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International Immunopharmacology, ISSN 1567-5769, 11/2013, Volume 17, Issue 3, pp. 638 - 650
Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue... 
Signaling | Receptors | Inflammation | Kinases | Neutrophils | ACTIVATED PROTEIN-KINASE | COLONY-STIMULATING FACTOR | LEUKOCYTE ADHESION DEFICIENCY | IMMUNOLOGY | SRC-FAMILY KINASES | HUMAN POLYMORPHONUCLEAR LEUKOCYTES | HIGH-AFFINITY RECEPTOR | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | NF-KAPPA-B | Signal Transduction - immunology | Animals | Receptors, Cell Surface - immunology | Humans | Neutrophils - immunology | Selectins - immunology | Mycoses | Lectins | Fc receptors | Integrins | FcR, Fc-receptor | GPI, glycosylphosphatidylinositol anchor | CLEC, C-type lectin | OSCAR, osteoclast-associated receptor | PKB, protein kinase B | DAG, diacyl-glycerol | Tyk2, tyrosine protein kinase 2 | VCAM-1, vascular cell adhesion molecule 1 | ICAM-1, intercellular adhesion molecule 1 | FADD, Fas-associated protein with death domain | IκB, inhibitor of NF-κB | GM-CSF, granulocyte | MyD88, myeloid differentiation protein 88 | TNF, tumor necrosis factor | LTβ, lymphotoxin β | TRADD, TNFR1-associated death domain protein | Abl, Abelson leukemia proto-oncogene | SLP-76, SH2 domain-containing leukocyte protein of 76 kDa | CALDAG-GEFI, calcium and DAG-regulated guanine nucleotide exchange factor I | IL, interleukin | Src, Rous sarcoma virus proto-oncogene | IRF, IFN regulatory factor | RIG, retinoic acid-inducible gene | PLC, phospholipase C | TCR, T-cell receptor | IKK, IκB kinase | ITAM, immunoreceptor tyrosine-based activation motif | CARD, caspase activation and recruitment domain | IP3, inositol-tris-phosphate | CHO, Chinese hamster ovary cells | MKK, MAP kinase kinase | fMLP, formly-Met-Leu-Phe | TRAF, TNF receptor-associated factor | MIP, macrophage inflammatory protein | Rac, Ras-related C3 botulinum toxin substrate | monocyte colony-stimulating factor | PIP3, phosphatidylinositol-3-phosphate | VLA-4, very late antigen 4 (α4β1 integrin) | PAF, platelet activating factor | STAT, signal transducer and activator of transcription | TAK, TGFβ-activated kinase 1 | Mac-1, macrophage antigen 1 (αMβ2 integrin) | FcRγ, Fc-receptor γ-chain | Asc, apoptosis-associated speck-like protein containing a CARD | cIAP, cellular inhibitor of apoptosis | BCR, B-cell receptor | Fgr, Gardner–Rasheed feline sarcoma proto-oncogene | VASP, vasodilator-stimulated phosphoprotein | Hck, hematopoietic cell kinase | TGFβ, transforming growth factor β | Rap, Ras-related protein | SHP-1, SH2 domain-containing protein tyrosine phosphatase 1 | Syk, spleen tyrosine kinase | GPCR, G protein-coupled receptor | G-CSF, granulocyte colony-stimulating factor | TREM, triggering receptor expressed on myeloid cells | DISC, death-inducing signaling complex | MDL-1, myeloid DAP12-associating lectin 1 | C3G, Crk SH3 domain-binding guanine nucleotide exchange factor (RapGEF1) | NF-κB, nuclear factor κB | ERM, ezrin-radixin-moesin | Epac1, exchange protein activated by cyclic AMP 1 | LTB4, leukotriene B4 | Mcl, macrophage C-type lectin | SAP130, Sin3A-associated protein of 130 kDa | SH2, Src-homology 2 domain | MAP kinase, mitogen-activated protein kinase | PSGL-1, P-selectin glycoprotein ligand | PI3K, phoshoinositide-3-kinase | ADAP, adhesion and degranulation promoting adapter protein (Fyb, SLAP-130) | NLRP3, NOD-like receptor family, pyrin domain containing 3 | MDA5, melanoma differentiation-associated protein 5 | TLR, Toll-like receptor | GRK, GPCR kinase | LAD, leukocyte adhesion deficiency | MAPKAP-kinase, MAP kinase-associated protein kinase | ZAP-70, ζ-chain-associated protein of 70 kDa | TRAIL, TNF-related apoptosis-inducing ligand | JNK, c-Jun N-terminal kinase | LFA-1, lymphocyte function-associated receptor 1 (αLβ2 integrin) | ROS, reactive oxygen species | RIP3, receptor-interacting serine-threonine protein kinase 3 | DAP12, DNAX activating protein 12 | IFN, interferon | PIR, paired immunoglobulin-like receptor | PKC, protein kinase C | PAK, p21-activated kinase | ESL-1, E-selectin ligand 1 | GAP, GTPase activating protein | ERK, extracellular signal-regulated kinase | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | RANK, receptor activator of NF-κB | IRAK, IL-1 receptor-associated kinase | NOD, nucleotide-binding oligomerization domain containing protein | CEACAM3, carcinoembryonic antigen-related cell adhesion molecule 3 (CD66b)
Journal Article
Research and Reports in Biochemistry, 01/2016, Volume 6, p. 39
LL-37, a cationic antimicrobial peptide, has numerous immune-modulating effects. However, the identity of a receptor that mediates the responses in immune... 
Heparan sulfate | Proteins | Biofilms | Bacterial infections | Peptides | Laboratories | Neutrophils | Ligands | Infections
Journal Article
Cell Motility and the Cytoskeleton, ISSN 0886-1544, 11/2000, Volume 47, Issue 3, pp. 174 - 188
Pyk2 is a member of the focal adhesion kinase (FAK) family, highly expressed in the central nervous system and haemopoietic cells. Although Pyk2 is homologous... 
cell migration | αMβ2/Mac‐1 integrin | monocyte‐macrophage | focal adhesion kinase | cell adhesion | Monocyte-macrophage | Mac-1 integrin | Focal adhesion kinase | Cell migration | α(M)β | Cell adhesion
Journal Article
Annals of the New York Academy of Sciences, ISSN 0077-8923, 06/2001, Volume 936, Issue 1, pp. 368 - 385
Journal Article
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 03/2018, Volume 23, Issue 3, pp. 324 - 337.e5
The intracellular pathogen (L.m.) is targeted by the autophagic machinery, but the molecular mechanisms involved and consequences for anti-listerial immunity... 
LC3-associated phagocytosis | non-canonical autophagy | macrophages | NAPDH oxidase Nox2 | acid sphingomyelinase | ROS | Listeria monocytogenes | β2 integrin | Mac-1/CR3 | lysosome | integrin
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 10/2017, Volume 134, Issue 4, pp. 585 - 604
Treatment of acute ischemic stroke with the thrombolytic tissue plasminogen activator (tPA) can significantly improve neurological outcomes; however,... 
Pathology | Neurosciences | Stroke | Medicine & Public Health | LRP1 | Tissue plasminogen activator | α M β 2 | CD11b/CD18 | Mac-1 | Platelet-derived growth factor-CC | Blood–brain barrier | TISSUE-PLASMINOGEN ACTIVATOR | FOCAL CEREBRAL-ISCHEMIA | PATHOLOGY | IMATINIB TREATMENT | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | CLINICAL NEUROLOGY | alpha(M)beta | SUBSTRATE-SPECIFICITY | Blood-brain barrier | FACTOR-ALPHA RECEPTOR | INTRACEREBRAL HEMORRHAGE | CENTRAL-NERVOUS-SYSTEM | DENSITY-LIPOPROTEIN RECEPTOR | INNATE IMMUNITY | Capillary Permeability - physiology | Cerebral Hemorrhage - metabolism | Leukocytes - pathology | Microglia - metabolism | Brain Ischemia - metabolism | Capillary Permeability - drug effects | Male | Tissue Plasminogen Activator - adverse effects | Stroke - pathology | Fibrinolytic Agents - adverse effects | Lymphokines - metabolism | Microglia - pathology | Female | Macrophage-1 Antigen - metabolism | Disease Models, Animal | Cerebral Hemorrhage - chemically induced | Tumor Suppressor Proteins - metabolism | Mice, Inbred C57BL | Bone Marrow Cells - pathology | Cells, Cultured | Receptors, LDL - metabolism | Mice, Transgenic | Stroke - drug therapy | Arterioles - drug effects | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | Arterioles - pathology | Blood-Brain Barrier - pathology | Fibrinolytic Agents - pharmacology | Platelet-Derived Growth Factor - metabolism | Stroke - metabolism | Animals | Arterioles - metabolism | Tissue Plasminogen Activator - pharmacology | Macrophage-1 Antigen - genetics | Brain Ischemia - drug therapy | Brain Ischemia - pathology | CD11b Antigen - metabolism | Cerebral Hemorrhage - pathology | Leukocytes - metabolism | Bone Marrow Cells - metabolism | Stroke (Disease) | Platelet-derived growth factor | Ischemia | Analysis | Bone marrow | Transplantation | Permeability | Integrins | Phosphorylation | CD11b antigen | Arterioles | Membrane permeability | Leukocytes | Macrophages | Hemorrhage | Thrombolysis | t-Plasminogen activator | Microglia | Cerebrovascular system | Cell activation | Cerebral blood flow | Mac1 protein | Rodents | Immunofluorescence | αMβ2 | CD18 | Original Paper | CD11b
Journal Article
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 7/2013, Volume 70, Issue 13, pp. 2395 - 2410
Journal Article
Journal Article