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Nature Chemical Biology, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, pp. 705 - 712
Actin-targeting macrolides comprise a large, structurally diverse group of cytotoxins isolated from remarkably dissimilar micro- and macroorganisms. In spite... 
BACTERIAL SYMBIONT | GENE-CLUSTER | CYTOTOXIC MACROLIDES | NATURAL-PRODUCT DISCOVERY | CYANOBACTERIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNTHASES | IN-SITU HYBRIDIZATION | SPONGE THEONELLA-SWINHOEI | IDENTIFICATION | ANTIFUNGAL MACROLIDE | Cyanobacteria - genetics | Deltaproteobacteria - metabolism | Multigene Family | Peptides | Actins - metabolism | Bacterial Proteins - chemistry | Cyanobacteria - metabolism | Molecular Sequence Data | Polyketides - chemistry | Small Molecule Libraries - metabolism | Polyketides - metabolism | Polyketide Synthases - metabolism | Macrolides - chemistry | Pyrans - chemistry | Pyrans - metabolism | Base Sequence | Actins - chemistry | Symbiosis | Gene Expression | Bacterial Proteins - genetics | Macrolides - metabolism | Biological Evolution | Small Molecule Libraries - chemistry | Polyketide Synthases - chemistry | Animals | Deltaproteobacteria - genetics | Theonella - microbiology | Protein Binding | Bacterial Proteins - metabolism | Polyketide Synthases - genetics | Enzymes | Bacteria | Biosynthesis | Metabolism | Polyketide Synthases/metabolism | Actins/metabolism | Macrolides/chemistry | Polyketide Synthases/chemistry | Life Sciences | Cyanobacteria/metabolism | Deltaproteobacteria/genetics | Bacterial Proteins/chemistry | Macrolides/metabolism | Actins/chemistry | Polyketide Synthases/genetics | Deltaproteobacteria/metabolism | Small Molecule Libraries/metabolism | Theonella/microbiology | Cyanobacteria/genetics | Pyrans/metabolism | Small Molecule Libraries/chemistry | Microbiology and Parasitology | Bacterial Proteins/metabolism | Polyketides/chemistry | Polyketides/metabolism | Bacterial Proteins/genetics | Pyrans/chemistry
Journal Article
2002, 2nd ed., ISBN 0125264518, 654
Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their... 
Macrolide antibiotics | Biology, life sciences
eBook
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17152 - 17157
Differences between the structures of bacterial, archaeal, and eukaryotic ribosomes account for the selective action of antibiotics. Even minor variations in... 
Ketolides | Antibiotics | Macrolides | Drug interactions | Ribosomes | Bacteria | Nucleotides | Electron density | Genetic mutation | Binding sites | Ribosome structure | Chloramphenicol | Telithromycin | Erythromycin | Clindamycin | PROTEIN | BACTERIAL RIBOSOME | RNA GENE | MULTIDISCIPLINARY SCIENCES | telithromycin | RESISTANCE MUTATIONS | CONFERRING RESISTANCE | erythromycin | DOMAIN-II | BINDING-SITE | chloramphenicol | MACROLIDE ANTIBIOTICS | ribosome structure | clindamycin | PLEUROMUTILINS | Haloarcula marismortui - genetics | Haloarcula marismortui - metabolism | Chloramphenicol - chemistry | Erythromycin - metabolism | Molecular Sequence Data | Ribosomes - metabolism | Deinococcus - metabolism | Deinococcus - genetics | Haloarcula marismortui - chemistry | X-Ray Diffraction | Anti-Bacterial Agents - chemistry | Base Sequence | Escherichia coli - metabolism | Ketolides - metabolism | Deinococcus - chemistry | Molecular Structure | Clindamycin - chemistry | Peptidyl Transferases - metabolism | Clindamycin - metabolism | Peptidyl Transferases - chemistry | Ribosomes - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli - chemistry | RNA, Ribosomal, 23S - chemistry | Erythromycin - chemistry | Escherichia coli - genetics | Ketolides - chemistry | RNA, Ribosomal, 23S - metabolism | Chloramphenicol - metabolism | Escherichia coli | Crystals | Genetic aspects | Research | Properties | Structure | Observations | Peptidyl transferases | Drugs | lincosamides | Pathogens | rRNA | rRNA 23S | Data processing | Ribosomal subunits | Ionizing radiation | Peptidyltransferase | Crystal structure | Tunnels | Biological Sciences
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2014, Volume 57, Issue 2, pp. 278 - 295
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17158 - 17163
The increasing prevalence of antibiotic-resistant pathogens reinforces the need for structures of antibiotic-ribosome complexes that are accurate enough to... 
Molecules | Antibiotics | Macrolides | Drug interactions | Ribosomes | Drug design | Biochemistry | Potassium | Functional groups | Lactones | Structure-based drug design | Crystal structure | structure-based drug design | DESIGN | RNA | MULTIDISCIPLINARY SCIENCES | KETOLIDES | MITOCHONDRIAL-DNA | NUCLEOTIDE | CHLORAMPHENICOL ACETYLTRANSFERASE | PEPTIDYL TRANSFERASE CENTER | crystal structure | RESISTANCE | BINDING-SITE | MACROLIDE ANTIBIOTICS | Haloarcula marismortui - genetics | Haloarcula marismortui - metabolism | Chloramphenicol - chemistry | Azithromycin - metabolism | Bacterial Proteins - chemistry | Erythromycin - metabolism | Ribosomes - metabolism | Thermus thermophilus - metabolism | Deinococcus - metabolism | Deinococcus - genetics | Haloarcula marismortui - chemistry | Thermus thermophilus - genetics | Anti-Bacterial Agents - chemistry | Ketolides - metabolism | Deinococcus - chemistry | Molecular Structure | Binding Sites | Thermus thermophilus - chemistry | Azithromycin - chemistry | Ribosomes - chemistry | Anti-Bacterial Agents - metabolism | Erythromycin - chemistry | Ketolides - chemistry | Bacterial Proteins - metabolism | Chloramphenicol - metabolism | Crystals | Chemical properties | Research | Properties | Bacterial genetics | Structure | Observations | Antibacterial agents | Pathogens | lactones | Azithromycin | Macrolide antibiotics | Chloramphenicol | Telithromycin | Models | Erythromycin | Conformation | ANTIBIOTICS | CHLORAMPHENICOL | ESCHERICHIA COLI | LACTONES | SPECIFICITY | ERYTHROMYCIN | ELECTRON DENSITY | RIBOSOMES | 60 APPLIED LIFE SCIENCES | PATHOGENS | Biological Sciences
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 02/2013, Volume 19, Issue 8, pp. 2726 - 2740
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 38, pp. 13817 - 13821
The recent success of antibody-drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubuledestabilizing agents. Here, we... 
Microtubules | Drug interactions | Antineoplastics | Ligands | Dimers | Breast cancer | Molecular mechanisms of action | Crystallography | Binding sites | Crystal structure | X-ray crystallography | Microtubule-targeting agents | Drug mechanism | microtubule-targeting agents | BETA-TUBULIN | VINCA-DOMAIN | MAYTANSINE | MULTIDISCIPLINARY SCIENCES | RESOLUTION | ANTIMITOTIC AGENTS | MACROCYCLIC LACTONE ANTIBIOTICS | POTENT ANTITUMOR-ACTIVITY | BREAST-CANCER | STRUCTURAL BASIS | RHIZOXIN | drug mechanism | Tubulin Modulators - chemistry | Humans | Polyketides - chemistry | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Maytansine - therapeutic use | Breast Neoplasms - drug therapy | Tubulin Modulators - therapeutic use | Pyrones - chemistry | Animals | Antibiotics, Antineoplastic - chemistry | Antibiotics, Antineoplastic - therapeutic use | Macrolides - chemistry | Cattle | Maytansine - chemistry | Pyrones - therapeutic use | Female | Microtubules - chemistry | Tubulin - chemistry | Antineoplastic Agents, Phytogenic - therapeutic use | Macrolides - therapeutic use | Polyketides - therapeutic use | Binding Sites | Clinical Trials, Phase I as Topic | Antimitotic agents | Pharmaceutical research | Physiological aspects | Dosage and administration | Research | Tubulins | Antineoplastic agents | Binding sites (Biochemistry) | Biological Sciences
Journal Article