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1. Full Text Mutations in Myosin Light Chain Kinase Cause Familial Aortic Dissections
by Wang, Li and Guo, Dong-chuan and Cao, Jiumei and Gong, Limin and Kamm, Kristine E and Regalado, Ellen and Li, Li and Shete, Sanjay and He, Wei-Qi and Zhu, Min-Sheng and Offermanns, Stephan and Gilchrist, Dawna and Elefteriades, John and Stull, James T and Milewicz, Dianna M
The American Journal of Human Genetics, ISSN 0002-9297, 2010, Volume 87, Issue 5, pp. 701 - 707
Mutations in smooth muscle cell (SMC)-specific isoforms of α-actin and β-myosin heavy chain, two major components of the SMC contractile unit, cause familial... 
ACTIVATION | PHOSPHORYLATION | ANEURYSMS | MOUSE | GENETICS & HEREDITY | ANGIOTENSIN-II | TISSUES | PATHOLOGY | IDENTIFICATION | SMOOTH-MUSCLE CONTRACTION | EXPRESSION | Myosin-Light-Chain Kinase - genetics | Aneurysm, Dissecting - genetics | Aortic Aneurysm, Thoracic - genetics | Genetic Predisposition to Disease | Humans | Middle Aged | Male | Genetic Variation | Animals | Pedigree | Adolescent | Adult | Female | Mice | Mutation | Gene mutations | Analysis | Myosin | Aortic aneurysms | Genetic aspects | Chemical properties | Structure | Phosphotransferases | Health aspects | Report
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2. Full Text Myosin light chain kinase in microvascular endothelial barrier function
by Shen, Qiang and Rigor, Robert R and Pivetti, Christopher D and Wu, MacK H and Yuan, Sarah Y
Cardiovascular Research, ISSN 0008-6363, 2010, Volume 87, Issue 2, pp. 272 - 280
Microvascular barrier dysfunction is implicated in the initiation and progression of inflammation, posttraumatic complications, sepsis, ischaemia-reperfusion... 
Endothelial barrier function | Contractile cytoskeleton | MLCK | MLC | Microvascular permeability | CARDIAC & CARDIOVASCULAR SYSTEMS | CELL GAP FORMATION | THERMAL-INJURY | RHO-KINASE | ACUTE LUNG INJURY | VENULAR PERMEABILITY | FOCAL ADHESIONS | SMOOTH-MUSCLE MYOSIN | IN-VIVO | NITRIC-OXIDE | INDUCED HYPERPERMEABILITY | Microvessels - physiopathology | Myosin-Light-Chain Kinase - genetics | Phosphorylation | Humans | Capillary Permeability - drug effects | Endothelium, Vascular - drug effects | Myosin-Light-Chain Kinase - antagonists & inhibitors | Endothelium, Vascular - enzymology | Microvessels - immunology | Capillary Permeability - genetics | Inflammation Mediators - metabolism | Models, Animal | Microvessels - enzymology | Endothelium, Vascular - immunology | Signal Transduction | Myosin-Light-Chain Kinase - metabolism | Cells, Cultured | Endothelium, Vascular - physiopathology | Microvessels - drug effects | Mice, Transgenic | Actomyosin - metabolism | Animals | Body Fluids - metabolism | Mice | Myosin Light Chains - metabolism | Protein Kinase Inhibitors - pharmacology | Inflammation - enzymology | Inflammation - physiopathology | Spotlight Reviews
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3. Full Text Myosin light chain kinase: pulling the strings of epithelial tight junction function
by Cunningham, Kevin E and Turner, Jerrold R
Annals of the New York Academy of Sciences, ISSN 0077-8923, 07/2012, Volume 1258, Issue 1, pp. 34 - 42
Dynamic regulation of paracellular permeability is essential for physiological epithelial function, while dysregulated permeability is common in disease. The... 
TNF‐α | myosin light chain kinase | tight junction | inflammatory bowel disease | Inflammatory bowel disease | Tight junction | TNF-α | Myosin light chain kinase | BARRIER DYSFUNCTION | MEMBRANE-PERMEANT PEPTIDE | CROHNS-DISEASE | TNF-alpha | MULTIDISCIPLINARY SCIENCES | ACTIN-BINDING REGION | NECROSIS-FACTOR-ALPHA | GLUCOSE-TRANSPORT | INCREASED INTESTINAL PERMEABILITY | INFLAMMATORY-BOWEL-DISEASE | PHYSIOLOGICAL REGULATION | DIARRHEA IN-VIVO | Crohn Disease - enzymology | Intestinal Mucosa - physiology | Tight Junctions - physiology | Animals | Myosin-Light-Chain Kinase - metabolism | Humans | Intestinal Mucosa - enzymology | Tumor Necrosis Factor-alpha - physiology | Crohn Disease - physiopathology | Tight Junctions - enzymology | Disease Progression | Permeability | Regulators | Control | Pathogenesis | Myosin | Chains | Kinases | Strings | IBD
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4. Full Text Constitutive phosphorylation of cardiac myosin regulatory light chain in vivo
by Chang, Audrey N and Battiprolu, Pavan K and Cowley, Patrick M and Chen, Guohua and Gerard, Robert D and Pinto, Jose R and Hill, Joseph A and Baker, Anthony J and Kamm, Kristine E and Stull, James T
Journal of Biological Chemistry, ISSN 0021-9258, 04/2015, Volume 290, Issue 17, pp. 10703 - 10716
In beating hearts, phosphorylation of myosin regulatory light chain (RLC) at a single site to 0.45 mol of phosphate/mol by cardiac myosin light chain kinase... 
BINDING-PROTEIN-C | SMOOTH-MUSCLE MYOSIN | SKELETAL-MUSCLE | MYOFILAMENT PHOSPHORYLATION | HYPERTROPHIC CARDIOMYOPATHY | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | TARGET SUBUNIT | PERFUSED RAT-HEART | TROPONIN-I | DIFFERENTIAL ROLES | Phosphorylation | Calmodulin - metabolism | Myosin Light Chains - genetics | Calcium - metabolism | Myosin-Light-Chain Kinase - metabolism | Mice, Inbred C57BL | Myocardial Contraction - physiology | Rats | Male | Myosin Light Chains - deficiency | Rats, Sprague-Dawley | Mice, Knockout | Animals | Myocardium - metabolism | Myosin-Light-Chain Phosphatase - metabolism | Myocytes, Cardiac - metabolism | Heart Ventricles - metabolism | Mice | Myosin Light Chains - metabolism | Cardiac Muscle | Myosin Light Chain Kinase | Signal Transduction | Myosin | Calmodulin (CaM) | Phosphatase
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5. Full Text Myosin Light Chain Kinase Signaling in Endothelial Barrier Dysfunction
by Rigor, Robert R and Shen, Qiang and Pivetti, Christopher D and Wu, Mack H and Yuan, Sarah Y
Medicinal Research Reviews, ISSN 0198-6325, 09/2013, Volume 33, Issue 5, pp. 911 - 933
Microvascular barrier dysfunction is a serious problem that occurs in many inflammatory conditions, including sepsis, trauma, ischemia–reperfusion injury,... 
endothelial barrier dysfunction | protein kinases | myosin light chain kinase (MLCK) | edema | microvascular permeability | Edema | Endothelial barrier dysfunction | Myosin light chain kinase (MLCK) | Protein kinases | Microvascular permeability | INTERSTITIAL FLUID PRESSURE | CHEMISTRY, MEDICINAL | CELL GAP FORMATION | INDUCED LUNG INJURY | VASCULAR-PERMEABILITY | PARACELLULAR PERMEABILITY | MICROVASCULAR HYPERPERMEABILITY | OPERATED CALCIUM-ENTRY | IN-VIVO | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | C ACTIVATION | Endothelium - drug effects | Permeability - drug effects | Animals | Signal Transduction - drug effects | Myosin-Light-Chain Kinase - metabolism | Protective Agents - pharmacology | Humans | Endothelium - enzymology | Molecular Targeted Therapy | Myosin-Light-Chain Kinase - chemistry | Endothelium - physiopathology | Histamine | Nitric oxide | Sphingosine | Myosin | Thrombin | Muscle proteins | Phosphotransferases | Endothelium
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6. Full Text Signaling to myosin regulatory light chain in sarcomeres
by Kamm, Kristine E and Stull, James T
Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 12, pp. 9941 - 9947
Myosin regulatory light chain (RLC) phosphorylation in skeletal and cardiac muscles modulates Ca2+-dependent troponin regulation of contraction. RLC is... 
POSTACTIVATION POTENTIATION | SMOOTH-MUSCLE | FAMILIAL HYPERTROPHIC CARDIOMYOPATHY | CA2+ SENSITIVITY | PHOSPHATASE-ASSOCIATED KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SKELETAL-MUSCLE CONTRACTION | INTERACTING PROTEIN-KINASE | FORCE DEVELOPMENT | PERFUSED RABBIT HEART | CALCIUM SENSITIVITY | Phosphorylation | Animals | Heart Diseases - metabolism | Signal Transduction | Calcium - metabolism | Myosin-Light-Chain Kinase - metabolism | Sarcomeres - metabolism | Humans | Myosin Light Chains - metabolism | Cardiac Muscle | Myosin Light Chain Kinase | Protein Kinases | Myosin | Minireviews | Protein Phosphorylation | Sarcomere | Calmodulin
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7. Full Text The significance of regulatory light chain phosphorylation in cardiac physiology
by Scruggs, Sarah B and Solaro, R. John
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 2011, Volume 510, Issue 2, pp. 129 - 134
► Understanding of cardiac myosin regulatory light chain (RLC) phosphorylation has advanced. ► Advances include identification of unique kinase and phosphatase... 
Adrenergic control | Myosin light chain phosphatase | MYPT2 | Myosin light chain kinase | Myofilament Ca 2+ sensitivity | Hypertrophy | Myofilament Ca | sensitivity | PROTEIN-KINASE-C | BIOCHEMISTRY & MOLECULAR BIOLOGY | VERTEBRATE STRIATED-MUSCLE | TROPONIN-I | SMOOTH-MUSCLE | BIOPHYSICS | CA2+ SENSITIVITY | Myofilament Ca2+ sensitivity | CROSS-BRIDGE KINETICS | SKELETAL-MUSCLE FIBERS | FORCE DEVELOPMENT | PERFUSED RABBIT HEART | MYOSIN PHOSPHATASE | Amino Acid Sequence | Phosphorylation | Animals | Myosin-Light-Chain Kinase - metabolism | Heart - physiology | Humans | Myosin-Light-Chain Phosphatase - metabolism | Myosin Light Chains - chemistry | Molecular Sequence Data | Myosin-Light-Chain Phosphatase - chemistry | Myosin Light Chains - metabolism | Myosin-Light-Chain Kinase - chemistry | Physiological aspects | Phosphatases | Muscle proteins | Analysis | Myosin | adrenergic control | myosin light chain phosphatase | myofilament Ca2+ sensitivity | hypertrophy | myosin light chain kinase
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8. Full Text Signaling through myosin light chain kinase in smooth muscles
by Gao, Ning and Huang, Jian and He, Weiqi and Zhu, Minsheng and Kamm, Kristine E and Stull, James T
Journal of Biological Chemistry, ISSN 0021-9258, 03/2013, Volume 288, Issue 11, pp. 7596 - 7605
Ca2+/calmodulin-dependent myosin light chain kinase (MLCK) phosphorylates smooth muscle myosin regulatory light chain (RLC) to initiate contraction. We used a... 
CALYCULIN-A | PROTEIN PHOSPHATASE | CA2+ SENSITIZATION | ACTIVATION | CONTRACTION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CALCIUM | RHO-KINASE | BINDING | OKADAIC ACID | Myosin-Light-Chain Kinase - genetics | Phosphorylation | Calmodulin - metabolism | Signal Transduction | Urinary Bladder - metabolism | Myosin-Light-Chain Kinase - metabolism | Electrophoresis, Polyacrylamide Gel | Humans | Mice, Transgenic | Aorta - metabolism | Phosphoproteins - metabolism | Gene Expression Regulation, Enzymologic | Carbachol - pharmacology | Animals | Muscle Contraction | Phenylephrine - pharmacology | Muscle Proteins - metabolism | Mice | Muscle, Smooth - cytology | Aorta - enzymology | Muscle, Smooth - enzymology | Myosin Light Chain Kinase | Calcium | Myosin | Smooth Muscle | Calmodulin
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9. Full Text Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity
by Weber, Christopher R and Raleigh, David R and Su, Liping and Shen, Le and Sullivan, Erika A and Wang, Yingmin and Turner, Jerrold R
Journal of Biological Chemistry, ISSN 0021-9258, 04/2010, Volume 285, Issue 16, pp. 12037 - 12046
Intestinal barrier function is reduced in inflammatory bowel disease (IBD). Tumor necrosis factor (TNF) and interleukin (IL)-13, which are up-regulated in IBD,... 
NK-T-CELLS | BARRIER DYSFUNCTION | INCREASED INTESTINAL PERMEABILITY | INFLAMMATORY-BOWEL-DISEASE | CROHNS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ULCERATIVE-COLITIS | PARACELLULAR PORES | NECROSIS-FACTOR-ALPHA | DIARRHEA IN-VIVO | CLAUDIN-2 EXPRESSION | Myosin-Light-Chain Kinase - genetics | RNA, Small Interfering - genetics | Intestinal Mucosa - metabolism | Humans | Recombinant Proteins - biosynthesis | RNA, Messenger - metabolism | Intestinal Mucosa - drug effects | Interleukin-13 - biosynthesis | Intestinal Mucosa - immunology | Base Sequence | Ion Transport | Inflammatory Bowel Diseases - etiology | Caco-2 Cells | Tight Junctions - metabolism | Cell Line | Recombinant Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Myosin-Light-Chain Kinase - metabolism | Tissue Culture Techniques | RNA, Messenger - genetics | Mice, Transgenic | Recombinant Proteins - genetics | Recombinant Proteins - pharmacology | Interleukin-13 - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Claudins | Membrane Proteins - biosynthesis | Animals | Membrane Proteins - antagonists & inhibitors | Mice | Enzyme Activation | Molecular Bases of Disease | Action | Cytokines | Organisms | Epithelium | Cell Biology | Organ Systems | Tissue | Mouse | Intestine | Cell | Tumor Necrosis Factor | Epithelial
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10. Full Text Myosin light chain phosphorylation to the rescue
by Henk L. Granzier and Pieter P. de Tombe
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2015, Volume 112, Issue 30, pp. 9148 - 9149
COMMENTARY | HEART | HYPERTROPHIC CARDIOMYOPATHY | GENETICS | KINETICS | MULTIDISCIPLINARY SCIENCES | DISEASE | MUTATION | FAILURE | Animals | Myosin Light Chains - genetics | Cardiomyopathy, Hypertrophic - metabolism | Humans | Myosin Light Chains - chemistry | Female | Male | Phosphorylation | Observations | Health aspects | Myosin | Biological Sciences | Commentaries
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11. Full Text Identification of Cardiac-Specific Myosin Light Chain Kinase
by Chan, Jason Y and Takeda, Morihiko and Briggs, Laura E and Graham, Megan L and Lu, Jonathan T and Horikoshi, Nobuo and Weinberg, Ellen O and Aoki, Hiroki and Sato, Naruki and Chien, Kenneth R and Kasahara, Hideko
Circulation Research, ISSN 0009-7330, 03/2008, Volume 102, Issue 5, pp. 571 - 580
Two myosin light chain (MLC) kinase (MLCK) proteins, smooth muscle (encoded by mylk1 gene) and skeletal (encoded by mylk2 gene) MLCK, have been shown to be... 
Transcription | Kinase | Contraction | LOCALIZATION | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN | transcription | PHOSPHORYLATION | PERFUSED RAT-HEART | SMOOTH-MUSCLE MYOSIN | SKELETAL-MUSCLE | kinase | POTENTIATION | contraction | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | AUTOPHOSPHORYLATION | Animals, Newborn | Myocardial Contraction | Myosin-Light-Chain Kinase - genetics | Conserved Sequence - genetics | Phosphorylation | Myocytes, Cardiac - cytology | Sarcomeres - metabolism | Heart Failure - enzymology | Cells, Cultured | Heart Failure - physiopathology | Molecular Sequence Data | Rats | Organ Specificity | Myocardial Infarction - complications | Animals | Heart Ventricles - enzymology | Cloning, Molecular | Myocytes, Cardiac - metabolism | Mice | Myosin Light Chains - metabolism | Heart Atria - enzymology | Heart Failure - etiology | Cardiac Myosins - metabolism | Myosin-Light-Chain Kinase - biosynthesis
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12. Full Text Biochemistry of smooth muscle myosin light chain kinase
by Hong, Feng and Haldeman, Brian D and Jackson, Del and Carter, Mike and Baker, Jonathan E and Cremo, Christine R
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 2011, Volume 510, Issue 2, pp. 135 - 146
► We summarize biochemical work on smooth muscle MLCK pertaining to smooth muscle function. ► Focus is on discussion of new findings, areas that require... 
Motility | Actomyosin | Actin | Myosin light chain kinase | Myosin | Smooth muscle | Kinases | Contraction | ATP-DEPENDENT INTERACTION | F-ACTIN | THIN-FILAMENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BARRIER FUNCTION | HEAVY-MEROMYOSIN | TURKEY GIZZARD | ACTIN-BINDING DOMAIN | NONMUSCLE MYOSIN | BIOPHYSICS | C-TERMINAL DOMAIN | MOLECULAR-BASIS | Protein Structure, Tertiary | Amino Acid Sequence | Animals | Myosin-Light-Chain Kinase - metabolism | Humans | Muscle Proteins - metabolism | Conserved Sequence | Molecular Sequence Data | Muscle, Smooth - cytology | Muscle, Smooth - metabolism | Myosin-Light-Chain Kinase - chemistry | Muscle, Smooth - enzymology | Biochemistry | Muscle proteins | Phosphotransferases
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