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Nature Chemical Biology, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, pp. 705 - 712
Actin-targeting macrolides comprise a large, structurally diverse group of cytotoxins isolated from remarkably dissimilar micro- and macroorganisms. In spite... 
BACTERIAL SYMBIONT | GENE-CLUSTER | CYTOTOXIC MACROLIDES | NATURAL-PRODUCT DISCOVERY | CYANOBACTERIA | BIOCHEMISTRY & MOLECULAR BIOLOGY | SYNTHASES | IN-SITU HYBRIDIZATION | SPONGE THEONELLA-SWINHOEI | IDENTIFICATION | ANTIFUNGAL MACROLIDE | Cyanobacteria - genetics | Deltaproteobacteria - metabolism | Multigene Family | Peptides | Actins - metabolism | Bacterial Proteins - chemistry | Cyanobacteria - metabolism | Molecular Sequence Data | Polyketides - chemistry | Small Molecule Libraries - metabolism | Polyketides - metabolism | Polyketide Synthases - metabolism | Macrolides - chemistry | Pyrans - chemistry | Pyrans - metabolism | Base Sequence | Actins - chemistry | Symbiosis | Gene Expression | Bacterial Proteins - genetics | Macrolides - metabolism | Biological Evolution | Small Molecule Libraries - chemistry | Polyketide Synthases - chemistry | Animals | Deltaproteobacteria - genetics | Theonella - microbiology | Protein Binding | Bacterial Proteins - metabolism | Polyketide Synthases - genetics | Enzymes | Bacteria | Biosynthesis | Metabolism | Polyketide Synthases/metabolism | Actins/metabolism | Macrolides/chemistry | Polyketide Synthases/chemistry | Life Sciences | Cyanobacteria/metabolism | Deltaproteobacteria/genetics | Bacterial Proteins/chemistry | Macrolides/metabolism | Actins/chemistry | Polyketide Synthases/genetics | Deltaproteobacteria/metabolism | Small Molecule Libraries/metabolism | Theonella/microbiology | Cyanobacteria/genetics | Pyrans/metabolism | Small Molecule Libraries/chemistry | Microbiology and Parasitology | Bacterial Proteins/metabolism | Polyketides/chemistry | Polyketides/metabolism | Bacterial Proteins/genetics | Pyrans/chemistry
Journal Article
Nature Reviews Microbiology, ISSN 1740-1526, 12/2005, Volume 3, Issue 12, pp. 937 - 947
Journal Article
Science, ISSN 0036-8075, 11/2011, Volume 334, Issue 6058, pp. 986 - 990
Many prokaryotic species generate hydrogen sulfide (H₂S) in their natural environments. However, the biochemistry and physiological role of this gas in... 
Enzymes | Cell growth | Antibiotics | Cell walls | Protein synthesis | Macrolides | DNA | REPORTS | Bacteria | Lactams | Oxides | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | NITRIC-OXIDE | HYDROGEN-PEROXIDE | DEATH | IRON | DAMAGE | SULFIDE | Hydrogen Sulfide - metabolism | Cystathionine beta-Synthase - antagonists & inhibitors | Oxidative Stress | Antioxidants - metabolism | Escherichia coli - drug effects | Pseudomonas aeruginosa - growth & development | Bacteria - drug effects | Drug Resistance, Bacterial | Molecular Sequence Data | Cystathionine gamma-Lyase - metabolism | DNA Breaks, Double-Stranded | Bacteria - growth & development | Pseudomonas aeruginosa - metabolism | Drug Resistance, Multiple, Bacterial | Escherichia coli - metabolism | Bacillus anthracis - growth & development | Bacillus anthracis - drug effects | Cystathionine gamma-Lyase - genetics | Escherichia coli - growth & development | Cystathionine beta-Synthase - genetics | Bacillus anthracis - metabolism | Staphylococcus aureus - metabolism | Amino Acid Sequence | Bacteria - metabolism | Hydrogen Sulfide - pharmacology | Sulfurtransferases - genetics | Cystathionine beta-Synthase - metabolism | Pseudomonas aeruginosa - drug effects | Cystathionine gamma-Lyase - antagonists & inhibitors | Sulfurtransferases - antagonists & inhibitors | Anti-Bacterial Agents - pharmacology | Nitric Oxide - metabolism | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Sulfurtransferases - metabolism | Gases | E coli | Prokaryotes
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2012, Volume 165, Issue 5, pp. 1348 - 1360
BACKGROUND AND PURPOSE Azithromycin has been reported to modify activation of macrophages towards the M2 phenotype. Here, we have sought to identify the... 
dexamethasone | roflumilast | human macrophage | lysosome affecting agent | classical activation | azithromycin | human monocyte | SB203580 | anti‐inflammatory drug | TLR4 signalling | anti-inflammatory drug | IMMUNOMODULATORY MEDICATIONS | DENDRITIC CELLS | J774 MACROPHAGES | TUMOR-NECROSIS-FACTOR | TOLL-LIKE RECEPTORS | LIPOPOLYSACCHARIDE | STIMULATED MACROPHAGES | PHARMACOLOGY & PHARMACY | MACROLIDE ANTIBIOTICS | NF-KAPPA-B | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Gene Expression - drug effects | Humans | Lysosomes - genetics | Tumor Necrosis Factor-alpha - genetics | Monocytes - metabolism | NF-kappa B - metabolism | Chemokine CCL22 - metabolism | Antigens, CD - genetics | Antigens, CD - metabolism | STAT1 Transcription Factor - metabolism | Lysosomes - metabolism | Interleukin-10 - metabolism | Chemokine CCL2 - metabolism | Interleukin-6 - metabolism | Lysosomes - drug effects | Interleukin-6 - genetics | Anti-Inflammatory Agents - pharmacology | Cells, Cultured | Receptors, Cell Surface - metabolism | Toll-Like Receptor 4 - genetics | Chemokine CCL2 - genetics | Transcription Factors - genetics | Down-Regulation - drug effects | STAT1 Transcription Factor - genetics | Toll-Like Receptor 4 - metabolism | Antigens, Differentiation, Myelomonocytic - genetics | Azithromycin - pharmacology | Monocytes - drug effects | Transcription Factors - metabolism | Chemokine CCL22 - genetics | Macrophages - metabolism | NF-kappa B - genetics | Signal Transduction - drug effects | Antigens, Differentiation, Myelomonocytic - metabolism | Interleukin-10 - genetics | Chemokines, CC - genetics | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Macrophage Activation - drug effects | Interferon-gamma - pharmacology | Chemokines, CC - metabolism | Receptors, Cell Surface - genetics | Research Papers
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 02/2006, Volume 96, Issue 3, pp. 656 - 668
Glial subcellular re‐sealed particles (referred to as gliosomes here) were purified from rat cerebral cortex and investigated for their ability to release... 
exocytosis | gliosomes | glutamate release | SNARE proteins | Glutamate release | Exocytosis | Gliosomes | NEURONAL-ACTIVITY | SYNAPTIC VESICLES | HIPPOCAMPAL ASTROCYTES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLASMALEMMAL VESICLES | SYNAPTOSOMES | CALCIUM WAVES | NEUROSCIENCES | AMINO-ACIDS | CULTURED ASTROCYTES | H+-ATPASE | IN-SITU | Disks Large Homolog 4 Protein | L-Lactate Dehydrogenase - metabolism | Propionates - metabolism | Neuroglia - ultrastructure | Microscopy, Electron, Transmission - methods | Microtubule-Associated Proteins - metabolism | Vesicular Transport Proteins - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Synaptosomes - metabolism | Glial Fibrillary Acidic Protein - metabolism | Cerebral Cortex - cytology | Exocytosis - physiology | Dose-Response Relationship, Drug | Tubulin - metabolism | Tritium - metabolism | Time Factors | Macrolides - pharmacology | Membrane Proteins - metabolism | Ionophores - pharmacology | Calcium - pharmacology | Myelin Basic Protein - metabolism | Vesicular Glutamate Transport Protein 1 - metabolism | Fluorescent Antibody Technique - methods | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | S100 Proteins - metabolism | D-Aspartic Acid - metabolism | Microscopy, Confocal - methods | Rats, Sprague-Dawley | Synaptosomes - ultrastructure | Animals | Ionomycin - pharmacology | Neuroglia - metabolism | Glutamic Acid - metabolism | Synaptosomal-Associated Protein 25 - metabolism | CD11b Antigen - metabolism | Vesicle-Associated Membrane Protein 2 - metabolism | Proteins | Brain | Amino acids | Neurotransmitters | Neurons | Rodents
Journal Article
Molecular Cell, ISSN 1097-2765, 02/2006, Volume 21, Issue 4, pp. 481 - 493
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 40, pp. 17152 - 17157
Differences between the structures of bacterial, archaeal, and eukaryotic ribosomes account for the selective action of antibiotics. Even minor variations in... 
Ketolides | Antibiotics | Macrolides | Drug interactions | Ribosomes | Bacteria | Nucleotides | Electron density | Genetic mutation | Binding sites | Ribosome structure | Chloramphenicol | Telithromycin | Erythromycin | Clindamycin | PROTEIN | BACTERIAL RIBOSOME | RNA GENE | MULTIDISCIPLINARY SCIENCES | telithromycin | RESISTANCE MUTATIONS | CONFERRING RESISTANCE | erythromycin | DOMAIN-II | BINDING-SITE | chloramphenicol | MACROLIDE ANTIBIOTICS | ribosome structure | clindamycin | PLEUROMUTILINS | Haloarcula marismortui - genetics | Haloarcula marismortui - metabolism | Chloramphenicol - chemistry | Erythromycin - metabolism | Molecular Sequence Data | Ribosomes - metabolism | Deinococcus - metabolism | Deinococcus - genetics | Haloarcula marismortui - chemistry | X-Ray Diffraction | Anti-Bacterial Agents - chemistry | Base Sequence | Escherichia coli - metabolism | Ketolides - metabolism | Deinococcus - chemistry | Molecular Structure | Clindamycin - chemistry | Peptidyl Transferases - metabolism | Clindamycin - metabolism | Peptidyl Transferases - chemistry | Ribosomes - chemistry | Anti-Bacterial Agents - metabolism | Escherichia coli - chemistry | RNA, Ribosomal, 23S - chemistry | Erythromycin - chemistry | Escherichia coli - genetics | Ketolides - chemistry | RNA, Ribosomal, 23S - metabolism | Chloramphenicol - metabolism | Escherichia coli | Crystals | Genetic aspects | Research | Properties | Structure | Observations | Peptidyl transferases | Drugs | lincosamides | Pathogens | rRNA | rRNA 23S | Data processing | Ribosomal subunits | Ionizing radiation | Peptidyltransferase | Crystal structure | Tunnels | Biological Sciences
Journal Article
Autophagy, ISSN 1554-8627, 04/2010, Volume 6, Issue 3, pp. 330 - 344
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1529 - 9
Journal Article