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animals (89) 89
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Journal of Lipid Research, ISSN 0022-2275, 10/2003, Volume 44, Issue 10, pp. 1887 - 1901
Journal Article
Expert Opinion on Drug Safety, ISSN 1474-0338, 05/2019, Volume 18, Issue 5, pp. 403 - 414
Introduction: Homozygous familial hypercholesterolemia (HoFH) is a rare and life-threatening lipid disorder characterized by extremely elevated low-density... 
Lomitapide | homozygous familial hypercholesterolemia | rare lipid disorders | safety | MTP GENE | B SYNTHESIS INHIBITION | OPEN-LABEL | APOLIPOPROTEIN-B | SINGLE-ARM | CLINICAL-EXPERIENCE | DENSITY-LIPOPROTEIN CHOLESTEROL | ANTISENSE INHIBITOR | MOLECULAR DIAGNOSIS | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 06/2011, Volume 337, Issue 3, pp. 775 - 785
Journal Article
Journal Article
Current Opinion in Lipidology, ISSN 0957-9672, 06/2013, Volume 24, Issue 3, pp. 246 - 250
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 2011, Volume 17, Issue 9, pp. 943 - 949
Journal Article
Journal Article
Diabetes and Metabolism Journal (DMJ), ISSN 2233-6079, 2015, Volume 39, Issue 2, p. 87
Statins have been shown to be very effective and safe in numerous randomized clinical trials, and became the implacable first-line treatment against... 
PCSK9 inhibitor | MTP inhibitor | Dyslipidemia
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 07/2012, Volume 135, Issue 1, pp. 31 - 43
Elevated low density lipoprotein cholesterol (LDL-C) levels have been associated with an increased risk for cardiovascular disease (CVD). Despite a 25–30%... 
Apolipoprotein B | PCSK9 inhibitor | MTP inhibitor | Thyromimetics | Anti-sense oligonucleotides | TRIGLYCERIDE TRANSFER PROTEIN | NONHUMAN-PRIMATES | FAMILIAL HYPERCHOLESTEROLEMIA | ANTISENSE OLIGONUCLEOTIDE | LDL CHOLESTEROL | INTESTINE-SPECIFIC INHIBITOR | PLASMA-CHOLESTEROL | PHARMACOLOGY & PHARMACY | THYROID-HORMONE RECEPTOR | HUMAN APOLIPOPROTEIN B-100 | Proprotein Convertases - antagonists & inhibitors | Cardiovascular Diseases - prevention & control | Humans | Apolipoproteins B - blood | Cardiovascular Diseases - genetics | Hypercholesterolemia - drug therapy | Oligonucleotides, Antisense - therapeutic use | Cardiovascular Diseases - blood | Cholesterol, LDL - blood | Biomimetic Materials - therapeutic use | Cardiovascular Diseases - etiology | Hypercholesterolemia - blood | Down-Regulation | Proprotein Convertases - metabolism | Carrier Proteins - antagonists & inhibitors | Treatment Outcome | Apolipoproteins B - genetics | Biomarkers - blood | Anticholesteremic Agents - adverse effects | Anticholesteremic Agents - pharmacokinetics | Animals | Anticholesteremic Agents - therapeutic use | Carrier Proteins - metabolism | Protein Kinase Inhibitors - therapeutic use | Thyroid Hormones - metabolism | Hypercholesterolemia - complications | Serine Endopeptidases - metabolism | Hypercholesterolemia - genetics | Proprotein Convertase 9 | Hypercholesterolemia | RNA | Low density lipoproteins | Cytochrome P-450 | Triglycerides | Coronary heart disease | Health aspects | Cholesterol | Lipoprotein A
Journal Article
Journal Article
Journal Article
Molecular Simulation, ISSN 0892-7022, 10/2016, Volume 42, Issue 15, pp. 1223 - 1232
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 10/2012, Volume 19, Issue 28, pp. 4861 - 4868
Patients with homozygous familial hypercholesterolemia (HoFH) represent the most severe patients within the spectrum of dyslipidemias. Untreated Low-Density... 
PCSK9 inhibitors | Abetalipoproteinemia | Lomitapide | Severe hypercholesterolemia | Orthotopic liver transplantation | LDL-apheresis | Aortic valvular disease | HMGCoA-reductase inhibitors | Coronary artery disease | Combination lipid-lowering drug therapy | Atherosclerosis | LDL receptor mutation | Mipomersen | Familial hypercholesterolemia | MTP-inhibitors | coronary artery disease | TRIGLYCERIDE TRANSFER PROTEIN | BLOOD CHOLESTEROL | LOW-DENSITY-LIPOPROTEIN | APOLIPOPROTEIN-B | combination lipid-lowering drug therapy | familial hypercholesterolemia | PHARMACOLOGY & PHARMACY | orthotopic liver transplantation | atherosclerosis | CHEMISTRY, MEDICINAL | LIVER-TRANSPLANTATION | abetalipoproteinemia | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTISENSE OLIGONUCLEOTIDE | mipomersen | LDL CHOLESTEROL | lomitapide | aortic valvular disease | CORONARY-HEART-DISEASE | LOWERS PLASMA-CHOLESTEROL | Proprotein Convertases - antagonists & inhibitors | Microsomes - metabolism | Oligonucleotides - chemistry | Receptors, LDL - genetics | Oligonucleotides - therapeutic use | Humans | Proprotein Convertases - metabolism | Receptors, LDL - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry | Hypercholesterolemia - drug therapy | Hydroxymethylglutaryl CoA Reductases - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Cholesterol, LDL - blood | Hypolipidemic Agents - therapeutic use | Hydroxymethylglutaryl CoA Reductases - chemistry
Journal Article