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The Journal of Immunology, ISSN 0022-1767, 10/2009, Volume 183, Issue 8, pp. 4879 - 4886
The CD200 receptor (CD200R) acts as a negative regulator of myeloid cells by interacting with its widely expressed ligand CD200. Using mutants expressed in... 
STEM-CELLS | ACTIVATION | PROGNOSTIC-FACTOR | INHIBITION | DOCKING PROTEIN | PHOSPHORYLATION | NEGATIVE REGULATION | MACROPHAGES | DOWN-REGULATION | SURFACE-PROTEINS | IMMUNOLOGY | Phosphoproteins - immunology | Antigens, CD - immunology | p120 GTPase Activating Protein - metabolism | Humans | Glycoproteins - metabolism | p120 GTPase Activating Protein - genetics | Phosphoproteins - metabolism | Antigens, CD - metabolism | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | Matrilin Proteins | Signal Transduction - immunology | ras GTPase-Activating Proteins - genetics | Interleukin-4 - pharmacology | RNA, Small Interfering - immunology | Myeloid Cells - immunology | Adaptor Proteins, Signal Transducing - immunology | Antigens, Surface - metabolism | Myeloid Cells - drug effects | Interleukin-8 - metabolism | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | ras GTPase-Activating Proteins - metabolism | DNA-Binding Proteins - immunology | Cartilage Oligomeric Matrix Protein | RNA-Binding Proteins - immunology | Antigens, Surface - genetics | Rats | Receptors, Cell Surface - metabolism | Phosphoproteins - genetics | Receptors, Cell Surface - immunology | Glycoproteins - immunology | Macrophages - metabolism | Animals | Extracellular Matrix Proteins - immunology | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Myeloid Cells - metabolism | Macrophages - drug effects | Mice | ras GTPase-Activating Proteins - immunology | Adaptor Proteins, Signal Transducing - metabolism | Interleukin-8 - immunology | Antigens, Surface - immunology | RNA-Binding Proteins - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Index Medicus | Abridged Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2004, Volume 101, Issue 15, pp. 5547 - 5552
Angiopoietin-1 (Ang1) has potential therapeutic applications in inducing angiogenesis, enhancing endothelial cell survival, and preventing vascular leakage.... 
Proteins | COS cells | Angiogenesis | Pharmaceutical preparations | Biological Sciences | Receptors | Phosphorylation | Medical treatment | Recombinant proteins | Corneal neovascularization | Endothelial cells | VASCULARIZATION | ACTIVATION | OVEREXPRESSING ANGIOPOIETIN-1 | POSTNATAL NEOVASCULARIZATION | INDUCED APOPTOSIS | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | LIGAND | SECRETION | COILED-COIL | TIE2 RECEPTOR | Endothelium, Vascular - cytology | Recombinant Fusion Proteins - pharmacology | Apoptosis - drug effects | Humans | Molecular Sequence Data | Endothelium, Vascular - drug effects | Male | Matrilin Proteins | Cornea - blood supply | Umbilical Veins - drug effects | Angiogenesis Modulating Agents - chemistry | Protein Structure, Quaternary | Angiopoietin-1 - chemistry | Receptor, TIE-2 - metabolism | Glycoproteins - chemistry | Umbilical Veins - cytology | Angiopoietin-1 - pharmacology | Glycoproteins - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Extracellular Matrix Proteins - chemistry | Cartilage Oligomeric Matrix Protein | Extracellular Matrix Proteins - genetics | Cells, Cultured | Rats | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Angiogenesis Modulating Agents - pharmacology | Recombinant Fusion Proteins - chemistry | Recombinant Proteins - pharmacology | Mice, Inbred Strains | Angiopoietin-1 - genetics | Cell Movement - drug effects | Animals | Recombinant Fusion Proteins - genetics | Mice | Cells | Research | Cellular biology | Gene expression | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2007, Volume 282, Issue 43, pp. 31166 - 31173
We have previously reported that COMP ( c artilage o ligomeric m atrix p rotein) is prominent in cartilage but is also present in tendon and binds to collagens... 
FIBRIL FORMATION | IX COLLAGEN | TENDON | CORE PROTEINS | NATIVE COLLAGEN | FIBROMODULIN | ARTICULAR-CARTILAGE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELECTRON-MICROSCOPY | POLYACRYLAMIDE GELS | OLIGOMERIC MATRIX PROTEIN | Immunohistochemistry | Surface Plasmon Resonance | Temperature | Gold Colloid | Collagen Type I - chemistry | Glycoproteins - metabolism | Hydroxyproline - analysis | Extracellular Matrix Proteins - analysis | Collagen Type II - metabolism | Matrilin Proteins | Time Factors | Cattle | Collagen Type II - isolation & purification | Glycoproteins - isolation & purification | Extracellular Matrix Proteins - isolation & purification | Catalysis | Buffers | Glycoproteins - chemistry | Acids - pharmacology | Extracellular Matrix Proteins - metabolism | Collagen Type II - ultrastructure | Glycoproteins - genetics | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Nephelometry and Turbidimetry | Extracellular Matrix Proteins - chemistry | Collagen Type I - metabolism | Enzyme-Linked Immunosorbent Assay | Electrophoresis, Polyacrylamide Gel | Extracellular Matrix Proteins - genetics | Collagen Type I - isolation & purification | Recombinant Proteins - chemistry | Blotting, Western | Collagen Type I - ultrastructure | Hydrolysis | Particle Size | Collagen - metabolism | Skin - chemistry | Animals | HEPES - chemistry | Collagen Type II - chemistry | Pepsin A - pharmacology | Glycoproteins - analysis | Kinetics | Hydrogen-Ion Concentration | Index Medicus | Rheumatology and Autoimmunity | Clinical Medicine | Other Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Reumatologi och inflammation | Annan klinisk medicin | Klinisk medicin
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2008, Volume 283, Issue 1, pp. 648 - 659
Cartilage oligomeric matrix protein (COMP) is a component of cartilage, synovium, ligament, and tendon, yet its normal function is largely unknown. To identify... 
MULTIPLE EPIPHYSEAL DYSPLASIA | IX COLLAGEN | COMP | APOPTOSIS | ACTIVATION | SYNOVIAL-FLUID | BIOCHEMISTRY & MOLECULAR BIOLOGY | SMOOTH-MUSCLE-CELLS | NF-KAPPA-B | 5-STRANDED COILED-COIL | PSEUDOACHONDROPLASIA | Caspase 7 - metabolism | Caspase 6 - metabolism | RNA, Small Interfering - genetics | Microtubule-Associated Proteins - genetics | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Neoplasm Proteins - physiology | Caspase 3 - metabolism | Caspase 8 - metabolism | Glycoproteins - metabolism | Apoptosis - genetics | Immunoblotting | Neoplasm Proteins - metabolism | Inhibitor of Apoptosis Proteins - physiology | Caspase 8 - genetics | Matrilin Proteins | Caspase 3 - genetics | Inhibitor of Apoptosis Proteins - metabolism | Neoplasm Proteins - genetics | Chondrocytes - metabolism | Extracellular Matrix Proteins - metabolism | Glycoproteins - genetics | Cell Line | Cartilage Oligomeric Matrix Protein | Caspase 7 - genetics | Extracellular Matrix Proteins - genetics | Cells, Cultured | Extracellular Matrix Proteins - physiology | Reverse Transcriptase Polymerase Chain Reaction | Glycoproteins - physiology | X-Linked Inhibitor of Apoptosis Protein - genetics | Microtubule-Associated Proteins - physiology | Tumor Necrosis Factor-alpha - pharmacology | Caspase 6 - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Apoptosis - physiology | HeLa Cells | X-Linked Inhibitor of Apoptosis Protein - physiology | Index Medicus
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 10/2009, Volume 11, Issue 10, pp. 1197 - 1204
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2012, Volume 287, Issue 27, pp. 22549 - 22559
The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures... 
MULTIPLE EPIPHYSEAL DYSPLASIA | IX COLLAGEN | COMP | CAUSE PSEUDOACHONDROPLASIA | DIFFERENTIAL EXPRESSION | TENASCIN-X | ANCHORING FIBRILS | BIOCHEMISTRY & MOLECULAR BIOLOGY | VII COLLAGEN | ENDOPLASMIC-RETICULUM | SYSTEMIC-SCLEROSIS | Surface Plasmon Resonance | Humans | Glycoproteins - metabolism | Child, Preschool | Extracellular Matrix - metabolism | Collagen - chemistry | Infant | Microscopy, Immunoelectron | Matrilin Proteins | Collagen Type I - genetics | HEK293 Cells | Collagen - genetics | Glycoproteins - chemistry | Extracellular Matrix Proteins - metabolism | Fibroblasts - metabolism | Glycoproteins - genetics | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Extracellular Matrix Proteins - chemistry | Collagen Type I - metabolism | Dermis - metabolism | Cartilage Oligomeric Matrix Protein | Extracellular Matrix Proteins - genetics | Recombinant Proteins - genetics | Dermis - ultrastructure | Basement Membrane - metabolism | Collagen - metabolism | Collagen Type XII - chemistry | Animals | Keratinocytes - metabolism | Collagen Type XII - genetics | Collagen Type XII - metabolism | Mice | Index Medicus | Collagen I Fibril | FACIT Collagens | Surface Plasmon Resonance (SPR) | Extracellular Matrix | Collagen | Anchoring Plaques | Glycobiology and Extracellular Matrices | Skin | Fibroblast | Rheumatology and Autoimmunity | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Reumatologi och inflammation
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 09/2018, Volume 503, Issue 3, pp. 1273 - 1277
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 11/2011, Volume 13, Issue 6, pp. R184 - R184
Introduction: Adiponectin is an adipokine that regulates energy metabolism and insulin sensitivity, but recent studies have pointed also to a role in... 
RHEUMATOID-ARTHRITIS | LEPTIN | SYNOVIAL-FLUID | NITRIC-OXIDE SYNTHASE | HUMAN CHONDROCYTES | SERUM | RHEUMATOLOGY | NF-KAPPA-B | KNEE OSTEOARTHRITIS | EXPRESSION | TERMINAL KINASE | Chondrocytes - cytology | Humans | Glycoproteins - metabolism | Male | Cartilage - drug effects | Dose-Response Relationship, Drug | Matrilin Proteins | Chondrocytes - drug effects | HEK293 Cells | Adiponectin - metabolism | Flavonoids - pharmacology | Osteoarthritis - pathology | Interleukin-6 - metabolism | Chondrocytes - metabolism | Extracellular Matrix Proteins - metabolism | Severity of Illness Index | Adiponectin - pharmacology | Cartilage Oligomeric Matrix Protein | Tissue Culture Techniques | Cells, Cultured | Osteoarthritis - metabolism | Extracellular Matrix Proteins - blood | Matrix Metalloproteinase 3 - metabolism | Osteoarthritis - blood | Glycoproteins - blood | Biomarkers - blood | Cartilage - metabolism | Blotting, Western | Adiponectin - blood | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Aged | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 3 - blood | Nitric Oxide - metabolism | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Protein hormones | Research | Osteoarthritis | Protein kinases | Risk factors | Index Medicus
Journal Article
Molecular Biology Reports, ISSN 0301-4851, 9/2014, Volume 41, Issue 9, pp. 5549 - 5555
Journal Article