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Kidney international, ISSN 0085-2538, 2015, Volume 88, Issue 5, pp. 1030 - 1046
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 01/2007, Volume 13, Issue 3, pp. 333 - 346
The matrix metalloproteinase family of enzymes has been a pharmaceutical target for over 20 years. In that time, many drugs have been developed but none have... 
Cardiovascular disease | Inflammation | Topical | Acute therapy | Remodeling | SMOKE-INDUCED EMPHYSEMA | cardiovascular disease | remodeling | topical | ABDOMINAL AORTIC-ANEURYSMS | HEART-FAILURE | BLOOD-BRAIN-BARRIER | RESPIRATORY-DISTRESS-SYNDROME | MUSCLE-CELL-MIGRATION | OBSTRUCTIVE PULMONARY-DISEASE | TISSUE-PLASMINOGEN-ACTIVATOR | inflammation | acute therapy | MACROPHAGE ELASTASE MMP-12 | PHARMACOLOGY & PHARMACY | PREVENTS CARDIAC RUPTURE | Hypertrophy, Left Ventricular - enzymology | Humans | Eye Diseases - enzymology | Protease Inhibitors - pharmacology | Atherosclerosis - enzymology | Drug Design | Hypertrophy, Left Ventricular - drug therapy | Protease Inhibitors - therapeutic use | Vascular Diseases - drug therapy | Extracellular Matrix Proteins - metabolism | Myocardial Infarction - enzymology | Atherosclerosis - drug therapy | Heart Rupture, Post-Infarction - enzymology | Neoplasms - enzymology | Skin Diseases - drug therapy | Stroke - drug therapy | Respiratory Distress Syndrome, Adult - drug therapy | Vascular Diseases - enzymology | Arthritis - enzymology | Neoplasms - drug therapy | Pulmonary Disease, Chronic Obstructive - enzymology | Stroke - enzymology | Animals | Myocardial Infarction - drug therapy | Eye Diseases - drug therapy | Arthritis - drug therapy | Matrix Metalloproteinase Inhibitors | Matrix Metalloproteinases - metabolism | Heart Rupture, Post-Infarction - drug therapy | Respiratory Distress Syndrome, Adult - enzymology | Skin Diseases - enzymology | Pulmonary Disease, Chronic Obstructive - drug therapy
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2017, Volume 37, Issue 2, pp. 328 - 340
OBJECTIVE—The calcium composition of atherosclerotic plaque is thought to be associated with increased risk for cardiovascular events, but whether plaque... 
atherosclerosis | coronary artery disease | macrophages | inflammation | biomarkers | C-REACTIVE PROTEIN | CORONARY-ARTERY CALCIUM | CARDIOVASCULAR EVENTS | VASCULAR CALCIFICATION | VULNERABLE PATIENT | RECEPTOR | RISK-ASSESSMENT STRATEGIES | PLAQUE | SMOOTH-MUSCLE | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Up-Regulation | Prognosis | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Humans | Myocytes, Smooth Muscle - pathology | rac GTP-Binding Proteins - deficiency | rac GTP-Binding Proteins - metabolism | Male | Coronary Artery Disease - enzymology | Atherosclerosis - enzymology | Transfection | Interleukin-1beta - metabolism | rac GTP-Binding Proteins - genetics | Coronary Artery Disease - pathology | Inflammation Mediators - metabolism | Aortic Diseases - prevention & control | Vascular Calcification - mortality | Female | Vascular Calcification - enzymology | Aortic Diseases - enzymology | Interleukin 1 Receptor Antagonist Protein - pharmacology | Aorta - enzymology | Aortic Diseases - pathology | Atherosclerosis - pathology | Coronary Vessels - pathology | Genetic Predisposition to Disease | Coronary Vessels - enzymology | Macrophages - pathology | Signal Transduction | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Neuropeptides - metabolism | Coronary Artery Disease - mortality | Plaque, Atherosclerotic | Vascular Calcification - pathology | Macrophages - enzymology | Mice, Knockout | Aorta - pathology | Aortic Diseases - genetics | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Apolipoproteins E - genetics | Muscle, Smooth, Vascular - enzymology | Atherosclerosis - prevention & control | rac1 GTP-Binding Protein - metabolism
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 549, Issue 7672, pp. 389 - 393
The pathophysiology of neurodegenerative diseases is poorly understood and there are few therapeutic options. Neurodegenerative diseases are characterized by... 
DENDRITIC CELLS | PATTERN | LANGERHANS CELL HISTIOCYTOSIS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | KINASE | MICE | MODEL | ERDHEIM-CHESTER-DISEASE | EXPRESSION | Microglia - metabolism | Clone Cells - enzymology | Humans | Male | Myeloid Progenitor Cells - enzymology | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Erythroid Precursor Cells - enzymology | Histiocytosis - pathology | Microglia - pathology | Female | Proto-Oncogene Proteins B-raf - metabolism | Disease Models, Animal | Histiocytosis - enzymology | Myeloid Progenitor Cells - metabolism | Neurodegenerative Diseases - pathology | Macrophages - pathology | Microglia - enzymology | Neurodegenerative Diseases - genetics | Myeloid Progenitor Cells - pathology | Histiocytosis - metabolism | Neurodegenerative Diseases - metabolism | Clone Cells - metabolism | Macrophages - enzymology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Erythroid Precursor Cells - pathology | Macrophages - metabolism | Animals | Clone Cells - pathology | Proto-Oncogene Proteins B-raf - genetics | Histiocytosis - genetics | Erythroid Precursor Cells - metabolism | Mosaicism | Mice | Mutation | Neurodegenerative Diseases - enzymology | Physiological aspects | Nervous system | Development and progression | Degeneration | Genetic aspects | Research | Histiocytosis | Mitogen-activated protein kinases | Intervention | Disease | Stem cell transplantation | Activation | Genomes | Kinases | Macrophages | Neuronal-glial interactions | Genotype & phenotype | Allografts | Neurodegeneration | Rodents | Bone marrow | Ataxia | Alzheimer's disease | Myeloid cells | Cytokines | Neurodegenerative diseases | Fetuses | Extracellular signal-regulated kinase | MAP kinase | Cell lineage | Gene expression | Patients | Amyloid precursor protein | Microglia | Organogenesis | Diseases | Neurological diseases | Gliosis | Stem cells | Neural stem cells
Journal Article
Cancer prevention research (Philadelphia, Pa.), ISSN 1940-6215, 2011, Volume 4, Issue 7, pp. 1021 - 1029
Journal Article
Journal Article
Journal Article
Circulation research, ISSN 1524-4571, 2013, Volume 112, Issue 4, pp. 675 - 688
RATIONALE:Matrix metalloproteinase (MMP)-28 regulates the inflammatory and extracellular matrix responses in cardiac aging, but the roles of MMP-28 after... 
fibroblast | MMP-28 | inflammation | macrophage phenotype | myocardial infarction | LYSYL OXIDASE | CARDIAC & CARDIOVASCULAR SYSTEMS | TGF-BETA | VENTRICULAR-FUNCTION | HEART-FAILURE | CORONARY MICROEMBOLIZATION | REPAIR | MATRIX-METALLOPROTEINASE-9 | PERIPHERAL VASCULAR DISEASE | EPILYSIN MMP-28 | TNF-ALPHA | TARGETED DELETION | HEMATOLOGY | Myocardial Infarction - blood | Cell Adhesion Molecules - genetics | Cicatrix - etiology | Extracellular Matrix Proteins - biosynthesis | Male | Matrix Metalloproteinases, Secreted - deficiency | Pulmonary Edema - etiology | Myocytes, Cardiac - enzymology | Myofibroblasts - metabolism | Ventricular Dysfunction, Left - enzymology | Ventricular Remodeling - genetics | Female | Myocardial Infarction - physiopathology | Transcription, Genetic | Cytokines - genetics | Heart Rupture - enzymology | Receptors, Cytokine - genetics | Matrix Metalloproteinase 9 - blood | Myocardial Infarction - enzymology | Macrophage Activation - physiology | Macrophages - classification | Cell Adhesion Molecules - biosynthesis | Receptors, Cytokine - biosynthesis | Extracellular Matrix Proteins - genetics | Mice, Inbred C57BL | Gene Expression Regulation | Ventricular Dysfunction, Left - etiology | Inflammation | Ventricular Remodeling - physiology | Macrophages - enzymology | Mice, Knockout | Collagen - metabolism | Myocardial Infarction - complications | Heart Rupture - etiology | Animals | Pulmonary Edema - enzymology | Matrix Metalloproteinases, Secreted - genetics | Matrix Metalloproteinases, Secreted - physiology | Protein-Lysine 6-Oxidase - metabolism | Cicatrix - enzymology | Mice | Cytokines - biosynthesis
Journal Article
Annual review of physiology, ISSN 1545-1585, 2011, Volume 73, Issue 1, pp. 479 - 501
Journal Article
Journal Article
Archives of Oral Biology, ISSN 0003-9969, 2009, Volume 54, Issue 8, pp. 764 - 771
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 1559-7016, 2016, Volume 15, Issue 1, pp. 52 - 59
Journal Article