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1. Full Text Double-Strand Break End Resection and Repair Pathway Choice
by Symington, Lorraine S and Gautier, Jean
Annual Review of Genetics, ISSN 0066-4197, 12/2011, Volume 45, Issue 1, pp. 247 - 271
DNA double-strand breaks (DSBs) are cytotoxic lesions that can result in mutagenic events or cell death if left unrepaired or repaired inappropriately. Cells... 
checkpoint | Sae2 CtIP Ctp1 | MRX N | homologous recombination | nonhomologous end joining | Nonhomologous end joining | Sae2/CtIP/Ctp1 | MRX/N | Checkpoint | Homologous recombination | NUCLEASE ACTIVITY | DNA-DAMAGE RESPONSE | CYCLIN-DEPENDENT KINASE | CHROMOSOMAL TRANSLOCATION FORMATION | FANCONI-ANEMIA PATHWAY | GENETICS & HEREDITY | SACCHAROMYCES-CEREVISIAE MRE11 | CLASS-SWITCH RECOMBINATION | CELL-CYCLE | CHECKPOINT ACTIVATION | Gene Expression Regulation, Fungal | DNA Helicases - chemistry | Translocation, Genetic | Recombinational DNA Repair | Saccharomyces cerevisiae - genetics | Humans | Saccharomyces cerevisiae Proteins - genetics | DNA Breaks, Double-Stranded | Saccharomyces cerevisiae - chemistry | Animals | Cell Cycle | DNA End-Joining Repair | Genes, Fungal | Protein Conformation | Fanconi Anemia - genetics | Exodeoxyribonucleases - chemistry | Exodeoxyribonucleases - genetics | Genes, BRCA1 | DNA Helicases - genetics | Genes, cdc | Saccharomyces cerevisiae Proteins - chemistry | DNA repair | Research
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2. Full Text Plasticity of the Mre11-Rad50-Xrs2-Sae2 nuclease ensemble in the processing of DNA-bound obstacles
by Wang, Weibin and Daley, James M and Kwon, Youngho and Krasner, Danielle S and Sung, Patrick
Genes and Development, ISSN 0890-9369, 12/2017, Volume 31, Issue 23-24, pp. 2331 - 2336
The budding yeast Mre11-Rad50-Xrs2 (MRX) complex and Sae2 function together in DNA end resection during homologous recombination. Here we show that the Ku... 
MRX-Sae2 | RPA | Nuclease | DNA end resection | Nucleosome | Ku70-Ku80 | MRE11 | CLEAVAGE CENTER | DEVELOPMENTAL BIOLOGY | DOUBLE-STRAND BREAK | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | REPAIR | nuclease | EXO1 | GENETICS & HEREDITY | nucleosome | ECORI ENDONUCLEASE | HOMOLOGOUS RECOMBINATION | END RESECTION | PROTEINS | Saccharomyces cerevisiae - physiology | Saccharomyces cerevisiae - genetics | DNA Repair - physiology | Multienzyme Complexes - metabolism | Endonucleases - metabolism | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - metabolism | Multiprotein Complexes - metabolism | DNA End-Joining Repair | Endodeoxyribonucleases - metabolism | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Enzyme Activation - genetics | Exonucleases - metabolism | DNA Cleavage | Research Communication | Ku70–Ku80 | MRX–Sae2
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3. Full Text Magnetic relaxation of magnetic nanoparticles under the influence of shear flow
by Slabu, I and Liebl, M and Wiekhorst, F and Eberbeck, D
JOURNAL OF PHYSICS D-APPLIED PHYSICS, ISSN 0022-3727, 05/2019, Volume 52, Issue 20, p. 205002
We investigate the magnetic relaxation behavior of magnetic nanoparticles (MNP) under the influence of shear flow. To this end, we employed magnetorelaxometry... 
magnetic relaxation | magnetorelaxometry (MRX) | PHYSICS, APPLIED | magnetic properties | shear flow | SUSPENSIONS | interparticle interactions | hydrodynamic interaction | MAGNETORELAXOMETRY
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4. Full Text Keeping it real: MRX-Sae2 clipping of natural substrates
by Gnügge, Robert and Symington, Lorraine S
Genes and Development, ISSN 0890-9369, 12/2017, Volume 31, Issue 23-24, pp. 2311 - 2312
The yeast Mre11-Rad50-Xrs2 (MRX) complex and Sae2 function together to initiate DNAend resection, an essential early step in homology-dependent repair of DNA... 
MRX-Sae2 | RPA | Homologous recombination | Nucleosome | Nuclease | DNA end resection | Ku70-Ku80 | MRE11 | DOUBLE-STRAND BREAKS | DEVELOPMENTAL BIOLOGY | DNA-END RESECTION | CELL BIOLOGY | homologous recombination | nuclease | EXO1 | GENETICS & HEREDITY | nucleosome | SAE2 | Endodeoxyribonucleases - genetics | Saccharomyces cerevisiae - genetics | DNA Repair | Exodeoxyribonucleases - genetics | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | DNA Breaks, Double-Stranded | Outlook | Ku70–Ku80 | MRX–Sae2
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5. Full Text The MRX complex regulates Exo1 resection activity by altering DNA end structure
by Gobbini, Elisa and Cassani, Corinne and Vertemara, Jacopo and Wang, Weibin and Mambretti, Fabiana and Casari, Erika and Sung, Patrick and Tisi, Renata and Zampella, Giuseppe and Longhese, Maria Pia
The EMBO Journal, ISSN 0261-4189, 08/2018, Volume 37, Issue 16, p. n/a
Homologous recombination is triggered by nucleolytic degradation (resection) of DNA double‐strand breaks (DSBs). DSB resection requires the Mre11‐Rad50‐Xrs2... 
MRX | Exo1 | Sae2 | double‐strand break | resection | double-strand break | MRE11 | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEASE ACTIVITIES | MRE11-RAD50-XRS2 | KU PROTEIN | CELL BIOLOGY | REPAIR | HOMOLOGOUS RECOMBINATION | CHECKPOINT ACTIVATION | FUNCTIONAL MRX | DNA, Fungal - genetics | Saccharomyces cerevisiae - genetics | Multiprotein Complexes - genetics | Saccharomyces cerevisiae Proteins - genetics | DNA Breaks, Double-Stranded | Saccharomyces cerevisiae - metabolism | Multiprotein Complexes - metabolism | Endodeoxyribonucleases - genetics | DNA, Fungal - metabolism | Endodeoxyribonucleases - metabolism | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Domains | Exodeoxyribonucleases - genetics | Biodegradation | DNA structure | Capping | Yeast | Melting | DNA damage | Homologous recombination | Unwinding | Molecular dynamics | Homology | Double-strand break repair | Rotation | MRE11 protein | Nuclease | Deoxyribonucleic acid--DNA | DNA Replication, Repair & Recombination
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6. Full Text Structural analysis of DEMO divertor cassette body and design study based on RCC-MRx
by Frosi, Paolo and Bachmann, Christian and Di Gironimo, Giuseppe and Mazzone, Giuseppe and Marzullo, Domenico and You, Jeong-Ha
Fusion Engineering and Design, ISSN 0920-3796, 11/2017, Volume 124, pp. 628 - 632
This paper refers to the activity of structural design of DEMO Divertor in the framework of the EUROfusion Consortium. The structural analysis and its... 
RCC-MRx | Thermal analysis | DEMO | Divertor | FEM | Structural analysis | LOCKING SYSTEM | NUCLEAR SCIENCE & TECHNOLOGY | VACUUM VESSEL | Plasma physics
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7. Full Text The DEMO Helium Cooled Lithium Lead “advanced-plus” Breeding Blanket: Design improvement and FEM studies
by Boullon, Rémi and Aubert, Julien and Aiello, Giacomo and Jaboulay, Jean-Charles and Morin, Alexandre
Fusion Engineering and Design, ISSN 0920-3796, 09/2019, Volume 146, pp. 2026 - 2030
In the framework of the European “HORIZON 2020” research program, the EUROfusion Consortium develops a design of a fusion demonstrator (DEMO). CEA-Saclay, with... 
Finite elements | HCLL | Breeding Blanket | DEMO | Thermo-mechanic | RCC-MRx code
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8. Full Text Engineering C‐integral and COD estimates for nonidealized circumferential through‐wall cracked pipes at elevated temperature
by Won, Min‐Gu and Kim, Kyunghoon and Huh, Nam‐Su and Kim, Woo‐Gon and Lee, Hyeong‐Yeon
Fatigue & Fracture of Engineering Materials & Structures, ISSN 8756-758X, 02/2019, Volume 42, Issue 2, pp. 494 - 503
In this study, creep fracture mechanics parameters, C*‐integral and crack opening displacement (COD) rate, are estimated for a nonidealized circumferential... 
RCC‐MRx creep model | GE/EPRI method | nonidealized through‐wall crack | creep fracture mechanics parameter | enhanced reference stress method | Norton creep model | nonidealized through-wall crack | RCC-MRx creep model | MATERIALS SCIENCE, MULTIDISCIPLINARY | OPENING DISPLACEMENT | ENGINEERING, MECHANICAL | Axial stress | Finite element method | Crack opening displacement | Bending moments | Fracture mechanics | Integrals | Circumferences | Mathematical models | High temperature | Pipes | Internal pressure
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9. Full Text Thermo-mechanical analyses and ways of optimization of the helium cooled DEMO First Wall under RCC-MRx rules
by Aubert, J and Aiello, G and Arena, P and Boullon, R and Jaboulay, J.-C and Morin, A
Fusion Engineering and Design, ISSN 0920-3796, 11/2017, Volume 124, pp. 473 - 477
The EUROfusion Consortium develops a design of a fusion power demonstrator plant (DEMO) in the framework of the European “Horizon 2020” innovation and research... 
RCC-MRx | Thermo-mechanics | Breeding Blanket | Cast3M | HCLL | DEMO | First Wall | NUCLEAR SCIENCE & TECHNOLOGY | BLANKET | Analysis | Nuclear reactors
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10. Full Text Role of the Mre11 complex in preserving genome integrity
by Oh, Julyun and Symington, Lorraine S
Genes, ISSN 2073-4425, 12/2018, Volume 9, Issue 12, p. 589
DNA double-strand breaks (DSBs) are hazardous lesions that threaten genome integrity and cell survival. The DNA damage response (DDR) safeguards the genome by... 
DNA damage checkpoint | MRX/N | Rad50 | DSB | Mre11 | Homologous recombination | Sae2/Ctp1/ctIP | DNA repair | Tel1/ATM | Xrs2/Nbs1 | SISTER-CHROMATID COHESION | Sae2/Ctp1/CtIP | FORKHEAD-ASSOCIATED DOMAIN | SACCHAROMYCES-CEREVISIAE | S-PHASE CHECKPOINT | DOUBLE-STRAND-BREAK | DAMAGE RESPONSE | homologous recombination | GROSS CHROMOSOMAL REARRANGEMENTS | GENETICS & HEREDITY | TELANGIECTASIA-MUTATED ATM | RAD50 HOOK DOMAIN | DNA-END-RESECTION
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