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Journal of Hepatology, ISSN 0168-8278, 2013, Volume 58, Issue 1, pp. 155 - 168
Summary Bile acid (BA) transporters are critical for maintenance of the enterohepatic BA circulation where BAs exert their multiple physiological functions... 
Gastroenterology and Hepatology | Gallstones | Liver cancer | Bile acids | Fatty liver disease | Cholestasis | Liver regeneration | RAT-LIVER | SALT EXPORT PUMP | GROWTH-FACTOR 19 | ORGANIC ANION TRANSPORTERS | 90-PERCENT PARTIAL-HEPATECTOMY | URSODEOXYCHOLIC ACID | PRIMARY BILIARY-CIRRHOSIS | FARNESOID-X-RECEPTOR | GASTROENTEROLOGY & HEPATOLOGY | PHOSPHOLIPID-ASSOCIATED CHOLELITHIASIS | FAMILIAL INTRAHEPATIC CHOLESTASIS | Animals | Carrier Proteins - metabolism | Cholestasis - metabolism | Membrane Glycoproteins - metabolism | Humans | Liver - metabolism | Bile Acids and Salts - metabolism | Liver Diseases - metabolism | Liver Regeneration - physiology | Receptors, Cytoplasmic and Nuclear - metabolism | Drug resistance in microorganisms | Corticosteroids | Glucagon | Calcifediol | Ursodiol | Deoxycholic acid | Epidermal growth factor | Vitamin D | Physiological aspects | Fibroblast growth factors | Alfacalcidol | IBABP (FABP6, ILBP), intestinal bile acid-binding protein, fatty acid-binding protein 6 | PFIC, progressive familial intrahepatic cholestasis | TNFα, tumor necrosis factor α | 3 (human) | SRC2, p160 steroid receptor coactivator | NAFLD, non-alcoholic fatty liver disease | BA, bile acid | bile acid receptor | 8, cholesterol efflux pump, ATP-binding cassette, subfamily G, member 5 | UDCA, ursodeoxycholic acid | LRH-1 (NR5A2), liver receptor homolog-1 | LCA, lithocholic acid | LXRα (NR1H3), liver X receptor alpha | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | OSTαβ, organic solute transporter alpha | ABCG5 | AMPK, AMP activated protein kinase | NASH, non-alcoholic steatohepatitis | SHP (NR0B2), short heterodimer partner | OATP1A2 (SLCO1A2, OATP1, OATP-A, SLC21A3), solute carrier organic anion transporter family, member 1A2 | EGFR, epidermal growth factor receptor | IL6, interleukin 6 | TGR5, G protein-coupled bile acid receptor | PH, partial hepatectomy | AE2, anion exchanger 2 | PSC, primary sclerosing cholangitis | OATP1B1 (SLCO1B1, OATP2, OATP-C, SLC21A6), solute carrier organic anion transporter family, member 1B1 | RARα (NR1B1), retinoic acid receptor alpha | GLP-1, glucagon like peptide 1 | VDR (NR1I1), vitamin D receptor. Please note that for the convenience of better readability and clarity, abbreviations for transporters and nuclear receptors were capitalized throughout this article when symbols were identical for human and rodents | MRP2 (ABCC2), multidrug resistance-associated protein 2, ATP-binding cassette, subfamily C, member 2 | NTCP (SLC10A1), sodium | CAR (NR1I3), constitutive androstane receptor | taurocholate cotransporting polypeptide, solute carrier family 10, member 1 | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | GR (NR3C1), glucocorticoid receptor | Bile acids, Cholestasis, Fatty liver disease, Gallstones, Liver regeneration, Liver cancer | 19, fibroblast growth factor 15 | Mdr2 | ICP, intrahepatic cholestasis of pregnancy | BRIC, benign recurrent intrahepatic cholestasis | OATP1B3 (SLCO1B3, OATP8, SLC21A8), solute carrier organic anion transporter family, member 1B3 | MRP3 (ABCC3), multidrug resistance-associated protein 3, ATP-binding cassette, subfamily C, member 3 | beta | MDR1 (ABCB1), p-glycoprotein, ATP-binding cassette, subfamily B, member 1 | norUDCA, norursodeoxycholic acid | 6-ECDCA, 6-ethylchenodeoxycholic acid | FXR (NR1H4), farnesoid X receptor | BCRP (ABCG2), breast cancer resistance protein, ATP-binding cassette, subfamily G, member 2 | HNF4α (NR2A1), hepatocyte nuclear factor 4 alpha | PBC, primary biliary cirrhosis | MDR3 (ABCB4), multidrug resistance protein 2 (rodents) | HNF1α, hepatocyte nuclear factor 1 alpha | NR, nuclear receptor | FGF15 | RXRα (NR2B1), retinoid X receptor alpha | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | HCC, hepatocellular carcinoma | MRP4 (ABCC4), multidrug resistance-associated protein 4, ATP-binding cassette, subfamily C, member 4 | TPN, total parenteral nutrition
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2012, Volume 109, Issue 27, pp. 10832 - 10836
The study of membrane proteins remains a challenging task, and approaches to unravel their dynamics are scarce. Here, yve applied hydrogen/deuterium exchange... 
ATP binding cassette transporters | Deuterium | Hydrolysis | Average linear density | Mass spectroscopy | Biochemistry | Dimers | Detergents | Exporters | Membrane proteins | ATPase cycle | Structural biology | Detergent | DOMAIN | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | HYDROLYSIS | MASS-SPECTROMETRY | ATP-BINDING | BINDING CASSETTE TRANSPORTER | detergent | P-GLYCOPROTEINS | ALTERNATING ACCESS | structural biology | MOLECULAR-BASIS | HYDROGEN-EXCHANGE | Protein Structure, Tertiary | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Multidrug Resistance-Associated Proteins - chemistry | Adenosine Triphosphatases - metabolism | Trypsin - metabolism | Bacillus subtilis - genetics | Membrane Transport Proteins - chemistry | Deuterium Exchange Measurement | Trypsin - pharmacology | Peptide Mapping | Escherichia coli - genetics | Membrane Transport Proteins - genetics | Mass Spectrometry | Bacterial Proteins - metabolism | Membrane Transport Proteins - metabolism | Multidrug Resistance-Associated Proteins - genetics | Protein Conformation | Mutagenesis - physiology | Catalysis | Multidrug Resistance-Associated Proteins - metabolism | Bacillus subtilis - metabolism | Physiological aspects | Molecular dynamics | Research | Binding proteins | Adenosine triphosphate | Bacillus subtilis | Escherichia coli | Biochemistry, Molecular Biology | Bacterial Proteins | Life Sciences | Trypsin | Mutagenesis | Adenosine Triphosphatases | Membrane Transport Proteins | Biomolecules | Multidrug Resistance-Associated Proteins | Biological Sciences
Journal Article
Anti-Cancer Drugs, ISSN 0959-4973, 03/2017, Volume 28, Issue 3, pp. 281 - 288
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2016, Volume 113, Issue 13, pp. 3509 - 3514
Journal Article
Toxicological Sciences, ISSN 1096-6080, 06/2015, Volume 145, Issue 2, pp. 307 - 320
Journal Article
Molecules (Basel, Switzerland), ISSN 1420-3049, 2017, Volume 22, Issue 4, p. 600
Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are highly expressed in tumor cells, as well as in organs involved in absorption and secretion... 
P-glycoprotein | Multidrug resistance-associated protein 1 | Activators | ATP-binding cassette transporters | Membrane assays | Breast cancer resistance protein | Cell-based assays | Cellular models | In vitro assays | Inducers | in vitro assays | GLYCOPROTEIN EXPRESSION | breast cancer resistance protein | BIOCHEMISTRY & MOLECULAR BIOLOGY | cell-based assays | multidrug resistance-associated protein 1 | BINDING CASSETTE TRANSPORTERS | BLOOD-BRAIN-BARRIER | CHEMISTRY, MULTIDISCIPLINARY | DRUG EFFLUX TRANSPORTERS | ABC-TRANSPORTERS | SANDWICH-CULTURED HEPATOCYTES | activators | inducers | cellular models | MICROSOMAL-ENZYME INDUCERS | MULTIDRUG-RESISTANCE | membrane assays | CACO-2 CELLS | CANCER RESISTANCE PROTEIN | Drug Evaluation, Preclinical - methods | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Multidrug Resistance-Associated Proteins - chemistry | Drug Resistance - drug effects | Structure-Activity Relationship | Organ Specificity | Drug Discovery | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Animals | Models, Biological | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - chemistry | ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry | Multidrug Resistance-Associated Proteins - metabolism | Cardiovascular system | Efflux | Kidneys | Secretion | Tumor cells | Liver | Multidrug resistance | Organs | Breast cancer | Glycoproteins | Assaying | Modulators | Proteins | Screening | Blood-brain barrier | Intestine | In vivo methods and tests | Xenobiotics | P-Glycoprotein | ATP | Adenosine triphosphate | Bile
Journal Article
Pflügers Archiv, ISSN 1432-2013, 2006, Volume 453, Issue 5, pp. 643 - 659
ABCC2 is a member of the multidrug resistance protein subfamily localized exclusively to the apical membrane domain of polarized cells, such as hepatocytes,... 
Substrate specificity of ABCC2 | Biomedicine | Sequence variants of ABCC2 | Human Physiology | ABCC2 transporter | Membrane topology predicted for ABCC2 | Apical conjugate export pump | Dubin–Johnson syndrome | Multidrug resistance protein 2 | Detoxification by ABCC2 | Dubin-Johnson syndrome | membrane topology predicted for ABCC2 | PHYSIOLOGY | ATP-DEPENDENT TRANSPORT | KIDNEY PROXIMAL TUBULES | detoxification by ABCC2 | multidrug resistance protein 2 | substrate specificity of ABCC2 | CMRP/CMOAT GENE-EXPRESSION | ORGANIC ANION-TRANSPORTER | apical conjugate export pump | BILE-SALT TRANSPORTERS | PRIMARY ACTIVE-TRANSPORT | DUBIN-JOHNSON-SYNDROME | sequence variants of ABCC2 | MULTIDRUG-RESISTANCE PROTEIN-2 | SINGLE NUCLEOTIDE POLYMORPHISMS | HEPATOCYTE CANALICULAR ISOFORM | Amino Acid Sequence | Humans | Gene Expression Regulation | Substrate Specificity | Jaundice, Chronic Idiopathic - genetics | Multidrug Resistance-Associated Proteins - biosynthesis | Membrane Transport Proteins - physiology | Genetic Variation | Membrane Transport Proteins - biosynthesis | Animals | Membrane Transport Proteins - genetics | Base Sequence | Multidrug Resistance-Associated Proteins - physiology | Multidrug Resistance-Associated Proteins - genetics | Bile Canaliculi - metabolism | Cell Membrane - metabolism | Disease Models, Animal | Proteins | ABC transporters
Journal Article