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Journal of mammary gland biology and neoplasia, ISSN 0183-3021, 1996
Journal
Journal Article
Nature (London), ISSN 0028-0836, 2018, Volume 554, Issue 7692, pp. 378 - 381
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2014, Volume 74, Issue 11, pp. 2962 - 2973
Journal Article
Nature chemical biology, ISSN 1552-4469, 2014, Volume 10, Issue 7, pp. 558 - 566
PTP1B, a validated therapeutic target for diabetes and obesity, has a critical positive role in HER2 signaling in breast tumorigenesis. Efforts to develop... 
LAPATINIB | OVEREXPRESSION | TYROSINE-PHOSPHATASE 1B | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACQUIRED-RESISTANCE | BINDING-SITE | MECHANISMS | INDUCTION | HUMAN BREAST-CANCER | CONTRIBUTES | TUMORS | Receptor, ErbB-2 - genetics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Molecular Targeted Therapy | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - enzymology | Protein Binding - drug effects | Mammary Neoplasms, Experimental - pathology | Female | Antineoplastic Agents - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Mammary Neoplasms, Experimental - enzymology | Spermine - analogs & derivatives | Mammary Neoplasms, Experimental - drug therapy | Allosteric Regulation - drug effects | Protein Structure, Tertiary | Catalytic Domain | Protein Structure, Secondary | Signal Transduction | Allosteric Site - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Spermine - chemistry | Models, Molecular | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Animals | Breast Neoplasms - genetics | Spermine - pharmacology | Breast Neoplasms - pathology | Cholestanes - chemistry | Cholestanes - pharmacology | Mice | Kinetics | Breast cancer | Tumorigenesis | Diabetes | Drug therapy | Cholestanes | Allosteric Regulation | Breast Neoplasms | Life Sciences | Biomolecules | Biochemistry, Molecular Biology | Antineoplastic Agents | Spermine | Protein Tyrosine Phosphatase, Non-Receptor Type 1 | Mammary Neoplasms, Experimental | Allosteric Site | Protein Binding | Receptor, ErbB-2
Journal Article
Journal Article
PLoS Biology, ISSN 1544-9173, 2014, Volume 12, Issue 9, p. e1001945
Malignant carcinomas that recur following therapy are typically de-differentiated and multidrug resistant (MDR). De-differentiated cancer cells acquire MDR by... 
EPITHELIAL-MESENCHYMAL TRANSITION | UNFOLDED PROTEIN RESPONSE | DIFFERENTIATION THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | PANCREATIC-CANCER | BIOLOGY | NRF2 TRANSCRIPTION FACTOR | HEME OXYGENASE-1 GENE | ENDOPLASMIC-RETICULUM STRESS | DRUG-RESISTANCE | CANCER STEM-CELLS | ACUTE PROMYELOCYTIC LEUKEMIA | Phosphorylation | eIF-2 Kinase - metabolism | Humans | Gene Expression Regulation, Neoplastic | Neoplasm Recurrence, Local - drug therapy | Gene Expression Profiling | Mammary Neoplasms, Experimental - metabolism | Mammary Neoplasms, Experimental - genetics | Breast Neoplasms - metabolism | Neoplasm Recurrence, Local - pathology | Neoplasm Grading | Mammary Neoplasms, Experimental - pathology | Female | NF-E2-Related Factor 2 - genetics | Transcription, Genetic | Antineoplastic Agents - pharmacology | Carcinoma - pathology | Mammary Neoplasms, Experimental - drug therapy | eIF-2 Kinase - genetics | Carcinoma - drug therapy | Neoplasm Recurrence, Local - metabolism | Oxidation-Reduction | Signal Transduction | Mammary Glands, Animal - pathology | Mammary Glands, Animal - drug effects | Mice, SCID | Breast Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Mammary Glands, Animal - metabolism | Breast Neoplasms - pathology | NF-E2-Related Factor 2 - metabolism | Cell Line, Tumor | Carcinoma - genetics | Mice, Inbred NOD | Neoplasm Recurrence, Local - genetics | Carcinoma - metabolism | Cell Dedifferentiation - genetics | Cell research | Oncology, Experimental | Cancer cells | Cellular signal transduction | Research | Drug resistance | Cell differentiation | Health aspects | Cancer | Medical research | Enzymes | Transcription factors | Biomedical research | Breast cancer | Kinases | Gene expression | Experiments | Cancer therapies | Antioxidants | Medical prognosis | Data collection | Tumors
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3660 - 3663
in this issue of the JCI, two reports provide intriguing new information on the role of the inflammatory cytokine IL-6 in breast and lung cancer. The study by... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | PATHWAY | STAT3 | NOTCH | STEM/PROGENITOR CELLS | GROWTH-FACTOR | INTERLEUKIN-6 | IDENTIFICATION | TUMORIGENESIS | Receptor, Epidermal Growth Factor - genetics | Transcription, Genetic - drug effects | Interleukin-6 - antagonists & inhibitors | Carbonic Anhydrases - biosynthesis | Cytokine Receptor gp130 - genetics | Receptors, Notch - metabolism | Humans | Lung Neoplasms - metabolism | Antigens, Neoplasm - biosynthesis | Spheroids, Cellular - pathology | Neoplasm Proteins - pharmacology | Receptors, Notch - genetics | Janus Kinases - metabolism | RNA, Messenger - metabolism | Serrate-Jagged Proteins | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Gene Expression Regulation, Neoplastic - genetics | STAT3 Transcription Factor - genetics | Cytokine Receptor gp130 - metabolism | Interleukin-6 - genetics | Membrane Proteins - genetics | Spheroids, Cellular - metabolism | Enzyme Inhibitors - pharmacology | Mammary Glands, Human - pathology | Lung Neoplasms - therapy | Signal Transduction - genetics | Autocrine Communication - genetics | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | RNA, Neoplasm - genetics | Stem Cells - pathology | Carcinoma - genetics | Mice | Mutation | Transcription, Genetic - genetics | Cell Hypoxia - genetics | Calcium-Binding Proteins - genetics | Neoplasm Transplantation | Carbonic Anhydrases - genetics | Lung Neoplasms - pathology | Autocrine Communication - drug effects | Mammary Glands, Human - metabolism | Neoplasm Proteins - metabolism | Stem Cells - metabolism | Breast Neoplasms - metabolism | Breast Neoplasms - therapy | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Female | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma - pathology | STAT3 Transcription Factor - metabolism | Carbonic Anhydrase IX | Calcium-Binding Proteins - metabolism | Lung Neoplasms - genetics | Antigens, Neoplasm - genetics | Cell Hypoxia - drug effects | Janus Kinases - genetics | Neoplasm Invasiveness | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Up-Regulation - genetics | Up-Regulation - drug effects | Animals | Interleukin-6 - pharmacology | Breast Neoplasms - pathology | Interleukin-6 - biosynthesis | Carcinoma - therapy | Receptor, Notch3 | Carcinoma - metabolism | Antagonists (Biochemistry) | Epithelial tumors | Dosage and administration | Diagnosis | Research | Drug therapy | Health aspects | Interleukin-6
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 05/2011, Volume 71, Issue 9, pp. 3364 - 3376
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 12/2014, Volume 96, Issue 6, pp. 1109 - 1118
Interactions between MDSC, macrophages, and tumor cells alter the cytokine milieu, impacting inflammation in the tumor microenvironment. MDSC and macrophages... 
Cytokines | Tumor microenvironment | Nitric oxide | IL-10 | IL-6 | Cancer | nitric oxide | IFN-GAMMA | PROLIFERATION | INTERLEUKIN-10 | IMMUNOLOGY | CELL BIOLOGY | RESPONSES | MICROENVIRONMENT | NITRIC-OXIDE | cancer | cytokines | tumor microenvironment | HEMATOLOGY | POLARIZATION | PROGRESSION | Mammary Neoplasms, Experimental - immunology | Neoplasm Transplantation | Interleukin-12 - genetics | Stromal Cells - pathology | Myeloid Cells - physiology | Tumor Necrosis Factor-alpha - genetics | Cell Communication - physiology | Tumor Microenvironment - physiology | Mammary Neoplasms, Experimental - metabolism | Colonic Neoplasms - metabolism | Neoplasms, Experimental - pathology | STAT3 Transcription Factor - physiology | Colonic Neoplasms - immunology | Neoplasms, Experimental - immunology | Mammary Neoplasms, Experimental - pathology | Interleukin-10 - secretion | Gene Expression Regulation, Neoplastic - physiology | Interleukin-12 - secretion | Interleukin-12 - biosynthesis | Macrophages - physiology | Nitric Oxide - biosynthesis | Interleukin-6 - genetics | Mice, Inbred C57BL | Stromal Cells - metabolism | Tumor Necrosis Factor-alpha - secretion | Inflammation | Interleukin-6 - secretion | Transplantation, Isogeneic | Disease Progression | Nitric Oxide - secretion | Animals | Colonic Neoplasms - pathology | Interleukin-10 - genetics | Cell Line, Tumor | Interleukin-6 - biosynthesis | Interleukin-10 - biosynthesis | Signal Transduction - physiology | Mice | Mice, Inbred BALB C | Neoplasms, Experimental - metabolism | Tumor Necrosis Factor-alpha - biosynthesis
Journal Article