X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1519) 1519
Book Review (316) 316
Publication (220) 220
Book Chapter (18) 18
Conference Proceeding (12) 12
Newsletter (6) 6
Newspaper Article (4) 4
Book / eBook (2) 2
Presentation (1) 1
Reference (1) 1
Trade Publication Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (1390) 1390
humans (1181) 1181
marfan-syndrome (740) 740
animals (591) 591
male (497) 497
female (494) 494
fibrillins (469) 469
marfan syndrome (467) 467
fibrillin-1 (376) 376
adult (329) 329
mice (324) 324
mutation (323) 323
marfan syndrome - genetics (313) 313
microfilament proteins - genetics (294) 294
marfan syndrome - metabolism (285) 285
microfilament proteins - metabolism (280) 280
biochemistry & molecular biology (266) 266
fibrillin (235) 235
middle aged (208) 208
adolescent (203) 203
genetics & heredity (195) 195
cell biology (194) 194
child (180) 180
transforming growth factor beta - metabolism (177) 177
phenotype (165) 165
abridged index medicus (160) 160
cells, cultured (160) 160
marfan syndrome - pathology (160) 160
expression (157) 157
cardiac & cardiovascular systems (156) 156
molecular sequence data (156) 156
gene (151) 151
mutations (150) 150
marfan syndrome - complications (148) 148
microfibrils (139) 139
aneurysms (138) 138
amino acid sequence (132) 132
article (130) 130
disease models, animal (129) 129
extracellular matrix (127) 127
pathogenesis (127) 127
aneurysm (125) 125
collagen (120) 120
tgf-beta (120) 120
growth-factor-beta (119) 119
signal transduction (119) 119
mouse model (118) 118
extracellular matrix - metabolism (117) 117
proteins (117) 117
extracellular-matrix (116) 116
aged (115) 115
genetic aspects (113) 113
analysis (112) 112
collagen - metabolism (110) 110
fibroblasts - metabolism (109) 109
extracellular matrix proteins - metabolism (104) 104
microfilament proteins - chemistry (101) 101
child, preschool (99) 99
genes (99) 99
immunohistochemistry (99) 99
disease (98) 98
marfan syndrome - diagnosis (98) 98
research (97) 97
elastin (96) 96
genetics (96) 96
marfan's syndrome (96) 96
aorta (95) 95
musculoskeletal diseases (93) 93
peripheral vascular disease (93) 93
base sequence (88) 88
mice, inbred c57bl (87) 87
mice, knockout (86) 86
fibroblasts (85) 85
smooth-muscle-cells (85) 85
aorta - pathology (84) 84
gene expression (83) 83
congenital, hereditary, and neonatal diseases and abnormalities (80) 80
microfibrils - metabolism (80) 80
risk factors (80) 80
research article (79) 79
physiological aspects (77) 77
cardiovascular system (76) 76
marfan syndrome - physiopathology (76) 76
pathology (76) 76
surgery (76) 76
elastin - metabolism (75) 75
fibrillin-2 (73) 73
pedigree (73) 73
activation (72) 72
diagnosis (72) 72
aorta - metabolism (70) 70
aortic aneurysm, thoracic - genetics (70) 70
cells (70) 70
protein binding (70) 70
component (69) 69
genetic predisposition to disease (67) 67
medicine, research & experimental (67) 67
extracellular microfibrils (66) 66
medicine (64) 64
rodents (64) 64
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1463) 1463
Russian (18) 18
Italian (15) 15
German (13) 13
French (12) 12
Japanese (9) 9
Polish (3) 3
Spanish (3) 3
Danish (2) 2
Dutch (2) 2
Chinese (1) 1
Finnish (1) 1
Hungarian (1) 1
Norwegian (1) 1
Portuguese (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


by Iglesias, Adriana I and Mishra, Aniket and Vitart, Veronique and Bykhovskaya, Yelena and Höhn, René and Springelkamp, Henriët and Cuellar-Partida, Gabriel and Gharahkhani, Puya and Bailey, Jessica N. Cooke and Willoughby, Colin E and Li, Xiaohui and Yazar, Seyhan and Nag, Abhishek and Khawaja, Anthony P and Polašek, Ozren and Siscovick, David and Mitchell, Paul and Tham, Yih Chung and Haines, Jonathan L and Kearns, Lisa S and Hayward, Caroline and Shi, Yuan and Van Leeuwen, Elisabeth M and Taylor, Kent D and Wang, Jie Jin and Rochtchina, Elena and Attia, John and Scott, Rodney and Holliday, Elizabeth G and Baird, Paul N and Xie, Jing and Inouye, Michael and Viswanathan, Ananth and Sim, Xueling and Bonnemaijer, Pieter and Rotter, Jerome I and Martin, Nicholas G and Zeller, Tanja and Mills, Richard A and Staffieri, Sandra E and Jonas, Jost B and Schmidtmann, Irene and Boutin, Thibaud and Kang, Jae H and Lucas, Sionne E. M and Wong, Tien Yin and Beutel, Manfred E and Wilson, James F and Allingham, R. Rand and Brilliant, Murray H and Budenz, Donald L and Christen, William G and Fingert, John and Friedman, David S and Gaasterland, Douglas and Gaasterland, Terry and Hauser, Michael A and Kraft, Peter and Lee, Richard K and Lichter, Paul R and Liu, Yutao and Loomis, Stephanie J and Moroi, Sayoko E and Pericak-Vance, Margaret A and Realini, Anthony and Richards, Julia E and Schuman, Joel S and Scott, William K and Singh, Kuldev and Sit, Arthur J and Vollrath, Douglas and Weinreb, Robert N and Wollstein, Gadi and Zack, Donald J and Zhang, Kang and Donnelly, Peter and Barroso, Ines and Blackwell, Jenefer M and Bramon, Elvira and Brown, Matthew A and Casas, Juan P and Corvin, Aiden and Deloukas, Panos and Duncanson, Audrey and Jankowski, Janusz and Markus, Hugh S and Mathew, Christopher G and Palmer, Colin N. A and Plomin, Robert and Rautanen, Anna and Sawcer, Stephen J and Trembath, Richard C and Wood, Nicholas W and Spencer, Chris C. A and Band, Gavin and Bellenguez, Céline and Freeman, Colin and Hellenthal, Garrett and Giannoulatou, Eleni and Pirinen, Matti and ... and Blue Mountains Eye Study-GWAS Grp and NEIGHBORHOOD Consortium and Wellcome Trust Case Control Consor and Blue Mountains Eye Study—GWAS group and Wellcome Trust Case Control Consortium 2 (WTCCC2)
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1 - 11
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide... 
DECORIN | CHROMATIN STATES | POLYMORPHISMS | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | MOUSE | GENE-EXPRESSION | MUTATIONS | HERITABILITY | LUMICAN | KERATOCONUS | Glaucoma | Cornea | Genes | Myopia | Association analysis | Genomes | Gene expression | Tissues | Connective tissues | Keratoconus | Collagen | Eye diseases | Extracellular matrix | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2015, Volume 35, Issue 4, pp. 960 - 972
Objective-Marfan's syndrome is characterized by the formation of ascending aortic aneurysms resulting from altered assembly of extracellular matrix... 
focal adhesion | actin | aortic stiffness | myocardin | TGF-β | aortic aneurysms | extracellular matrix | RhoA | TRANSCRIPTION FACTORS | SMAD2 PATHWAY | EPIGENETIC CONTROL | THORACIC AORTIC-ANEURYSMS | SIGNAL-TRANSDUCTION | TGF-beta | GROWTH-FACTOR-BETA | MOUSE MODEL | DISEASE | PERIPHERAL VASCULAR DISEASE | EXTRACELLULAR-MATRIX | DIFFERENTIATION | HEMATOLOGY | Vascular Remodeling | Aortic Aneurysm - metabolism | Muscle, Smooth, Vascular - metabolism | Humans | Actins - metabolism | Myocytes, Smooth Muscle - pathology | rhoA GTP-Binding Protein - metabolism | Aorta - metabolism | Aortic Aneurysm - etiology | Case-Control Studies | Muscle Proteins - metabolism | Cytoskeletal Proteins - metabolism | Cell Differentiation | Marfan Syndrome - complications | Microfilament Proteins - metabolism | Aortic Aneurysm - pathology | Dilatation, Pathologic | Myocytes, Smooth Muscle - metabolism | Biomarkers - metabolism | Calcium-Binding Proteins - metabolism | Collagen Type I - metabolism | Signal Transduction | Nuclear Proteins - metabolism | Aorta - pathology | Muscle, Smooth, Vascular - pathology | Phenotype | Stress Fibers - metabolism | Focal Adhesions - metabolism | Cell Line, Tumor | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Trans-Activators - metabolism | Transforming Growth Factor beta - metabolism | Index Medicus | Biological Sciences | Medical and Health Sciences | Medicin och hälsovetenskap | Naturvetenskap | Biologiska vetenskaper | Natural Sciences
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 01/2014, Volume 124, Issue 1, pp. 448 - 460
Journal Article
Nature communications, ISSN 2041-1723, 05/2018, Volume 9, Issue 1, p. 1864
Central corneal thickness (CCT) is a highly heritable trait associated with complex eye diseases such as keratoconus and glaucoma. We perform a genome-wide... 
Lumican - metabolism | Glaucoma, Open-Angle - genetics | Humans | Corneal Diseases - metabolism | Corneal Dystrophies, Hereditary - ethnology | Corneal Diseases - genetics | Ehlers-Danlos Syndrome - genetics | Corneal Dystrophies, Hereditary - pathology | Loeys-Dietz Syndrome - metabolism | Mendelian Randomization Analysis | Fibrillin-1 - metabolism | Cornea - pathology | Keratoconus - pathology | Corneal Diseases - pathology | Decorin - genetics | Gene Expression | Eye Diseases, Hereditary - pathology | Lumican - genetics | ADAMTS Proteins - metabolism | Proteoglycans - metabolism | Ehlers-Danlos Syndrome - ethnology | European Continental Ancestry Group | Myopia - pathology | Cornea - metabolism | Myopia - ethnology | Loeys-Dietz Syndrome - pathology | Corneal Diseases - ethnology | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Cornea - abnormalities | Quantitative Trait Loci | Proteoglycans - genetics | ADAMTS Proteins - genetics | Transforming Growth Factor beta2 - metabolism | Corneal Dystrophies, Hereditary - genetics | Glaucoma, Open-Angle - pathology | Keratoconus - metabolism | Loeys-Dietz Syndrome - ethnology | Glaucoma, Open-Angle - ethnology | Myopia - metabolism | Ehlers-Danlos Syndrome - pathology | Marfan Syndrome - ethnology | Keratoconus - genetics | Glaucoma, Open-Angle - metabolism | Fibrillin-1 - genetics | Eye Diseases, Hereditary - ethnology | Genome-Wide Association Study | Quantitative Trait, Heritable | Corneal Dystrophies, Hereditary - metabolism | Marfan Syndrome - genetics | Eye Diseases, Hereditary - genetics | Myopia - genetics | Asian Continental Ancestry Group | Keratoconus - ethnology | Ehlers-Danlos Syndrome - metabolism | Loeys-Dietz Syndrome - genetics | Polymorphism, Single Nucleotide | Transforming Growth Factor beta2 - genetics | Genome, Human | Decorin - metabolism | Eye Diseases, Hereditary - metabolism | Cornea | Decorin | Corneal Dystrophies, Hereditary | Myopia | Corneal Diseases | Marfan Syndrome | Keratoconus | ADAMTS Proteins | Lumican | Transforming Growth Factor beta2 | Ehlers-Danlos Syndrome | Glaucoma, Open-Angle | Fibrillin-1 | Eye Diseases, Hereditary | Proteoglycans | Wellcome Trust Case Control Consortium 2 (WTCCC2) | Blue Mountains Eye Study—GWAS group | Loeys-Dietz Syndrome | NEIGHBORHOOD Consortium
Journal Article
Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6027, pp. 358 - 361
Transforming growth factor—β (TGFβ) signaling drives aneurysm progression in multiple disorders, including Marfan syndrome (MFS), and therapies that inhibit... 
Transcriptional regulatory elements | Echocardiography | Aortic diseases | Root growth | REPORTS | Placebos | Aneurysms | Aorta | Mice | Aortic aneurysm | Marfan syndrome | PATHOGENESIS | CELLS | ACTIVATION | VALSALVA | MULTIDISCIPLINARY SCIENCES | N-TERMINAL KINASE | MOUSE MODEL | NOONANS-SYNDROME | RECEPTOR | MUTATIONS | INHIBITOR | Diphenylamine - pharmacology | Aortic Aneurysm - metabolism | Mitogen-Activated Protein Kinase 8 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Anthracenes - therapeutic use | MAP Kinase Signaling System | Diphenylamine - analogs & derivatives | Marfan Syndrome - drug therapy | Smad4 Protein - genetics | Transforming Growth Factor beta - antagonists & inhibitors | Aortic Aneurysm - pathology | Aortic Aneurysm - prevention & control | Disease Models, Animal | Transforming Growth Factor beta - immunology | Diphenylamine - therapeutic use | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 8 - metabolism | Aortic Aneurysm - physiopathology | Losartan - pharmacology | Smad2 Protein - metabolism | Sulfonamides - pharmacology | Anthracenes - pharmacology | Disease Progression | Aorta - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Losartan - therapeutic use | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Protein Kinase Inhibitors - pharmacology | Smad4 Protein - deficiency | Enzyme Activation | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | Therapy | Progressions | Pathways | Strategy | Activation | Inhibition | Kinases
Journal Article
Circulation Research, ISSN 0009-7330, 01/2012, Volume 110, Issue 2, pp. 312 - 324
RATIONALE:Marfan syndrome (MFS) is a systemic connective tissue disorder notable for the development of aortic root aneurysms and the subsequent... 
aneurysm | apoptosis | microRNA | extracellular matrix | Marfan syndrome | FIBROSIS | KAPPA-B ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | AORTIC-ANEURYSM | KINASE | FAILURE | MICRORNA EXPRESSION SIGNATURE | INFLAMMATION | METALLOPROTEINASE SECRETION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | REVEALS | Up-Regulation | Age Factors | Aortic Aneurysm - metabolism | Male | MicroRNAs - metabolism | NF-kappa B - metabolism | Aorta - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Marfan Syndrome - therapy | Female | Marfan Syndrome - complications | Microfilament Proteins - metabolism | Aortic Aneurysm - pathology | Microfilament Proteins - genetics | Real-Time Polymerase Chain Reaction | Aortic Aneurysm - prevention & control | Disease Models, Animal | Elastin - metabolism | Fibrillin-1 | Matrix Metalloproteinase 2 - metabolism | Mice, Inbred C57BL | Cells, Cultured | Losartan - pharmacology | Fibrillins | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Marfan Syndrome - genetics | Apoptosis Regulatory Proteins - metabolism | Aorta - pathology | Animals | Elastin - genetics | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Oligonucleotides, Antisense - administration & dosage | Mice | MicroRNAs - genetics | Aortic Aneurysm - genetics | Transforming Growth Factor beta - metabolism | Apoptosis | Genetic Therapy - methods | Index Medicus
Journal Article
Nature genetics, ISSN 1061-4036, 2012, Volume 44, Issue 11, pp. 1249 - 1254
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2015, Volume 35, Issue 4, pp. 911 - 917
Objective-Studies of mice with mild Marfan syndrome (MFS) have correlated the development of thoracic aortic aneurysm (TAA) with improper stimulation of... 
aortic aneurysm | receptor, angiotensin, type 1 | losartan | transforming growth factor β | Marfan syndrome | PATHOGENESIS | TGF-BETA | type 1 | transforming growth factor beta | MOUSE MODEL | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | receptor, angiotensin | Aortic Aneurysm, Thoracic - genetics | Phosphorylation | Aortic Aneurysm, Thoracic - prevention & control | Humans | Aortic Rupture - metabolism | Mice, 129 Strain | Angiotensin II Type 1 Receptor Blockers - pharmacology | Marfan Syndrome - drug therapy | Aortic Aneurysm, Thoracic - pathology | Time Factors | Mice, Mutant Strains | Aortic Rupture - prevention & control | Transforming Growth Factor beta - antagonists & inhibitors | Aorta, Thoracic - drug effects | Microfilament Proteins - genetics | Aorta, Thoracic - pathology | Disease Models, Animal | Transforming Growth Factor beta - immunology | Fibrillin-1 | Mice, Inbred C57BL | Losartan - pharmacology | Smad2 Protein - metabolism | Aorta, Thoracic - metabolism | Antibodies, Neutralizing - pharmacology | Aortic Rupture - pathology | Fibrillins | Disease Progression | Marfan Syndrome - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Aortic Aneurysm, Thoracic - metabolism | Receptor, Angiotensin, Type 1 - metabolism | Aortic Rupture - genetics | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Mutation | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2014, Volume 124, Issue 3, pp. 1329 - 1339
Patients with Marfan syndrome (MFS), a multisystem disorder caused by mutations in the gene encoding the extracellular matrix (ECM) protein fibrillin 1, are... 
MEDICINE, RESEARCH & EXPERIMENTAL | LOSARTAN | AORTIC-ANEURYSM | MYOCARDIAL FIBROSIS | MECHANICAL-STRESS | SIGNIFICANT VALVULAR REGURGITATION | MOUSE MODEL | ANGIOTENSIN-II | DILATED CARDIOMYOPATHY | DYSFUNCTION | LEFT-VENTRICULAR FUNCTION | Cardiomyopathy, Dilated - pathology | Humans | Extracellular Matrix - metabolism | Male | Marfan Syndrome - physiopathology | Angiotensin II Type 1 Receptor Blockers - pharmacology | MAP Kinase Signaling System | Myocardium - metabolism | Adult | Marfan Syndrome - complications | Microfilament Proteins - metabolism | Child | Focal Adhesion Kinase 1 - metabolism | Fibrillin-1 | Cross-Sectional Studies | Losartan - pharmacology | Organ Size | Fibrillins | Mice, Transgenic | Myocardium - pathology | Cardiomyopathy, Dilated - metabolism | Mechanotransduction, Cellular | Animals | Myocytes, Cardiac - drug effects | Cardiomyopathy, Dilated - etiology | Cardiomyopathy, Dilated - physiopathology | Receptor, Angiotensin, Type 1 - metabolism | Marfan Syndrome - metabolism | Myocytes, Cardiac - metabolism | Marfan Syndrome - pathology | Mice | Heart cells | Physiological aspects | Cellular signal transduction | Glycoproteins | Research | Properties | Marfan syndrome | Studies | Heart | Microscopy | Pathogenesis | Cardiomyopathy | Rodents | Homeostasis | Cardiomyocytes | Mutation | Bioavailability | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Science, ISSN 0036-8075, 4/2011, Volume 332, Issue 6027, pp. 361 - 365
Angiotensin II (AngII) mediates progression of aortic aneurysm, but the relative contribution of its type 1 (AT1) and type 2 (AT2) receptors remains unknown.... 
Connective tissues | Receptors | Root growth | Medical treatment | REPORTS | Aneurysms | Placebos | Aorta | Mice | Aortic aneurysm | Marfan syndrome | PATHOGENESIS | ACTIVATION | MECHANISM | MULTIDISCIPLINARY SCIENCES | MARFAN-SYNDROME | MOUSE MODEL | GROWTH | SMOOTH-MUSCLE-CELLS | BLOCKADE | CONTRIBUTES | EXPRESSION | Aortic Aneurysm - metabolism | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Aortic Rupture - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Enalapril - therapeutic use | MAP Kinase Signaling System | Marfan Syndrome - drug therapy | Angiotensin-Converting Enzyme Inhibitors - therapeutic use | Aortic Rupture - prevention & control | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Aortic Aneurysm - pathology | Aortic Aneurysm - prevention & control | Disease Models, Animal | Receptor, Angiotensin, Type 2 - genetics | Angiotensin II - metabolism | Signal Transduction | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Losartan - pharmacology | Aortic Rupture - pathology | Disease Progression | Mice, Knockout | Animals | Enalapril - pharmacology | Receptor, Angiotensin, Type 2 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Aortic Aneurysm - drug therapy | Losartan - therapeutic use | Marfan Syndrome - metabolism | Marfan Syndrome - pathology | Transforming Growth Factor beta - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Aortic aneurysms | Development and progression | Genetic aspects | Health aspects | Angiotensin | Signal transduction | Peptides | Cellular biology | Coronary vessels | Rodents | Index Medicus | Progressions | Inhibitors | Blocking | Attenuation | Kinases
Journal Article
Journal Article