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Nature, ISSN 0028-0836, 2015, Volume 521, Issue 7553, pp. 541 - U308
Journal Article
Cell, ISSN 0092-8674, 05/2018, Volume 173, Issue 4, pp. 972 - 988.e23
Repair of damaged DNA is essential for maintaining genome integrity and for preventing genome-instability-associated diseases, such as cancer. By combining... 
DNA damage repair | proximity labeling | shieldin | proteomics | 53BP1 | PARP inhibitors | telomere maintenance | antibody class-switch recombination | NHEJ | BRCA1 | PATHWAYS | CELLS | RESECTION | DAMAGE-RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CLASS-SWITCH RECOMBINATION | HOMOLOGOUS RECOMBINATION | DOUBLE-STRAND BREAK | TELOMERES | CELL BIOLOGY | Mad2 Proteins - metabolism | Humans | Ubiquitin-Protein Ligases - antagonists & inhibitors | DNA Breaks, Double-Stranded | Mad2 Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Telomere-Binding Proteins - genetics | RNA Interference | BRCA1 Protein - metabolism | Trans-Activators - genetics | Immunoglobulin Class Switching - drug effects | Nuclear Proteins - genetics | Telomere-Binding Proteins - metabolism | Tumor Suppressor p53-Binding Protein 1 - metabolism | DNA End-Joining Repair - drug effects | DNA-Binding Proteins - antagonists & inhibitors | Mutagenesis, Site-Directed | Tumor Suppressor p53-Binding Protein 1 - genetics | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Telomere-Binding Proteins - antagonists & inhibitors | Tumor Suppressor p53-Binding Protein 1 - antagonists & inhibitors | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | BRCA1 Protein - antagonists & inhibitors | Mad2 Proteins - genetics | Cell Line, Tumor | Trans-Activators - metabolism | Ubiquitin-Protein Ligases - genetics | RNA, Small Interfering - metabolism | DNA damage | Genomics | Antibodies | Genomes | DNA repair | Proteins | Viral antibodies | Telomeres | Evolutionary biology | Analysis | DNA | Genetic research | Mass spectrometry
Journal Article
Journal Article
Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7393, pp. 208 - 213
In mitosis, the spindle assembly checkpoint (SAC) ensures genome stability by delaying chromosome segregation until all sister chromatids have achieved bipolar... 
ANAPHASE-PROMOTING COMPLEX | FISSION YEAST | KEN BOX | BUDDING YEAST | PROTEIN BUBR1 | MULTIDISCIPLINARY SCIENCES | PSEUDOSUBSTRATE INHIBITION | DESTRUCTION BOX | SACCHAROMYCES-CEREVISIAE | MAD2 ACTIVATION | SPINDLE-ASSEMBLY CHECKPOINT | Anaphase-Promoting Complex-Cyclosome | Schizosaccharomyces pombe Proteins - chemistry | M Phase Cell Cycle Checkpoints | Schizosaccharomyces - chemistry | Humans | Ubiquitin-Protein Ligase Complexes - antagonists & inhibitors | Substrate Specificity | Crystallography, X-Ray | Structure-Activity Relationship | Spindle Apparatus | Cell Cycle Proteins - chemistry | Multiprotein Complexes - metabolism | Cdh1 Proteins | Protein Structure, Quaternary | Schizosaccharomyces pombe Proteins - metabolism | Conserved Sequence | Mad2 Proteins | Cdc20 Proteins | Protein Structure, Tertiary | Cell Cycle Proteins - metabolism | Models, Molecular | Nuclear Proteins - metabolism | Saccharomyces cerevisiae Proteins - genetics | Nuclear Proteins - chemistry | Ubiquitin-Protein Ligase Complexes - chemistry | Amino Acid Motifs | Multiprotein Complexes - chemistry | Ubiquitin-Protein Ligase Complexes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Ubiquitin-Protein Ligase Complexes - ultrastructure | Proteins | Kinases | Binding sites | Crystal structure
Journal Article
Journal Article
eLife, ISSN 2050-084X, 04/2015, Volume 2015, Issue 4, pp. 1 - 44
The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved... 
N-Ethylmaleimide-Sensitive Proteins - metabolism | Mad2 Proteins - metabolism | Molecular Chaperones - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Crystallography, X-Ray | Phylogeny | N-Ethylmaleimide-Sensitive Proteins - genetics | Amino Acid Sequence | Gene Expression | Caenorhabditis elegans - genetics | Cell Cycle Proteins - metabolism | Molecular Chaperones - genetics | Adenosine Triphosphatases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Nuclear Proteins - chemistry | Caenorhabditis elegans - classification | Escherichia coli - genetics | Adenosine Triphosphatases - genetics | Escherichia coli Proteins - chemistry | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Adaptor Proteins, Signal Transducing - chemistry | Endopeptidase Clp - chemistry | M Phase Cell Cycle Checkpoints | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Molecular Chaperones - chemistry | Cell Cycle Proteins - chemistry | Spindle Apparatus - genetics | Escherichia coli - metabolism | Cell Cycle Proteins - genetics | Carrier Proteins - chemistry | Nuclear Proteins - genetics | N-Ethylmaleimide-Sensitive Proteins - chemistry | Protein Structure, Tertiary | Recombinant Proteins - metabolism | ATPases Associated with Diverse Cellular Activities | Endopeptidase Clp - genetics | Escherichia coli Proteins - metabolism | Nuclear Proteins - metabolism | Endopeptidase Clp - metabolism | Mad2 Proteins - chemistry | Recombinant Proteins - genetics | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Sequence Alignment | Animals | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mad2 Proteins - genetics | Escherichia coli Proteins - genetics | Protein Binding | Adenosine Triphosphatases - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Spindle Apparatus - enzymology | Proteins | Medical research | Recombination | Software | Meiosis | Mammals | Chromosomes | DNA repair | Deoxyribonucleic acid--DNA | Adenosine triphosphatase
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 7/2010, Volume 190, Issue 1, pp. 25 - 34
Mps1 is an essential component of the spindle assembly checkpoint. In this study, we describe a novel Mps1 inhibitor, AZ3146, and use it to probe the role of... 
HEK293 cells | Mitosis | Auroras | Kinetochores | Cell lines | Centromeres | HeLa cells | Antibodies | Reports | Chromosomes | Cells | MITOTIC CHECKPOINT PROTEINS | MAD2 | ACTIVATION | KINASE | DYNAMICS | CENP-E | CHROMOSOME ALIGNMENT | BUB1 | KINETOCHORE LOCALIZATION | SPINDLE-ASSEMBLY CHECKPOINT | CELL BIOLOGY | Phosphorylation - physiology | Humans | Multiprotein Complexes - genetics | Cell Cycle Proteins - antagonists & inhibitors | Aurora Kinase B | Multiprotein Complexes - metabolism | Protein Multimerization - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Mad2 Proteins | Phosphorylation - drug effects | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Calcium-Binding Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Aurora Kinases | Chromosomal Proteins, Non-Histone - genetics | Mitosis - drug effects | Mitosis - physiology | Signal Transduction - drug effects | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Protein-Tyrosine Kinases | Protein Multimerization - drug effects | Calcium-Binding Proteins - genetics | Genetic aspects | Chemical properties
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2014, Volume 204, Issue 5, pp. 647 - 657
Journal Article
Developmental Cell, ISSN 1534-5807, 01/2009, Volume 16, Issue 1, pp. 105 - 117
Journal Article