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1. Full Text Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms
by Ueoka, Reiko and Uria, Agustinus R and Reiter, Silke and Mori, Tetsushi and Karbaum, Petra and Peters, Eike E and Helfrich, Eric J N and Morinaka, Brandon I and Gugger, Muriel and Takeyama, Haruko and Matsunaga, Shigeki and Piel, Jörn
Nature chemical biology, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, pp. 705 - 712
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cyanobacteria - genetics | Deltaproteobacteria - metabolism | Multigene Family | Peptides | Actins - metabolism | Bacterial Proteins - chemistry | Cyanobacteria - metabolism | Molecular Sequence Data | Polyketides - chemistry | Small Molecule Libraries - metabolism | Polyketides - metabolism | Polyketide Synthases - metabolism | Macrolides - chemistry | Pyrans - chemistry | Pyrans - metabolism | Base Sequence | Actins - chemistry | Symbiosis | Gene Expression | Bacterial Proteins - genetics | Macrolides - metabolism | Biological Evolution | Small Molecule Libraries - chemistry | Polyketide Synthases - chemistry | Animals | Deltaproteobacteria - genetics | Theonella - microbiology | Protein Binding | Bacterial Proteins - metabolism | Polyketide Synthases - genetics | Enzymes | Bacteria | Biosynthesis | Metabolism | Index Medicus | Polyketide Synthases/metabolism | Actins/metabolism | Macrolides/chemistry | Polyketide Synthases/chemistry | Life Sciences | Cyanobacteria/metabolism | Deltaproteobacteria/genetics | Bacterial Proteins/chemistry | Macrolides/metabolism | Actins/chemistry | Polyketide Synthases/genetics | Deltaproteobacteria/metabolism | Small Molecule Libraries/metabolism | Theonella/microbiology | Cyanobacteria/genetics | Pyrans/metabolism | Small Molecule Libraries/chemistry | Microbiology and Parasitology | Bacterial Proteins/metabolism | Polyketides/chemistry | Polyketides/metabolism | Bacterial Proteins/genetics | Pyrans/chemistry
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2. Full Text Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures
by Kellogg, Elizabeth H and Hejab, Nisreen M.A and Howes, Stuart and Northcote, Peter and Miller, John H and Díaz, J. Fernando and Downing, Kenneth H and Nogales, Eva and Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Journal of molecular biology, ISSN 0022-2836, 03/2017, Volume 429, Issue 5, pp. 633 - 646
microtubule | peloruside | microtubule-stabilizing agents | Taxol | cryo-EM | zampanolide | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cryoelectron Microscopy | Taxoids - chemistry | Paclitaxel - chemistry | Bridged-Ring Compounds - chemistry | Image Processing, Computer-Assisted | Macrolides - chemistry | Microtubules - chemistry | Proteins - chemistry | Tubulin - chemistry | Antineoplastic Agents - chemistry | Binding Sites | Antimitotic agents | Antineoplastic agents | Tubulins | Analysis | Index Medicus | BASIC BIOLOGICAL SCIENCES
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3. Full Text Recent Advances in Efficient and Selective Synthesis of Di-, Tri-, and Tetrasubstituted Alkenes via Pd-Catalyzed Alkenylation−Carbonyl Olefination Synergy
by Negishi, Ei-ichi and Huang, Zhihong and Wang, Guangwei and Mohan, Swathi and Wang, Chao and Hattori, Hatsuhiko
Accounts of chemical research, ISSN 0001-4842, 11/2008, Volume 41, Issue 11, pp. 1474 - 1485
Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Stereoisomerism | Carbonic Acid - chemistry | Alkenes - chemical synthesis | Alkenes - chemistry | Lactones - chemical synthesis | Pyrones - chemistry | Fatty Acids, Unsaturated - chemistry | Macrolides - chemistry | Thiazoles - chemical synthesis | Macrolides - chemical synthesis | Fatty Acids, Unsaturated - chemical synthesis | Thiazoles - chemistry | Molecular Structure | Catalysis | Pyrones - chemical synthesis | Palladium - chemistry | Lactones - chemistry | Palladium catalysts | Substitution reactions | Chemical properties | Olefins | Analysis | Index Medicus
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4. Full Text An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins
by Tian, Zhenhua and Tian, Zhenhua and Sun, Peng and Sun, Peng and Yan, Yan and Yan, Yan and Wu, Zhuhua and Wu, Zhuhua and Zheng, Qingfei and Zheng, Qingfei and Zhou, Shuaixiang and Zhou, Shuaixiang and Zhang, Hua and Zhang, Hua and Yu, Futao and Yu, Futao and Jia, Xinying and Jia, Xinying and Chen, Dandan and Chen, Dandan and Mándi, Attila and Mándi, Attila and Kurtán, Tibor and Kurtán, Tibor and Liu, Wen and Liu, Wen
Nature chemical biology, ISSN 1552-4450, 04/2015, Volume 11, Issue 4, pp. 259 - 265
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Models, Chemical | Stereoisomerism | Cyclohexenes - chemistry | Recombinant Proteins - chemistry | DNA, Bacterial - chemistry | Plasmids - metabolism | Pyrrolidinones - chemistry | Streptomyces - metabolism | Alkenes - chemistry | Pyrrolidinones - chemical synthesis | Biological Products - chemistry | Cyclization | Macrolides - chemistry | Macrolides - chemical synthesis | Intramolecular Lyases - chemical synthesis | Molecular Structure | Catalysis | Mutation | Chemistry - methods | Intramolecular Lyases - chemistry | Index Medicus
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5. Full Text Computational planning of the synthesis of complex natural products
by Mikulak-Klucznik, Barbara and Gołębiowska, Patrycja and Bayly, Alison A and Popik, Oskar and Klucznik, Tomasz and Szymkuć, Sara and Gajewska, Ewa P and Dittwald, Piotr and Staszewska-Krajewska, Olga and Beker, Wiktor and Badowski, Tomasz and Scheidt, Karl A and Molga, Karol and Mlynarski, Jacek and Mrksich, Milan and Grzybowski, Bartosz A
Nature (London), ISSN 0028-0836, 12/2020, Volume 588, Issue 7836, pp. 83 - 88
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Chemistry, Organic - methods | Artificial Intelligence - standards | Sesquiterpenes - chemical synthesis | Tetrahydroisoquinolines - chemical synthesis | Chemistry Techniques, Synthetic - standards | Chemistry Techniques, Synthetic - methods | Benzylisoquinolines - chemistry | Lactones - chemical synthesis | Indole Alkaloids - chemical synthesis | Macrolides - chemistry | Tetrahydroisoquinolines - chemistry | Automation - methods | Chemistry, Organic - standards | Indole Alkaloids - chemistry | Lactones - chemistry | Software - standards | Indans - chemistry | Knowledge Bases | Reproducibility of Results | Sesquiterpenes - chemistry | Automation - standards | Benzylisoquinolines - chemical synthesis | Biological Products - chemical synthesis | Macrolides - chemical synthesis | Indans - chemical synthesis | Optimization | Design | Organic chemistry | Knowledge bases (artificial intelligence) | Algorithms | Cost estimates | Natural products | Computation | Chemists | Computer applications | Planning | Logic | Artificial intelligence | Index Medicus
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6. Full Text Nickel catalysis: Synergy between method development and total synthesis
by Standley, Eric A and Tasker, Sarah Z and Jensen, Kim L and Jamison, Timothy F
Accounts of chemical research, ISSN 0001-4842, 05/2015, Volume 48, Issue 5, pp. 1503 - 1514
Physical Sciences | Chemistry | Chemistry, Multidisciplinary | Science & Technology | Bridged Bicyclo Compounds - chemical synthesis | Nickel - chemistry | Stereoisomerism | Indolizines - chemical synthesis | Bridged Bicyclo Compounds - chemistry | Lactones - chemical synthesis | Macrolides - chemistry | Indolizines - chemistry | Macrolides - chemical synthesis | Organometallic Compounds - chemistry | Molecular Structure | Catalysis | Lactones - chemistry | Aziridines | Chemical properties | Research | Ring formation (Chemistry) | Chemical synthesis | Metal catalysts | Index Medicus
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7. Full Text Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex
by Teng, Teng and Tsai, Jennifer Hc and Puyang, Xiaoling and Seiler, Michael and Peng, Shouyong and Prajapati, Sudeep and Aird, Daniel and Buonamici, Silvia and Caleb, Benjamin and Chan, Betty and Corson, Laura and Feala, Jacob and Fekkes, Peter and Gerard, Baudouin and Karr, Craig and Korpal, Manav and Liu, Xiang and Lowe, Jason T and Mizui, Yoshiharu and Palacino, James and Park, Eunice and Smith, Peter G and Subramanian, Vanitha and Wu, Zhenhua Jeremy and Zou, Jian and Yu, Lihua and Chicas, Agustin and Warmuth, Markus and Larsen, Nicholas and Zhu, Ping
Nature communications, ISSN 2041-1723, 05/2017, Volume 8, Issue 1, pp. 15522 - 15522
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cell Proliferation | Alternative Splicing | Exons | Humans | Crystallography, X-Ray | RNA Splicing Factors - chemistry | Fatty Alcohols - chemistry | Phosphoproteins - metabolism | Phosphoproteins - chemistry | RNA Splicing Factors - metabolism | Spliceosomes - metabolism | Macrolides - chemistry | RNA Interference | Pyrans - chemistry | Mass Spectrometry | Myeloid Cell Leukemia Sequence 1 Protein - chemistry | Carrier Proteins - chemistry | Adenosine - chemistry | Spiro Compounds - chemistry | Mutagenesis, Site-Directed | Cell Survival | Introns | HCT116 Cells | Recombinant Proteins - chemistry | Cryoelectron Microscopy | Sequence Analysis, RNA | Epoxy Compounds - chemistry | Protein Binding | Protein Conformation | Mutation | Index Medicus
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8. Full Text pH regulation in glycosomes of procyclic form Trypanosoma brucei
by Lin, Sheng and Voyton, Charles and Morris, Meredith T and Ackroyd, P. Christine and Morris, James C and Christensen, Kenneth A
The Journal of biological chemistry, ISSN 0021-9258, 05/2017, Volume 292, Issue 19, pp. 7795 - 7805
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Digitonin - chemistry | Amiloride - analogs & derivatives | Homeostasis | Trypanosoma brucei brucei - chemistry | Deoxyglucose - chemistry | Cytosol - chemistry | Potassium - chemistry | Proline - chemistry | Animals | Macrolides - chemistry | Sodium Azide - chemistry | Glucose - chemistry | Microbodies - chemistry | Protein Domains | Protozoan Proteins - chemistry | Adenosine Triphosphate - chemistry | Amiloride - chemistry | Microscopy, Fluorescence | Hydrogen-Ion Concentration | Index Medicus | parasite metabolism | biosensor | Microbiology | trypanosome | fluorescence | proton pump | microscopy | Trypanosoma brucei | glucose metabolism | parasitology
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9. Full Text The solithromycin journey—It is all in the chemistry
by Fernandes, Prabhavathi and Martens, Evan and Bertrand, Daniel and Pereira, David
Bioorganic & medicinal chemistry, ISSN 0968-0896, 12/2016, Volume 24, Issue 24, pp. 6420 - 6428
Fluroketolide | Pneumonia | Solithromycin | Macrolide | Antibiotic-resistance | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Science & Technology | Triazoles - administration & dosage | Macrolides - administration & dosage | Triazoles - chemistry | Humans | Molecular Conformation | Bacteria - drug effects | Respiratory Tract Infections - drug therapy | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Triazoles - pharmacology | Macrolides - chemistry | Anti-Bacterial Agents - chemistry | Macrolides - pharmacology | Anti-Bacterial Agents - pharmacology | Anti-Bacterial Agents - administration & dosage | Index Medicus
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