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Nature, ISSN 0028-0836, 11/2010, Volume 468, Issue 7320, pp. 103 - 107
RANK ligand (RANKL), a TNF-related molecule, is essential for osteoclast formation, function and survival through interaction with its receptor RANK(1,2).... 
CELL FUNCTION | OSTEOPROTEGERIN-LIGAND | MULTIDISCIPLINARY SCIENCES | MEDROXYPROGESTERONE ACETATE | RECEPTOR | HORMONE REPLACEMENT THERAPY | HUMAN BREAST-TUMORS | OSTEOCLAST DIFFERENTIATION | EXPRESSION | GLAND DEVELOPMENT | TRANSGENIC MICE | Epithelial Cells - metabolism | RANK Ligand - metabolism | Progesterone - administration & dosage | Epithelial Cells - drug effects | Humans | Progestins - adverse effects | Cell Transformation, Neoplastic - chemically induced | Mammary Neoplasms, Experimental - metabolism | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - metabolism | Lung Neoplasms - secondary | Mammary Neoplasms, Experimental - pathology | Medroxyprogesterone Acetate - adverse effects | Female | Precancerous Conditions - pathology | Receptor Activator of Nuclear Factor-kappa B - metabolism | Disease Models, Animal | 9,10-Dimethyl-1,2-benzanthracene - administration & dosage | Neoplasm Invasiveness | Mice, Inbred C57BL | Epithelial Cells - pathology | Mice, Transgenic | Progesterone - adverse effects | Mammary Neoplasms, Experimental - chemically induced | RANK Ligand - genetics | Animals | RANK Ligand - antagonists & inhibitors | Breast Neoplasms - pathology | Progestins - administration & dosage | Receptor Activator of Nuclear Factor-kappa B - genetics | Cell Proliferation - drug effects | Medroxyprogesterone Acetate - administration & dosage | Mice | Cell Transformation, Neoplastic - drug effects | Precancerous Conditions - prevention & control | Cell Transformation, Neoplastic - pathology | Mammary Tumor Virus, Mouse - genetics | Mammary Tumor Virus, Mouse - physiology | 9,10-Dimethyl-1,2-benzanthracene - adverse effects | Immunohistochemistry | Care and treatment | Usage | Physiological aspects | Breast cancer | Genetic aspects | Research | Progesterone | Tumor proteins | Health aspects | Risk factors | Proteins | Hormone replacement therapy | Rodents | Apoptosis | Index Medicus
Journal Article
Cancer Letters, ISSN 0304-3835, 2010, Volume 294, Issue 1, pp. 1 - 12
Abstract Vanadium, a dietary micronutrient, is yet to be established as an essential part of the human diet. Over the past century, several biological effects... 
Hematology, Oncology and Palliative Medicine | Therapy | Detection | Chemoprevention | Vanadium | Cancer | SPRAGUE-DAWLEY RATS | DEPENDENT DIABETES-MELLITUS | RAT-LIVER CARCINOGENESIS | DIETHYLNITROSAMINE-INDUCED HEPATOCARCINOGENESIS | XENOBIOTIC-METABOLIZING ENZYMES | EHRLICH ASCITES TUMOR | PROTEIN CROSS-LINKS | TRANSPLANTABLE MURINE LYMPHOMA | ONCOLOGY | GLUTATHIONE-S-TRANSFERASE | ABERRANT CRYPT FOCI | Mammary Neoplasms, Experimental - diagnosis | Neoplasm Transplantation | Humans | Trace Elements - therapeutic use | Male | Neoplasms - prevention & control | Transplantation, Heterologous | Neoplasms - diagnosis | Neoplasms, Experimental - pathology | Vanadium - toxicity | Organometallic Compounds - therapeutic use | Female | Disease Models, Animal | Mammary Neoplasms, Experimental - drug therapy | Vanadium - therapeutic use | Rats | Vanadium Compounds - therapeutic use | Cell Division - drug effects | Neoplasms - drug therapy | Mammary Neoplasms, Experimental - chemically induced | Animals | Vanadium Compounds - toxicity | 9,10-Dimethyl-1,2-benzanthracene | Glioblastoma - drug therapy | Neoplasm Staging | Neoplasms, Experimental - drug therapy | Enzymes | Drinking water | Dehydrogenases | Diarrhea | Breast cancer | DNA repair | Insulin | Abdomen | Studies | Weightlifting | Cell growth | Rodents | Trace elements | Diabetes | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 11/2010, Volume 468, Issue 7320, pp. 98 - 102
Breast cancer is one of the most common cancers in humans and will on average affect up to one in eight women in their lifetime in the United States and... 
EPITHELIAL-CELLS | OSTEOPROTEGERIN-LIGAND | MULTIDISCIPLINARY SCIENCES | MEDROXYPROGESTERONE ACETATE | RECEPTOR ACTIVATOR | HORMONE-REPLACEMENT THERAPY | STEM-CELL | BONE METASTASIS | POSTMENOPAUSAL WOMEN | GLAND DEVELOPMENT | ESTROGEN-PLUS-PROGESTIN | Phosphoproteins - immunology | Gamma Rays | Epithelial Cells - metabolism | RANK Ligand - metabolism | Apoptosis - radiation effects | Epithelial Cells - drug effects | Progestins - adverse effects | NF-kappa B - metabolism | Stem Cells - cytology | Mammary Neoplasms, Experimental - metabolism | Osteoclasts - cytology | Stem Cells - metabolism | Mammary Neoplasms, Experimental - genetics | Receptor Activator of Nuclear Factor-kappa B - deficiency | Phosphoproteins - analysis | Mammary Neoplasms, Experimental - pathology | Medroxyprogesterone Acetate - adverse effects | Female | Cell Differentiation | Receptor Activator of Nuclear Factor-kappa B - metabolism | Epithelial Cells - cytology | Epithelial Cells - radiation effects | Signal Transduction | Mammary Neoplasms, Experimental - chemically induced | RANK Ligand - genetics | Integrin alpha6 - metabolism | Animals | Progestins - administration & dosage | Receptor Activator of Nuclear Factor-kappa B - genetics | Stem Cells - drug effects | RANK Ligand - deficiency | Cell Proliferation - drug effects | Medroxyprogesterone Acetate - administration & dosage | Mice | DNA Damage | Prevention | Complications and side effects | Care and treatment | Hormone therapy | Medroxyprogesterone | Development and progression | Breast cancer | Research | Cell differentiation | Health aspects | Risk factors | Cancer | Proteins | Womens health | Rodents | Cell cycle | Mammography | Females | Apoptosis
Journal Article
Oncogene, ISSN 0950-9232, 01/2019, Volume 38, Issue 1, pp. 47 - 59
Estrogen dependence is major driver of ER + breast cancer, which is associated with PI3K mutation. PI3K inhibition (PI3Ki) can restore dependence on ER... 
Apoptosis - drug effects | Bcl-2-Like Protein 11 - physiology | Neoplasm Proteins - physiology | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Thiazoles - administration & dosage | Mutation, Missense | Fulvestrant - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Mammary Neoplasms, Experimental - genetics | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Neoplasms, Hormone-Dependent - genetics | Neoplasms, Hormone-Dependent - chemically induced | Mammary Neoplasms, Experimental - pathology | Fulvestrant - administration & dosage | Female | Bcl-2-Like Protein 11 - agonists | Estrogen Receptor alpha - physiology | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Aniline Compounds - administration & dosage | BH3 Interacting Domain Death Agonist Protein - antagonists & inhibitors | Mammary Neoplasms, Experimental - drug therapy | Aniline Compounds - pharmacology | Antineoplastic Agents, Hormonal - pharmacology | Bcl-2-Like Protein 11 - genetics | Sulfonamides - pharmacology | Bcl-2-Like Protein 11 - biosynthesis | Gene Knock-In Techniques | Cocarcinogenesis | Drug Synergism | Estrogen Receptor alpha - drug effects | Mammary Neoplasms, Experimental - chemically induced | Phosphatidylinositol 3-Kinases - genetics | Animals | Estradiol - toxicity | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Mice, Nude | Neoplasms, Hormone-Dependent - pathology | Apoptosis Regulatory Proteins - antagonists & inhibitors | Cell Line, Tumor | Phosphatidylinositol 3-Kinases - physiology | Mice | Thiazoles - pharmacology | Neoplasms, Hormone-Dependent - drug therapy | Sulfonamides - administration & dosage | Drug Screening Assays, Antitumor | Neuropeptides - antagonists & inhibitors | Cell death | Estrogen receptors | Cytotoxicity | Tumorigenesis | Breast cancer | Supplementation | BIM protein | 1-Phosphatidylinositol 3-kinase | Apoptosis
Journal Article
Carcinogenesis, ISSN 0143-3334, 2014, Volume 35, Issue 8, pp. 1872 - 1880
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 1/2018, Volume 437, Issue 1, pp. 1 - 12
In the present study, we investigated the effect of allyl isothiocyanate (AITC) on liver detoxification signaling pathway in 7,12-dimethylbenz(a)anthracene... 
Life Sciences | Biochemistry, general | Detoxification enzymes | Aryl hydrocarbon receptor | 7,12-Dimethylbenz(a)anthracene | Medical Biochemistry | Oncology | Allyl isothiocyanate | Cardiology | Mammary carcinogenesis | Nuclear factor erythroid 2-related factor 2 | RAT-LIVER | LIPID-PEROXIDATION | ANTIOXIDANT ENZYMES | PHASE-II ENZYMES | CYTOCHROME-C REDUCTASE | CELL BIOLOGY | BREAST-CANCER | NRF2-MEDIATED ANTIOXIDANT | PARTIAL-PURIFICATION | GLUCURONYL TRANSFERASE | ADAPTIVE RESPONSE | 9,10-Dimethyl-1,2-benzanthracene - toxicity | Mammary Neoplasms, Experimental - prevention & control | Rats | Cell Transformation, Neoplastic - chemically induced | Mammary Neoplasms, Experimental - metabolism | Neoplasm Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Rats, Sprague-Dawley | Mammary Neoplasms, Experimental - chemically induced | Animals | Basic Helix-Loop-Helix Transcription Factors - metabolism | Signal Transduction - drug effects | NF-E2-Related Factor 2 - metabolism | Mammary Neoplasms, Experimental - pathology | Receptors, Aryl Hydrocarbon - metabolism | Female | Cell Transformation, Neoplastic - pathology | Isothiocyanates - pharmacology | Antioxidants | Prevention | Enzymes | Analysis | Liver | Dosage and administration | Carcinogenesis | Cancer | Hydrophobicity | Kinases | Molecular docking | Strong interactions (field theory) | Proteins | Signal transduction | Carcinogens | Rodents | Animal tissues | Mammary gland | Anthracene | Markers | Detoxification | Oral administration | Isothiocyanate | Chemicals | Signaling | 9,10-Dimethyl-1,2-benzanthracene | Tumors | Biochemical markers
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