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Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SUBSTRATE-SPECIFICITY | HYDROPHOBIC MOTIF PHOSPHORYLATION | cancer | serum and glucocorticoid protein kinase (SGK) | COMPLEX 2 | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 46, pp. 18988 - 19000
Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange reactions to reduce proteins with disulfide bonds. As such, Trx1 helps... 
MAMMALIAN TARGET | APOPTOSIS | COMPLEX | ACTIVATION | mechanistic target of rapamycin (mTOR) | redox regulation | thioredoxin | MITOCHONDRIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | heart | INHIBITION | PATHWAY | CARDIAC-HYPERTROPHY | DISEASE | oxidative stress | Index Medicus | Cell Biology
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2011, Volume 54, Issue 21, pp. 7579 - 7587
Journal Article
Breast Cancer Research, ISSN 1465-5411, 09/2004, Volume 6, Issue 5, pp. 219 - 224
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2015, Volume 290, Issue 28, pp. 17495 - 17504
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 08/2018, Volume 48, Issue 1, pp. 54 - 62
Background/Aims: Bortezomib (BTZ) is largely used as a chemotherapeutic agent for the treatment of cancer. However, one of the significant limiting... 
Original Paper | Signal pathway | Rapamycin | Mammalian target of rapamycin | Neuropathic pain | PHYSIOLOGY | RAT | BONE CANCER PAIN | SYNAPTIC PLASTICITY | CELL BIOLOGY | MEMORY | MORPHINE-TOLERANCE | OPIOID RECEPTOR | PROTEASOME | NOCICEPTION | Spinal Cord - drug effects | Spinal Cord - metabolism | TOR Serine-Threonine Kinases - metabolism | Neuralgia - metabolism | Male | Phosphatidylinositol 3-Kinases - metabolism | Bortezomib - pharmacology | Neuralgia - pathology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphoproteins - metabolism | TOR Serine-Threonine Kinases - antagonists & inhibitors | Neuralgia - chemically induced | Behavior, Animal - drug effects | Phosphorylation - drug effects | Calcitonin Gene-Related Peptide - metabolism | Chromones - pharmacology | Disease Models, Animal | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Morpholines - pharmacology | Rats | Calcitonin Gene-Related Peptide - genetics | Rats, Sprague-Dawley | Sirolimus - pharmacology | Up-Regulation - drug effects | Animals | Carrier Proteins - metabolism | Signal Transduction - drug effects | Substance P - genetics | Substance P - metabolism | Phosphorylation | Spinal cord | Cold | Multiple myeloma | Diabetic neuropathy | Inflammation | Kinases | Cancer therapies | Proteins | Pain | Protein synthesis | Rodents | Cell cycle | Diabetes | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 02/2016, Volume 291, Issue 9, pp. 4462 - 4472
Journal Article