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1. Full Text T(H)9 cells are required for tissue mast cell accumulation during allergic inflammation
by Sehra, S and Yao, WG and Nguyen, ET and Glosson-Byers, NL and Akhtar, N and Zhou, BH and Kaplan, MH
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 08/2015, Volume 136, Issue 2, pp. 433 - 433
Background: IL-9 is important for the growth and survival of mast cells. IL-9 is produced by T cells, natural killer T cells, mast cells, eosinophils, and... 
T(H)9 cells | allergic inflammation | ASTHMA MODEL | T(H)2 cells | INTERLEUKIN-9 | TRANSCRIPTION FACTOR PU.1 | IMMUNOLOGY | mast cells | PU.1 | MURINE MODEL | IL-9 EXPRESSION | EPITHELIAL-CELLS | ALLERGY | AIRWAY HYPERRESPONSIVENESS | TNF-ALPHA | LUNG INFLAMMATION | T-CELLS
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2. Full Text Cre-Mediated Cell Ablation Contests Mast Cell Contribution in Models of Antibody- and T Cell-Mediated Autoimmunity
by Feyerabend, Thorsten B and Weiser, Anne and Tietz, Annette and Stassen, Michael and Harris, Nicola and Kopf, Manfred and Radermacher, Peter and Möller, Peter and Benoist, Christophe and Mathis, Diane and Fehling, Hans Jörg and Rodewald, Hans-Reimer
Immunity, ISSN 1074-7613, 2011, Volume 35, Issue 5, pp. 832 - 844
Immunological functions of mast cells remain poorly understood. Studies in mutant mice suggest key roles for mast cells in certain antibody- and... 
MURINE MODEL | W-SH | IN-VIVO | DISEASE | C-KIT | RECEPTOR | CARBOXYPEPTIDASE-A | MICE | IMMUNOLOGY | EXPRESSION | DEFICIENCY | Arthritis, Experimental - genetics | Intestinal Mucosa - metabolism | Encephalomyelitis, Autoimmune, Experimental - immunology | Gene Expression Profiling | Th2 Cells - immunology | Immunoglobulin E - immunology | T-Lymphocytes - metabolism | Autoimmunity - immunology | Intestinal Mucosa - immunology | Mast Cells - metabolism | Anaphylaxis - immunology | Integrases - metabolism | Encephalomyelitis, Autoimmune, Experimental - genetics | Disease Models, Animal | Gene Targeting | Mast Cells - immunology | Genetic Predisposition to Disease | Mice, Inbred C57BL | Tumor Suppressor Protein p53 - metabolism | Carboxypeptidases A - metabolism | Stem Cell Factor - deficiency | Arthritis, Experimental - immunology | Mice, Knockout | Anaphylaxis - genetics | Autoantibodies - immunology | Animals | T-Lymphocytes - immunology | Carboxypeptidases A - genetics | Mice | Intestinal Mucosa - pathology | Viral antibodies | Autoimmunity | Antibodies | Models | Arthritis | Analysis | Histamine | Disease | Software | Skin | Kinases | Gene expression | Allergies
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3. Full Text Mast Cell Interleukin-2 Production Contributes to Suppression of Chronic Allergic Dermatitis
by Hershko, Alon Y and Suzuki, Ryo and Charles, Nicolas and Alvarez-Errico, Damiana and Sargent, Jennifer L and Laurence, Arian and Rivera, Juan
Immunity, ISSN 1074-7613, 2011, Volume 35, Issue 4, pp. 562 - 571
The incidence of chronic allergic dermatitis is rapidly increasing. Regulatory control of this disease has not been adequately explored. Here we report that... 
ATOPIC-DERMATITIS | MURINE MODEL | IMMUNE-RESPONSES | IN-VIVO | DISEASE | MOUSE | REGULATORY T-CELLS | CONTACT HYPERSENSITIVITY | ULTRAVIOLET-B | MICE | IMMUNOLOGY | Mast Cells - immunology | Oxazolone | Spleen - immunology | Dermatitis, Atopic - pathology | Mice, Knockout | Dermatitis, Atopic - chemically induced | Animals | Immunoglobulin E - immunology | Interleukin-2 - immunology | Interleukin-2 - deficiency | Dermatitis, Atopic - immunology | Mice | Interleukin-2 - biosynthesis | Chronic Disease | Flow cytometry | Skin diseases | Genetic engineering | Statistical analysis | Disease | Laboratory animals
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4. Full Text Fluvastatin suppresses mast cell and basophil IgE responses: Genotype-dependent effects
by Kolawole, Elizabeth Motunrayo and McLeod, Jamie Josephine Avila and Ndaw, Victor and Abebayehu, Daniel and Barnstein, Brian O and Faber, Travis and Spence, Andrew J and Taruselli, Marcela and Paranjape, Anuya and Haque, Tamara T and Qayum, Amina A and Kazmi, Qasim A and Wijesinghe, Dayanjan S and Sturgill, Jamie L and Chalfant, Charles E and Straus, David B and Oskeritzian, Carole A and Ryan, John J
Journal of Immunology, ISSN 0022-1767, 02/2016, Volume 196, Issue 4, pp. 1461 - 1470
Mast cell (MC)- and basophil-associated inflammatory diseases are a considerable burden to society. A significant portion of patients have symptoms despite... 
SYNTHASE | MURINE MODEL | LOVASTATIN | INFLAMMATION | DECREASE | INHIBITORS | IMMUNOLOGY | SIMVASTATIN | EXPRESSION | STATINS | ATORVASTATIN | Basophils - drug effects | Mevalonic Acid - pharmacology | Mast Cells - immunology | Fatty Acids, Monounsaturated - pharmacology | Humans | Immunoglobulin E - biosynthesis | Mice, Inbred C57BL | Cells, Cultured | Acyl Coenzyme A - genetics | Genotype | Th2 Cells - immunology | Mast Cells - drug effects | Farnesyltranstransferase - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Immunoglobulin E - immunology | Signal Transduction - drug effects | Basophils - immunology | Female | Indoles - pharmacology | Mice | Acyl Coenzyme A - immunology | Cytokines - biosynthesis | Apoptosis | statin | signal transduction | mast cell | cholesterol | allergy | anaphylaxis | basophil | immunoglobulin E
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5. Full Text Ameliorative effect of atractylenolide III in the mast cell proliferation induced by TSLP
by Yoou, Myoung-schook and Nam, Sun-Young and Jin, Mu Hyun and Lee, So Young and Kim, Mi-Sun and Kim, Hyung-Min and Kim, Dong Hyun and Roh, Seok Seon and Choi, In Hwa and Woo, Nariyah and Lim, SeokWon and Jang, Jae-Bum and Jeong, Hyun-Ja
Food and Chemical Toxicology, ISSN 0278-6915, 08/2017, Volume 106, Issue Pt A, pp. 78 - 85
Atractylenolide III (ATL-III) is an active compound of , which has been widely used for the treatment of cancer. Cancer is closely connected with inflammation,... 
Atractylenolide III | Signal transducer and activator of transcription 6 | Mast cell | Thymic stromal lymphopoietin | Interleukin-13 | Murine double minute 2 | APOPTOSIS | ACTIVATION | FOOD SCIENCE & TECHNOLOGY | KERATINOCYTES | RECEPTOR | ALPHA | CANCER | ATOPIC-DERMATITIS | GENE-EXPRESSION | MDM2 | TOXICOLOGY | NF-KAPPA-B | Cell Line | Phosphorylation | Proto-Oncogene Proteins c-mdm2 - genetics | Anti-Inflammatory Agents - pharmacology | Plant Extracts - pharmacology | Humans | Caspase 3 - metabolism | STAT6 Transcription Factor - genetics | STAT6 Transcription Factor - metabolism | Interleukin-13 - metabolism | Mast Cells - drug effects | Atractylodes - chemistry | Lactones - pharmacology | Interleukin-13 - genetics | Caspase 3 - genetics | Mast Cells - metabolism | Mast Cells - cytology | Cell Proliferation - drug effects | Sesquiterpenes - pharmacology | Proto-Oncogene Proteins c-mdm2 - metabolism | Cytokines - pharmacology | Interleukins | Tumor proteins | Inflammation | Index Medicus
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6. Full Text CD4+CD25+ Regulatory T Cells Suppress Mast Cell Degranulation and Allergic Responses through OX40-OX40L Interaction
by Gri, Giorgia and Piconese, Silvia and Frossi, Barbara and Manfroi, Vanessa and Merluzzi, Sonia and Tripodo, Claudio and Viola, Antonella and Odom, Sandra and Rivera, Juan and Colombo, Mario P and Pucillo, Carlo E
Immunity, ISSN 1074-7613, 11/2008, Volume 29, Issue 5, pp. 771 - 781
T regulatory (Treg) cells play a role in the suppression of immune responses, thus serving to induce tolerance and control autoimmunity. Here, we explored... 
CELLIMMUNO | B-CELLS | MURINE MODEL | ACTIVATION | OX40 LIGAND | INFLAMMATION | IN-VIVO | ASTHMA | MONOCLONAL-ANTIBODY | IMMUNOLOGY | EXPRESSION | CUTTING EDGE | Mast Cells - immunology | T-Lymphocytes, Regulatory - metabolism | Phospholipase C gamma - metabolism | Cell Degranulation | Membrane Glycoproteins - metabolism | Calcium - metabolism | Humans | Mice, Inbred C57BL | Tumor Necrosis Factors - metabolism | Hypersensitivity - immunology | Gene Knockdown Techniques | T-Lymphocytes, Regulatory - immunology | Receptors, OX40 - metabolism | Animals | Hypersensitivity - metabolism | Histamine Release | Mast Cells - metabolism | T-Lymphocytes, Regulatory - cytology | Cell Line, Tumor | Mast Cells - cytology | Mice | Mice, Inbred BALB C | Software | Cytokines | Cloning | Allergies | regulatory T cells | allergy | calcium | cAMP | mast cells | IgE
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7. Full Text Treatment with galectin-1 eye drops regulates mast cell degranulation and attenuates the severity of conjunctivitis
by Mello-Bosnic, Claudia and Gimenes, Alexandre Dantas and Oliani, Sonia Maria and Gil, Cristiane Damas
European Journal of Pharmacology, ISSN 0014-2999, 08/2018, Volume 833, pp. 124 - 130
Galectin-1 (Gal-1) is a β-galactoside-binding protein with diverse biological activities in the pathogenesis of inflammation, however the mechanisms by which... 
Compound 48/80 | Eye | Inflammation | Eosinophil | Mitogen-activated protein kinases | APOPTOSIS | PROTEIN | ALLERGIC CONJUNCTIVITIS | MURINE MODEL | IN-VITRO | MOUSE MODEL | DISEASE | PHARMACOLOGY & PHARMACY | EXPRESSION | T-CELLS | Histamine | Evaluation | Analysis | Ophthalmic drugs | Cromolyn sodium | Conjunctivitis | Mitogens | Protein kinases | Protein binding
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8. Full Text Mast cell-nerve interactions
by Bauer, Omri and Razin, Ehud
News in Physiological Sciences, ISSN 0886-1714, 10/2000, Volume 15, Issue 5, pp. 213 - 218
Mutual associations between nerves and mast cells have been observed in normal conditions and in pathological ones such as human irritable bowel syndrome,... 
NEUROTENSIN | FIBERS | PHYSIOLOGY | MICE | SKIN | MURINE
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9. Full Text Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient Kit(W-sh/W-sh) mice
by Piconese, S and Costanza, M and Musio, S and Tripodo, C and Poliani, PL and Gri, G and Burocchi, A and Pittoni, P and Gorzanelli, A and Colombo, MP and Pedotti, R
LABORATORY INVESTIGATION, ISSN 0023-6837, 04/2011, Volume 91, Issue 4, pp. 627 - 641
Mast cell (MC)-deficient c-Kit mutant Kit(W/W-v) mice are protected against experimental autoimmune encephalomyelitis (EAE), an animal model of multiple... 
granulocytes | MEDICINE, RESEARCH & EXPERIMENTAL | MULTIPLE-SCLEROSIS LESIONS | C-kit mutations | EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS | BONE-MARROW | C-KIT | PATHOLOGY | mast cells | BLOOD-BRAIN-BARRIER | NEUTROPHIL RECRUITMENT | MURINE MODEL | experimental autoimmune encephalomyelitis | IMMUNE-SYSTEM | REGULATORY T-CELLS | CENTRAL-NERVOUS-SYSTEM
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10. Full Text Mast Cell 5-Lipoxygenase Activity Promotes Intestinal Polyposis in APC(Delta 468) Mice
by Cheon, EC and Khazaie, K and Khan, MW and Strouch, MJ and Krantz, SB and Phillips, J and Blatner, NR and Hix, LM and Zhang, M and Dennis, KL and Salabat, MR and Heiferman, M and Grippo, PJ and Munshi, HG and Gounaris, E and Bentrem, DJ
CANCER RESEARCH, ISSN 0008-5472, 03/2011, Volume 71, Issue 5, pp. 1627 - 1636
Arachidonic acid metabolism has been implicated in colon carcinogenesis, but the role of hematopoietic 5-lipoxygenase (5LO) that may impact tumor immunity in... 
MURINE MODEL | LEUKOTRIENE B-4 | POLYMORPHONUCLEAR LEUKOCYTES | EPITHELIAL-CELLS | ONCOLOGY | SLOW-REACTING SUBSTANCE | RECEPTOR | SUPPRESSOR-CELLS | ARACHIDONIC-ACID | MYELOID CELLS | PANCREATIC-CANCER CELLS
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11. Full Text Evidence that vitamin D-3 promotes mast cell-dependent reduction of chronic UVB-nduced skin pathology in mice
by Biggs, L and Yu, CP and Fedoric, B and Lopez, AF and Galli, SJ and Grimbaldeston, MA
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 03/2010, Volume 207, Issue 3, pp. 455 - 463
Mast cell production of interleukin-10 (IL-10) can limit the skin pathology induced by chronic low-dose ultraviolet (UV)-B irradiation. Although the mechanism... 
MEDICINE, RESEARCH & EXPERIMENTAL | CONTACT HYPERSENSITIVITY RESPONSES | INDUCED SYSTEMIC SUPPRESSION | SUSCEPTIBILITY | ULTRAVIOLET-B | UROCANIC ACID | NECROSIS-FACTOR-ALPHA | 1,25-DIHYDROXYVITAMIN D-3 | INTERLEUKIN-10 | IMMUNOLOGY | MURINE SKIN | T-CELLS
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12. Full Text Inhibition of MDM2 expression by rosmarinic acid in TSLP-stimulated mast cell
by Yoou, Myoung-schook and Park, Chan Lee and Kim, Min-Ho and Kim, Hyung-Min and Jeong, Hyun-Ja
European Journal of Pharmacology, ISSN 0014-2999, 01/2016, Volume 771, pp. 191 - 198
Rosmarinic acid (RA) has an anti-inflammatory property while thymic stromal lymphopoietin (TSLP) has an important role in mast cell-mediated inflammatory... 
Rosmarinic acid | Signal transducer and activator of transcription 6 | Thymic stromal lymphopoietin | Interleukin-13 | Murine double minute 2 | CANCER-CELLS | ALLERGIC INFLAMMATION | APOPTOSIS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | PROLIFERATION | VGX-1027 | IN-VITRO | GENES | PHARMACOLOGY & PHARMACY | MICE | Cell Line | Cytokines - metabolism | Humans | Caspase 3 - metabolism | Ambrosia - immunology | Conjunctivitis, Allergic - drug therapy | STAT6 Transcription Factor - genetics | Cinnamates - pharmacology | STAT6 Transcription Factor - biosynthesis | Depsides - pharmacology | Interleukin-13 - biosynthesis | Animals | Mast Cells - metabolism | Mice | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Cytokines - pharmacology | Proto-Oncogene Proteins c-mdm2 - biosynthesis | Conjunctivitis | Tumor proteins | Analysis | Sugars | Monosaccharides
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13. Full Text IL‐33 drives airway hyper‐responsiveness through IL‐13‐mediated mast cell: airway smooth muscle crosstalk
by Kaur, D and Gomez, E and Doe, C and Berair, R and Woodman, L and Saunders, R and Hollins, F and Rose, F.R and Amrani, Y and May, R and Kearley, J and Humbles, A and Cohen, E.S and Brightling, C.E
Allergy, ISSN 0105-4538, 05/2015, Volume 70, Issue 5, pp. 556 - 567
Background Mast cell localization within the airway smooth muscle (ASM)‐bundle plays an important role in the development of airway hyper‐responsiveness (AHR).... 
mast cells | IL‐33 | ASM | IL-33 | IL-13 PRODUCTION | SEVERE ASTHMA | INTERLEUKIN-33 | INNATE LYMPHOID-CELLS | IMMUNOLOGY | THYMIC STROMAL LYMPHOPOIETIN | MURINE MODEL | ALLERGY | INFLAMMATION | IN-VIVO | EXPRESSION | PROMOTES | Immunohistochemistry | Mast Cells - immunology | Bronchial Hyperreactivity - immunology | Enzyme-Linked Immunosorbent Assay | Humans | Mice, Inbred C57BL | Middle Aged | Interleukin-13 - immunology | Muscle, Smooth - metabolism | Muscle, Smooth - immunology | Interleukin-33 - immunology | Receptor Cross-Talk - immunology | Animals | Flow Cytometry | Asthma - immunology | Fluorescent Antibody Technique | Polymerase Chain Reaction | Adult | Mice | Mice, Inbred BALB C | Histamine | Care and treatment | RNA | Analysis | Smooth muscle | Wounds and injuries | Asthma | Cytokines | Cells | Original
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14. Full Text Mast Cell Tryptase Induces Microglia Activation via Protease-activated Receptor 2 Signaling
by Zhang, Shu and Zeng, Xiaoning and Yang, Haiwei and Hu, Gang and He, Shaoheng
Cellular Physiology and Biochemistry, ISSN 1015-8987, 06/2012, Volume 29, Issue 5-6, pp. 931 - 940
Background: Mast cell tryptase can stimulate peripheral mononuclear cells activation to cause widespread inflammation. However, the influence of tryptase on... 
Original Paper | Microglia activation | NF-kappa B | MAPK | Protease-activated receptor 2 | Tryptase | IMMUNE-RESPONSE | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | OXIDATIVE STRESS | PHYSIOLOGY | NF- kappa B | CELL BIOLOGY | TUMOR-NECROSIS-FACTOR | MULTIPLE-SCLEROSIS | NITRIC-OXIDE | CENTRAL-NERVOUS-SYSTEM | TNF-ALPHA | INFLAMMATORY RESPONSE | MURINE MICROGLIA | Tryptases - metabolism | Microglia - metabolism | Animals | Reactive Oxygen Species - metabolism | Signal Transduction | Receptor, PAR-2 - metabolism | Interleukin-6 - biosynthesis | Rats | NF-kappa B - metabolism | Tumor Necrosis Factor-alpha - biosynthesis | MAP Kinase Signaling System
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15. Full Text Mast Cell-Mediated Antigen Presentation Regulates CD8+ T Cell Effector Functions
by Stelekati, Erietta and Bahri, Rajia and D'Orlando, Orietta and Orinska, Zane and Mittrücker, Hans-Willi and Langenhaun, Rabea and Glatzel, Markus and Bollinger, Annalena and Paus, Ralf and Bulfone-Paus, Silvia
Immunity, ISSN 1074-7613, 10/2009, Volume 31, Issue 4, pp. 665 - 676
The characteristics, importance, and molecular requirements for interactions between mast cells (MCs) and CD8 T cells have not been elucidated. Here, we... 
MOLIMMUNO | CELLIMMUNO | MURINE MODEL | DENDRITIC CELLS | MULTIPLE-SCLEROSIS | SEVERE DISEASE | IMMUNE-RESPONSES | PRESENTING CELLS | BONE-MARROW | LYMPH-NODES | GENE-EXPRESSION PROFILES | ITO CELLS | IMMUNOLOGY | Chemokine CCL3 - immunology | Encephalomyelitis, Autoimmune, Experimental - metabolism | Ovalbumin - immunology | Coculture Techniques | Granzymes - metabolism | Encephalomyelitis, Autoimmune, Experimental - immunology | Osteopontin - metabolism | Adoptive Transfer | Listeria monocytogenes - immunology | Mast Cells - microbiology | Histocompatibility Antigens Class I - metabolism | Interleukin-2 - immunology | Chemokine CCL3 - biosynthesis | Peptide Fragments - immunology | Listeriosis - immunology | Mast Cells - metabolism | CD8-Positive T-Lymphocytes - metabolism | Granzymes - immunology | Mast Cells - immunology | CD8-Positive T-Lymphocytes - microbiology | Encephalomyelitis, Autoimmune, Experimental - pathology | Mice, Inbred C57BL | Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology | Histocompatibility Antigens Class I - immunology | Myelin-Oligodendrocyte Glycoprotein | Mice, Transgenic | Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism | Antigen Presentation - immunology | Cell Degranulation - immunology | Osteopontin - immunology | Glycoproteins - immunology | Animals | Cross-Priming - immunology | Interferon-gamma - immunology | Listeriosis - microbiology | Mice | CD8-Positive T-Lymphocytes - immunology | Interleukin-2 - biosynthesis | Interferon-gamma - biosynthesis | T cell receptors | Peptides | Immune system | Cell adhesion & migration
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