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phosphorylation (137) 137
cdc20 proteins (135) 135
protein (133) 133
mutation (132) 132
article (127) 127
protein binding (126) 126
assembly checkpoint (119) 119
mitosis - physiology (116) 116
unattached kinetochores (116) 116
spindle-assembly checkpoint (114) 114
cell line, tumor (113) 113
nuclear proteins (112) 112
nuclear proteins - genetics (112) 112
molecular sequence data (106) 106
binding (104) 104
anaphase-promoting complex-cyclosome (101) 101
multidisciplinary sciences (99) 99
physiological aspects (99) 99
signal transduction (99) 99
chromosomal instability (98) 98
repressor proteins - genetics (98) 98
kinetochore (97) 97
male (95) 95
amino acid sequence (94) 94
mad2 proteins - genetics (94) 94
bubr1 (92) 92
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complex (90) 90
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spindle apparatus - genetics (78) 78
gene expression (75) 75
m phase cell cycle checkpoints (74) 74
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cell cycle proteins - physiology (72) 72
dna damage (68) 68
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Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7393, pp. 208 - 213
In mitosis, the spindle assembly checkpoint (SAC) ensures genome stability by delaying chromosome segregation until all sister chromatids have achieved bipolar... 
ANAPHASE-PROMOTING COMPLEX | FISSION YEAST | KEN BOX | BUDDING YEAST | PROTEIN BUBR1 | MULTIDISCIPLINARY SCIENCES | PSEUDOSUBSTRATE INHIBITION | DESTRUCTION BOX | SACCHAROMYCES-CEREVISIAE | MAD2 ACTIVATION | SPINDLE-ASSEMBLY CHECKPOINT | Anaphase-Promoting Complex-Cyclosome | Schizosaccharomyces pombe Proteins - chemistry | M Phase Cell Cycle Checkpoints | Schizosaccharomyces - chemistry | Humans | Ubiquitin-Protein Ligase Complexes - antagonists & inhibitors | Substrate Specificity | Crystallography, X-Ray | Structure-Activity Relationship | Spindle Apparatus | Cell Cycle Proteins - chemistry | Multiprotein Complexes - metabolism | Cdh1 Proteins | Protein Structure, Quaternary | Schizosaccharomyces pombe Proteins - metabolism | Conserved Sequence | Mad2 Proteins | Cdc20 Proteins | Protein Structure, Tertiary | Cell Cycle Proteins - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Saccharomyces cerevisiae Proteins - genetics | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligase Complexes - chemistry | Amino Acid Motifs | Multiprotein Complexes - chemistry | Ubiquitin-Protein Ligase Complexes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Ubiquitin-Protein Ligase Complexes - ultrastructure | Proteins | Kinases | Binding sites | Crystal structure | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 05/2018, Volume 173, Issue 4, pp. 972 - 988.e23
Repair of damaged DNA is essential for maintaining genome integrity and for preventing genome-instability-associated diseases, such as cancer. By combining... 
DNA damage repair | proximity labeling | shieldin | proteomics | 53BP1 | PARP inhibitors | telomere maintenance | antibody class-switch recombination | NHEJ | BRCA1 | PATHWAYS | CELLS | RESECTION | DAMAGE-RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLASS-SWITCH RECOMBINATION | HOMOLOGOUS RECOMBINATION | DOUBLE-STRAND BREAK | TELOMERES | CELL BIOLOGY | Mad2 Proteins - metabolism | Humans | Ubiquitin-Protein Ligases - antagonists & inhibitors | DNA Breaks, Double-Stranded | Mad2 Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Telomere-Binding Proteins - genetics | RNA Interference | BRCA1 Protein - metabolism | Trans-Activators - genetics | Immunoglobulin Class Switching - drug effects | Nuclear Proteins - genetics | Telomere-Binding Proteins - metabolism | Tumor Suppressor p53-Binding Protein 1 - metabolism | DNA End-Joining Repair - drug effects | DNA-Binding Proteins - antagonists & inhibitors | Mutagenesis, Site-Directed | Tumor Suppressor p53-Binding Protein 1 - genetics | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Telomere-Binding Proteins - antagonists & inhibitors | Tumor Suppressor p53-Binding Protein 1 - antagonists & inhibitors | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | BRCA1 Protein - antagonists & inhibitors | Mad2 Proteins - genetics | Cell Line, Tumor | Trans-Activators - metabolism | Ubiquitin-Protein Ligases - genetics | RNA, Small Interfering - metabolism | DNA damage | Genomics | Antibodies | Genomes | DNA repair | Proteins | Viral antibodies | Telomeres | Evolutionary biology | Analysis | DNA | Genetic research | Mass spectrometry | Index Medicus
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 7/2010, Volume 190, Issue 1, pp. 25 - 34
Mps1 is an essential component of the spindle assembly checkpoint. In this study, we describe a novel Mps1 inhibitor, AZ3146, and use it to probe the role of... 
HEK293 cells | Mitosis | Auroras | Kinetochores | Cell lines | Centromeres | HeLa cells | Antibodies | Reports | Chromosomes | Cells | MITOTIC CHECKPOINT PROTEINS | MAD2 | ACTIVATION | KINASE | DYNAMICS | CENP-E | CHROMOSOME ALIGNMENT | BUB1 | KINETOCHORE LOCALIZATION | SPINDLE-ASSEMBLY CHECKPOINT | CELL BIOLOGY | Phosphorylation - physiology | Humans | Multiprotein Complexes - genetics | Cell Cycle Proteins - antagonists & inhibitors | Aurora Kinase B | Multiprotein Complexes - metabolism | Protein Multimerization - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Mad2 Proteins | Phosphorylation - drug effects | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Calcium-Binding Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Aurora Kinases | Chromosomal Proteins, Non-Histone - genetics | Mitosis - drug effects | Mitosis - physiology | Signal Transduction - drug effects | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Protein-Tyrosine Kinases | Protein Multimerization - drug effects | Calcium-Binding Proteins - genetics | Genetic aspects | Chemical properties | Proteins | Cell division | Biochemistry | Cell cycle | Index Medicus | s
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/2011, Volume 30, Issue 16, pp. 3322 - 3336
The spindle assembly checkpoint (SAC) restrains anaphase until all chromosomes become bi‐oriented on the mitotic spindle. The SAC protein Mad2 can fold into... 
p31comet | Mad2 template model | mitotic timing | closed‐Mad2 | spindle assembly checkpoint | RAD52 | c-ABL | tyrosine phosphorylation | ssDNA annealing | DNA repair | ANAPHASE-PROMOTING COMPLEX | PROTEIN BUBR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONFORMATIONAL DIMERIZATION | MONOCLONAL-ANTIBODY | MAD2 ACTIVATION | CORE COMPLEX | CELL BIOLOGY | CDC20 | MITOSIS | closed-Mad2 | BINDING | UNATTACHED KINETOCHORES | Humans | Cell Cycle Proteins - chemistry | Repressor Proteins - physiology | Cell Cycle Proteins - immunology | Time Factors | Calcium-Binding Proteins - immunology | Adaptor Proteins, Signal Transducing - immunology | Mad2 Proteins | Cdc20 Proteins | Spindle Apparatus - physiology | Dimerization | Antibodies, Monoclonal - immunology | Calcium-Binding Proteins - chemistry | Rabbits | Repressor Proteins - chemistry | Kinetochores - metabolism | RNA, Small Interfering - pharmacology | Anaphase - physiology | Nuclear Pore - metabolism | Nuclear Proteins - chemistry | Nuclear Proteins - immunology | Protein Folding | Macromolecular Substances | Protein Interaction Mapping | Adaptor Proteins, Signal Transducing - physiology | Animals | Mitosis - drug effects | Mitosis - physiology | Calcium-Binding Proteins - physiology | Repressor Proteins - immunology | Protein Conformation | Mice | Mice, Inbred BALB C | Nuclear Proteins - physiology | Cell Cycle Proteins - physiology | Proteins | Cell division | Molecular biology | Signal to noise ratio | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2015, Volume 521, Issue 7553, pp. 541 - U308
Journal Article
eLife, ISSN 2050-084X, 04/2015, Volume 2015, Issue 4, pp. 1 - 44
The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved... 
N-Ethylmaleimide-Sensitive Proteins - metabolism | Mad2 Proteins - metabolism | Molecular Chaperones - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Crystallography, X-Ray | Phylogeny | N-Ethylmaleimide-Sensitive Proteins - genetics | Amino Acid Sequence | Gene Expression | Caenorhabditis elegans - genetics | Cell Cycle Proteins - metabolism | Molecular Chaperones - genetics | Adenosine Triphosphatases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Nuclear Proteins - chemistry | Caenorhabditis elegans - classification | Escherichia coli - genetics | Adenosine Triphosphatases - genetics | Escherichia coli Proteins - chemistry | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Adaptor Proteins, Signal Transducing - chemistry | Endopeptidase Clp - chemistry | M Phase Cell Cycle Checkpoints | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Molecular Chaperones - chemistry | Cell Cycle Proteins - chemistry | Spindle Apparatus - genetics | Escherichia coli - metabolism | Cell Cycle Proteins - genetics | Carrier Proteins - chemistry | Nuclear Proteins - genetics | N-Ethylmaleimide-Sensitive Proteins - chemistry | Protein Structure, Tertiary | Recombinant Proteins - metabolism | ATPases Associated with Diverse Cellular Activities | Endopeptidase Clp - genetics | Escherichia coli Proteins - metabolism | Nuclear Proteins - metabolism | Endopeptidase Clp - metabolism | Mad2 Proteins - chemistry | Recombinant Proteins - genetics | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Sequence Alignment | Animals | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mad2 Proteins - genetics | Escherichia coli Proteins - genetics | Protein Binding | Adenosine Triphosphatases - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Spindle Apparatus - enzymology | Proteins | Medical research | Recombination | Software | Meiosis | Mammals | Chromosomes | DNA repair | Deoxyribonucleic acid--DNA | Adenosine triphosphatase | Index Medicus
Journal Article
Developmental Cell, ISSN 1534-5807, 01/2009, Volume 16, Issue 1, pp. 105 - 117
Journal Article
Structure, ISSN 0969-2126, 10/2015, Volume 23, Issue 10, pp. 1848 - 1857
The ULK1 complex, consisting of the ULK1 protein kinase itself, FIP200, Atg13, and Atg101, controls the initiation of autophagy in animals. We determined the... 
protein structure | hydrogen-deuterium exchange | X-ray crystallography | Atg1 | autophagy | DOMAIN | PROTEIN | MECHANISM | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | AUTOPHAGY | IDENTIFICATION | CELL BIOLOGY | BIOPHYSICS | ROLES | ARCHITECTURE | KINASE ULK1 | BINDING | Adaptor Proteins, Signal Transducing - chemistry | Autophagy-Related Proteins | Mad2 Proteins - metabolism | Vesicular Transport Proteins - metabolism | Humans | Protein Multimerization | Molecular Sequence Data | Crystallography, X-Ray | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy-Related Protein-1 Homolog | Spodoptera | Schizosaccharomyces - genetics | Sf9 Cells | Autophagy - genetics | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Gene Expression | Protein Structure, Secondary | Vesicular Transport Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Models, Molecular | Recombinant Proteins - chemistry | Vesicular Transport Proteins - chemistry | Mad2 Proteins - chemistry | Recombinant Proteins - genetics | Benzamidines - chemistry | Schizosaccharomyces - metabolism | Sequence Alignment | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Adaptor Proteins, Signal Transducing - genetics | Mad2 Proteins - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Protein-Serine-Threonine Kinases - chemistry | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Proteins | Cells | Hydrogen | Protein kinases | Index Medicus
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2014, Volume 204, Issue 5, pp. 647 - 657
Recruitment of Mad1-Mad2 complexes to unattached kinetochores is a central event in spindle checkpoint signaling. Despite its importance, the mechanism that... 
KINASE-ACTIVITY | RECRUITMENT | ASSEMBLY CHECKPOINT | CAENORHABDITIS-ELEGANS | BUDDING YEAST | MICROTUBULE-BINDING | CENP-E | CHROMOSOME SEGREGATION | MITOTIC CHECKPOINT | BUB1 | CELL BIOLOGY | Meiosis - physiology | M Phase Cell Cycle Checkpoints | Mad2 Proteins - metabolism | Caenorhabditis elegans Proteins - metabolism | Cell Cycle Proteins - genetics | Chromosomes - metabolism | Nuclear Proteins - genetics | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Caenorhabditis elegans - metabolism | Kinetochores - metabolism | Signal Transduction | Caenorhabditis elegans - genetics | Protein-Serine-Threonine Kinases - physiology | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Anaphase - physiology | Nuclear Proteins - metabolism | Mad2 Proteins - physiology | Two-Hybrid System Techniques | Animals | Caenorhabditis elegans - cytology | Mutagenesis | Models, Biological | Mad2 Proteins - genetics | Caenorhabditis elegans Proteins - physiology | Nuclear Proteins - physiology | Caenorhabditis elegans Proteins - genetics | Cell Cycle Proteins - physiology | Kinetochores - physiology | Spindle (Cell division) | Physiological aspects | Cell interaction | Cell research | Research | Kinetochores | Nematodes | Mutation | Kinases | Chromosomes | Index Medicus | Life Sciences
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 9/2001, Volume 154, Issue 5, pp. 925 - 936
The mitotic checkpoint prevents cells with unaligned chromosomes from prematurely exiting mitosis by inhibiting the anaphase-promoting complex/cyclosome... 
Gels | Mitosis | Interphase | Kinetochores | Ubiquitins | Cell cycle | HeLa cells | Antibodies | Chromosomes | Anaphase | MAD2 | Kinetochore | Anaphase promoting complex | Mitotic checkpoint | hBUBR1 | mitotic checkpoint | ANAPHASE-PROMOTING COMPLEX | BUDDING YEAST | UBIQUITIN LIGASE | PROTEIN-KINASE | CYCLIN-B | SPINDLE ASSEMBLY CHECKPOINT | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | kinetochore | anaphase promoting complex | CENP-E | UNATTACHED KINETOCHORES | Protein Kinases - metabolism | Anaphase-Promoting Complex-Cyclosome | Cell Fractionation | Ligases - isolation & purification | Humans | Protein-Serine-Threonine Kinases | Immunoblotting | Recombinant Fusion Proteins - metabolism | Ubiquitin-Protein Ligase Complexes | Poly-ADP-Ribose Binding Proteins | Genes, cdc - physiology | Mad2 Proteins | Cdc20 Proteins | Carrier Proteins | Calcium-Binding Proteins - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Ligases - metabolism | Genes, Reporter - genetics | Macromolecular Substances | Nuclear Proteins | Ubiquitin-Protein Ligases | Proteins - metabolism | Ligases - antagonists & inhibitors | Mitosis - physiology | Saccharomyces cerevisiae Proteins | Recombinant Fusion Proteins - genetics | HeLa Cells | Fungal Proteins - metabolism | Physiological aspects | Chromosomal proteins | Research | Cell division | Cellular biology | Genes | Cells | Index Medicus | kinetochore; hBUBR1; anaphase promoting complex; MAD2; mitotic checkpoint
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