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Current Drug Targets, ISSN 1389-4501, 2011, Volume 12, Issue 3, pp. 332 - 347
Journal Article
Current Opinion in Genetics & Development, ISSN 0959-437X, 2008, Volume 18, Issue 1, pp. 19 - 26
A connection between inflammation and carcinogenesis has long been known, but the precise mechanisms are just beginning to be understood. NF-κB proteins,... 
Medical Education | EPITHELIAL-MESENCHYMAL TRANSITION | MULTIPLE-MYELOMA | BREAST-CANCER | REGULATORY SUBUNIT | INDUCED APOPTOSIS | COLORECTAL-CANCER | GENETICS & HEREDITY | IKK-BETA | RISK MYELODYSPLASTIC SYNDROME | ACUTE MYELOID-LEUKEMIA | TNF-ALPHA | CELL BIOLOGY | IKK | NF-κB | cancer | inflammation
Journal Article
Nature Reviews Neurology, ISSN 1759-4758, 09/2016, Volume 12, Issue 9, pp. 539 - 551
Journal Article
Journal Article
Nature, ISSN 0028-0836, 06/2012, Volume 486, Issue 7401, pp. 80 - 84
The complexity of cancer has led to recent interest in polypharmacological approaches for developing kinase-inhibitor drugs; however, optimal kinase-inhibition... 
PATHWAYS | RET | CHROMOSOME | DROSOPHILA MODEL | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | CELL-PROLIFERATION | PD-0325901 | INHIBITOR | SORAFENIB | CARCINOMA | Niacinamide - analogs & derivatives | Proto-Oncogene Proteins c-ret - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Phenylurea Compounds | Extracellular Signal-Regulated MAP Kinases - metabolism | Protein Kinase Inhibitors - adverse effects | Drosophila Proteins - metabolism | Molecular Targeted Therapy | Drosophila melanogaster - genetics | Heterocyclic Compounds, 4 or More Rings - pharmacology | Multiple Endocrine Neoplasia Type 2b - genetics | Multiple Endocrine Neoplasia Type 2b - enzymology | Benzenesulfonates - pharmacology | Multiple Endocrine Neoplasia Type 2b - drug therapy | Protein Kinase Inhibitors - chemistry | Polypharmacy | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Drug-Related Side Effects and Adverse Reactions | src-Family Kinases - metabolism | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Drug Evaluation, Preclinical | Drosophila Proteins - antagonists & inhibitors | Disease Models, Animal | src-Family Kinases - antagonists & inhibitors | Heterocyclic Compounds, 4 or More Rings - chemistry | Heterocyclic Compounds, 4 or More Rings - adverse effects | Survival Rate | Drosophila melanogaster - drug effects | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Sorafenib | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Cell Transformation, Neoplastic - drug effects | Drosophila Proteins - genetics | Cell Transformation, Neoplastic - pathology | Proto-Oncogene Proteins c-ret - genetics | Chemotherapy | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Carcinogenesis | Risk factors | Cancer | Proteins | Nuclear magnetic resonance--NMR | Insects | Toxicity | Mutation | Kinases | Drug dosages | Cell adhesion & migration
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 01/2011, Volume 10, Issue 1, pp. 29 - 46
The ubiquitin-proteasome system (UPS) and ubiquitin-like protein (UBL) conjugation pathways are integral to cellular protein homeostasis. The growing... 
MYCOBACTERIUM-TUBERCULOSIS | NEURODEGENERATIVE DISEASE | CULLIN-RING LIGASES | KAPPA-B ACTIVATION | X-LINKED INHIBITOR | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | VHL TUMOR-SUPPRESSOR | PHARMACOLOGY & PHARMACY | NEDD8-ACTIVATING ENZYME | MULTIPLE-MYELOMA CELLS | CANCER-THERAPY |