504
Myofibroblasts are characterized by de novo expression of α-smooth muscle actin (α-SMA) and play a key role in tissue repair and remodeling. In addition to... 
p75NTR | MRTF-A | NGF | Differentiation | Myofibroblast | CELLS | CYTOKINES | FACTOR PROMOTES ANGIOGENESIS | TISSUE | TRANSCRIPTION | FIBROBLASTS | NERVE GROWTH-FACTOR | CELL BIOLOGY | INHIBITION | p75(NTR) | ONCOLOGY | SKIN | EXPRESSION
Journal Article
BBA - Gene Regulatory Mechanisms, ISSN 1874-9399, 09/2018, Volume 1861, Issue 9, pp. 905 - 915
Excessive reactive oxygen species (ROS) causes irreparable damages to cells and commit cells to programmed cell death or apoptosis. A panel of well-documented... 
Epigenetics | Transcriptional regulation | ROS | Apoptosis | COMPLEX | MRTF-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | MODEL | HISTONE | FAMILY | P53 | PATHOPHYSIOLOGY | BIOPHYSICS | GENE-EXPRESSION | PRO-INFLAMMATORY TRANSCRIPTION | INDUCED CARDIAC-HYPERTROPHY
Journal Article
Journal of Cell Science, ISSN 0021-9533, 03/2019, Volume 132, Issue 5, p. jcs223230
Fibroblasts show a high range of phenotypic plasticity, including transdifferentiation into myofibroblasts. Myofibroblasts are responsible for generation of... 
ARHGAP29 | Hypoxia | MRTF-A | Hypoxia-inducible-factor | Myofibroblast | RhoA | SMOOTH MUSCLE ACTIN | INDUCIBLE FACTOR | ACTIVATION | PULMONARY-ARTERY | CELL BIOLOGY | GTPASES | HIF-1-ALPHA | HIF-ALPHA | PROMOTES | EXPRESSION | GENOME-WIDE ASSOCIATION
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 20, pp. 15239 - 15251
MRTF-A is a transcriptional co-activator being critical for multiple processes including tissue fibrosis and cancer metastasis. The Rho-actin signaling... 
Breast cancer | Rho-actin | Metastasis | MRTF-A | Wnt-β-catenin
Journal Article
MOLECULAR CANCER RESEARCH, ISSN 1541-7786, 05/2018, Volume 16, Issue 5, pp. 880 - 893
Although enhanced thymosin beta 4 (TMSB4X/T beta 4) expression is associated with tumor progression and metastasis, its tumor-promoting functions remain... 
TRANSCRIPTION FACTORS | MIGRATION | MYOCARDIN | GROWTH-FACTOR-BETA | ACTIVATION | METASTASIS | MRTF-A | ONCOLOGY | SMOOTH-MUSCLE-CELLS | ACTIN-BINDING | INDUCED RHOA | CELL BIOLOGY
Journal Article
Human Gene Therapy, ISSN 1043-0342, 12/2018, Volume 29, Issue 12, pp. 147 - 1415
Viral vectors have been frequently used in a variety of preclinical animal models to deliver genetic constructs into tissues. Among the vectors used,... 
Research Articles | thymosin b4 | MRTF-A | vessel maturation | AAV | neovascularization | Cytomegalovirus | Animal models | Angiopoietin | Myocardial ischemia | Gene expression | Tissues | Vectors (Biology) | Density | Promoters | Vascularization | Ischemia | Immunogenicity | Perfusion
Journal Article
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