Seminars in Cell and Developmental Biology, ISSN 1084-9521, 12/2017, Volume 72, pp. 87 - 98
Pluripotent stem cells represent important tools for both basic and translational science as they enable to study mechanisms of development, model diseases in...
Cell therapy | Disease modeling | Paraxial mesoderm | MyoD | Pax3 | ES cells | Pluripotent stem cells | Myogenic progenitor | Myogenesis | iPS cells | WNT activation | TGFβ inhibitor | Pax7 | BMP inhibitor | Mesoderm specification | Somite | Muscle development | GSK3 inhibitor | Muscle regeneration | Myf5 | HUMAN ES | SATELLITE CELLS | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | IN-VITRO | EMBRYONAL CARCINOMA-CELLS | GENE-EXPRESSION | DUCHENNE MUSCULAR-DYSTROPHY | MOUSE EMBRYO | TGF beta inhibitor | SKELETAL-MUSCLE REGENERATION | NEURAL CREST | Pluripotent Stem Cells - cytology | Mesoderm - embryology | Humans | Muscle, Skeletal - metabolism | Mesoderm - cytology | Muscle, Skeletal - cytology | Muscle Proteins - genetics | Pluripotent Stem Cells - metabolism | Cell Differentiation - genetics | Animals | Gene Expression Regulation, Developmental | Muscle Development - genetics | Mesoderm - metabolism | Muscle, Skeletal - embryology | Cell Lineage - genetics | Medicine, Experimental | Medical research | Transplantation | Transforming growth factors | Analysis | Stem cells
Cell therapy | Disease modeling | Paraxial mesoderm | MyoD | Pax3 | ES cells | Pluripotent stem cells | Myogenic progenitor | Myogenesis | iPS cells | WNT activation | TGFβ inhibitor | Pax7 | BMP inhibitor | Mesoderm specification | Somite | Muscle development | GSK3 inhibitor | Muscle regeneration | Myf5 | HUMAN ES | SATELLITE CELLS | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | IN-VITRO | EMBRYONAL CARCINOMA-CELLS | GENE-EXPRESSION | DUCHENNE MUSCULAR-DYSTROPHY | MOUSE EMBRYO | TGF beta inhibitor | SKELETAL-MUSCLE REGENERATION | NEURAL CREST | Pluripotent Stem Cells - cytology | Mesoderm - embryology | Humans | Muscle, Skeletal - metabolism | Mesoderm - cytology | Muscle, Skeletal - cytology | Muscle Proteins - genetics | Pluripotent Stem Cells - metabolism | Cell Differentiation - genetics | Animals | Gene Expression Regulation, Developmental | Muscle Development - genetics | Mesoderm - metabolism | Muscle, Skeletal - embryology | Cell Lineage - genetics | Medicine, Experimental | Medical research | Transplantation | Transforming growth factors | Analysis | Stem cells
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 10/2002, Volume 159, Issue 1, pp. 123 - 134
Skeletal muscle contains myogenic progenitors called satellite cells and muscle-derived stem cells that have been suggested to be pluripotent. We further...
Skeletal muscle satellite cells | Artificial satellites | Stem cells | Cell lines | Muscles | Muscle fibers | Cellular differentiation | Cells | Hematopoietic stem cells | Myoblasts | Satellite cell | Hematopoiesis | Pax7 | Sca-1 | Stem cell | PROGENITORS | REGENERATION | MOUSE | SATELLITE CELLS | TRANSPLANTATION | CELL BIOLOGY | hematopoiesis | satellite cell | stem cell | DYSTROPHIN | HEMATOPOIETIC STEM-CELLS | DIFFERENTIATION | EXPRESSION | LINEAGE | Leukocyte Common Antigens - metabolism | Coculture Techniques | Homeodomain Proteins - metabolism | PAX7 Transcription Factor | Muscle, Skeletal - cytology | Recombinant Fusion Proteins - metabolism | Myoblasts, Skeletal - cytology | Muscle Development | Flow Cytometry | Myoblasts, Skeletal - physiology | Muscle Proteins - metabolism | Satellite Cells, Skeletal Muscle - physiology | Hematopoietic Stem Cells - physiology | Antigens, Ly - metabolism | Membrane Proteins - metabolism | Cell Differentiation - physiology | Genes, Reporter | DNA-Binding Proteins | Cell Separation | Satellite Cells, Skeletal Muscle - cytology | Trans-Activators | Cells, Cultured | Cell Transplantation | Mice, Transgenic | Muscle, Skeletal - physiology | Myogenic Regulatory Factor 5 | Transcription Factors - genetics | Mice, SCID | Homeodomain Proteins - genetics | Muscle Proteins - genetics | Transcription Factors - metabolism | Animals | Hematopoietic Stem Cells - cytology | Mice | MyoD Protein | Cytology | Physiological aspects | Genetic aspects | Research | Gene expression | Myogenesis | stem cell; satellite cell; Pax7; hematopoiesis; Sca-1
Skeletal muscle satellite cells | Artificial satellites | Stem cells | Cell lines | Muscles | Muscle fibers | Cellular differentiation | Cells | Hematopoietic stem cells | Myoblasts | Satellite cell | Hematopoiesis | Pax7 | Sca-1 | Stem cell | PROGENITORS | REGENERATION | MOUSE | SATELLITE CELLS | TRANSPLANTATION | CELL BIOLOGY | hematopoiesis | satellite cell | stem cell | DYSTROPHIN | HEMATOPOIETIC STEM-CELLS | DIFFERENTIATION | EXPRESSION | LINEAGE | Leukocyte Common Antigens - metabolism | Coculture Techniques | Homeodomain Proteins - metabolism | PAX7 Transcription Factor | Muscle, Skeletal - cytology | Recombinant Fusion Proteins - metabolism | Myoblasts, Skeletal - cytology | Muscle Development | Flow Cytometry | Myoblasts, Skeletal - physiology | Muscle Proteins - metabolism | Satellite Cells, Skeletal Muscle - physiology | Hematopoietic Stem Cells - physiology | Antigens, Ly - metabolism | Membrane Proteins - metabolism | Cell Differentiation - physiology | Genes, Reporter | DNA-Binding Proteins | Cell Separation | Satellite Cells, Skeletal Muscle - cytology | Trans-Activators | Cells, Cultured | Cell Transplantation | Mice, Transgenic | Muscle, Skeletal - physiology | Myogenic Regulatory Factor 5 | Transcription Factors - genetics | Mice, SCID | Homeodomain Proteins - genetics | Muscle Proteins - genetics | Transcription Factors - metabolism | Animals | Hematopoietic Stem Cells - cytology | Mice | MyoD Protein | Cytology | Physiological aspects | Genetic aspects | Research | Gene expression | Myogenesis | stem cell; satellite cell; Pax7; hematopoiesis; Sca-1
Journal Article
Developmental Cell, ISSN 1534-5807, 02/2016, Volume 36, Issue 4, pp. 375 - 385
Most transcription factor families contain highly related paralogs generated by gene duplication, and functional divergence is generally accomplished by...
TRANSCRIPTIONAL ACTIVATION | MUTANT MICE | MYOGENIC CELL-POPULATIONS | CHROMATIN | MOUSE EMBRYOGENESIS | MRF4 | DEVELOPMENTAL BIOLOGY | REGULATORY GENE | EXPRESSION | BINDING | FAMILY | CELL BIOLOGY | Cell Lineage | Animals | Muscle Proteins - metabolism | Muscle, Skeletal - metabolism | Mice | MyoD Protein - metabolism | Myogenic Regulatory Factor 5 - metabolism | Transcriptional Activation - physiology | Muscle, Skeletal - cytology | Cell Differentiation - physiology | Gene Expression Regulation, Developmental - physiology | Muscles | Medical colleges | Genetic transcription | DNA binding proteins | Genes | Genomics
TRANSCRIPTIONAL ACTIVATION | MUTANT MICE | MYOGENIC CELL-POPULATIONS | CHROMATIN | MOUSE EMBRYOGENESIS | MRF4 | DEVELOPMENTAL BIOLOGY | REGULATORY GENE | EXPRESSION | BINDING | FAMILY | CELL BIOLOGY | Cell Lineage | Animals | Muscle Proteins - metabolism | Muscle, Skeletal - metabolism | Mice | MyoD Protein - metabolism | Myogenic Regulatory Factor 5 - metabolism | Transcriptional Activation - physiology | Muscle, Skeletal - cytology | Cell Differentiation - physiology | Gene Expression Regulation, Developmental - physiology | Muscles | Medical colleges | Genetic transcription | DNA binding proteins | Genes | Genomics
Journal Article
Development (Cambridge), ISSN 0950-1991, 12/2012, Volume 139, Issue 24, pp. 4536 - 4548
During organogenesis, a continuum of founder stem cells produces temporally distinct progeny until development is complete. Similarly, in skeletal myogenesis,...
Nfix | Pax7 | Notch | Stem cells | Rbpj | Skeletal muscle | Spatiotemporal differentiation | Myf5 | PROGENITOR CELLS | SELF-RENEWAL | SATELLITE CELLS | DEVELOPMENTAL BIOLOGY | MYOGENIC CELLS | FETAL MYOBLASTS | IN-VIVO | DIFFERENTIATION | DROSOPHILA NEUROBLASTS | EXPRESSION | LINEAGE | Cell Division - genetics | Embryonic Stem Cells - metabolism | Embryo, Mammalian | Cells, Cultured | Embryonic Development - genetics | Embryonic Development - physiology | Mice, Transgenic | Muscle, Skeletal - metabolism | Receptor, Notch1 - metabolism | Embryonic Stem Cells - physiology | Cell Differentiation - genetics | Organ Specificity - genetics | Animals | Time Factors | Gene Expression Regulation, Developmental | Myoblasts, Skeletal - physiology | DNA Replication - genetics | Mice | Muscle, Skeletal - embryology | Receptor, Notch1 - genetics | Receptor, Notch1 - physiology | Myoblasts, Skeletal - metabolism
Nfix | Pax7 | Notch | Stem cells | Rbpj | Skeletal muscle | Spatiotemporal differentiation | Myf5 | PROGENITOR CELLS | SELF-RENEWAL | SATELLITE CELLS | DEVELOPMENTAL BIOLOGY | MYOGENIC CELLS | FETAL MYOBLASTS | IN-VIVO | DIFFERENTIATION | DROSOPHILA NEUROBLASTS | EXPRESSION | LINEAGE | Cell Division - genetics | Embryonic Stem Cells - metabolism | Embryo, Mammalian | Cells, Cultured | Embryonic Development - genetics | Embryonic Development - physiology | Mice, Transgenic | Muscle, Skeletal - metabolism | Receptor, Notch1 - metabolism | Embryonic Stem Cells - physiology | Cell Differentiation - genetics | Organ Specificity - genetics | Animals | Time Factors | Gene Expression Regulation, Developmental | Myoblasts, Skeletal - physiology | DNA Replication - genetics | Mice | Muscle, Skeletal - embryology | Receptor, Notch1 - genetics | Receptor, Notch1 - physiology | Myoblasts, Skeletal - metabolism
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/2004, Volume 23, Issue 16, pp. 3430 - 3439
The paired‐box transcription factor Pax7 has been claimed to specify the muscle stem cell lineage since inactivation of Pax7 led to a failure to detect muscle...
stem cells | muscle regeneration | muscle cell proliferation | muscle satellite cells | Pax7 | Muscle cell proliferation | Muscle satellite cells | Muscle regeneration | Stem cells | MYF-5 | REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | CELL BIOLOGY | SKELETAL-MUSCLE | MUTANT MICE | GENE | HEMATOPOIETIC STEM-CELLS | QUIESCENT | DIFFERENTIATION | EXPRESSION | Up-Regulation | Cell Proliferation | Homeodomain Proteins - metabolism | PAX7 Transcription Factor | DNA-Binding Proteins - metabolism | Muscle Development | Gene Expression Regulation, Developmental | Gene Deletion | Muscle Proteins - metabolism | Cell Differentiation | PAX3 Transcription Factor | Paired Box Transcription Factors | Satellite Cells, Skeletal Muscle - cytology | Cells, Cultured | Satellite Cells, Skeletal Muscle - metabolism | MyoD Protein - metabolism | Myogenic Regulatory Factor 5 | Microscopy, Electron | Mutation - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Regeneration | Animals | Aging - physiology | Trans-Activators - metabolism | Mice
stem cells | muscle regeneration | muscle cell proliferation | muscle satellite cells | Pax7 | Muscle cell proliferation | Muscle satellite cells | Muscle regeneration | Stem cells | MYF-5 | REGENERATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | CELL BIOLOGY | SKELETAL-MUSCLE | MUTANT MICE | GENE | HEMATOPOIETIC STEM-CELLS | QUIESCENT | DIFFERENTIATION | EXPRESSION | Up-Regulation | Cell Proliferation | Homeodomain Proteins - metabolism | PAX7 Transcription Factor | DNA-Binding Proteins - metabolism | Muscle Development | Gene Expression Regulation, Developmental | Gene Deletion | Muscle Proteins - metabolism | Cell Differentiation | PAX3 Transcription Factor | Paired Box Transcription Factors | Satellite Cells, Skeletal Muscle - cytology | Cells, Cultured | Satellite Cells, Skeletal Muscle - metabolism | MyoD Protein - metabolism | Myogenic Regulatory Factor 5 | Microscopy, Electron | Mutation - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Regeneration | Animals | Aging - physiology | Trans-Activators - metabolism | Mice
Journal Article
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Full Text
Environmental physical cues determine the lineage specification of mesenchymal stem cells
BBA - General Subjects, ISSN 0304-4165, 06/2015, Volume 1850, Issue 6, pp. 1261 - 1266
Physical cues of cellular environment affect cell fate and differentiation. For example, an environment with high stiffness drives mesenchymal stem cells...
Mesenchymal stem cell | Cytoskeleton | Stiffness | Topography | Physical cue | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | PROMOTES OSTEOGENIC DIFFERENTIATION | MECHANICAL REGULATION | FOCAL ADHESIONS | MODELED MICROGRAVITY | BIOPHYSICS | MYOGENIC DIFFERENTIATION | EXTRACELLULAR-MATRIX | IN-VITRO DIFFERENTIATION | MARROW STROMAL CELLS | ADIPOSE-TISSUE | Physical Stimulation | Stem Cell Niche | Humans | Extracellular Matrix - metabolism | Mesenchymal Stromal Cells - metabolism | Stress, Mechanical | Pressure | Cell Lineage | Mechanotransduction, Cellular | Animals | Cell Shape | Cytoskeleton - physiology | Mesenchymal Stromal Cells - physiology | Cell differentiation | Stem cells
Mesenchymal stem cell | Cytoskeleton | Stiffness | Topography | Physical cue | BIOCHEMISTRY & MOLECULAR BIOLOGY | BONE-MARROW | PROMOTES OSTEOGENIC DIFFERENTIATION | MECHANICAL REGULATION | FOCAL ADHESIONS | MODELED MICROGRAVITY | BIOPHYSICS | MYOGENIC DIFFERENTIATION | EXTRACELLULAR-MATRIX | IN-VITRO DIFFERENTIATION | MARROW STROMAL CELLS | ADIPOSE-TISSUE | Physical Stimulation | Stem Cell Niche | Humans | Extracellular Matrix - metabolism | Mesenchymal Stromal Cells - metabolism | Stress, Mechanical | Pressure | Cell Lineage | Mechanotransduction, Cellular | Animals | Cell Shape | Cytoskeleton - physiology | Mesenchymal Stromal Cells - physiology | Cell differentiation | Stem cells
Journal Article
Annual Review of Cell and Developmental Biology, ISSN 1081-0706, 11/2002, Volume 18, Issue 1, pp. 747 - 783
Embryological and genetic studies of mouse, bird, zebrafish, and frog embryos are providing new insights into the regulatory functions of the myogenic...
Myogenin | MyoD | MRF4 | Myf5 | myogenin | NEURAL-TUBE | SATELLITE CELLS | DEVELOPMENTAL BIOLOGY | AVIAN SOMITE | BHLH GENE-EXPRESSION | XENOPUS-EMBRYOS | CELL-TYPE SPECIFICATION | PRECURSOR CELLS | ADULT SKELETAL-MUSCLE | SONIC-HEDGEHOG | MESODERM INDUCTION | MyoD Protein - genetics | Humans | Trans-Activators | Vertebrates - embryology | Muscle, Skeletal - metabolism | MyoD Protein - metabolism | Stem Cells - cytology | Myogenic Regulatory Factor 5 | Muscle, Skeletal - cytology | Stem Cells - metabolism | Embryo, Mammalian - metabolism | Muscle Proteins - genetics | Cell Differentiation - genetics | Genes, Regulator - genetics | Animals | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Embryo, Nonmammalian | Muscle Proteins - metabolism | Muscle, Skeletal - embryology | Vertebrates - metabolism | DNA-Binding Proteins
Myogenin | MyoD | MRF4 | Myf5 | myogenin | NEURAL-TUBE | SATELLITE CELLS | DEVELOPMENTAL BIOLOGY | AVIAN SOMITE | BHLH GENE-EXPRESSION | XENOPUS-EMBRYOS | CELL-TYPE SPECIFICATION | PRECURSOR CELLS | ADULT SKELETAL-MUSCLE | SONIC-HEDGEHOG | MESODERM INDUCTION | MyoD Protein - genetics | Humans | Trans-Activators | Vertebrates - embryology | Muscle, Skeletal - metabolism | MyoD Protein - metabolism | Stem Cells - cytology | Myogenic Regulatory Factor 5 | Muscle, Skeletal - cytology | Stem Cells - metabolism | Embryo, Mammalian - metabolism | Muscle Proteins - genetics | Cell Differentiation - genetics | Genes, Regulator - genetics | Animals | Embryo, Mammalian - embryology | Embryo, Mammalian - cytology | Embryo, Nonmammalian | Muscle Proteins - metabolism | Muscle, Skeletal - embryology | Vertebrates - metabolism | DNA-Binding Proteins
Journal Article