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06/2010
Retinoblastoma is the prototype genetic cancer caused by mutations disrupting the RB1 tumor suppressor gene. Following loss of RB1, retinoblastoma acquires... 
MYCN | Genetics | Retinoblastoma | aCGH
Dissertation
Frontiers in Oncology, ISSN 2234-943X, 10/2019, Volume 9
Background: Amplification of the MYCN oncogene is the most unfavorable genetic factor in neuroblastoma patients. However, knowledge about the clinical impact... 
Care and treatment | Patient outcomes | Neuroblastoma | 2p gain | neuroblastoma | structural chromosomal aberrations | MYCN amplification | MYCN gain
Journal Article
CANCER, ISSN 0008-543X, 10/2013, Volume 119, Issue 20, pp. 3718 - 3726
BACKGROUNDThis study sought to investigate biological/clinicopathological characteristics of neuroblastoma, undifferentiated subtype (NBUD). METHODSThis study... 
neuroblastoma | PHENOTYPE | undifferentiated subtype | prognostic factors | COMMITTEE | TUMORS | SCHWANNIAN STROMA-POOR | PATHOLOGY CLASSIFICATION | AMPLIFICATION | ONCOLOGY | C-MYC PROTEIN | MYC | MYCN expression | CHILDHOOD MEDULLOBLASTOMA | N-MYC | MYCN amplification | PROGRESSION
Journal Article
Zhonghua Shiyan Yanke Zazhi/Chinese Journal of Experimental Ophthalmology, ISSN 2095-0160, 08/2017, Volume 35, Issue 8, pp. 756 - 760
Journal Article
PLOS ONE, ISSN 1932-6203, 05/2012, Volume 7, Issue 5
Background: Neuroblastoma is one of the most challenging malignancies of childhood, being associated with the highest death rate in paediatric oncology,... 
CANCER-CELLS | LUNG-CANCER | SUPPRESSOR | THERAPY | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DOWN-REGULATION | N-MYC | PHASE-I | EXPRESSION | MYCN ONCOGENE
Journal Article
BBA - Gene Regulatory Mechanisms, ISSN 1874-9399, 03/2018, Volume 1861, Issue 3, pp. 235 - 245
Childhood neuroblastoma, a disease of the sympathetic nervous system, is the most common solid tumour of infancy, remarkably refractory to therapeutic... 
MYCN | Neuroblastoma | MAX | MYCN gene amplification | ONCOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE DEVELOPMENT | BIOPHYSICS | PHEOCHROMOCYTOMA | HEREDITARY | DISEASE | GENES | N-MYC | DIFFERENTIATION | MUTATIONS | EXPRESSION
Journal Article
International Journal of Oncology, ISSN 1019-6439, 10/2010, Volume 37, Issue 4, pp. 983 - 991
Journal Article
Surgery Today, ISSN 0941-1291, 9/2019, Volume 49, Issue 9, pp. 721 - 727
Neuroblastoma is one of the most frequent, yet distinctive and challenging childhood tumors. The uniqueness of this tumor depends on its biological markers,... 
ALK | MYCN | Medicine & Public Health | Surgery | Neuroblastoma | Trk | Surgical Oncology | SURGERY | SOLID TUMORS | TARGETING MYCN | CELL FATE | IN-VITRO | AMPLIFICATION | N-MYC | LYMPHOMA | RECEPTORS | UP-REGULATION | EXPRESSION
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2016, Volume 11, Issue 8, p. e0161039
Journal Article
Oncotarget, ISSN 1949-2553, 2018, Volume 9, Issue 2, pp. 2591 - 2602
Maternal embryonic leucine zipper kinase (MELK) is known to modulate intracellular signaling and control cellular processes. However, the role of MELK in... 
Chemotherapy | MELK | Neuroblastoma | MYCN/MYC | OTSSP167 | CANCER-CELLS | ACTIVATION | ZIPPER KINASE MELK | GLIOMA | neuroblastoma | PROLIFERATION | chemotherapy | CELL BIOLOGY | POTENT | GROWTH | INHIBITOR | EXPRESSION
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 07/2019, Volume 25, Issue 13, pp. 4063 - 4078
Purpose: Neuroblastoma is a pediatric malignancy of the sympathetic nervous system with diverse clinical behaviors. Genomic amplification of MYCN oncogene has... 
ACTIVATION | MYCN | GENE | SERINE | ONCOLOGY | DIFFERENTIATION | IDENTIFICATION | REARRANGEMENTS | CANCER | EXPRESSION | NICLOSAMIDE
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 03/2019, Volume 62, Issue 5, pp. 2618 - 2637
Concomitant inhibition of anaplastic lymphoma kinase (ALK) and bromodomain-4 (BRD4) is a potential therapeutic strategy for targeting two key oncogenic drivers... 
POTENT | CHEMISTRY, MEDICINAL | MYCN | NEUROBLASTOMA | TUMOR-GROWTH | CANCER | DISCOVERY | PROBES
Journal Article
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