X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
alzheimer's disease (107) 107
multifunctional agents (102) 102
index medicus (99) 99
chemistry, medicinal (98) 98
humans (87) 87
alzheimer disease - drug therapy (76) 76
cholinesterase inhibitors - pharmacology (64) 64
acetylcholinesterase (61) 61
acetylcholinesterase inhibitors (59) 59
cholinesterase inhibitors - chemistry (56) 56
animals (55) 55
biochemistry & molecular biology (55) 55
biological evaluation (47) 47
acetylcholinesterase - metabolism (46) 46
drug design (44) 44
oxidative stress (44) 44
cholinesterase inhibitors - chemical synthesis (42) 42
cholinesterase-inhibitors (41) 41
drug therapy (38) 38
structure-activity relationship (38) 38
target-directed ligands (38) 38
beta-amyloid aggregation (33) 33
chemistry, organic (33) 33
neurodegenerative diseases (33) 33
antioxidant (32) 32
design (32) 32
pharmacology & pharmacy (32) 32
alzheimers-disease (31) 31
analysis (31) 31
butyrylcholinesterase (31) 31
derivatives (30) 30
tacrine (29) 29
molecular structure (28) 28
antioxidants (27) 27
cholinesterase inhibitors - therapeutic use (27) 27
enzyme inhibitors (26) 26
butyrylcholinesterase - metabolism (24) 24
models, molecular (24) 24
alzheimer’s disease (23) 23
amyloid beta-peptides - metabolism (23) 23
hybrids (22) 22
molecular docking simulation (22) 22
dose-response relationship, drug (21) 21
multifunctional drugs (21) 21
cholinesterase (20) 20
rats (20) 20
alzheimer disease - metabolism (19) 19
antioxidants - chemistry (19) 19
kinetics (19) 19
mice (18) 18
amyloid beta-peptides - antagonists & inhibitors (17) 17
antioxidants - pharmacology (17) 17
drugs (17) 17
in-vitro (17) 17
inhibitors (17) 17
tacrine - chemistry (17) 17
chemistry, multidisciplinary (16) 16
surface active agents (16) 16
binding sites (15) 15
neurosciences (15) 15
alzheimer disease - enzymology (14) 14
antioxidants - chemical synthesis (14) 14
cholinesterase inhibitors (14) 14
neuroprotective agents - pharmacology (14) 14
monoamine oxidase inhibitors - pharmacology (13) 13
butyrylcholinesterase inhibitors (12) 12
cell line, tumor (12) 12
cholinergic hypothesis (12) 12
ligands (12) 12
male (12) 12
neuroprotection (12) 12
tacrine - pharmacology (12) 12
cell survival - drug effects (11) 11
donepezil (11) 11
monoamine oxidase - metabolism (11) 11
acetylcholinesterase - chemistry (10) 10
directed ligands (10) 10
hypothesis (10) 10
molecular modeling (10) 10
monoamine oxidase inhibitors - chemistry (10) 10
multi-target-directed ligands (10) 10
neuroprotective properties (10) 10
a beta aggregation (9) 9
amyloid beta-peptides - chemistry (9) 9
amyloid-beta (9) 9
blood-brain barrier - metabolism (9) 9
cell line (9) 9
disease (9) 9
drug discovery (9) 9
in-vivo (9) 9
inhibitory concentration 50 (9) 9
monoamine oxidase (9) 9
neuroprotective agents - chemistry (9) 9
organic chemistry (9) 9
pc12 cells (9) 9
pharmacological evaluation (9) 9
potential multifunctional agents (9) 9
ache inhibitors (8) 8
alzheimer disease (8) 8
alzheimers disease (8) 8
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2017, Volume 125, pp. 1200 - 1212
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2013, Volume 23, Issue 24, pp. 6737 - 6742
Journal Article
Molecules, ISSN 1420-3049, 02/2013, Volume 18, Issue 2, pp. 2397 - 2418
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 144, pp. 128 - 136
A novel series of tacrine-bifendate (THA-DDB) conjugates ( ) were synthesized and evaluated as potential anti-Alzheimer's agents. These compounds showed potent... 
Hepatoprotective | Bifendate | Alzheimer's disease | Tacrine | Cholinesterase | BUTYRYLCHOLINESTERASE | CHEMISTRY, MEDICINAL | ANALOGS | BETA AGGREGATION | DRUG DESIGN STRATEGY | MULTIFUNCTIONAL AGENTS | FLAVONOID DERIVATIVES | DISEASE | BIOLOGICAL EVALUATION | ANTI-ALZHEIMER AGENTS | HYBRIDS
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 2017, Volume 25, Issue 12, pp. 3006 - 3017
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 08/2016, Volume 26, Issue 16, pp. 4140 - 4145
In recent years, multitarget-directed ligands have become an interesting strategy in a search for a new treatment of Alzheimer's disease. Combination of both:... 
BUTYRYLCHOLINESTERASE | TARGET-DIRECTED LIGANDS | CHEMISTRY, MEDICINAL | Chlorophenoxy derivatives | Histamine H3 receptor | ALZHEIMERS-DISEASE | DOCKING | Acetylcholinesterase inhibitors | CHEMISTRY, ORGANIC | ACHE INHIBITORS | AGONISTS | DIETHER DERIVATIVES | POTENT | Butyrylcholinesterase inhibitors | Multifunctional ligands | CANDIDATES | ANTAGONISTS
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 03/2019, Volume 27, Issue 6, pp. 895 - 930
The medicinal chemistry and pharmacological properties of the lead molecules of 92 hybrids published since 1998-Dec 2017 have been reviewed. Alzheimer’s... 
Multifunctional molecules | Hybrids |