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Nature, ISSN 0028-0836, 2016, Volume 539, Issue 7629, pp. 443 - 447
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2015, Volume 125, Issue 11, pp. 4223 - 4238
A high intake of dietary salt (NaCl) has been implicated in the development of hypertension, chronic inflammation, and autoimmune diseases. We have recently... 
MEDICINE, RESEARCH & EXPERIMENTAL | M2 MACROPHAGES | NA+ STORAGE | TISSUE | GENE-EXPRESSION | URINARY SODIUM | TRANSCRIPTION FACTOR | POTASSIUM EXCRETION | ALTERNATIVE ACTIVATION | BLOOD-PRESSURE | T-CELLS | Sodium Chloride, Dietary - pharmacology | Sodium Chloride - pharmacology | Male | Glycolysis - drug effects | Proto-Oncogene Proteins c-akt - genetics | Oxidative Phosphorylation - drug effects | Interleukin-4 - pharmacology | Histone Code - drug effects | Bone Marrow Cells - drug effects | TOR Serine-Threonine Kinases - physiology | Wound Healing - drug effects | Macrophages - immunology | Macrophages - classification | Immunity, Innate - drug effects | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Inflammation | Proto-Oncogene Proteins c-akt - physiology | Mitochondria - drug effects | Random Allocation | Interleukin-13 - pharmacology | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Sodium Chloride, Dietary - toxicity | Chitin - toxicity | Macrophages - drug effects | Mice | Macrophage Activation - drug effects | Salt | Medical research | Immune response | Medicine, Experimental | Research | Macrophages | Properties | Observations | Biological control systems | Health aspects | Hypertension | Wound healing | Sodium | Cytokines | Kinases | Metabolism | Gene expression | Experiments | Acquisitions & mergers | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 04/2013, Volume 496, Issue 7444, pp. 238 - 242
Journal Article
Gastroenterology, ISSN 0016-5085, 2014, Volume 146, Issue 7, pp. 1763 - 1774
Background & Aims The NACHT, LRR, and pyrin domain–containing protein 3 (NLRP3) inflammasome induces inflammation in response to organ injury, but little is... 
Gastroenterology and Hepatology | Innate Immune Response | Immune Regulation | Pancreas | Mouse Model | ACTIVATION | NLRP3 INFLAMMASOME | GPR81 | AGONISTS | GENE | TLR9 | MICE | HEPATOTOXICITY | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | SEVERITY | Liver - pathology | Inflammasomes - metabolism | Receptors, G-Protein-Coupled - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Male | NF-kappa B - metabolism | Monocytes - immunology | Lipopolysaccharides | Liver - immunology | Liver - drug effects | RNA Interference | Interleukin-1beta - metabolism | Toll-Like Receptors - drug effects | Anti-Inflammatory Agents - administration & dosage | Toll-Like Receptors - metabolism | Cytoprotection | Disease Models, Animal | Galactosamine | Chemical and Drug Induced Liver Injury - prevention & control | Anti-Inflammatory Agents - pharmacology | Down-Regulation | Liver - metabolism | Injections, Intraperitoneal | Pancreas - pathology | Pancreas - metabolism | Pancreas - immunology | Toll-Like Receptor 4 - metabolism | Chemical and Drug Induced Liver Injury - immunology | Monocytes - drug effects | Macrophages - metabolism | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Sodium Lactate - pharmacology | beta-Arrestins | Mice | Receptors, G-Protein-Coupled - genetics | RNA, Small Interfering - metabolism | Monocytes - metabolism | Pancreatitis - prevention & control | Arrestins - metabolism | Dose-Response Relationship, Drug | Pancreatitis - genetics | Transfection | Inflammasomes - drug effects | Sodium Lactate - administration & dosage | Pancreatitis - immunology | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Macrophages - immunology | Cell Line | Immunity, Innate - drug effects | Toll-Like Receptor 4 - drug effects | Mice, Inbred C57BL | Pancreas - drug effects | Chemical and Drug Induced Liver Injury - genetics | Pancreatitis - chemically induced | Animals | Carrier Proteins - metabolism | beta-Arrestin 2 | Inflammasomes - immunology | Macrophages - drug effects | Pancreatitis - pathology | Pancreatitis - metabolism | Ceruletide | Lactates | Gastrointestinal diseases | Inflammation | Index Medicus | Abridged Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 6, pp. e1004174 - e1004174
Bacterial signaling systems are prime drug targets for combating the global health threat of antibiotic resistant bacterial infections including those caused... 
NADPH OXIDASE | ANTIBIOTICS | LYTTR DOMAIN | GLOBAL GENE-EXPRESSION | MICROBIOLOGY | VIRULENCE | IDENTIFICATION | DISCOVERY | VIROLOGY | DISEASE | INFECTION | SKIN | PARASITOLOGY | Staphylococcus epidermidis - physiology | Skin - microbiology | Molecular Conformation | Bacterial Proteins - chemistry | Male | Promoter Regions, Genetic - drug effects | Trans-Activators - chemistry | Staphylococcal Skin Infections - immunology | Anti-Bacterial Agents - adverse effects | Macrophages - microbiology | Triazoles - therapeutic use | Bacterial Proteins - antagonists & inhibitors | Quorum Sensing - drug effects | Mice, Knockout | Macrophages - metabolism | Staphylococcus epidermidis - growth & development | Staphylococcus aureus - immunology | Anti-Bacterial Agents - pharmacology | Molecular Docking Simulation | Quinazolinones - chemistry | Mutation | Staphylococcal Skin Infections - microbiology | Triazoles - adverse effects | Staphylococcus epidermidis - drug effects | Staphylococcus aureus - physiology | Staphylococcus epidermidis - immunology | Triazoles - chemistry | Anti-Bacterial Agents - therapeutic use | Staphylococcal Skin Infections - drug therapy | Anti-Bacterial Agents - chemistry | Trans-Activators - genetics | Macrophages - immunology | Quinazolinones - pharmacology | Molecular Targeted Therapy - adverse effects | Phagocytosis - drug effects | Immunity, Innate - drug effects | Bacterial Proteins - genetics | Mice, Hairless | Drug Discovery | Triazoles - pharmacology | Animals | High-Throughput Screening Assays | Bacterial Proteins - metabolism | Genes, Reporter - drug effects | Macrophages - drug effects | Trans-Activators - metabolism | Quinazolinones - therapeutic use | Trans-Activators - antagonists & inhibitors | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Cell Line, Transformed | Quinazolinones - adverse effects | Skin - drug effects | Staphylococcus aureus infections | Physiological aspects | Development and progression | Genetic aspects | Quorum sensing | Virulence (Microbiology) | Research | Staphylococcus aureus | Index Medicus | Medical research | Bacteria | Staphylococcus infections | Bacterial infections | Antibiotics | Bacteriology
Journal Article
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 08/2013, Volume 38, Issue 9, pp. 1609 - 1616
We have previously demonstrated that lipopolysaccharide (LPS) induces depressive-like behavior by activating indoleamine 2,3 dioxygenase (IDO; O'Connor et al,... 
AMPA receptor | depression | lipopolysaccharide | NMDA receptor | inflammation | ketamine | BACILLUS-CALMETTE-GUERIN | PSYCHIATRY | MACROPHAGES | INDOLEAMINE 2,3-DIOXYGENASE | INDUCTION | NEUROSCIENCES | HIPPOCAMPUS | QUINOLINIC ACID | SICKNESS | IMMUNE ACTIVATION | PHARMACOLOGY & PHARMACY | BRAIN | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Body Weight - drug effects | Motor Activity - drug effects | Male | Ketamine - antagonists & inhibitors | Lipopolysaccharides - antagonists & inhibitors | Brain - metabolism | Quinoxalines - pharmacology | Depression - drug therapy | Drug Interactions | Liver - drug effects | Depression - chemically induced | Immobility Response, Tonic - drug effects | Antidepressive Agents - pharmacology | Brain-Derived Neurotrophic Factor - biosynthesis | Ketamine - therapeutic use | Cytokines - metabolism | Drug Administration Schedule | Food Preferences - drug effects | Liver - metabolism | Mice, Inbred C57BL | Excitatory Amino Acid Antagonists - pharmacology | Antidepressive Agents - therapeutic use | Brain - drug effects | Eating - drug effects | Animals | Signal Transduction - drug effects | Mice | Ketamine - pharmacology | Receptors, AMPA - antagonists & inhibitors | Index Medicus | Antidepressants | biological psychiatry | animal models | behavioral science | bipolar | unipolar | Original
Journal Article
The EMBO Journal, ISSN 0261-4189, 12/2006, Volume 25, Issue 24, pp. 5826 - 5839
Journal Article