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Oncotarget, ISSN 1949-2553, 06/2018, Volume 9, Issue 47, pp. 28625 - 28637
Genotype specific vulnerabilities of cancer cells constitute a promising strategy for the development of new therapeutics. Deletions of non-essential genes in... 
PRMT5 | MTAP | Target | RIOK1 | Cancer
Journal Article
Cell Reports, ISSN 2211-1247, 09/2019, Volume 28, Issue 12, pp. 3199 - 3211.e5
H2AX safeguards genomic stability in a dose-dependent manner; however, mechanisms governing its proteostasis are poorly understood. Here, we identify a... 
H2AX | RNF168 | PRMT5 | MTAP | glioblastoma | SMURF2 | METHYLATION | PROTEIN | RECOGNITION | METHYLTHIOADENOSINE | PHOSPHORYLASE MTAP EXPRESSION | UBIQUITIN | ARGININE METHYLTRANSFERASE | HISTONE H2AX | DNA-REPAIR | CELL BIOLOGY
Journal Article
Journal Article
EJSO, ISSN 0748-7983, 09/2014, Volume 40, Issue 9, pp. 1143 - 1150
Objectives: Methylthioadenosine phosphorylase (MTAP), a ubiquitously expressed protein, plays important roles in purine biosynthesis. Locating near to each... 
Immunohistochemistry | SURGERY | HOMOZYGOUS DELETION | MESOTHELIOMAS | CODELETION | Prognosis | Lung cancer | DOWN-REGULATION | MALIGNANT-MELANOMA | DEFICIENCY | Methylthioadenosine phosphorylase (MTAP) | HEPATOCELLULAR-CARCINOMA | p16 | GENE | ONCOLOGY | METHYLTHIOADENOSINE PHOSPHORYLASE MTAP | PROGRESSION
Journal Article
Journal of Cancer, ISSN 1837-9664, 2019, Volume 10, Issue 4, pp. 927 - 936
While the metabolic changes in cancer tissues were first observed by Warburg Otto almost a century ago, altered metabolism has recently returned as a focus of... 
MTAP | Polyamine | MTA | Metabolism | Cancer | RAT-LIVER CARCINOGENESIS | ORNITHINE-DECARBOXYLASE ACTIVITY | HUMAN BREAST-CANCER | POLYAMINE METABOLISM | COLON-CANCER | S-ADENOSYLMETHIONINE | ADENOSYL-L-METHIONINE | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | METHYLTHIOADENOSINE PHOSPHORYLASE MTAP | GENE-EXPRESSION
Journal Article
by Hmeljak, Julija and Sanchez-Vega, Francisco and Hoadley, Katherine A and Shih, Juliann and Stewart, Chip and Heiman, David and Tarpey, Patrick and Danilova, Ludmila and Drill, Esther and Gibb, Ewan A and Bowlby, Reanne and Kanchi, Rupa and Osmanbeyoglu, Hatice U and Sekido, Yoshitaka and Takeshita, Jumpei and Newton, Yulia and Graim, Kiley and Gupta, Manaswi and Gay, Carl M and Diao, Lixia and Gibbs, David L and Thorsson, Vesteinn and Iype, Lisa and Kantheti, Havish and Severson, David T and Ravegnini, Gloria and Desmeules, Patrice and Jungbluth, Achim A and Travis, William D and Dacic, Sanja and Chirieac, Lucian R and Galateau-Sallé, Françoise and Fujimoto, Junya and Husain, Aliya N and Silveira, Henrique C and Rusch, Valerie W and Rintoul, Robert C and Pass, Harvey and Kindler, Hedy and Zauderer, Marjorie G and Kwiatkowski, David J and Bueno, Raphael and Tsao, Anne S and Creaney, Jenette and Lichtenberg, Tara and Leraas, Kristen and Bowen, Jay and Felau, Ina and Zenklusen, Jean Claude and Akbani, Rehan and Cherniack, Andrew D and Byers, Lauren A and Noble, Michael S and Fletcher, Jonathan A and Robertson, A. Gordon and Shen, Ronglai and Aburatani, Hiroyuki and Robinson, Bruce W and Campbell, Peter and Ladanyi, Marc and Ally, Adrian and Anur, Pavana and Armenia, Joshua and Auman, J. Todd and Balasundaram, Miruna and Balu, Saianand and Baylin, Stephen B and Becich, Michael and Behrens, Carmen and Beroukhim, Rameen and Bielski, Craig and Bodenheimer, Tom and Bootwalla, Moiz S and Brooks, Denise and Byers, Lauren A and Cárcano, Flávio M and Carlsen, Rebecca and Carvalho, Andre L and Cheung, Dorothy and Chirieac, Lucian and Cho, Juok and Chuah, Eric and Chudamani, Sudha and Cibulskis, Carrie and Cope, Leslie and Crain, Daniel and Curley, Erin and De Rienzo, Assunta and DeFreitas, Timothy and Demchok, John A and Dhalla, Noreen and Dhir, Rajiv and Feldman, Michael and Ferguson, Martin L and Fukuda, Shiro and Gabriel, Stacey B and Sallé, Françoise Galateau and Gao, Jianjiong and Gardner, Johanna and Gastier-Foster, Julie M and ... and TCGA Res Network and TCGA Research Network
Cancer Discovery, ISSN 2159-8274, 12/2018, Volume 8, Issue 12, pp. 1549 - 1565
Journal Article
American journal of surgical pathology, ISSN 0147-5185, 2019, Volume 43, Issue 9, pp. 1297 - 1302
Germline mutations in CDKN2A result in Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM), which is associated with an increased risk for pancreatic... 
SURGERY | HOMOZYGOUS DELETION | GERMLINE MUTATION | SUPPRESSOR GENE | CDKN2A | PRONE FAMILIES | PATHOLOGY | METHYLTHIOADENOSINE PHOSPHORYLASE | MTAP | P16 | cancer syndrome | INCREASED RISK | pancreas | ACUTE LYMPHOBLASTIC-LEUKEMIA | neuroendocrine tumor | cancer | early detection | molecular pathology
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2019, Volume 36, Issue 1, pp. 100 - 114.e25
Journal Article
MELANOMA RESEARCH, ISSN 0960-8931, 12/2019, Volume 29, Issue 6, pp. 590 - 595
The rising incidence of cutaneous melanoma (CM). an aggressive skin cancer, emphasizes the need for novel biomarkers to guide personalized care and better... 
MEDICINE, RESEARCH & EXPERIMENTAL | INHERITED VARIATION | PROGNOSIS | survival | melanoma | LOCI | DERMATOLOGY | MTAP | MC1R | ONCOLOGY | IRF4 | germline variants | single nucleotide polymorphisms | EXPRESSION | GENOME-WIDE ASSOCIATION
Journal Article
Biomarkers in Medicine, ISSN 1752-0363, 01/2018, Volume 12, Issue 1, pp. 35 - 44
Aim: The Ewing sarcoma family of tumors (ESFT) is a group of malignant small round cell neoplasms of bones and soft tissues closely histogenetically related.... 
Ewing sarcoma family of tumors | methylthioadenosine phosphorylase | MTAP | ESFT | prognosis | biomarkers | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | METHYLTHIOADENOSINE PHOSPHORYLASE MTAP | CANCER | REGISTRY
Journal Article