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The Journal of Immunology, ISSN 0022-1767, 10/2009, Volume 183, Issue 8, pp. 5208 - 5220
The role of proinflammatory cytokine production in the pathogenesis of malaria is well established, but the identification of the parasite products that... 
TUMOR-NECROSIS-FACTOR | DENDRITIC CELLS | INTERFERON-GAMMA | TOLL-LIKE RECEPTOR-9 | PLASMODIUM-FALCIPARUM | EXPERIMENTAL CEREBRAL MALARIA | ENDOTHELIAL-CELLS | IMMUNOLOGY | NF-KAPPA-B | INNATE IMMUNE ACTIVATION | INTRACELLULAR COMPARTMENTS | Interleukin-1alpha - immunology | Chemokine CCL2 - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | NF-kappa B - metabolism | Inflammation - parasitology | Endothelial Cells - parasitology | Extracellular Signal-Regulated MAP Kinases - immunology | Plasmodium falciparum | Interleukin-1beta - metabolism | Tumor Necrosis Factor-alpha - immunology | Interleukin-8 - metabolism | Toll-Like Receptors - metabolism | Chemokine CXCL1 - metabolism | Interleukin-6 - metabolism | Carrier Proteins - immunology | Toll-Like Receptors - immunology | Chemokine CXCL1 - immunology | Signal Transduction - drug effects | Interleukin-6 - immunology | Malaria, Falciparum - immunology | Uric Acid - antagonists & inhibitors | Mice | Interleukin-8 - immunology | Inflammation - chemically induced | Tumor Necrosis Factor-alpha - metabolism | NF-kappa B - immunology | Interleukin-1alpha - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Hemeproteins - immunology | Macrophages - parasitology | Signal Transduction - immunology | Myeloid Differentiation Factor 88 - immunology | Cytoskeletal Proteins - metabolism | Chemokine CCL2 - metabolism | Macrophages - immunology | Uric Acid - metabolism | Interleukin-1beta - immunology | Hemeproteins - pharmacology | Inflammation - immunology | Endothelial Cells - immunology | Malaria, Falciparum - parasitology | Animals | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | Cytoskeletal Proteins - immunology | CARD Signaling Adaptor Proteins | Allopurinol - pharmacology | Macrophages - drug effects | Myeloid Differentiation Factor 88 - metabolism | Interferon-gamma - pharmacology | Endothelial Cells - drug effects | Index Medicus | Abridged Index Medicus | Chemokine | TLR9 | Plasmodium | Inflammasome | NALP3 | Cytokine
Journal Article
Immunity, ISSN 1074-7613, 09/2012, Volume 37, Issue 3, pp. 549 - 562
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2014, Volume 193, Issue 3, pp. 1246 - 1257
Malarial infection is initiated when the sporozoite form of the Plasmodium parasite is inoculated into the skin by a mosquito. Sporozoites invade hepatocytes... 
LIVER-STAGE | IMMUNIZATION | RODENT MALARIA PARASITES | PROTECTIVE IMMUNITY | CD8+ T-CELLS | CIRCUMSPOROZOITE PROTEIN | HOST-CELL TRAVERSAL | MOSQUITO | DRAINING LYMPH-NODE | IMMUNOLOGY | STERILE PROTECTION | Inflammation - pathology | Plasmodium berghei - immunology | Skin - cytology | Humans | CD8-Positive T-Lymphocytes - parasitology | Inflammation - parasitology | Sporozoites - immunology | Female | Injections, Intradermal | Skin - immunology | Plasmodium berghei - parasitology | Cell Line | Sporozoites - transplantation | Anopheles - parasitology | Malaria - immunology | Mice, Inbred C57BL | Skin - parasitology | Sporozoites - radiation effects | Mice, Transgenic | Host-Parasite Interactions - immunology | Inflammation - immunology | Lymph Nodes - immunology | Antigen Presentation - immunology | Hep G2 Cells | Animals | Lymph Nodes - parasitology | Ear | Malaria - parasitology | Mice | Anopheles - immunology | CD8-Positive T-Lymphocytes - immunology | Index Medicus | Abridged Index Medicus | Malaria/immunology | Antigen Presentation/immunology | Lymph Nodes/immunology | Sporozoites/transplantation | Inflammation/immunology | Life Sciences | Lymph Nodes/parasitology | CD8-Positive T-Lymphocytes/immunology | Immunology | Skin/cytology | Sporozoites/radiation effects | Anopheles/immunology | Inflammation/pathology | Plasmodium berghei/parasitology | Plasmodium berghei/immunology | Inflammation/parasitology | Skin/parasitology | CD8-Positive T-Lymphocytes/parasitology | Sporozoites/immunology | Host-Parasite Interactions/immunology | Skin/immunology | Anopheles/parasitology | Malaria/parasitology
Journal Article
2002, 2nd, rev. and enl. ed., Chemical immunology, ISBN 3805573766, Volume 80., xv, 406
Despite extensive efforts to control it, malaria is still one of the most devastating infectious diseases worldwide. This book, now in its second edition,... 
Immunological aspects | Malaria
Book
Nature, ISSN 0028-0836, 01/2016, Volume 529, Issue 7584, pp. 105 - 109
Plasmodium falciparum antigens expressed on the surface of infected erythrocytes are important targets of naturally acquired immunity against malaria, but... 
LIFE-CYCLE | GENE | V(D)J RECOMBINASE | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | SURFACE | LYMPHOMA | TARGETS | DELETIONS | TRANSPOSITION | GENOME | Antibody Specificity | Clone Cells - cytology | Receptors, Immunologic - chemistry | Antigens, Protozoan - immunology | Epitopes, B-Lymphocyte - chemistry | Humans | DNA Transposable Elements - immunology | Molecular Sequence Data | Antibodies, Monoclonal - therapeutic use | Epitopes, B-Lymphocyte - immunology | Plasmodium falciparum - immunology | Malaria Vaccines - chemistry | Clone Cells - immunology | DNA Transposable Elements - genetics | Malaria Vaccines - immunology | Protozoan Proteins - chemistry | Conserved Sequence - immunology | Receptors, Immunologic - immunology | Antigenic Variation - immunology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Erythrocytes - immunology | Amino Acid Sequence | B-Lymphocytes - cytology | Collagen - immunology | Malaria - immunology | Membrane Proteins - immunology | Protein Structure, Tertiary - genetics | Kenya | Mutagenesis, Insertional - genetics | Antibodies, Monoclonal - genetics | Collagen - metabolism | B-Lymphocytes - immunology | Membrane Proteins - chemistry | Erythrocytes - metabolism | Malaria - parasitology | Erythrocytes - parasitology | Receptors, Immunologic - genetics | Protozoan Proteins - immunology | Receptors, Immunologic - metabolism | Antigen-antibody reactions | Host-parasite relationships | Genetic aspects | Malaria | Observations | Genetic variation | Antigens | Immunoglobulins | Genes | Erythrocytes | Monoclonal antibodies | Mutation | Chromosomes | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 06/2013, Volume 110, Issue 24, pp. E2209 - E2218
Microbial capsular antigens are effective vaccines but are chemically and immunologically diverse, resulting in a major barrier to their use against multiple... 
Carbohydrates | Animal models | Infectious diseases | Malaria | Immunotherapy | carbohydrates | UNITED-STATES | animal models | PNEUMOCOCCAL DISEASE | ACTINOMYCETEMCOMITANS | MULTIDISCIPLINARY SCIENCES | infectious diseases | malaria | DISPERSIN-B | CONJUGATE VACCINES | immunotherapy | RESISTANCE | STAPHYLOCOCCUS-AUREUS | HUMAN MONOCLONAL-ANTIBODIES | MOLECULAR-BASIS | POLYSACCHARIDE | Plasmodium berghei - immunology | Gram-Positive Bacteria - physiology | Acetylglucosamine - immunology | Plasmodium berghei - physiology | Bacterial Capsules - metabolism | Humans | Antibodies, Bacterial - pharmacology | Mycoses - microbiology | Host-Pathogen Interactions - drug effects | Gram-Negative Bacteria - immunology | Host-Pathogen Interactions - immunology | Fungi - immunology | Time Factors | Bacterial Infections - immunology | Immunoglobulin G - immunology | Fungi - physiology | Immunoglobulin G - pharmacology | Gram-Positive Bacteria - immunology | Gram-Negative Bacteria - physiology | Antibodies, Monoclonal - immunology | Bacterial Infections - microbiology | Staphylococcus aureus - metabolism | Mycoses - prevention & control | Opsonin Proteins - immunology | Antibodies, Monoclonal - pharmacology | Malaria - immunology | Mice, Inbred C57BL | Protein Binding - immunology | Malaria - prevention & control | Bacterial Infections - prevention & control | Animals | Malaria - parasitology | Survival Analysis | Antibodies, Bacterial - immunology | Staphylococcus aureus - immunology | Mice | Mycoses - immunology | Bacterial Capsules - immunology | Proteins | Pathogens | Eukaryotes | Microbiology | Prokaryotes | Staphylococcus infections | Cell adhesion & migration | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Book
Nature, ISSN 0028-0836, 07/2015, Volume 523, Issue 7562, pp. 612 - 616
The clinical course of autoimmune and infectious disease varies greatly, even between individuals with the same condition. An understanding of the molecular... 
RESPONSES | INTERFERON | PREDICTS PROGNOSIS | ACUTE HEPATITIS-C | MULTIDISCIPLINARY SCIENCES | DISEASE | BIOLOGY | GENE-EXPRESSION | ACTIVITY INDEX | SIGNATURE | Inflammation - pathology | CD8-Positive T-Lymphocytes - pathology | Humans | Inflammatory Bowel Diseases - immunology | Transcriptome | Autoimmunity - genetics | Infection - virology | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - pathology | Autoimmune Diseases - genetics | CD4-Positive T-Lymphocytes - immunology | Autoimmunity - immunology | Inflammatory Bowel Diseases - pathology | Inflammatory Bowel Diseases - genetics | Lupus Erythematosus, Systemic - immunology | CD8-Positive T-Lymphocytes - metabolism | Receptors, Antigen, T-Cell - immunology | Autoimmune Diseases - pathology | Receptors, Interleukin-7 - immunology | Receptors, Interleukin-7 - metabolism | Infection - immunology | Autoimmune Diseases - immunology | CD4-Positive T-Lymphocytes - metabolism | Inflammation - virology | Programmed Cell Death 1 Receptor - metabolism | Inflammation - immunology | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - genetics | Infection - genetics | Phenotype | Animals | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology | Infection - pathology | Lupus Erythematosus, Systemic - genetics | Mice | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Lupus Erythematosus, Systemic - pathology | CD2 Antigens - immunology | Viral antibodies | Antibodies | Interferon | T cells | Health aspects | Analysis | Hepatitis | Disease | Lymphocytes | T cell receptors | Infections | Genetic engineering | Regression analysis | Gene expression | Viral infections | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, pp. e106241 - e106241
Background: Fifteen volunteers were immunized with three doses of plasmid DNA encoding P. falciparum circumsporozoite protein (CSP) and apical membrane... 
APICAL MEMBRANE ANTIGEN-1 | RESPONSES | IMMUNOGENICITY | PROTEIN | PROTECTION | LIVER STAGES | SAFETY | MULTIDISCIPLINARY SCIENCES | VACCINE | CANDIDATE | CD8(+) T-CELLS | Antigens, Protozoan - immunology | DNA - immunology | Humans | Malaria, Falciparum - pathology | DNA - administration & dosage | Membrane Proteins - immunology | Plasmodium falciparum - immunology | Epitopes - immunology | Membrane Proteins - administration & dosage | Malaria, Falciparum - parasitology | Interleukin-2 - immunology | Malaria Vaccines - administration & dosage | Interferon-gamma - immunology | Antigens, Protozoan - administration & dosage | Malaria Vaccines - immunology | Malaria, Falciparum - immunology | Tumor Necrosis Factor-alpha - immunology | Plasmodium falciparum - pathogenicity | Adult | Immunologic Memory | Protozoan Proteins - administration & dosage | Adenoviridae - immunology | CD8-Positive T-Lymphocytes - immunology | Protozoan Proteins - immunology | Infection | Plasmodium falciparum | Immunization | Malaria | Adenoviruses | DNA | Interferon | T cells | Health aspects | Antigenic determinants | CD8 antigen | Liver | Effector cells | Lymphocytes T | Infections | Vaccines | Immunity | Proteins | Immunology | Interleukin 2 | Lymphocytes | Plasmid DNA | Volunteers | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Circumsporozoite protein | Vector-borne diseases | Antigens | Medical research | Immunological memory | Memory cells | Priming | Epitopes | Tumor necrosis factor-α | Vectors (Biology) | Membrane proteins | Plasmids | γ-Interferon | Comparative analysis | Index Medicus | Deoxyribonucleic acid
Journal Article
The Journal of Immunology, ISSN 0022-1767, 03/2010, Volume 184, Issue 5, pp. 2528 - 2538
Malaria results in >1,000,000 deaths per year worldwide. Although no licensed vaccine exists, much effort is currently focused on subunit vaccines that elicit... 
X-IRRADIATED SPOROZOITES | LISTERIA-MONOCYTOGENES | PROTECTIVE IMMUNITY | INTERFERON-GAMMA | LIVER STAGES | NITRIC-OXIDE SYNTHASE | IFN-GAMMA | INFLUENZA-VIRUS | IMMUNOLOGY | MALARIA HEPATIC STAGES | STERILE PROTECTION | Tumor Necrosis Factor-alpha - metabolism | Plasmodium berghei - immunology | Fas Ligand Protein - metabolism | Perforin - genetics | Dendritic Cells - immunology | Liver Diseases, Parasitic - immunology | Listeria monocytogenes - immunology | Sporozoites - immunology | Fas Ligand Protein - immunology | Signal Transduction - immunology | Malaria Vaccines - immunology | TNF-Related Apoptosis-Inducing Ligand - deficiency | Tumor Necrosis Factor-alpha - immunology | CD8-Positive T-Lymphocytes - metabolism | Female | Perforin - immunology | Interferon-gamma - genetics | Interferon-gamma - deficiency | Dendritic Cells - metabolism | Immunologic Memory - immunology | Malaria - immunology | Plasmodium yoelii - immunology | TNF-Related Apoptosis-Inducing Ligand - immunology | Liver Diseases, Parasitic - parasitology | Mice, Knockout | Malaria - prevention & control | Perforin - deficiency | Animals | Malaria Vaccines - administration & dosage | Interferon-gamma - immunology | Malaria - parasitology | Culicidae - parasitology | Mice | Mice, Inbred BALB C | CD8-Positive T-Lymphocytes - immunology | TNF-Related Apoptosis-Inducing Ligand - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Plos Pathogens, ISSN 1553-7366, 2010, Volume 6, Issue 5, pp. e1000877 - 13
Journal Article
Journal Article