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Angewandte Chemie - International Edition, ISSN 1433-7851, 2009, Volume 48, Issue 33, pp. 6112 - 6116
Journal Article
06/2013
In 2006, an amphoteric molecule containing both an aldehyde and an unprotected amine was reported in the Yudin group by Dr. Ryan Hili. The unprotected... 
Ugi four component condensation | peptide macrocyclization | 0490
Dissertation
Tetrahedron, ISSN 0040-4020, 04/2018, Volume 74, Issue 14, pp. 1581 - 1612
Journal Article
European Journal of Inorganic Chemistry, ISSN 1434-1948, 11/2019, Volume 2019, Issue 41, pp. 4477 - 4485
Cationic nickel(II), palladium(II), and copper(II) isocorrole complexes were obtained from linear tetrapyrrolic 2,2′‐bidipyrrin precursors by metal‐templated... 
Porphyrinoids | N ligands | Nickel | Redox reactions | Macrocyclization
Journal Article
NATURE CHEMISTRY, ISSN 1755-4330, 02/2016, Volume 8, Issue 2, pp. 120 - 128
Site-selective functionalization of complex molecules is one of the most significant challenges in chemistry. Typically, protecting groups or catalysts must be... 
DRUG | IN-VITRO | PROTEIN | CHEMISTRY | LIGATION | SURFACE | TAG | CHEMISTRY, MULTIDISCIPLINARY | SITE-SPECIFIC CONJUGATION | PEPTIDE | MACROCYCLIZATION
Journal Article
Chemical Communications, ISSN 1359-7345, 2019, Volume 55, Issue 19, pp. 2841 - 2844
S-Arylation of cysteine residues is an increasingly powerful tool for site-specific modification of proteins, providing novel structure and electronic... 
BIOMOLECULES | BIOCONJUGATION | CHEMISTRY, MULTIDISCIPLINARY | MACROCYCLIZATION | UNPROTECTED PEPTIDES | PROTEIN MODIFICATION
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2020, Volume 59, Issue 2, pp. 674 - 678
Small peptides containing combinations of cysteine, tyrosine, histidine, and serine residues react with octafluorocyclopentene (OFCP) to afford atypically... 
macrocyclization | peptidomimetics | vinylic substitution | fluorinated compounds | heterocycles
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 10/2019, Volume 141, Issue 43, pp. 17388 - 17393
Protein ligases of defined substrate specificity are versatile tools for protein engineering. Upon completion of the reaction, the products of currently... 
CHEMISTRY, MULTIDISCIPLINARY | PEPTIDE MACROCYCLIZATION | BUTELASE 1
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 09/2019, Volume 21, Issue 18, pp. 7307 - 7310
A solid-phase approach including on-resin Ugi reactions was developed for the construction of beta-hairpins. Various N-alkylated dipeptide fragments proved... 
CHEMISTRY, ORGANIC | AMINO-ACID | MACROCYCLIZATION | GRAMICIDIN-S ANALOGS
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 03/2017, Volume 56, Issue 12, pp. 3177 - 3181
Journal Article
Organic Letters, ISSN 1523-7060, 2019, Volume 21, Issue 7, pp. 2029 - 2032
A biomimetic one-step ligase-catalyzed cyclo-oligomerization mediated by butelase 1, an Asn/Asp-specific ligase, is introduced that is time-, concentration-,... 
SIZE | ANTIMICROBIAL PEPTIDE | ANTIBACTERIAL | CHEMISTRY, ORGANIC | CYCLIZATION | MACROCYCLIZATION | MEMBRANOLYTIC SELECTIVITY
Journal Article
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 04/2019, Volume 84, Issue 8, pp. 4932 - 4939
The key macrocyclization step in the synthesis of simeprevir, a hepatitis C virus (HCV) antiviral drug, was studied. N-Boc substitution on the diene precursor... 
EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | HEPATITIS-C | MACROCYCLIZATION | TMC435
Journal Article
ChemBioChem, ISSN 1439-4227, 12/2019, Volume 20, Issue 24, pp. 2971 - 2971
UNC119 proteins mediate the activation and transport of N‐myristoylated proteins. In particular, UNC119a (grey mesh, PDB ID: 3RBQ) plays a crucial role in... 
protein–protein interaction | macrocyclization | peptidomimetics | trafficking | alpha-helixes
Journal Article
ChemBioChem, ISSN 1439-4227, 12/2019, Volume 20, Issue 24, pp. 2987 - 2990
The acyl‐binding UNC119 proteins mediate the activation and transport of various N‐myristoylated proteins. In particular, UNC119a plays a crucial role in the... 
protein–protein interaction | macrocyclization | peptidomimetics | trafficking | alpha-helixes
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 06/2018, Volume 140, Issue 22, pp. 6797 - 6800
Targeting tryptophan is a promising strategy to achieve high levels of selectivity for peptide or protein modification. A chemoselective peptide modification... 
VISIBLE-LIGHT PHOTOCATALYSIS | ALKYLATION | TRANSITION-METAL | SELECTIVE BIOCONJUGATION | FUTURE | CHEMISTRY, MULTIDISCIPLINARY | MACROCYCLIZATION | FEATURES
Journal Article
Angewandte Chemie (International ed. in English), ISSN 1433-7851, 7/2015, Volume 54, Issue 30, pp. 8665 - 8668
Macrocyclization is a broadly applied approach for overcoming the intrinsically disordered nature of linear peptides. For example, significant efforts have... 
Labelling | Bioconjugation | Oxime Ligation | Macrocyclization | Tether
Journal Article
ACCOUNTS OF CHEMICAL RESEARCH, ISSN 0001-4842, 03/2014, Volume 47, Issue 3, pp. 925 - 938
During the last century, conceptual advances in organo-metallic chemistry were often rapidly embraced by target oriented synthesis. Feedback provided by such... 
REARRANGEMENT | ALKYNE METATHESIS | ENANTIOSELECTIVE SYNTHESIS | (-)-RHAZINILAM | COMPLEXES | CHEMISTRY, MULTIDISCIPLINARY | CYCLOISOMERIZATION REACTIONS | MACROCYCLIZATION | F METHYL-ESTER | ELEMENTARY STEPS | ENYNES | Gold | Chemical properties | Research | Catalysis | Platinum | Synthesis (chemistry) | Cross coupling | Synthesis | Olefins | Metalorganic compounds | Metathesis | Arenas
Journal Article
Accounts of Chemical Research, ISSN 0001-4842, 06/2018, Volume 51, Issue 6, pp. 1475 - 1486
Conspectus Multicomponent reactions (MCRs) encompass an exciting class of chemical transformations that have proven success in almost all fields of synthetic... 
CYCLIC LIPOPEPTIDES | PEPTIDES | ANALOGS | TYROSINE BIOCONJUGATION | BUILDING-BLOCKS | ISOCYANIDES | UGI REACTION | CHEMISTRY, MULTIDISCIPLINARY | MACROCYCLIZATION | STRATEGIES | HYBRIDS
Journal Article
Synlett, ISSN 0936-5214, 09/2017, Volume 28, Issue 15, pp. 1913 - 1916
Abstract Cyclic peptides are attracting attention of medicinal chemists due to their increased stability in biological milieu as well as improved target... 
cluster | 2-APBA | Dap | peptide cyclization | iminoboronate | reversible | CHEMISTRY, ORGANIC | MACROCYCLIZATION
Journal Article
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