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1. Full Text Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms
by Ueoka, Reiko and Uria, Agustinus R and Reiter, Silke and Mori, Tetsushi and Karbaum, Petra and Peters, Eike E and Helfrich, Eric J N and Morinaka, Brandon I and Gugger, Muriel and Takeyama, Haruko and Matsunaga, Shigeki and Piel, Jörn
Nature Chemical Biology, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, pp. 705 - 712
Actin-targeting macrolides comprise a large, structurally diverse group of cytotoxins isolated from remarkably dissimilar micro- and macroorganisms. In spite... 
BACTERIAL SYMBIONT | GENE-CLUSTER | CYTOTOXIC MACROLIDES | NATURAL-PRODUCT DISCOVERY | CYANOBACTERIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNTHASES | IN-SITU HYBRIDIZATION | SPONGE THEONELLA-SWINHOEI | IDENTIFICATION | ANTIFUNGAL MACROLIDE | Cyanobacteria - genetics | Deltaproteobacteria - metabolism | Multigene Family | Peptides | Actins - metabolism | Bacterial Proteins - chemistry | Cyanobacteria - metabolism | Molecular Sequence Data | Polyketides - chemistry | Small Molecule Libraries - metabolism | Polyketides - metabolism | Polyketide Synthases - metabolism | Macrolides - chemistry | Pyrans - chemistry | Pyrans - metabolism | Base Sequence | Actins - chemistry | Symbiosis | Gene Expression | Bacterial Proteins - genetics | Macrolides - metabolism | Biological Evolution | Small Molecule Libraries - chemistry | Polyketide Synthases - chemistry | Animals | Deltaproteobacteria - genetics | Theonella - microbiology | Protein Binding | Bacterial Proteins - metabolism | Polyketide Synthases - genetics | Enzymes | Bacteria | Biosynthesis | Metabolism | Polyketide Synthases/metabolism | Actins/metabolism | Macrolides/chemistry | Polyketide Synthases/chemistry | Life Sciences | Cyanobacteria/metabolism | Deltaproteobacteria/genetics | Bacterial Proteins/chemistry | Macrolides/metabolism | Actins/chemistry | Polyketide Synthases/genetics | Deltaproteobacteria/metabolism | Small Molecule Libraries/metabolism | Theonella/microbiology | Cyanobacteria/genetics | Pyrans/metabolism | Small Molecule Libraries/chemistry | Microbiology and Parasitology | Bacterial Proteins/metabolism | Polyketides/chemistry | Polyketides/metabolism | Bacterial Proteins/genetics | Pyrans/chemistry
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2. Full Text Macrolide antibiotics
: chemistry, biology, and practice
by Ōmura, Satoshi, 1935
2002, 2nd ed., ISBN 0125264518, 654
Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their... 
Macrolide antibiotics | Biology, life sciences
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3. Full Text Evolution of multi-component anion relay chemistry (ARC): Construction of architecturally complex natural and unnatural products
by Smith III, Amos B and Wuest, William M
Chemical Communications, ISSN 1359-7345, 2008, Issue 45, pp. 5883 - 5895
Efficient construction of architecturally complex natural and unnatural products is the hallmark of organic chemistry. Anion relay chemistry (ARC) - a... 
CHROMIUM TRICARBONYL COMPLEXES | ASYMMETRIC-SYNTHESIS | ENANTIOSELECTIVE SYNTHESIS | FINAL ELABORATION | C SPONGISTATIN 2 | REVERSE BROOK REARRANGEMENT | RETRO <1,4>-BROOK REARRANGEMENTS | SILYL DITHIANES | PART 1 | SPIRASTRELLOLIDE-A | CHEMISTRY, MULTIDISCIPLINARY | Indolizidines - chemical synthesis | Benzaldehydes - chemistry | Sesquiterpenes - chemistry | Stereoisomerism | Indolizidines - chemistry | Sesquiterpenes - chemical synthesis | Anions - chemistry | Acrolein - chemical synthesis | Bryostatins - chemistry | Spiro Compounds | Chemistry, Organic | Combinatorial Chemistry Techniques | Macrolides - chemistry | Acetonitriles - chemical synthesis | Macrolides - chemical synthesis | Bryostatins - chemical synthesis | Acetonitriles - chemistry | Molecular Structure | Sulfur Compounds - chemical synthesis | Sulfur Compounds - chemistry | Acrolein - chemistry | Benzaldehydes - chemical synthesis | Quinolizines - chemical synthesis | Quinolizines - chemistry
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4. Full Text Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action
by Jack A. Dunkle and Liqun Xiong and Alexander S. Mankin and Jamie H. D. Cate
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17152 - 17157
Differences between the structures of bacterial, archaeal, and eukaryotic ribosomes account for the selective action of antibiotics. Even minor variations in... 
Ketolides | Antibiotics | Macrolides | Drug interactions | Ribosomes | Bacteria | Nucleotides | Electron density | Genetic mutation | Binding sites | Ribosome structure | Chloramphenicol | Telithromycin | Erythromycin | Clindamycin | PROTEIN | BACTERIAL RIBOSOME | RNA GENE | MULTIDISCIPLINARY SCIENCES | telithromycin | RESISTANCE MUTATIONS | CONFERRING RESISTANCE | erythromycin | DOMAIN-II | BINDING-SITE | chloramphenicol | MACROLIDE ANTIBIOTICS | ribosome structure | clindamycin | PLEUROMUTILINS | Haloarcula marismortui - genetics | Haloarcula marismortui - metabolism | Chloramphenicol - chemistry | Erythromycin - metabolism | Molecular Sequence Data | Ribosomes - metabolism | Deinococcus - metabolism | Deinococcus - genetics | Haloarcula marismortui - chemistry | X-Ray Diffraction | Anti-Bacterial Agents - chemistry | Base Sequence | Escherichia coli - metabolism | Ketolides - metabolism | Deinococcus - chemistry | Molecular Structure | Clindamycin - chemistry | Peptidyl Transferases - metabolism | Clindamycin - metabolism | Peptidyl Transferases - chemistry | Ribosomes - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli - chemistry | RNA, Ribosomal, 23S - chemistry | Erythromycin - chemistry | Escherichia coli - genetics | Ketolides - chemistry | RNA, Ribosomal, 23S - metabolism | Chloramphenicol - metabolism | Escherichia coli | Crystals | Genetic aspects | Research | Properties | Structure | Observations | Peptidyl transferases | Drugs | lincosamides | Pathogens | rRNA | rRNA 23S | Data processing | Ribosomal subunits | Ionizing radiation | Peptidyltransferase | Crystal structure | Tunnels | Biological Sciences
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5. Full Text pH regulation in glycosomes of procyclic form Trypanosoma brucei
by Lin, Sheng and Voyton, Charles and Morris, Meredith T and Ackroyd, P. Christine and Morris, James C and Christensen, Kenneth A
Journal of Biological Chemistry, ISSN 0021-9258, 05/2017, Volume 292, Issue 19, pp. 7795 - 7805
Here we report the use of a fluorescein-tagged peroxisomal targeting sequence peptide (F-PTS1, acetyl-C{K(FITC)} GGAKL) for investigating pH regulation of... 
MOLECULAR CHARACTERIZATION | ATP DEPLETION | ACIDOCALCISOMES | PROTEIN | NUCLEAR TRANSPORT | METABOLISM | PEROXISOMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTRACELLULAR PH | BLOOD-STREAM | DEHYDROGENASE | Digitonin - chemistry | Amiloride - analogs & derivatives | Homeostasis | Trypanosoma brucei brucei - chemistry | Deoxyglucose - chemistry | Cytosol - chemistry | Potassium - chemistry | Proline - chemistry | Animals | Macrolides - chemistry | Sodium Azide - chemistry | Glucose - chemistry | Microbodies - chemistry | Protein Domains | Protozoan Proteins - chemistry | Adenosine Triphosphate - chemistry | Amiloride - chemistry | Microscopy, Fluorescence | Hydrogen-Ion Concentration | parasite metabolism | biosensor | Microbiology | trypanosome | fluorescence | proton pump | microscopy | Trypanosoma brucei | glucose metabolism | parasitology
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6. Macrolide antibiotics
: chemistry, biology, and practice
by Ōmura, Satoshi
1984, ISBN 9780125264501, xiv, 635
Macrolide antibiotics
Book
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7. Full Text Polyketide construction via hydrohydroxyalkylation and related alcohol C-H functionalizations: reinventing the chemistry of carbonyl addition
by Dechert-Schmitt, Anne-Marie R and Schmitt, Daniel C and Gao, Xin and Itoh, Takahiko and Krische, Michael J
Natural Product Reports, ISSN 0265-0568, 3/2014, Volume 31, Issue 4, pp. 54 - 513
Covering: up to the end of 2013 Despite the longstanding importance of polyketide natural products in human medicine, nearly all commercial polyketide-based... 
MACROLIDE ANTIBIOTIC ROXATICIN | SCYTOPHYCIN-C | CHEMISTRY, MEDICINAL | ASYMMETRIC-SYNTHESIS | FORMAL SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ALDEHYDE OXIDATION LEVEL | OXA-CONJUGATE CYCLIZATION | STEREOSELECTIVE-SYNTHESIS | 6-DEOXYERYTHRONOLIDE B | CONCISE SYNTHESIS | STEREOCONTROLLED SYNTHESIS | Rifamycins - chemical synthesis | Stereoisomerism | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Humans | Erythromycin - analogs & derivatives | Polyketides - chemistry | Erythromycin - chemical synthesis | Hydrogenation | Bryostatins - chemistry | Biological Products - chemical synthesis | Biological Products - chemistry | Erythromycin - chemistry | Macrolides - chemistry | Rifamycins - chemistry | Macrolides - chemical synthesis | Bryostatins - chemical synthesis | Polyketides - chemical synthesis | Molecular Structure | Catalysis | Bridged Bicyclo Compounds, Heterocyclic - chemical synthesis
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8. Full Text An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins
by Tian, Zhenhua and Tian, Zhenhua and Sun, Peng and Sun, Peng and Yan, Yan and Yan, Yan and Wu, Zhuhua and Wu, Zhuhua and Zheng, Qingfei and Zheng, Qingfei and Zhou, Shuaixiang and Zhou, Shuaixiang and Zhang, Hua and Zhang, Hua and Yu, Futao and Yu, Futao and Jia, Xinying and Jia, Xinying and Chen, Dandan and Chen, Dandan and Mándi, Attila and Mándi, Attila and Kurtán, Tibor and Kurtán, Tibor and Liu, Wen and Liu, Wen
Nature Chemical Biology, ISSN 1552-4450, 04/2015, Volume 11, Issue 4, pp. 259 - 265
The [4+2] cycloaddition remains one of the most intriguing transformations in synthetic and natural products chemistry. In nature, however, there are... 
CATALYZE | LL-42D005 | GENE-CLUSTER | POLYKETIDE SYNTHASE | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIELS-ALDER REACTION | SPIROTETRONATE ANTIBIOTICS | INSIGHTS | STEPS | PREDICTION | Models, Chemical | Stereoisomerism | Cyclohexenes - chemistry | Recombinant Proteins - chemistry | DNA, Bacterial - chemistry | Plasmids - metabolism | Pyrrolidinones - chemistry | Streptomyces - metabolism | Alkenes - chemistry | Pyrrolidinones - chemical synthesis | Biological Products - chemistry | Cyclization | Macrolides - chemistry | Macrolides - chemical synthesis | Intramolecular Lyases - chemical synthesis | Molecular Structure | Catalysis | Mutation | Chemistry - methods | Intramolecular Lyases - chemistry
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9. Full Text Macrocyclic drugs and clinical candidates: What can medicinal chemists learn from their properties?
by Giordanetto, Fabrizio and Kihlberg, Jan and Teknisk-naturvetenskapliga vetenskapsområdet and Uppsala universitet and Organisk kemi and Institutionen för kemi - BMC and Kemiska sektionen
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2014, Volume 57, Issue 2, pp. 278 - 295
Macrocycles are ideal in efforts to tackle "difficult" targets, but our understanding of what makes them cell permeable and orally bioavailable is limited.... 
ATOPIC-DERMATITIS | CHEMISTRY, MEDICINAL | PHARMACOKINETICS | MEMBRANE-PERMEABILITY | CONFORMATIONAL FLEXIBILITY | PRECLINICAL PROFILE | VIRUS NS3/4A PROTEASE | INHIBITOR | PHASE-I | CYCLIC-PEPTIDES | DISCOVERY | Drug Administration Routes | Drugs, Investigational - pharmacology | Macrolides - administration & dosage | Macrocyclic Compounds - chemistry | Humans | Peptides, Cyclic - pharmacology | Clinical Trials as Topic | Lactams, Macrocyclic - pharmacology | Peptides, Cyclic - administration & dosage | Peptides, Cyclic - chemistry | Macrocyclic Compounds - pharmacology | Drugs, Investigational - chemistry | Lactams, Macrocyclic - chemistry | Macrolides - chemistry | Databases, Chemical | Drug Design | Pharmaceutical Preparations - chemistry | Drugs, Investigational - administration & dosage | Macrolides - pharmacology | Lactams, Macrocyclic - administration & dosage | Macrocyclic Compounds - administration & dosage | Pharmaceutical Preparations - administration & dosage | Pharmacokinetics | Medicinal Chemistry | Naturvetenskap | Natural Sciences | Läkemedelskemi
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10. Full Text Revisiting the structures of several antibiotics bound to the bacterial ribosome
by David Bulkley and C. Axel Innis and Gregor Blaha and Thomas A. Steitz and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17158 - 17163
The increasing prevalence of antibiotic-resistant pathogens reinforces the need for structures of antibiotic-ribosome complexes that are accurate enough to... 
Molecules | Antibiotics | Macrolides | Drug interactions | Ribosomes | Drug design | Biochemistry | Potassium | Functional groups | Lactones | Structure-based drug design | Crystal structure | structure-based drug design | DESIGN | RNA | MULTIDISCIPLINARY SCIENCES | KETOLIDES | MITOCHONDRIAL-DNA | NUCLEOTIDE | CHLORAMPHENICOL ACETYLTRANSFERASE | PEPTIDYL TRANSFERASE CENTER | crystal structure | RESISTANCE | BINDING-SITE | MACROLIDE ANTIBIOTICS | Haloarcula marismortui - genetics | Haloarcula marismortui - metabolism | Chloramphenicol - chemistry | Azithromycin - metabolism | Bacterial Proteins - chemistry | Erythromycin - metabolism | Ribosomes - metabolism | Thermus thermophilus - metabolism | Deinococcus - metabolism | Deinococcus - genetics | Haloarcula marismortui - chemistry | Thermus thermophilus - genetics | Anti-Bacterial Agents - chemistry | Ketolides - metabolism | Deinococcus - chemistry | Molecular Structure | Binding Sites | Thermus thermophilus - chemistry | Azithromycin - chemistry | Ribosomes - chemistry | Anti-Bacterial Agents - metabolism | Erythromycin - chemistry | Ketolides - chemistry | Bacterial Proteins - metabolism | Chloramphenicol - metabolism | Crystals | Chemical properties | Research | Properties | Bacterial genetics | Structure | Observations | Antibacterial agents | Pathogens | lactones | Azithromycin | Macrolide antibiotics | Chloramphenicol | Telithromycin | Models | Erythromycin | Conformation | ANTIBIOTICS | CHLORAMPHENICOL | ESCHERICHIA COLI | LACTONES | SPECIFICITY | ERYTHROMYCIN | ELECTRON DENSITY | RIBOSOMES | 60 APPLIED LIFE SCIENCES | PATHOGENS | Biological Sciences
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11. Full Text Efficient and Selective Formation of Macrocyclic Disubstituted Z Alkenes by Ring‐Closing Metathesis (RCM) Reactions Catalyzed by Mo‐ or W‐Based Monoaryloxide Pyrrolide (MAP) Complexes: Applications to Total Syntheses of Epilachnene, Yuzu Lactone, Ambrettolide, Epothilone C, and Nakadomarin A
by Wang, Chenbo and Yu, Miao and Kyle, Andrew F and Jakubec, Pavol and Dixon, Darren J and Schrock, Richard R and Hoveyda, Amir H
Chemistry – A European Journal, ISSN 0947-6539, 02/2013, Volume 19, Issue 8, pp. 2726 - 2740
The first broadly applicable set of protocols for efficient Z ‐selective formation of macrocyclic disubstituted alkenes through catalytic ring‐closing... 
olefin metathesis | synthesis | tungsten | catalysis | macrocyclic | alkenes | molybdenum | macrocyclic Z alkenes | IMIDO ALKYLIDENE COMPLEXES | ALKYNE METATHESIS | ENANTIOSELECTIVE SYNTHESIS | OLEFIN CROSS-METATHESIS | MACROLIDES | CHEMISTRY, MULTIDISCIPLINARY | MICROTUBULE-STABILIZING AGENTS | NATURAL-PRODUCT SYNTHESIS | ENYNE METATHESIS | (-)-NAKADOMARIN | Molybdenum - chemistry | Carbolines - chemical synthesis | Macrocyclic Compounds - chemistry | Cycloparaffins - chemistry | Epothilones - chemistry | Stereoisomerism | Alkaloids - chemical synthesis | Epothilones - chemical synthesis | Macrocyclic Compounds - chemical synthesis | Ruthenium - chemistry | Biological Products - chemical synthesis | Biological Products - chemistry | Carbolines - chemistry | Lactones - chemical synthesis | Bridged-Ring Compounds - chemistry | Cyclization | Cycloparaffins - chemical synthesis | Molecular Structure | Catalysis | Kinetics | Bridged-Ring Compounds - chemical synthesis | Alkaloids - chemistry | Lactones - chemistry | Chemical synthesis | Molybdenum | Olefins | Isomerization | Macrocyclic compounds | Alkenes | Catalysts | Decomposition reactions | Metathesis | Selectivity | RCM
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12. Full Text The solithromycin journey—It is all in the chemistry
by Fernandes, Prabhavathi and Martens, Evan and Bertrand, Daniel and Pereira, David
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 12/2016, Volume 24, Issue 24, pp. 6420 - 6428
The macrolide class of antibiotics, including the early generation macrolides erythromycin, clarithromycin and azithromycin, have been used broadly for... 
Fluroketolide | Pneumonia | Solithromycin | Macrolide | Antibiotic-resistance | COMMUNITY-ACQUIRED PNEUMONIA | CHEMISTRY, MEDICINAL | RESISTANT MYCOPLASMA-PNEUMONIAE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | TERMINAL ALKYNES | BACTERIAL PNEUMONIA | STREPTOCOCCUS-PNEUMONIAE | ORAL SOLITHROMYCIN | NICOTINIC ACETYLCHOLINE-RECEPTOR | DOUBLE-BLIND | MACROLIDE RESISTANCE | IN-VITRO ACTIVITY | Triazoles - administration & dosage | Macrolides - administration & dosage | Triazoles - chemistry | Humans | Molecular Conformation | Bacteria - drug effects | Respiratory Tract Infections - drug therapy | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Triazoles - pharmacology | Macrolides - chemistry | Anti-Bacterial Agents - chemistry | Macrolides - pharmacology | Anti-Bacterial Agents - pharmacology | Anti-Bacterial Agents - administration & dosage
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13. Full Text A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
by Andrea E. Prota and Katja Bargsten and J. Fernando Diaz and May Marsh and Carmen Cuevas and Marc Liniger and Christian Neuhaus and Jose M. Andreu and Karl-Heinz Altmann and Michel O. Steinmetz
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 38, pp. 13817 - 13821
The recent success of antibody-drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubuledestabilizing agents. Here, we... 
Microtubules | Drug interactions | Antineoplastics | Ligands | Dimers | Breast cancer | Molecular mechanisms of action | Crystallography | Binding sites | Crystal structure | X-ray crystallography | Microtubule-targeting agents | Drug mechanism | microtubule-targeting agents | BETA-TUBULIN | VINCA-DOMAIN | MAYTANSINE | MULTIDISCIPLINARY SCIENCES | RESOLUTION | ANTIMITOTIC AGENTS | MACROCYCLIC LACTONE ANTIBIOTICS | POTENT ANTITUMOR-ACTIVITY | BREAST-CANCER | STRUCTURAL BASIS | RHIZOXIN | drug mechanism | Tubulin Modulators - chemistry | Humans | Polyketides - chemistry | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Maytansine - therapeutic use | Breast Neoplasms - drug therapy | Tubulin Modulators - therapeutic use | Pyrones - chemistry | Animals | Antibiotics, Antineoplastic - chemistry | Antibiotics, Antineoplastic - therapeutic use | Macrolides - chemistry | Cattle | Maytansine - chemistry | Pyrones - therapeutic use | Female | Microtubules - chemistry | Tubulin - chemistry | Antineoplastic Agents, Phytogenic - therapeutic use | Macrolides - therapeutic use | Polyketides - therapeutic use | Binding Sites | Clinical Trials, Phase I as Topic | Antimitotic agents | Pharmaceutical research | Physiological aspects | Dosage and administration | Research | Tubulins | Antineoplastic agents | Binding sites (Biochemistry) | Biological Sciences
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