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Autophagy, ISSN 1554-8627, 08/2014, Volume 10, Issue 8, pp. 1391 - 1402
Journal Article
Journal Article
Journal Article
Biochimica et biophysica acta. Molecular basis of disease, 09/2019, pp. 165552 - 165552
Accumulating evidence indicates that necroptosis contributes to cardiovascular diseases. We recently reported suppression of autophagy by necroptotic signals... 
Index Medicus
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 10/2014, Volume 289, Issue 40, pp. 27692 - 27701
Journal Article
Cell, ISSN 0092-8674, 12/2016, Volume 167, Issue 7, pp. 1705 - 1718.e13
Metformin has utility in cancer prevention and treatment, though the mechanisms for these effects remain elusive. Through genetic screening in , we uncover two... 
NPC | RagC GTPase | lifespan | C. elegans | nuclear pore complex | mitochondrial respiratory capacity | nuclear transport | mechanistic target of rapamycin complex 1 | growth | cancer | Metformin | acyl-CoA dehydrogenase family member 10 | ACAD10 | mTORC1 | diabetes | C. elegans | MAMMALIAN TARGET | CELLS | CAENORHABDITIS-ELEGANS | RAG GTPASES | GLUCONEOGENESIS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR-PORE COMPLEX | PANCREATIC-CANCER | SACCHAROMYCES-CEREVISIAE | MTOR | CELL BIOLOGY | Acyl-CoA Dehydrogenase - genetics | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - growth & development | TOR Serine-Threonine Kinases - metabolism | Body Size | Humans | Metformin - pharmacology | Oxidative Phosphorylation | Caenorhabditis elegans Proteins - metabolism | Mitochondria - metabolism | Longevity | Nuclear Pore - metabolism | Mechanistic Target of Rapamycin Complex 1 | Neoplasms - drug therapy | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Multiprotein Complexes - metabolism | Animals | Monomeric GTP-Binding Proteins - metabolism | Signal Transduction - drug effects | Aging | Cell Line, Tumor | Caenorhabditis elegans Proteins - genetics | Prevention | Growth | Pancreatic cancer | Melanoma | Molecular biology | Gross domestic product | Cells | Cancer | Index Medicus
Journal Article
Cancer Letters, ISSN 0304-3835, 2014, Volume 358, Issue 2, pp. 170 - 179
Highlights • Baicalein, a natural compound, causes tumor suppression of cancer cells both in vitro and in vivo. • Baicalein upregulates DDIT4 which inhibits... 
Hematology, Oncology and Palliative Medicine | Baicalein | mTOR | Cellular stress | IRF1 | DDIT4 | MTOR | APOPTOSIS | DNA-DAMAGE RESPONSE | WOGONIN | P53 | LIPOXYGENASE | ONCOLOGY | PATHWAY | COLORECTAL-CANCER | RESISTANCE | STRESS | REDD1 | Neoplasms - metabolism | Up-Regulation | TOR Serine-Threonine Kinases - metabolism | Humans | Gene Expression Profiling | Antineoplastic Agents - administration & dosage | Tumor Suppressor Protein p53 - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Neoplasms - genetics | Time Factors | Female | Transcription, Genetic | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Disease Models, Animal | Flavanones - pharmacology | Tumor Suppressor Protein p53 - metabolism | Transcription Factors - genetics | Flavanones - administration & dosage | Transcription Factors - metabolism | Protein Kinase Inhibitors - administration & dosage | Animals | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Neoplasms - pathology | Prevention | Chemotherapy | Growth | Cancer cells | Cancer | TOR protein | Phosphorylation | Transcription | p53 Protein | Clinical trials | Kinases | Anticancer properties | Proteins | Cell growth | Platinum | Rodents | Inhibition | Charitable foundations | Deoxyribonucleic acid--DNA | RNA-mediated interference | Breast cancer | Tumor cell lines | Gene expression | Polymerase chain reaction | Ribonucleic acids | Cell lines | Interferon | Tumors | Index Medicus | baicalein | cellular stress
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2014, Volume 20, Issue 1, pp. 133 - 144
Obesity can result in insulin resistance, hepatosteatosis, and nonalcoholic steatohepatitis (NASH) and increases liver cancer risk. Obesity-induced insulin... 
RAPAMYCIN | LIFE-SPAN | HEPATOCELLULAR-CARCINOMA | ACTIVATION | SIGNALING PATHWAY | ENDOCRINOLOGY & METABOLISM | COMPLEX 1 | PROLIFERATION | CANCER | PROGRESSION | TRANSPLANTATION | CELL BIOLOGY | Diethylnitrosamine - toxicity | Inflammation - pathology | Cell Proliferation | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Fatty Liver - pathology | Mitosis | Humans | Male | Hepatocytes - metabolism | Sirolimus - toxicity | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | Liver - injuries | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | Hepatocytes - cytology | Liver - drug effects | Diet, High-Fat | Liver Neoplasms - pathology | Regulatory-Associated Protein of mTOR | Interleukin-6 - metabolism | STAT3 Transcription Factor - metabolism | DNA Damage - drug effects | Glucose Tolerance Test | Fatty Liver - metabolism | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Animals | Cell Transformation, Neoplastic | Adaptor Proteins, Signal Transducing - deficiency | Adaptor Proteins, Signal Transducing - genetics | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Mice, Obese | Mice | Adaptor Proteins, Signal Transducing - metabolism | Carcinoma, Hepatocellular - metabolism | Liver cancer | Ablation (Surgery) | Liver | Analysis | Physiological aspects | Insulin resistance | Cellular signal transduction | Inflammation | Tumors | Medical colleges | Interleukins | Index Medicus
Journal Article
PROTEOMICS, ISSN 1615-9853, 11/2017, Volume 17, Issue 22, pp. 1700233 - n/a
Mycobacterium tuberculosis (Mtb) cell wall glycolipid mannose‐capped lipoarabinomannan (ManLAM) inhibits CD4 + T‐cell activation by inhibiting proximal T‐cell... 
ManLAM | CD4 | label‐free mass spectrophotometry | mTOR | T‐cell | Akt | M. tuberculosis | T-cell | label-free mass spectrophotometry | IMMUNITY | ACTIVATION | PHOSPHORYLATION | TOLERANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | PROLIFERATION | KAPPA-B | Man-LAM | MASS-SPECTROMETRY | CD4(+) T-cell | CO-STIMULATION | GRAIL | ANERGY | Signal Transduction | TOR Serine-Threonine Kinases - metabolism | Mice, Inbred C57BL | Oncogene Protein v-akt - antagonists & inhibitors | CD4-Positive T-Lymphocytes - metabolism | Gene Regulatory Networks | TOR Serine-Threonine Kinases - antagonists & inhibitors | Animals | Cell Cycle | Mass Spectrometry | Lipopolysaccharides - pharmacology | Female | Mice | Proteomics - methods | Oncogene Protein v-akt - metabolism | Mycobacterium tuberculosis - metabolism | Mannose - chemistry | Enzymes | Tuberculosis | Peptides | Analysis | Physiological aspects | T cells | Sugars | Monosaccharides | TOR protein | Tricarboxylic acid cycle | Phosphorylation | Modules | AKT protein | Activation | Mannose | Lymphocytes T | CD28 antigen | Proteins | T-cell receptor | Cell activation | Lymphocytes | Network analysis | Cell cycle | Proliferating cell nuclear antigen | Inhibition | NF-κB protein | Cell walls | CD3 antigen | T cell receptors | Metabolism | Ribonucleic acid--RNA | CD4 antigen | Costimulator | Bridges | Signaling | Proteomics | Index Medicus | CD4+ T‐cell | Systems Biology
Journal Article