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Science Translational Medicine, ISSN 1946-6234, 05/2015, Volume 7, Issue 289, pp. 289ra85 - 289ra85
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2009, Volume 119, Issue 5, pp. 1109 - 1123
Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, RESEARCH & EXPERIMENTAL | MALIGNANT GLIOMA-CELLS | BLAST CRISIS | CLINICAL RESISTANCE | BCR-ABL MUTATIONS | ENDOPLASMIC-RETICULUM | CYTOCHROME-C RELEASE | CASPASE ACTIVATION | IMATINIB RESISTANCE | CHRONIC MYELOID-LEUKEMIA | Transcription Factor CHOP - genetics | Neoplastic Stem Cells - cytology | Gene Expression - drug effects | Calcium - metabolism | Gene Expression - genetics | Microtubule-Associated Proteins - metabolism | Neoplastic Stem Cells - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Endoplasmic Reticulum - metabolism | Antineoplastic Agents - therapeutic use | Autophagy - physiology | Thiazoles - therapeutic use | Autophagy - drug effects | Chloroquine - pharmacology | Neoplastic Stem Cells - metabolism | RNA Interference | Endoplasmic Reticulum - drug effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Macrolides - pharmacology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Dasatinib | Chloroquine - therapeutic use | Piperazines - therapeutic use | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Mice, Inbred C3H | Xenograft Model Antitumor Assays | Fusion Proteins, bcr-abl - genetics | Animals | Cell Death - physiology | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Benzamides | Macrolides - therapeutic use | Protein-Tyrosine Kinases - antagonists & inhibitors | Causes of | Physiological aspects | Genetic aspects | Chronic myeloid leukemia | Research | Drug therapy | Phagocytosis | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2014, Volume 111, Issue 38, pp. 13817 - 13821
The recent success of antibody-drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubuledestabilizing agents. Here, we... 
Microtubules | Drug interactions | Antineoplastics | Ligands | Dimers | Breast cancer | Molecular mechanisms of action | Crystallography | Binding sites | Crystal structure | X-ray crystallography | Microtubule-targeting agents | Drug mechanism | microtubule-targeting agents | BETA-TUBULIN | VINCA-DOMAIN | MAYTANSINE | MULTIDISCIPLINARY SCIENCES | RESOLUTION | ANTIMITOTIC AGENTS | MACROCYCLIC LACTONE ANTIBIOTICS | POTENT ANTITUMOR-ACTIVITY | BREAST-CANCER | STRUCTURAL BASIS | RHIZOXIN | drug mechanism | Tubulin Modulators - chemistry | Humans | Polyketides - chemistry | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Maytansine - therapeutic use | Breast Neoplasms - drug therapy | Tubulin Modulators - therapeutic use | Pyrones - chemistry | Animals | Antibiotics, Antineoplastic - chemistry | Antibiotics, Antineoplastic - therapeutic use | Macrolides - chemistry | Cattle | Maytansine - chemistry | Pyrones - therapeutic use | Female | Microtubules - chemistry | Tubulin - chemistry | Antineoplastic Agents, Phytogenic - therapeutic use | Macrolides - therapeutic use | Polyketides - therapeutic use | Binding Sites | Clinical Trials, Phase I as Topic | Antimitotic agents | Pharmaceutical research | Physiological aspects | Dosage and administration | Research | Tubulins | Antineoplastic agents | Binding sites (Biochemistry) | Mutagenesis | Medical treatment | Cancer | Index Medicus | Biological Sciences
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 01/2015, Volume 191, Issue 1, pp. 96 - 103
Journal Article
Neuron, ISSN 0896-6273, 01/2014, Volume 81, Issue 1, pp. 49 - 60
Although biotherapeutics have vast potential for treating brain disorders, their use has been limited due to low exposure across the blood-brain barrier (BBB).... 
CLATHRIN-MEDIATED ENDOCYTOSIS | TRANSFERRIN RECEPTOR | BARRIER | MICE | EXPRESSION | BINDING | NEUROSCIENCES | DELIVERY | Humans | Transcytosis - genetics | Protein Transport - physiology | Protein Transport - drug effects | Alzheimer Disease - pathology | Brain - metabolism | Dose-Response Relationship, Drug | Single-Chain Antibodies - metabolism | Lysosomes - metabolism | Time Factors | Protein Binding - drug effects | Amyloid beta-Peptides - metabolism | Single-Chain Antibodies - therapeutic use | Macrolides - pharmacology | Disease Models, Animal | Lysosomes - drug effects | Single-Chain Antibodies - pharmacology | Subcellular Fractions - drug effects | Alzheimer Disease - therapy | Enzyme Inhibitors - pharmacology | Presenilin-1 - genetics | Mice, Transgenic | Transcytosis - immunology | Protein Binding - immunology | Blood-Brain Barrier - drug effects | Receptors, Transferrin - metabolism | Subcellular Fractions - metabolism | Blood-Brain Barrier - metabolism | Brain - drug effects | Models, Immunological | Amyloid beta-Protein Precursor - genetics | Animals | Receptors, Transferrin - immunology | Amyloid beta-Peptides - immunology | Mice | Transcytosis - drug effects | Alzheimer Disease - genetics | Brain - immunology | Cell Line, Transformed | Viral antibodies | Analysis | Amyloid beta-protein | Antibodies | Chemical properties | Health aspects | Alzheimer's disease | Biopharmaceutics | Transferrin | Proteins | Cell culture | Ligands | Recycling | Membrane filters | Index Medicus
Journal Article
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 02/2015, Volume 60, Issue 4, pp. 566 - 577
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2015, Volume 372, Issue 14, pp. 1312 - 1323
Journal Article
Journal Article