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British Journal of Pharmacology, ISSN 0007-1188, 12/2002, Volume 137, Issue 7, pp. 1021 - 1030
The mechanism(s) by which vascular endothelial growth factor (VEGF) induces endothelial nitric oxide synthase (eNOS) activation remain(s) unclear up to a... 
NO | eNOS | 2 | PAF | PI3K | PLA | VEGF | PLC | PKC | PROTEIN-KINASE-C | ANGIOGENESIS | PERMEABILITY | PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | CALMODULIN | CALCIUM | PAF SYNTHESIS | PHARMACOLOGY & PHARMACY | PLATELET-ACTIVATING-FACTOR | GROWTH-FACTOR | Endothelium, Vascular - cytology | Vascular Endothelial Growth Factors | Platelet Activating Factor - pharmacology | Protein-Serine-Threonine Kinases | Type C Phospholipases - metabolism | Endothelium, Vascular - drug effects | Endothelial Growth Factors - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, Cell Surface - antagonists & inhibitors | Lactones - pharmacology | Platelet Membrane Glycoproteins - antagonists & inhibitors | Calcium - antagonists & inhibitors | Time Factors | Cattle | Protein Kinase C - metabolism | Phosphorylation - drug effects | Chromones - pharmacology | Enzyme Inhibitors - pharmacology | Nitric Oxide Synthase Type III | Receptors, G-Protein-Coupled | Chelating Agents - pharmacology | Serine - metabolism | 1-Methyl-3-isobutylxanthine - pharmacology | Ginkgolides | Platelet Activating Factor - metabolism | Cyclic GMP - metabolism | Endothelium, Vascular - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Nitric Oxide Synthase - metabolism | Vascular Endothelial Growth Factor A | Maleimides - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Nitroprusside - pharmacology | Type C Phospholipases - antagonists & inhibitors | Dose-Response Relationship, Drug | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Lymphokines - pharmacology | Nitric Oxide Donors - pharmacology | Ionophores - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Proto-Oncogene Proteins - metabolism | Cells, Cultured | Morpholines - pharmacology | Protein Kinase C - antagonists & inhibitors | Calcimycin - pharmacology | Proto-Oncogene Proteins c-akt | Animals | Egtazic Acid - pharmacology | Androstadienes - pharmacology | Diterpenes | Signal Transduction - physiology | Nitric Oxide - metabolism | Index Medicus | Papers | PLA2
Journal Article
Psychopharmacology, ISSN 0033-3158, 12/2008, Volume 201, Issue 3, pp. 443 - 458
Fluoxetine has relatively high affinity for Gq/11 protein-coupled 5-HT2 receptors. Part of these receptors in brain are on astrocytes, where fluoxetine causes... 
Neurosciences | Biomedicine | Serotonin | Astrocytes | Fluoxetine | EGFR transactivation | fosB | c-fos | Pharmacology/Toxicology | Psychiatry | ERK | 5-HT 2B receptor | receptor | C-fos | FosB | 5-HT | SIGNALING PATHWAYS | PSYCHIATRY | TYROSINE KINASE | PHARMACOLOGICAL CHARACTERIZATION | CELL-PROLIFERATION | 5-HT2B receptor | NEUROSCIENCES | SEROTONIN REUPTAKE INHIBITORS | MESSENGER-RNA | TISSUE DISTRIBUTION | MECHANICAL-STRESS | CULTURED ASTROCYTES | PHARMACOLOGY & PHARMACY | R-FLUOXETINE | Receptor, Epidermal Growth Factor - genetics | Up-Regulation | Phosphorylation | Transcriptional Activation - genetics | Nitriles - pharmacology | Calcium - metabolism | Maleimides - pharmacology | Substrate Specificity | Extracellular Signal-Regulated MAP Kinases - metabolism | Quinazolines | Calcium - chemistry | Receptor, Serotonin, 5-HT2B - physiology | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Receptor, Epidermal Growth Factor - metabolism | Piperidines - pharmacology | Receptor, Serotonin, 5-HT2B - drug effects | Urea - analogs & derivatives | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Proto-Oncogene Proteins c-fos - antagonists & inhibitors | Astrocytes - drug effects | Fluoxetine - pharmacology | Butadienes - pharmacology | Gene Expression | Signal Transduction | Dipeptides - pharmacology | RNA, Messenger - genetics | Cells, Cultured | Proto-Oncogene Proteins c-fos - metabolism | Antidepressive Agents, Second-Generation - pharmacology | Protein Kinase C - antagonists & inhibitors | Tyrphostins - pharmacology | Chelating Agents - pharmacology | Antidepressive Agents, Second-Generation - antagonists & inhibitors | Fluoxetine - antagonists & inhibitors | Astrocytes - physiology | Animals | Egtazic Acid - pharmacology | Aminopyridines - pharmacology | Proto-Oncogene Proteins c-fos - genetics | Mice | Urea - pharmacology | Brain | Neurotransmitters | Antidepressants | Psychopharmacology | Cells | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 10/2004, Volume 95, Issue 7, pp. 726 - 733
Altered gap junction coupling of cardiac myocytes during ischemia may contribute to development of lethal arrhythmias. The phosphoprotein connexin 43 (Cx43) is... 
Ischemia | Gap junctions | Glycolysis | Okadaic acid | Protein phosphatases | Connexin43 | Protein phosphorylation | AMP kinase | gap junctions | PROTEIN-KINASE-C | CARDIAC & CARDIOVASCULAR SYSTEMS | connexin43 | PHOSPHORYLATION | GAP JUNCTIONAL COMMUNICATION | glycolysis | CARDIAC MYOCYTES | ACTIN GENE | protein phosphorylation | okadaic acid | ischemia | IN-VITRO | INTERCELLULAR COMMUNICATION | PERIPHERAL VASCULAR DISEASE | JUN KINASE | protein phosphatases | RAT VENTRICULAR MYOCYTES | HEMATOLOGY | ADRENERGIC REGULATION | Okadaic Acid - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Maleimides - pharmacology | Recombinant Fusion Proteins - physiology | Myocardial Contraction - drug effects | Brefeldin A - pharmacology | Phenanthridines - pharmacology | Antimycin A - pharmacology | Aminoimidazole Carboxamide - pharmacology | Cell Hypoxia | Ribonucleotides - pharmacology | Alkaloids | Protein Processing, Post-Translational - drug effects | Adenosine Triphosphate - metabolism | Deoxyglucose - pharmacology | Tacrolimus - pharmacology | Indoles - pharmacology | Flavonoids - pharmacology | Potassium Cyanide - pharmacology | JNK Mitogen-Activated Protein Kinases - genetics | Phosphorylation - drug effects | Ouabain - pharmacology | Cells, Cultured - drug effects | Connexin 43 - metabolism | Rats | Imidazoles - pharmacology | Cycloheximide - pharmacology | Pyrroles - pharmacology | Animals | Myocytes, Cardiac - drug effects | Aminoimidazole Carboxamide - analogs & derivatives | Benzophenanthridines | JNK Mitogen-Activated Protein Kinases - physiology | Myocytes, Cardiac - metabolism | Cells, Cultured - metabolism | Pyridines - pharmacology | Carbazoles - pharmacology | Staurosporine - pharmacology | Index Medicus
Journal Article
The Journal of Physiology, ISSN 0022-3751, 07/2010, Volume 588, Issue 14, pp. 2605 - 2619
In vertebrate retina, melatonin regulates various physiological functions. In this work we investigated the mechanisms underlying melatonin‐induced... 
CIRCADIAN CLOCK | XENOPUS-LAEVIS | BIPOLAR CELLS | PROTEIN-KINASE-C | PHYSIOLOGY | FISH RETINA | PHOSPHOLIPASE-C | VISUAL PATHWAY | FUNCTIONAL-ROLE | MT2 MELATONIN | RECEPTORS | NEUROSCIENCES | Cyclic GMP - pharmacology | Receptor, Melatonin, MT2 - antagonists & inhibitors | Tetradecanoylphorbol Acetate - pharmacology | Maleimides - pharmacology | Male | Calcium - analysis | Melatonin - physiology | Type C Phospholipases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic GMP-Dependent Protein Kinases - physiology | Isoquinolines - pharmacology | Cyclic GMP - analogs & derivatives | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Bridged-Ring Compounds - pharmacology | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Guanosine Diphosphate - pharmacology | Pertussis Toxin - pharmacology | Retinal Ganglion Cells - physiology | Protein Kinase C - physiology | Retinal Ganglion Cells - enzymology | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Rats | Protein Kinase C - antagonists & inhibitors | Receptor, Melatonin, MT2 - physiology | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Animals | Egtazic Acid - pharmacology | Glycine - physiology | Guanosine Diphosphate - analogs & derivatives | Signal Transduction - drug effects | Tetrahydronaphthalenes - pharmacology | Thiones - pharmacology | Carbazoles - pharmacology | Type C Phospholipases - physiology | Melatonin | Phospholipids | Glycine | Ganglion | Gross domestic product | Protein kinases | Kinases | Retina | Physiology | Index Medicus | Neuroscience
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 05/2016, Volume 117, Issue 5, pp. 1240 - 1249
We demonstrated that in human platelets the endocannabinoid 2-arachidonoylglycerol (2-AG) decreased dose-and time-dependently cAMP intracellular levels. No... 
2‐ARACHIDONOYLGLYCEROL | HUMAN PLATELETS | PHOSPHODIESTERASE 3A | cAMP | 2-ARACHIDONOYLGLYCEROL | CELLS | ACTIVATION | PHOSPHORYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCANNABINOID SYSTEM | ARACHIDONIC-ACID | CELL BIOLOGY | BLOOD-PLATELETS | CYCLIC-AMP | CB1 | CANNABINOID RECEPTOR-LIGAND | Endocannabinoids - pharmacology | Phosphodiesterase 3 Inhibitors - pharmacology | Humans | Maleimides - pharmacology | Type C Phospholipases - metabolism | Immunoblotting | Phosphatidylinositol 3-Kinases - metabolism | Cannabinoid Receptor Agonists - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Type C Phospholipases - antagonists & inhibitors | Dose-Response Relationship, Drug | Blood Platelets - cytology | Protein Kinase C - metabolism | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Receptors, Thromboxane - antagonists & inhibitors | Indoles - pharmacology | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Chromones - pharmacology | Cyclic AMP - metabolism | Milrinone - pharmacology | Hydrazines - pharmacology | Adenine - analogs & derivatives | Intracellular Space - drug effects | Adenylyl Cyclase Inhibitors - pharmacology | Cells, Cultured | Morpholines - pharmacology | Adenine - pharmacology | Protein Kinase C - antagonists & inhibitors | Adenylyl Cyclases - metabolism | Arachidonic Acids - pharmacology | Glycerides - pharmacology | Blood Platelets - metabolism | Intracellular Space - metabolism | Receptors, Thromboxane - metabolism | Index Medicus
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 04/2004, Volume 94, Issue 7, pp. 960 - 966
ABSTRACT—Glycogen synthase kinase (GSK) inhibition produced by ischemic preconditioning has been previously shown to be regulated through... 
Phosphatidylinositol-3 kinase | Reperfusion | Glycogen synthase kinase | Target of rapamycin | Opioids | LOCALIZATION | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTECTION | PHOSPHORYLATION | phosphatidylinositol-3 kinase | PHOSPHATIDYLINOSITOL 3-KINASE | CELL-SURVIVAL | KINASE-3-BETA | INSULIN | P70S6 KINASE | INDUCED DELAYED CARDIOPROTECTION | glycogen synthase kinase | PERIPHERAL VASCULAR DISEASE | target of rapamycin | HEMATOLOGY | reperfusion | opioids | Glycogen Synthase Kinase 3 - physiology | Maleimides - pharmacology | Receptors, Retinoic Acid - physiology | Glycogen Synthase Kinase 3 beta | Male | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, Thyroid Hormone - antagonists & inhibitors | Aminophenols - pharmacology | Cardiotonic Agents - therapeutic use | Myocardial Infarction - pathology | Indoles - pharmacology | Benzamides - pharmacology | Chromones - pharmacology | Nuclear Receptor Subfamily 1, Group F, Member 3 | Morphine - pharmacology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Morpholines - pharmacology | Rats | Receptors, Retinoic Acid - antagonists & inhibitors | Cardiotonic Agents - pharmacology | Myocardial Infarction - metabolism | Receptors, Opioid, delta - drug effects | Piperazines - pharmacology | Rats, Sprague-Dawley | Receptors, Thyroid Hormone - physiology | Sirolimus - pharmacology | Animals | Androstadienes - pharmacology | Signal Transduction - drug effects | Narcotic Antagonists - pharmacology | Phosphatidylinositol 3-Kinases - physiology | Premedication | Index Medicus
Journal Article
The Journal of Physiology, ISSN 0022-3751, 12/2016, Volume 594, Issue 23, pp. 7027 - 7047
Candesartan, an inverse agonist of the type 1 angiotensin II receptor (AT 1 R), causes a concentration‐dependent inhibition of pressure‐dependent myogenic tone... 
type 1 angiotensin II receptor | cytoskeleton | mechanotransduction | actin stress fibres | vascular smooth muscle cell signalling | myogenic response | protein kinase C | RHO-ASSOCIATED KINASE | INTRAVASCULAR PRESSURE | PHYSIOLOGY | CEREBRAL PARENCHYMAL ARTERIOLES | RESISTANCE ARTERIES | PROTEIN-COUPLED RECEPTORS | MYOSIN PHOSPHORYLATION | STRETCH-ACTIVATION | CYTOSKELETON REORGANIZATION | NEUROSCIENCES | VASCULAR SMOOTH-MUSCLE | LIGHT-CHAIN PHOSPHORYLATION | Arterioles - physiology | Antihypertensive Agents - pharmacology | Receptor, Angiotensin, Type 1 - physiology | Tetrazoles - pharmacology | Captopril - pharmacology | Maleimides - pharmacology | Male | Angiotensin II Type 1 Receptor Blockers - pharmacology | Muscle Development | Receptor, Angiotensin, Type 1 - genetics | Diglycerides - pharmacology | Indoles - pharmacology | Muscle Fibers, Skeletal - physiology | Vasoconstrictor Agents - pharmacology | Protein Kinase C - physiology | Abdominal Muscles - physiology | Cells, Cultured | Losartan - pharmacology | Imidazoles - pharmacology | Protein Kinase C - antagonists & inhibitors | Arterioles - drug effects | Pressure | Rats, Sprague-Dawley | Vasoconstriction - drug effects | Animals | Benzimidazoles - pharmacology | Pyridines - pharmacology | Actins - physiology | Atomic force microscopy | Actin | Angiotensin | Polymerization | Muscles | G proteins | Muscle proteins | Protein kinases | Arteries | Membrane proteins | Index Medicus | Cardiovascular Physiology | Skeletal Muscle | Cardiovascular | Research Paper
Journal Article
Circulation, ISSN 0009-7322, 09/2006, Volume 114, Issue 13, pp. 1372 - 1379
Background - At birth, the increase in oxygen causes contraction of the ductus arteriosus, thus diverting blood flow to the lungs. Although this contraction is... 
Oxygen | Ion channels | Vasoconstriction | Ductus arteriosus, patent | Heart defects, congenital | heart defects | CARDIAC & CARDIOVASCULAR SYSTEMS | ductus arteriosus, patent | TRPC1 | RECEPTOR | CLOSURE | congenital | CAPACITATIVE CA2+ ENTRY | PULMONARY VASOCONSTRICTION | CYTOSOLIC CALCIUM | ion channels | CONSTRICTION | PERIPHERAL VASCULAR DISEASE | vasoconstriction | SMOOTH-MUSCLE-CELLS | RABBIT | oxygen | Oxygen - pharmacology | Tetraethylammonium - pharmacology | Calcium Signaling - physiology | Maleimides - pharmacology | Potassium Channels - physiology | Thiourea - pharmacology | Polyunsaturated Alkamides | Isoquinolines - pharmacology | rho-Associated Kinases | Niflumic Acid - pharmacology | Indoles - pharmacology | Endocannabinoids | Ductus Arteriosus - physiology | Boron Compounds - pharmacology | Mibefradil - pharmacology | Nifedipine - pharmacology | Calcium - pharmacology | Oxidation-Reduction | Protein-Serine-Threonine Kinases - physiology | Rabbits - embryology | Calcium Channels, L-Type - physiology | Imidazoles - pharmacology | Calcium Channel Blockers - pharmacology | Potassium Channels - drug effects | Sulfonamides - pharmacology | Arachidonic Acids - pharmacology | Ductus Arteriosus - embryology | Patch-Clamp Techniques | Animals | Menthol - pharmacology | Ruthenium Red - pharmacology | Muscle Contraction - drug effects | Calcium Channels, L-Type - drug effects | Muscle Contraction - physiology | Thapsigargin - pharmacology | Cytosol - metabolism | In Vitro Techniques | Intracellular Signaling Peptides and Proteins - physiology | Thiourea - analogs & derivatives | Index Medicus | Abridged Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2012, Volume 448, Issue 1, pp. 93 - 102
The discovery of epigenetic processes as possible pivotal regulatory mechanisms in psychiatric diseases raised the question of how psychoactive drugs may... 
Antidepressant | Epigenetics | Histone methyltransferase | DNA methyltransferase 1 (DNMT1) | Astrocyte | Mood stabilizer | METHYLATION | INDUCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | antidepressant | FLUVOXAMINE | mood stabilizer | FLUOXETINE | epigenetics | P-GLYCOPROTEIN | histone methyltransferase | GDNF | PHARMACOKINETICS | DEMETHYLATION | IN-VIVO | astrocyte | BRAIN | Citalopram - pharmacology | Maleimides - pharmacology | Astrocytes - enzymology | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Cerebral Cortex - cytology | DNA (Cytosine-5-)-Methyltransferases - metabolism | Histone-Lysine N-Methyltransferase - antagonists & inhibitors | Neurons - physiology | Indoles - pharmacology | Antidepressive Agents - pharmacology | Cyclohexanols - pharmacology | Neurons - drug effects | Astrocytes - drug effects | Carbamazepine - pharmacology | Nerve Tissue Proteins - antagonists & inhibitors | Cells, Cultured - drug effects | Histone-Lysine N-Methyltransferase - pharmacology | DNA (Cytosine-5-)-Methyltransferase 1 | Enzyme Inhibitors - pharmacology | Glycolipids - pharmacology | Neural Stem Cells - drug effects | Cells, Cultured - physiology | Neural Stem Cells - physiology | Rats | Recombinant Proteins - pharmacology | Neural Stem Cells - enzymology | Rats, Sprague-Dawley | Cells, Cultured - enzymology | Protein Interaction Mapping | Nerve Tissue Proteins - metabolism | Venlafaxine Hydrochloride | Astrocytes - physiology | Animals | Cerebral Cortex - embryology | Histone-Lysine N-Methyltransferase - metabolism | Neurons - enzymology | Mice | Imipramine - pharmacology | Paroxetine - pharmacology | DNA Methylation - drug effects | Index Medicus
Journal Article
Cardiovascular Research, ISSN 0008-6363, 06/2007, Volume 74, Issue 3, pp. 406 - 415
Objectives: Canine atrial cardiomyocytes display a constitutively active, acetylcholine-regulated, time-dependent K current (I ) that contributes to atrial... 
Second-messengers | Signal transduction | Ion-channels | PROTEIN-KINASE-C | CARDIAC & CARDIOVASCULAR SYSTEMS | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | signal transduction | RECTIFYING K+ CHANNELS | FORM STABLE COMPLEXES | VENTRICULAR MYOCYTES | GUINEA-PIG | second-messengers | SIGNALING COMPLEX | TRANSIENT OUTWARD CURRENT | ion-channels | ADENYLYL-CYCLASE | XENOPUS-OOCYTES | Maleimides - pharmacology | Adrenergic alpha-Antagonists - pharmacology | Phorbol 12,13-Dibutyrate - pharmacology | Type C Phospholipases - antagonists & inhibitors | Dose-Response Relationship, Drug | Propranolol - pharmacology | Isoquinolines - pharmacology | Phenylephrine - pharmacology | Prazosin - pharmacology | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Clonidine - pharmacology | Indoles - pharmacology | Receptors, Adrenergic, beta-1 - drug effects | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Action Potentials - drug effects | Acetylcholine - pharmacology | Heart Atria | Receptors, Adrenergic, alpha-1 - drug effects | Bee Venoms - pharmacology | Imidazoles - pharmacology | Protein Kinase C - antagonists & inhibitors | Potassium Channels - drug effects | Sulfonamides - pharmacology | Adrenergic Agents - pharmacology | Piperazines - pharmacology | Clonidine - analogs & derivatives | Patch-Clamp Techniques | Animals | Myocytes, Cardiac - drug effects | Isoproterenol - pharmacology | Dogs | Dihydropyridines - pharmacology | Myocytes, Cardiac - metabolism | Adrenergic alpha-Agonists - pharmacology | Propanolamines - pharmacology | Heart cells | Index Medicus
Journal Article
Journal of Endocrinology, ISSN 0022-0795, 08/2002, Volume 174, Issue 2, pp. 233 - 246
Glucose-dependent insulinotropic polypeptide (GIP) acts as a glucose-dependent growth factor for beta-cells. Here we show that GIP and glucose also act... 
PATHWAYS | IGF-I | RECEPTOR TYROSINE KINASES | ACTIVATED PROTEIN-KINASE | PHOSPHATIDYLINOSITOL 3-KINASE | MAP KINASE | ENDOCRINOLOGY & METABOLISM | ELEMENT-BINDING PROTEIN | INS-1 CELLS | GROWTH-FACTOR | FACTOR-I | Apoptosis - drug effects | Calcium - metabolism | Humans | Maleimides - pharmacology | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | MAP Kinase Kinase 1 | Isoquinolines - pharmacology | Deoxyglucose - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Indoles - pharmacology | Flavonoids - pharmacology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Gastric Inhibitory Polypeptide - pharmacology | B-Lymphocytes - metabolism | Cell Line | Enzyme Inhibitors - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Arginase - genetics | Protein Kinase C - antagonists & inhibitors | Chelating Agents - pharmacology | Calcium-Calmodulin-Dependent Protein Kinases - antagonists & inhibitors | Sulfonamides - pharmacology | Egtazic Acid - pharmacology | MAP Kinase Signaling System - drug effects | Mitosis - drug effects | Androstadienes - pharmacology | Signal Transduction - drug effects | Glucokinase - antagonists & inhibitors | Plasmids | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Genistein - pharmacology | Glucose - metabolism | Alloxan - pharmacology | Benzylamines - pharmacology | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 7/2011, Volume 384, Issue 1, pp. 59 - 70
The present study was aimed at investigating the effect and the possible mechanism of idebenone on endogenous glutamate release in nerve terminals of rat... 
Protein kinase A | Neurosciences | Glutamate release | Cerebral cortex | Biomedicine | Idebenone | Ca v 2.2 (N-type) and Ca v 2.1 (P/Q-type) channels | Synaptosomes | Pharmacology/Toxicology | 2.1 (P/Q-type) channels | 2.2 (N-type) and Ca | OXIDATIVE STRESS | CA2+ ENTRY | N-TYPE | Ca(v)2.2 (N-type) and Ca(v)2.1 (P/Q-type) channels | NEUROTRANSMITTER RELEASE | PRESYNAPTIC MODULATION | CORTICAL-NEURONS | PHARMACOLOGY & PHARMACY | TERMINALS SYNAPTOSOMES | INDUCED NEUROTOXICITY | ENERGY-METABOLISM | BRAIN | Synaptosomes - drug effects | Calcium Channels - metabolism | Maleimides - pharmacology | Male | Nerve Endings - metabolism | Synaptosomes - metabolism | omega-Conotoxins | Cerebral Cortex - cytology | Calcium - deficiency | Ubiquinone - pharmacology | Dose-Response Relationship, Drug | Calcium - antagonists & inhibitors | Isoquinolines - pharmacology | Macrolides - pharmacology | Indoles - pharmacology | Sodium-Calcium Exchanger - antagonists & inhibitors | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | 4-Aminopyridine - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Membrane Potentials - drug effects | Calcium - pharmacology | Clonazepam - analogs & derivatives | Ubiquinone - analogs & derivatives | Enzyme Inhibitors - pharmacology | Clonazepam - pharmacology | Rats | Protein Kinase C - antagonists & inhibitors | Thiazepines - pharmacology | Dantrolene - pharmacology | Calcium Channel Blockers - pharmacology | Potassium - pharmacology | Sulfonamides - pharmacology | Rats, Sprague-Dawley | Glutamate Plasma Membrane Transport Proteins - antagonists & inhibitors | Pyrroles - pharmacology | Animals | Calcium Signaling - drug effects | Nerve Endings - drug effects | Glutamic Acid - metabolism | Protein Kinase Inhibitors - pharmacology | Carbazoles - pharmacology | Aspartic Acid - pharmacology | Brain | Amino acids | Glutamate | Protein kinases | Nerve endings | Calcium (intracellular) | Calcium channels (N-type) | Calcium channels (voltage-gated) | Cortex | Potassium channels | Calcium influx | Calcium channels (Q-type) | Glutamic acid transporter | Membrane potential | vesicular transporters | Calcium (extracellular) | Na super(+)/Ca super(2+)-exchanging ATPase | Index Medicus
Journal Article