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Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7549, pp. 683 - 687
Journal Article
Nature, ISSN 0028-0836, 05/2010, Volume 465, Issue 7296, pp. 305 - 310
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 538, Issue 7625, pp. 344 - 349
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether... 
IN-VITRO | TRANSFER-RNA SYNTHETASE | MALARIA CONTROL | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | LIVER | TARGETS | PROTEIN-SYNTHESIS | NEXT-GENERATION | HEPATIC STAGES | Azabicyclo Compounds - pharmacology | Plasmodium falciparum - enzymology | Malaria, Falciparum - prevention & control | Male | Plasmodium falciparum - cytology | Azetidines - pharmacology | Plasmodium falciparum - drug effects | Cytosol - enzymology | Malaria, Falciparum - transmission | Liver - drug effects | Azabicyclo Compounds - chemical synthesis | Azabicyclo Compounds - therapeutic use | Female | Safety | Antimalarials - chemical synthesis | Disease Models, Animal | Life Cycle Stages - drug effects | Malaria, Falciparum - drug therapy | Azabicyclo Compounds - administration & dosage | Azetidines - adverse effects | Phenylurea Compounds - therapeutic use | Antimalarials - therapeutic use | Macaca mulatta - parasitology | Phenylalanine-tRNA Ligase - antagonists & inhibitors | Drug Discovery | Antimalarials - pharmacology | Animals | Azetidines - administration & dosage | Phenylurea Compounds - chemical synthesis | Antimalarials - administration & dosage | Azetidines - therapeutic use | Phenylurea Compounds - administration & dosage | Mice | Phenylurea Compounds - pharmacology | Liver - parasitology | Plasmodium falciparum - growth & development | Prevention | Antimalarials | Disease transmission | Health aspects | Transfer RNA | Proteins | Cytochrome | Malaria | Liver | Parasites | Kinases | Drug resistance | Drug dosages
Journal Article
Nature, ISSN 0028-0836, 02/2010, Volume 463, Issue 7281, pp. 632 - 636
During their intraerythrocytic development, malaria parasites export hundreds of proteins to remodel their host cell. Nutrient acquisition, cytoadherence and... 
CALPAIN | FALCIPARUM | MULTIDISCIPLINARY SCIENCES | FOOD VACUOLE | TRAFFICKING | ENDOPLASMIC-RETICULUM | MALARIA PARASITES | VIRULENCE | REVEALS | Plasmodium falciparum - enzymology | Humans | Malaria, Falciparum - pathology | Endoplasmic Reticulum - metabolism | Substrate Specificity | Aspartic Acid Endopeptidases - genetics | Pepstatins - pharmacology | HIV Protease Inhibitors - pharmacology | Malaria, Falciparum - blood | Multiprotein Complexes - metabolism | Protozoan Proteins - metabolism | Genes, Dominant | Biocatalysis - drug effects | Plasmodium falciparum - genetics | Plasmids - genetics | Malaria, Falciparum - metabolism | Erythrocytes - cytology | Plasmodium falciparum - metabolism | Protozoan Proteins - chemistry | Endoplasmic Reticulum - enzymology | Protein Structure, Tertiary | Aspartic Acid Endopeptidases - chemistry | Aspartic Acid Endopeptidases - antagonists & inhibitors | Genes, Essential | Protein Sorting Signals | Amino Acid Motifs | Antimalarials - pharmacology | Protein Transport | Malaria, Falciparum - parasitology | Phenotype | Animals | Aspartic Acid Endopeptidases - metabolism | Erythrocytes - metabolism | Proteomics | Plasmodium falciparum - pathogenicity | Protein Binding | Erythrocytes - parasitology | Plasmodium falciparum | Research | Malaria | Proteases | Erythrocytes | Proteins | Genotype & phenotype | Mass spectrometry | International trade | Enzymes | Protease | Parasites | Endoplasmic reticulum | Exports
Journal Article
Nature, ISSN 0028-0836, 02/2010, Volume 463, Issue 7281, pp. 627 - 631
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2010, Volume 285, Issue 49, pp. 37964 - 37975
Using a pharmacological inhibitor of Hsp90 in cultured malarial parasite, we have previously implicated Plasmodium falciparum Hsp90 (PfHsp90) as a drug target... 
CELLS | HSP90 MOLECULAR CHAPERONE | ATPASE ACTIVITY | INHIBITION | HEAT-SHOCK-PROTEIN-90 | PLASMODIUM-FALCIPARUM | HUMAN ERYTHROCYTES | GELDANAMYCIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | EXPRESSION | Malaria, Falciparum - enzymology | Plasmodium falciparum - enzymology | Malaria, Falciparum - genetics | Protozoan Proteins - antagonists & inhibitors | Trypanosoma - genetics | Humans | Plasmodium berghei - genetics | Trypanosomiasis - enzymology | Protozoan Proteins - genetics | Protozoan Proteins - metabolism | Plasmodium berghei - enzymology | Plasmodium falciparum - genetics | HSP90 Heat-Shock Proteins - genetics | Trypanosoma - enzymology | Disease Models, Animal | Protein Structure, Tertiary | Malaria, Falciparum - drug therapy | Trypanosomiasis - genetics | Enzyme Inhibitors - pharmacology | Adenosine Triphosphatases - metabolism | Lactams, Macrocyclic - pharmacology | Antiprotozoal Agents - pharmacology | Benzoquinones - pharmacology | Trypanosomiasis - drug therapy | Adenosine Triphosphatases - antagonists & inhibitors | Acetylation - drug effects | Animals | HSP90 Heat-Shock Proteins - antagonists & inhibitors | HSP90 Heat-Shock Proteins - metabolism | Adenosine Triphosphatases - genetics | Mice | Hsp90 | Trypanosoma evansi | Molecular Bases of Disease | Plasmodium falciparum | Parasitology | Post-translational Modification | Protozoan | Geldanamycin | Preclinical Study | Protein-Drug Interactions | Heat Shock Protein
Journal Article