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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Index Medicus | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | ACTIVATED PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | mitogen-activated protein kinase (MAPK) | MSK1 | INDUCTION | IDENTIFICATION | INACTIVATION | CREB | GROWTH | BI-DI870 | SUPPRESSES | phosphorylation | kinase-specific inhibitor | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | protein kinase C | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2005, Volume 387, Issue 2, pp. 507 - 517
MSK1 (mitogen- and stress-activated protein kinase) is a kinase activated in cells downstream of both the ERK1/2 (extracellular-signal-regulated kinase) and... 
MSK2 | Mitogen- and stress-activated protein kinase (MSK1) | 3-Phosphoinositide-dependent protein kinase 1 (PDK1) | P38 | Extracellular-signal-regulated kinase (ERK) | P90 ribosomal S6 kinase (RSK) | Amino Acid Sequence | Cell Line | Phosphorylation | Mutagenesis, Site-Directed | Humans | Molecular Sequence Data | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Enzyme Activation | Mitogens | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | mitogen- and stress-activated protein kinase (MSK1) | 3-phosphoinositide-dependent protein kinase 1 (PDK1) | PDK1, 3-phosphoinositide-dependent protein kinase 1 | GST, glutathione S-transferase | HEK-293 cells, human embryonic kidney 293 cells | RSK, p90 ribosomal S6 kinase | extracellular-signal-regulated kinase (ERK) | ERK, extracellular-signal-regulated kinase | MALDI–TOF, matrix-assisted laser-desorption ionization–time of flight | PEI, polyethyleneimine | p38 | DMEM, Dulbecco's modified Eagle's medium | MAPKAP-K, MAPK-activated protein kinase | MEF, mouse embryonic fibroblast | PH domain, pleckstrin homology domain | MSK, mitogen- and stress-activated protein kinase | p90 ribosomal S6 kinase (RSK) | PIP3, phosphatidylinositol 3,4,5-trisphosphate | MAPK, mitogen-activated protein kinase | PKA, PKB, PKC and PKG, protein kinases A, B, C and G respectively | TFA, trifluoroacetic acid
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2016, Volume 64, Issue 2, pp. 347 - 361
Journal Article
FEBS Letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7‐tetrabromo‐2‐azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase‐2 (CK2), has been examined... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | DRB, 1-(β | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | ribofuranosyl)-5,6-dichlorobenzimidazole | PKA, cAMP-dependent protein kinase | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects | Index Medicus
Journal Article
FEBS Letters, ISSN 0014-5793, 2003, Volume 550, Issue 1, pp. 107 - 113
The receptor for advanced glycation end‐products (RAGE)‐mediated cellular activation through the mitogen‐activated protein kinase (MAPK) cascade, activation of... 
Extracellular signal-regulated kinase | Receptor for advanced glycation end-products | Amphoterin | ERK, extracellular signal-regulated kinase | RSK, ribosomal S6 kinase | RAGE, receptor for AGE | 2D-PAGE, two-dimensional polyacrylamide gel electrophoresis | MSK, mitogen- and stress-activated protein kinase | AGE, advanced glycation end-product | MnK, MAPK-interacting kinase | MAPK, mitogen-activated protein kinase | extracellular signal-regulated kinase | DNA-BINDING | amphoterin | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR-KAPPA-B | MAP KINASES | CELL BIOLOGY | SUBSTRATE-SPECIFICITY | PTP-SL | INTERACTION MOTIF | BIOPHYSICS | CELL-SURFACE RECEPTOR | NEURITE OUTGROWTH | ENDOTHELIAL-CELLS | ACTIVATED PROTEIN-KINASES | receptor for advanced glycation end-products | Sequence Deletion | Rats, Wistar | Mitogen-Activated Protein Kinases - isolation & purification | Humans | Lung - chemistry | Cytoplasm - metabolism | Male | Receptors, Immunologic - drug effects | HMGB1 Protein - pharmacology | Binding Sites - physiology | Conserved Sequence | Myelin Basic Protein - drug effects | Lung - metabolism | Phosphorylation - drug effects | Receptor for Advanced Glycation End Products | Protein Structure, Tertiary | Amino Acid Sequence | Myelin Basic Protein - metabolism | Cells, Cultured | Rats | Mitogen-Activated Protein Kinase 1 - isolation & purification | Animals | Cell Extracts | Mice | Receptors, Immunologic - genetics | Mitogen-Activated Protein Kinase 3 | Receptors, Immunologic - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Mitogen-Activated Protein Kinases - metabolism | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2005, Volume 390, Issue 3, pp. 749 - 759
MSK (mitogen- and stress-activated protein kinase) 1 and MSK2 are kinases activated downstream of either the ERK (extracellular-signal-regulated kinase) 1/2 or... 
Nurr1 | Nur77 | p38 | Mitogen- and stress-activated protein kinase (MSK) | Nor1 | Extracellular-signal-regulated kinase (ERK) | mitogen-and stress-activated protein kinase (MSK) | NEGATIVE INHIBITOR | ACTIVATED PROTEIN-KINASE | STRESS-INDUCED PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN | NERVE GROWTH-FACTOR | extracellular-signal-regulated kinase (ERK) | MEMBRANE DEPOLARIZATION | NGFI-B | EMBRYONIC STEM-CELLS | GENE-EXPRESSION | NF-KAPPA-B | Tetradecanoylphorbol Acetate | Ribosomal Protein S6 Kinases - metabolism | Nuclear Receptor Subfamily 4, Group A, Member 1 | Nuclear Receptor Subfamily 4, Group A, Member 2 | MAP Kinase Signaling System | CREB-Binding Protein - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Receptors, Thyroid Hormone - genetics | Fibroblasts | Transcription, Genetic | Promoter Regions, Genetic | Cells, Cultured | Receptors, Cytoplasmic and Nuclear - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | Tumor Necrosis Factor-alpha | Epidermal Growth Factor | Mice, Knockout | Animals | Anisomycin | Receptors, Steroid - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Mice | Ribosomal Protein S6 Kinases - genetics | Index Medicus | TCR, T-cell receptor | AP-1, activator protein-1 | EGF, epidermal growth factor | NGFI-B, NGF-induced B factor | TNF, tumour necrosis factor α | NGF, nerve growth factor | CRE, cAMP response element | MEF2D, myocyte-enhancer-binding factor 2D | mitogen- and stress-activated protein kinase (MSK) | ATF1, activating transcription factor-1 | ERK, extracellular-signal-regulated kinase | PKI, PKA inhibitor | DMEM, Dulbecco's modified Eagle's medium | CREB, CRE-binding protein | MEF, murine embryonic fibroblast | NBRE, NGFI-B response element | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | PKA, protein kinase A
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2013, Volume 450, Issue 2, pp. 351 - 363
ERK1/2 (extracellular-signal-regulated kinase 1/2) and their substrates RSKs (p90 ribosomal S6 kinases) phosphorylate different transcription factors,... 
Endothelin | α1-adrenergic receptor | P90 ribosomal S6 kinase (p90 RSK) | Transcriptomics | Cardiomyocyte | Mitogen-activated protein kinase (MAPK) | SNK, Student–Newman–Keuls | Lif, leukaemia inhibitory factor | Olr1, oxidized low-density lipoprotein (lectin-like) receptor 1 | Dusp, dual-specificity phosphatase | MNK, MAPK-interacting protein kinase | CREB, cAMP-response-element-binding protein | PKB, protein kinase B | ERK1 | RSK, ribosomal S6 kinase | transcriptomics | PE, phenylephrine | p90 ribosomal S6 kinase (p90 RSK) | AR, adrenergic receptor | Egr, early growth response | BH-MTC, Benjamini and Hochberg multiple testing correction | mitogen-activated protein kinase (MAPK) | ET-1, endothelin-1 | β, glycogen synthase kinase 3α | AMPKα, AMP-activated protein kinase α | Areg, amphiregulin | MKK, MAPK kinase | Rgs2, regulator of G-protein signalling 2, 24 kDa | 2, extracellular-signal-regulated kinase 1 | Atf3, activating transcription factor 3 | Klf, Krüppel-like factor | endothelin | GSK3α | Gapdh, glyceraldehyde 3-phosphate dehydrogenase | Plk2, polo-like kinase 2 | Nr4a, nuclear receptor subfamily 4, group A | Sik1, salt-inducible kinase 1 | cardiomyocyte | FDR, false discovery rate | Fosb, FBJ murine osteosarcoma viral oncogene homologue B | MSK, mitogen- and stress-activated protein kinase | IL11, interleukin 11 | NPE, nuclear protein-enriched | MAPK, mitogen-activated protein kinase | Ptgs2, prostaglandin-endoperoxide synthase 2, qPCR, quantitative PCR | Has, hyaluronan synthase
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2012, Volume 586, Issue 19, pp. 3471 - 3476
► TPCK inhibits all tested AGC kinases with phenylalanine-directed, cysteine-containing activation loops, including RSK1, Akt1, S6K1, MSK1 and MSK2. ► Mass... 
Signal transduction | Reversible phosphorylation | Mass spectrometry | Kinase inhibitor | TPCK | MSK | mitogen and stress-activated protein kinase | phosphatidylinositol-3 kinase | related to protein kinase A, protein kinase G and protein kinase C | PKA | S6 kinase | S6K | RSK | N-alpha-tosyl | PI3K | ribosomal S6 kinase | 3-phosphoinositide dependent protein kinase-1 | protein kinase A | phenylalanyl chloromethyl ketone | AGC | PDK1 | ERK | extracellular signal regulated kinase | SIGNAL | PROTEIN KINASE-1 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | CANCER | CELL BIOLOGY | BIOPHYSICS | PATHWAY | RESISTANCE | MURINE BRAIN | S6 KINASE | Amino Acid Sequence | Protein Kinases - genetics | Mutagenesis, Site-Directed | Proto-Oncogene Proteins c-akt - chemistry | Humans | Molecular Sequence Data | Protein Kinases - chemistry | DNA Primers - genetics | Cysteine - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Proto-Oncogene Proteins c-akt - genetics | Amino Acid Motifs | Sequence Homology, Amino Acid | Phenylalanine - chemistry | Base Sequence | Ribosomal Protein S6 Kinases, 90-kDa - genetics | HEK293 Cells | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Conserved Sequence | Protein Kinase Inhibitors - pharmacology | Tosylphenylalanyl Chloromethyl Ketone - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Amino Acid Substitution | Amino acids | Thiols | Mitogens | Protein kinases | Index Medicus
Journal Article
Inflammation Research, ISSN 1023-3830, 12/2009, Volume 58, Issue 12, pp. 863 - 872
Lipopolysaccharide (LPS) stimulates the production of inflammatory cytokines and the amplification of immune responses via MAPK pathways. MAPK phosphatases... 
MAPK phosphatase 1 (MKP-1) | CAMP response element binding protein (CREB) | Protein kinase A (PKA) | Mitogen- and stress-activated protein kinase (MSK) | Toll-like receptor ligand (TLRL) | CELLS | SIGNALING PATHWAYS | CYCLOOXYGENASE-2 | SPECIFICITY | PHOSPHORYLATION | IMMUNOLOGY | CELL BIOLOGY | CREB | GENE | INNATE IMMUNE-RESPONSES | KINASE PHOSPHATASE-1 | cAMP response element binding protein (CREB) | EXPRESSION | Molecular Sequence Data | Lipopolysaccharides - immunology | Cell Line - drug effects | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Isoquinolines - pharmacology | Base Sequence | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Genes, Reporter | Cyclic AMP-Dependent Protein Kinases - metabolism | Dual Specificity Phosphatase 1 - genetics | Enzyme Induction | Sulfonamides - pharmacology | Cyclic AMP Response Element-Binding Protein - genetics | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Cyclic AMP Response Element-Binding Protein - metabolism | Lipopolysaccharides - pharmacology | Dual Specificity Phosphatase 1 - metabolism | Mitogen-Activated Protein Kinases - genetics | Signal Transduction - physiology | Mice | Protein Kinase Inhibitors - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Messenger RNA | Phosphatases | Immunotherapy | Pharmacy | Mitogens | Protein kinases | Protein binding | Index Medicus
Journal Article
FEBS Letters, ISSN 0014-5793, 05/2013, Volume 587, Issue 10, pp. 1510 - 1517
Journal Article
Biochemical Journal, ISSN 0264-6021, 10/2005, Volume 391, Issue 2, pp. 433 - 440
The neurite outgrowth inhibitor protein Nogo is one of 300 proteins that contain a reticulon homology domain, which is responsible for their association with... 
Nogo (neurite outgrowth inhibitor protein) | MAPK (mitogen-activated protein kinase)-activated protein kinase-K2 (MAPKAP-K2) | Microtubule | p38 (p38 MAPK) | microtubule | BIOCHEMISTRY & MOLECULAR BIOLOGY | Amino Acid Sequence | Cell Line | Phosphorylation | Molecular Weight | Humans | Intracellular Signaling Peptides and Proteins | Myelin Proteins - isolation & purification | Substrate Specificity | Mitogen-Activated Protein Kinase 11 - metabolism | Myelin Proteins - chemistry | Microtubules - metabolism | Animals | Mitogen-Activated Protein Kinase 14 - metabolism | RNA Interference | Antibodies, Phospho-Specific - immunology | Lipopolysaccharides - pharmacology | Myelin Proteins - immunology | Mice | Nogo Proteins | Myelin Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | MNK1, MAPK integrating kinase-1 | NgR, Nogo (neurite outgrowth inhibitor protein) receptor | MAPKAP, MAPK-activated protein kinase | SAPK, stress-activated protein kinase | 5-LO, 5-lipoxygenase | HSP27, heat-shock protein of 27 kDa | OMgp, oligodendrocyte myelin glycoprotein | GFP, green fluorescent protein | PKA, cyclic AMP-dependent protein kinase | GST, glutathione S-transferase | hnRNP A0, heterogeneous nuclear ribonucleoprotein A0 | ORF, open reading frame | siRNA, small interfering RNA | CNS, central nervous system | MEF, mouse embryonic fibroblast | LPS, lipopolysaccharide | MAG, myelin-associated glycoprotein | MSK, mitogen- and stress-activated protein kinase | MBP, maltose-binding protein | ER, endoplasmic reticulum | MKK6, MAPK kinase 6 | PDI, protein disulphide-isomerase | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2015, Volume 465, Issue 2, pp. 271 - 279
Macrophages switch to an anti-inflammatory, 'regulatory'-like phenotype characterized by the production of high levels of interleukin (IL)-10 and low levels of... 
Chemical biology | Dasatinib | Inflammation | Interleukin-10 | Salt-inducible kinase | Bosutinib | REGULATORY MACROPHAGES | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IL-10 PRODUCTION | interleukin-10 | MYELOID-LEUKEMIA PATIENT | SIGNAL-TRANSDUCTION | BRUTONS TYROSINE KINASE | dasatinib | chemical biology | inflammation | salt-inducible kinase | ENDOTOXIN TOLERANCE | IN-VIVO | SELECTIVITY | bosutinib | Aniline Compounds - pharmacology | Tumor Necrosis Factor Ligand Superfamily Member 14 - immunology | Immunity, Innate - drug effects | Nitriles - pharmacology | Phosphotransferases (Alcohol Group Acceptor) - immunology | Cells, Cultured | Macrophages - cytology | Pyrimidines - pharmacology | Quinolines - pharmacology | Arginase - immunology | Animals | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - immunology | Protein-Serine-Threonine Kinases - immunology | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Transcription Factors - immunology | Macrophages - immunology | Cytokines - immunology | Index Medicus | IRF, interferon regulatory factor | TLR, Toll-like receptor | IKK, IκB kinase | PGE2, prostaglandin E2 | Btk, Bruton’s tyrosine kinase | JNK, c-Jun N-terminal kinase | SIK, salt-inducible kinases | CREB, cAMP-response-element-binding protein | qPCR, quantitative real-time PCR | MSK, mitogen- and stress-activated protein kinases | HDAC, histone deacetylase | IκB, inhibitor of NF-κB | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | CRTC, CREB-regulated transcription co-activator | NF-κB, nuclear factor κB | Pam3CSK4, tripalmitoylcysteinylseryl-(lysyl)4 | M-CSF, macrophage colony-stimulating factor | HA, haemagglutinin | 2, extracellular-signal-regulated kinase 1 | DMEM, Dulbecco’s modified Eagle’s medium | IL, interleukin | LPS, lipopolysaccharide | ERK 1 | TBK1, TANK-binding kinase 1 | MAPK, mitogen-activated protein kinase
Journal Article