X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
multitarget-directed ligands (81) 81
alzheimer's disease (59) 59
chemistry, medicinal (57) 57
index medicus (56) 56
humans (41) 41
alzheimer disease - drug therapy (28) 28
ligands (24) 24
acetylcholinesterase (23) 23
biochemistry & molecular biology (22) 22
oxidative stress (20) 20
biological evaluation (19) 19
drug design (19) 19
pharmacology & pharmacy (19) 19
acetylcholinesterase inhibitors (18) 18
animals (18) 18
inhibitors (18) 18
neurodegenerative diseases (18) 18
alzheimers-disease (17) 17
cholinesterase inhibitors - chemistry (17) 17
structure-activity relationship (17) 17
cholinesterase inhibitors - pharmacology (16) 16
neurosciences (16) 16
derivatives (15) 15
analysis (13) 13
cholinesterase inhibitors - therapeutic use (13) 13
molecular docking simulation (13) 13
multitarget-directed ligand (13) 13
design (12) 12
discovery (12) 12
drug discovery (12) 12
amyloid beta-peptides - metabolism (11) 11
antioxidants (11) 11
molecular structure (11) 11
acetylcholinesterase - metabolism (10) 10
alzheimer’s disease (10) 10
chemistry, organic (10) 10
cholinesterase-inhibitors (10) 10
donepezil (10) 10
drug therapy (10) 10
drugs (10) 10
multifunctional agents (10) 10
polypharmacology (10) 10
binding sites (9) 9
butyrylcholinesterase inhibitors (9) 9
cholinesterase inhibitors - chemical synthesis (9) 9
enzyme inhibitors (9) 9
ache inhibitors (8) 8
alzheimers disease (8) 8
cholinesterase (8) 8
cholinesterase inhibitors (8) 8
hybrids (8) 8
organic chemistry (8) 8
tacrine (8) 8
aggregation (7) 7
amyloid beta-peptides - antagonists & inhibitors (7) 7
amyloid precursor protein (7) 7
butyrylcholinesterase - metabolism (7) 7
chemistry, multidisciplinary (7) 7
dose-response relationship, drug (7) 7
dual inhibitors (7) 7
peptide fragments - metabolism (7) 7
acetylcholinesterase - chemistry (6) 6
bace-1 (6) 6
beta-secretase (6) 6
butyrylcholinesterase (6) 6
designed multiple ligands (6) 6
mice (6) 6
monoamine oxidase - metabolism (6) 6
mouse model (6) 6
multitarget directed ligands (6) 6
neuroprotection (6) 6
target (6) 6
5-ht (5) 5
a beta aggregation (5) 5
agents (5) 5
alzheimer disease - enzymology (5) 5
alzheimer disease - metabolism (5) 5
cholinesterase inhibitors - metabolism (5) 5
cytotoxicity (5) 5
disease (5) 5
enzymes (5) 5
in-vitro (5) 5
in-vivo (5) 5
inflammation (5) 5
inhibitory concentration 50 (5) 5
monoamine oxidase (5) 5
monoamine oxidase inhibitors - chemistry (5) 5
monoamine oxidase inhibitors - pharmacology (5) 5
permeability (5) 5
pharmacology (5) 5
protein structure, tertiary (5) 5
tacrine - chemistry (5) 5
target-directed ligands (5) 5
virtual screening (5) 5
alzheimer disease - pathology (4) 4
amyloid beta-peptides - chemistry (4) 4
amyloid precursor protein secretases - metabolism (4) 4
antagonist (4) 4
antioxidants - chemistry (4) 4
antioxidants - pharmacology (4) 4
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 181, p. 111572
The discovery and development of multitarget-directed ligands (MTDLs) is a promising strategy to find new therapeutic solutions for neurodegenerative diseases... 
Multitarget-directed ligands | Alzheimer's disease | Synthetic strategies contents
Journal Article
ChemMedChem, ISSN 1860-7179, 06/2016, Volume 11, Issue 12, pp. 1264 - 1269
Novel indolotacrine analogues were designed, synthesized, and evaluated as potential drugs for the treatment of Alzheimer's disease. By using a... 
inhibitors | multitarget-directed ligands | cholinesterases | Alzheimer's disease | cytotoxicity | monoamine oxidase | MONOAMINE-OXIDASE | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | MULTIPOTENT | DONEPEZIL | CHOLINERGIC HYPOTHESIS | POTENTIAL TREATMENT | PHARMACOLOGY & PHARMACY | CHOLINESTERASE/MONOAMINE OXIDASE-INHIBITORS | PHARMACOLOGICAL EVALUATION | AGGREGATION | HYBRIDS | Cholinesterase Inhibitors - toxicity | Humans | Indoles - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Monoamine Oxidase Inhibitors - chemical synthesis | Tacrine - therapeutic use | Monoamine Oxidase - chemistry | Indoles - metabolism | Cholinesterase Inhibitors - metabolism | Drug Design | Inhibitory Concentration 50 | Quinolines - toxicity | Tacrine - chemistry | Monoamine Oxidase Inhibitors - therapeutic use | Cell Survival - drug effects | Tacrine - metabolism | Quinolines - chemistry | Alzheimer Disease - drug therapy | Indoles - toxicity | Acetylcholinesterase - chemistry | Blood-Brain Barrier - metabolism | Hep G2 Cells | Quinolines - chemical synthesis | Quinolines - metabolism | Monoamine Oxidase Inhibitors - toxicity | Monoamine Oxidase Inhibitors - metabolism | Indoles - therapeutic use | Ligands | Quinolines - therapeutic use | Cholinesterase Inhibitors - therapeutic use | Indoles - chemistry | Acetylcholinesterase - metabolism | Monoamine Oxidase - metabolism | Tacrine - toxicity | Antioxidants | Monoamine oxidase | Permeability | Drug therapy | Analysis | Index Medicus
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 163, pp. 512 - 526
Considering the importance of PDE4D inhibition and the modulation of biometals in Alzheimer's disease (AD) therapeutics, we have designed, synthesized and... 
PDE4D inhibitors | Multitarget-directed ligands | Alzheimer's disease | Metal chelating agents | OXIDATIVE STRESS | DESIGN | CHEMISTRY, MEDICINAL | COPPER | MOUSE MODEL | IMPROVEMENT | INHIBITOR | DERIVATIVES | A-BETA AGGREGATION | BRAIN | TRANSGENIC MICE
Journal Article
Bioorganic Chemistry, ISSN 0045-2068, 08/2019, Volume 89, p. 102992
Alzheimer’s disease (AD) is the most prevalent disease of old age leading to dementia. Complex AD pathogenesis involves multiple factors amyloid plaque... 
Quinoxalines | Inflammation | Multitarget-directed ligands | BACE-1 | Thiazoles
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2019, Volume 177, pp. 198 - 211
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 12/2017, Volume 8, Issue 12, pp. 2708 - 2721
Journal Article
BIOORGANIC CHEMISTRY, ISSN 0045-2068, 08/2019, Volume 89, p. 102992
Alzheimer's disease (AD) is the most prevalent disease of old age leading to dementia. Complex AD pathogenesis involves multiple factors viz. amyloid plaque... 
TARGET | DESIGN | MANAGEMENT | Multitarget-directed ligands | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | Quinoxalines | Inflammation | DISCOVERY | QUERCETIN | ANTIINFLAMMATORY AGENTS | BACE-1 | Thiazoles | CLINICAL CANDIDATE | DERIVATIVES | BACE-1 INHIBITORS | HYBRIDS
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 07/2018, Volume 9, Issue 7, pp. 1663 - 1679
Alzheimer's disease (AD) is associated with multiple neuropathological events including beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1)... 
drug discovery | multitarget-directed ligands | inflammation | BACE-1 | CHEMISTRY, MEDICINAL | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | PATHOLOGY | NEUROSCIENCES | DISCOVERY | IMPAIRMENT | QUERCETIN | LEADS | CLINICAL CANDIDATE | BINDING
Journal Article
Journal Article
Journal Article