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Journal of Cellular Physiology, ISSN 0021-9541, 09/2007, Volume 212, Issue 3, pp. 702 - 709
Adipose tissue serves as a source of adipokines and cytokines with both local and systemic actions in health and disease. In this study, we examine the... 
BREAST-CANCER | TUMOR-NECROSIS-FACTOR | IN-VITRO | PHYSIOLOGY | TEMPORAL-CHANGES | MURINE BONE-MARROW | INSULIN-RESISTANCE | HEPATOCYTE GROWTH-FACTOR | ENDOTHELIAL-CELLS | TISSUE | STROMAL CELLS | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Angiogenic Proteins - genetics | Cell Proliferation | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Coculture Techniques | Humans | Middle Aged | Multipotent Stem Cells - metabolism | Adipose Tissue - cytology | RNA, Messenger - metabolism | Hematopoiesis - drug effects | Adipose Tissue - metabolism | Multipotent Stem Cells - drug effects | Time Factors | Inflammation Mediators - metabolism | Fibroblast Growth Factor 2 - metabolism | Adult | Female | Cell Differentiation | Interleukin-8 - metabolism | Cytokines - genetics | Interleukin-6 - metabolism | Granulocyte Colony-Stimulating Factor - metabolism | Interleukin-7 - metabolism | Adult Stem Cells - drug effects | Adult Stem Cells - cytology | Cytokines - metabolism | Paracrine Communication | Endothelial Cells - metabolism | Ascorbic Acid - analogs & derivatives | Cells, Cultured | Epidermal Growth Factor - metabolism | Interleukin-11 - metabolism | Hematopoietic Stem Cells - metabolism | Hepatocyte Growth Factor - metabolism | Adult Stem Cells - metabolism | Adipocytes - metabolism | Ascorbic Acid - pharmacology | Lipopolysaccharides - pharmacology | Adipose Tissue - drug effects | Angiogenic Proteins - metabolism | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2011, Volume 186, Issue 11, pp. 6553 - 6561
Journal Article
Immunity, ISSN 1074-7613, 05/2013, Volume 38, Issue 5, pp. 1038 - 1049
Journal Article
Cell Metabolism, ISSN 1550-4131, 2005, Volume 1, Issue 2, pp. 107 - 119
Fatty acid binding proteins (FABPs) are cytosolic fatty acid chaperones whose biological role and mechanisms of action are not well understood. Here, we... 
LEPTIN | TARGETED DISRUPTION | AP2 | ENDOCRINOLOGY & METABOLISM | WEIGHT-LOSS | MUSCLE | MICE | TNF-ALPHA | INDUCED INSULIN-RESISTANCE | APOLIPOPROTEIN-E | ADIPOCYTE | CELL BIOLOGY | Fatty Acid-Binding Proteins | Phosphorylation | Body Weight | Adipose Tissue - cytology | Multienzyme Complexes - metabolism | Adipocytes - cytology | Immunoblotting | RNA, Messenger - metabolism | AMP-Activated Protein Kinases | Oxygen - metabolism | Tissue Distribution | Adipose Tissue - metabolism | Time Factors | Fatty Acids - metabolism | Protein-Serine-Threonine Kinases - metabolism | Cytokines - metabolism | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Insulin Resistance | Diabetes Mellitus - metabolism | Lipid Metabolism | Mice, Transgenic | Inflammation | Macrophages - cytology | Obesity - metabolism | Triglycerides - metabolism | Insulin - metabolism | Macrophages - metabolism | Phenotype | Animals | Carrier Proteins - metabolism | Adipocytes - metabolism | Glucose - metabolism | Stearoyl-CoA Desaturase - metabolism | Receptor, Insulin - metabolism | Arteriosclerosis - metabolism | Mice | Mutation | Type 2 diabetes | Obesity | Glucose | Macrophages | Fatty acids | Dextrose | Glucose metabolism | Atherosclerosis | Physiological aspects | Insulin resistance | Binding proteins | Public health | Protein binding | Diabetes therapy | Index Medicus
Journal Article
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1570 - 1573
Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33, an intronic microRNA (miRNA) located within the gene encoding... 
MicroRNA | Hepatocytes | HDL lipoproteins | Liver | Genes | REPORTS | Homeostasis | Gene expression regulation | Macrophages | Cholesterols | Endothelial cells | TANGIER-DISEASE | HDL | LIPID-METABOLISM | CASSETTE TRANSPORTER 1 | CELLULAR CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATIONS | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Membrane Glycoproteins - metabolism | Cholesterol, Dietary - administration & dosage | Lipoproteins - genetics | Lipoproteins, HDL - blood | Humans | Lipoproteins, HDL - metabolism | MicroRNAs - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Dietary Fats - administration & dosage | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cell Line | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Membrane Glycoproteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Macrophages, Peritoneal - metabolism | Hypercholesterolemia - metabolism | Physiological aspects | Control | Research | High density lipoproteins | Cholesterol metabolism | Lipoproteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Cholesterol | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2014, Volume 192, Issue 2, pp. 623 - 629
Chronic inflammation is known to promote metabolic dysregulation in obesity and type 2 diabetes. Although the precise origin of the unchecked inflammatory... 
IMMUNE-SYSTEM | INFLAMMATION | DISEASE | RESISTANCE | FAT | AKT | IMMUNOLOGY | DIET-INDUCED OBESITY | KEY PLAYERS | ADIPOSE-TISSUE | CUTTING EDGE | Tumor Necrosis Factor-alpha - metabolism | Antigens, CD - immunology | T-Lymphocytes, Regulatory - metabolism | Epithelial Cells - metabolism | TOR Serine-Threonine Kinases - metabolism | Obesity - immunology | Insulin - immunology | Interferon-gamma - metabolism | Antigens, CD - metabolism | T-Lymphocytes, Regulatory - immunology | Epithelium - immunology | Signal Transduction - immunology | Inflammation - metabolism | Tumor Necrosis Factor-alpha - immunology | Interleukin-10 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Receptor, Insulin - immunology | Macrophages - immunology | Hyperinsulinism - metabolism | Intra-Abdominal Fat - immunology | Transforming Growth Factor beta - immunology | Epithelium - metabolism | Mice, Inbred C57BL | Apyrase - metabolism | Cells, Cultured | Apyrase - immunology | CTLA-4 Antigen - metabolism | Inflammation - immunology | CTLA-4 Antigen - immunology | Intra-Abdominal Fat - metabolism | Obesity - metabolism | TOR Serine-Threonine Kinases - immunology | Insulin - metabolism | Macrophages - metabolism | Animals | Hyperinsulinism - immunology | Proto-Oncogene Proteins c-akt - immunology | Epithelial Cells - immunology | Interferon-gamma - immunology | Interleukin-10 - antagonists & inhibitors | Receptor, Insulin - metabolism | Mice | Interleukin-10 - immunology | Transforming Growth Factor beta - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Diabetes Care, ISSN 0149-5992, 04/2010, Volume 33, Issue 4, pp. 861 - 868
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 28, pp. 12611 - 12616
Asbestos carcinogenesis has been linked to the release of cytokines and mutagenic reactive oxygen species (ROS) from inflammatory cells. Asbestos is cytotoxic... 
Actinomycin | Asbestos | Cell death | Secretion | Plasma cells | Inflammation | Macrophages | Carcinogenesis | Necrosis | Apoptosis | Mesothelioma | Biomarker | Tumor necrosis factor-alpha | Chemoprevention | TRANSFORMATION | POLY(ADP-RIBOSE) POLYMERASE | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | CROCIDOLITE ASBESTOS | HMGB1 | biomarker | MAMMALIAN-CELLS | tumor necrosis factor-alpha | PATHOGENESIS | chemoprevention | NECROTIC CELLS | carcinogenesis | TNF-ALPHA | INHIBITORS | mesothelioma | Tumor Necrosis Factor-alpha - metabolism | Asbestos - metabolism | Epithelial Cells - metabolism | Reactive Oxygen Species - metabolism | Humans | Reactive Oxygen Species - pharmacology | Adenosine Diphosphate Ribose - metabolism | Adenosine Diphosphate Ribose - pharmacology | Carcinogens - metabolism | Asbestos - pharmacology | Pleural Neoplasms - metabolism | Inflammation - metabolism | Carcinogens - pharmacology | Cell Nucleus - metabolism | HMGB Proteins - pharmacology | HMGB1 Protein - pharmacology | HMGB1 Protein - metabolism | Cell Death | Mesocricetus | Female | HMGB Proteins - metabolism | Poly Adenosine Diphosphate Ribose - pharmacology | Epithelium - drug effects | Cricetinae | Cytokines - metabolism | Epithelium - metabolism | Hydrogen Peroxide - pharmacology | Necrosis - metabolism | Hydrogen Peroxide - metabolism | Tumor Necrosis Factor-alpha - pharmacology | Macrophages - metabolism | Poly(ADP-ribose) Polymerases - metabolism | Animals | Mesothelioma - metabolism | Poly(ADP-ribose) Polymerases - pharmacology | Cells - metabolism | Mice | Mice, Inbred BALB C | Cytokines - pharmacology | Prevention | Mesothelium | Chromosomal proteins | Research | Chemical properties | Health aspects | Proteins | Carcinogens | Cytokines | Oncology | Biochemistry | Cells | Index Medicus | Reactive oxygen species | Transformation | Deposits | Hydrogen peroxide | Cytotoxicity | HMGB1 protein | Nuclei | Tumor necrosis factor-a | ATP | Cytoplasm | Biological Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2012, Volume 287, Issue 31, pp. 25758 - 25769
The early initiation phase of acute inflammation is anabolic and primarily requires glycolysis with reduced mitochondrial glucose oxidation for energy, whereas... 
MACROPHAGE-MEDIATED INFLAMMATION | HOMEOSTASIS | T-CELL MEMORY | METABOLISM | ADIPONECTIN | INSULIN-RESISTANCE | IMMUNOSUPPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTOXIN TOLERANCE | SEPSIS | DIFFERENTIATION | Sirtuin 1 - metabolism | Humans | Monocyte-Macrophage Precursor Cells - immunology | Glucose Transporter Type 1 - metabolism | Monocyte-Macrophage Precursor Cells - metabolism | Leukocytes - immunology | Heat-Shock Proteins - genetics | Monocyte-Macrophage Precursor Cells - physiology | Nicotinamide Phosphoribosyltransferase - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Sepsis - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | NAD - biosynthesis | Fatty Acids - metabolism | Cell Line | Sepsis - immunology | Cytokines - metabolism | Oxidation-Reduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | Transcription Factors - genetics | Toll-Like Receptor 4 - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Adaptation, Physiological - immunology | Animals | Carrier Proteins - metabolism | Energy Metabolism | Lipopolysaccharides - pharmacology | Glucose - metabolism | Glycolysis | Mice | Leukocytes - metabolism | Sirtuins - metabolism | Index Medicus | NAD | Sirtuins | Immunology | Acute Inflammation | Bioenergetics | PGC-1 | Sepsis | HIF-1α | Biosensors | Macrophages | Metabolism
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 665 - 674
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride... 
RAT-LIVER | RISK-FACTORS | MACROPHAGE APOPTOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HMG-COA REDUCTASE | STEATOHEPATITIS | 3-HYDROXY-3-METHYLGLUTARYL COENZYME | PREVALENCE | MICRORNA EXPRESSION | MODULATION | CELL BIOLOGY | Sirtuin 1 - metabolism | Up-Regulation | Cholesterol - blood | Humans | Middle Aged | Sterol Esterase - metabolism | Male | MicroRNAs - metabolism | Desmosterol - metabolism | Cardiovascular Diseases - genetics | Cholesterol - genetics | Sirtuin 1 - genetics | Case-Control Studies | Phosphorylation - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Adenylate Kinase - metabolism | Non-alcoholic Fatty Liver Disease | Sterol O-Acyltransferase - metabolism | Adult | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Gene Expression | Fatty Liver - metabolism | Cardiovascular Diseases - metabolism | Fatty Liver - blood | Liver - metabolism | Receptors, LDL - metabolism | Cholesterol - metabolism | Cholesterol, LDL - genetics | Phenotype | Sterol Esterase - genetics | Desmosterol - blood | Cholesterol, LDL - metabolism | MicroRNAs - genetics | Sterol O-Acyltransferase - genetics | Adenylate Kinase - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Enzymes | Liver diseases | Low density lipoproteins | Genes | Esters | Triglycerides | Cholesterol | MicroRNA | Fatty liver | Blood cholesterol | Physiological aspects | Hydrolases | Blood lipids | Health aspects | Statins | Index Medicus | atherosclerosis | Nonalcoholic steatohepatitis | cholesterol | Nonalcoholic fatty liver disease | fatty liver | lipogenesis | hypercholesterolemia | HMG CoA reductase
Journal Article