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Arthritis & Rheumatology, ISSN 2326-5191, 05/2016, Volume 68, Issue 5, pp. 1111 - 1123
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 06/2015, Volume 74, Issue 6, pp. 1311 - 1316
Objective Tofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The pathways affected by tofacitinib and the... 
TRIAL | PATHOGENESIS | CRITERIA | CYTOKINES | PLACEBO | DISEASE | GENE-EXPRESSION | METHOTREXATE | RHEUMATOLOGY | COMBINATION | CP-690,550 | Humans | Middle Aged | STAT Transcription Factors - metabolism | Chemokines - drug effects | Male | Matrix Metalloproteinase 3 - drug effects | Synovial Membrane - drug effects | Methotrexate - therapeutic use | RNA, Messenger - metabolism | STAT Transcription Factors - drug effects | Arthritis, Rheumatoid - metabolism | Janus Kinase 1 - metabolism | Piperidines - pharmacology | Arthritis, Rheumatoid - drug therapy | Adult | Female | Antirheumatic Agents - pharmacology | Drug Therapy, Combination | Pyrroles - therapeutic use | Matrix Metalloproteinase 1 - genetics | Antirheumatic Agents - therapeutic use | RNA, Messenger - drug effects | Matrix Metalloproteinase 1 - drug effects | Double-Blind Method | Matrix Metalloproteinase 3 - metabolism | Treatment Outcome | Pyrimidines - pharmacology | Chemokines - genetics | Janus Kinase 1 - drug effects | Synovial Membrane - metabolism | Pyrroles - pharmacology | Signal Transduction - drug effects | Piperidines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Pyrimidines - therapeutic use | Aged | Chemokines - metabolism | Protein Kinase Inhibitors - pharmacology | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 3 - genetics | Tofacitinib | Rheumatoid arthritis | Dosage and administration | Genetic aspects | Research | Gene expression | Risk factors | Index Medicus | Basic and Translational Research | 1506
Journal Article
Hypertension, ISSN 0194-911X, 03/2014, Volume 63, Issue 3, pp. e60 - e67
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2015, Volume 290, Issue 15, pp. 9842 - 9854
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2012, Volume 7, Issue 2, pp. e31251 - e31251
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e63165 - e63165
Matrix metalloproteinases (MMPs) contribute to cancer through their involvement in cancer invasion and metastasis. We evaluated genetic variation in MMP1 (9... 
POPULATION | MATRIX-METALLOPROTEINASE-2 | WOMEN | MULTILOCUS GENOTYPE DATA | POLYMORPHISMS | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | INFERENCE | MMP-9 | Genetic Predisposition to Disease - genetics | Matrix Metalloproteinases - genetics | Humans | Middle Aged | Risk Factors | Hispanic Americans | European Continental Ancestry Group | Matrix Metalloproteinase 2 - genetics | Breast Neoplasms - enzymology | Breast Neoplasms - genetics | Matrix Metalloproteinase 9 - genetics | Polymorphism, Single Nucleotide - genetics | Adult | Female | Matrix Metalloproteinase 3 - genetics | Matrix Metalloproteinase 1 - genetics | Women | Societies, clubs, etc | Oncology, Experimental | Genes | Development and progression | Breast cancer | Metastasis | Research | Risk factors | Women's organizations | Genetic research | Genetic aspects | Single nucleotide polymorphisms | Native Americans | Cancer | Health care | Matrix metalloproteinases | Single-nucleotide polymorphism | Matrix metalloproteinase | Medical diagnosis | Epidemiology | Population genetics | Metastases | Population | Genetics | Metalloproteinase | Age | Medical research | Stromelysin 1 | Health risks | Genetic diversity | Preventive medicine | Cultural differences | Survival | Minority & ethnic groups | Gelatinase B | Gelatinase A | Disease prevention | Studies | Ethnicity | Womens health | Biomarkers | Breast | Hormone replacement therapy | Health risk assessment | Tumors | Health disparities | Index Medicus
Journal Article
Matrix Biology, ISSN 0945-053X, 2011, Volume 30, Issue 2, pp. 145 - 153
Aggrecan degradation in articular cartilage occurs predominantly through proteolysis and has been attributed to the action of members of the matrix... 
MMP | ADAMTS | Interglobular domain | Chondroitin-sulfate-2 region | Aggrecan catabolism | RHEUMATOID-ARTHRITIS | PROTEOLYTIC CLEAVAGE | CLEAVAGE SITE | ACTIVATION MECHANISMS | LARGE AGGREGATING PROTEOGLYCAN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | HUMAN ARTICULAR-CARTILAGE | MATRIX METALLOPROTEINASES | OSTEOARTHRITIC CARTILAGE | ONCOSTATIN-M | Matrix Metalloproteinases, Secreted - metabolism | Interleukin-1beta - pharmacology | Phenylmercuric Acetate - pharmacology | Matrix Metalloproteinase 12 - genetics | Cartilage - drug effects | Oncostatin M - pharmacology | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 7 - metabolism | Cattle | Isoenzymes - metabolism | Matrix Metalloproteinase 8 - metabolism | Gelatinases - metabolism | Matrix Metalloproteinase 1 - genetics | Recombinant Proteins - metabolism | Endopeptidases - metabolism | Matrix Metalloproteinase 8 - genetics | Peptide Fragments - metabolism | Isoenzymes - genetics | Matrix Metalloproteinase 2 - metabolism | Matrix Metalloproteinase 3 - metabolism | Aggrecans - metabolism | Matrix Metalloproteinase 12 - metabolism | Cartilage - metabolism | Aggrecans - genetics | ADAM Proteins - metabolism | Enzyme Precursors - metabolism | Matrix Metalloproteinase 7 - genetics | Animals | Endopeptidases - genetics | Matrix Metalloproteinases, Secreted - genetics | Phenylmercuric Acetate - analogs & derivatives | ADAM Proteins - genetics | Cartilage - enzymology | Matrix Metalloproteinase 1 - metabolism | Matrix Metalloproteinase 3 - genetics | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2016, Volume 11, Issue 3, pp. e0150020 - e0150020
Journal Article
Journal Article
Stem Cells, ISSN 1066-5099, 11/2009, Volume 27, Issue 11, pp. 2734 - 2743
Recent studies showed that mesenchymal stem cells (MSCs) transplantation significantly decreased cardiac fibrosis; however, the mechanisms involved in these... 
Myocardial infarction | Therapeutic efficacy | Cardiac fibroblasts | Matrix metalloproteinases | Mesenchymal stem cells | MARROW | HEPATOCYTE GROWTH-FACTOR | HEART-FAILURE | PARACRINE ACTIONS | RAT MODEL | TRANSPLANTATION | CELL & TISSUE ENGINEERING | CELL BIOLOGY | IN-VITRO | REPAIR | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | STROMAL CELLS | KIDNEY | HEMATOLOGY | Immunohistochemistry | Actins - metabolism | Culture Media, Conditioned - pharmacology | Myocardial Infarction - therapy | Tissue Inhibitor of Metalloproteinase-2 - metabolism | Matrix Metalloproteinase 9 - metabolism | Mesenchymal Stromal Cells - cytology | Matrix Metalloproteinase 9 - genetics | Myocardial Infarction - pathology | Polymerase Chain Reaction | Fibrosis - prevention & control | Heart Ventricles - pathology | Matrix Metalloproteinase 1 - genetics | Mesenchymal Stromal Cells - physiology | Fibroblasts - metabolism | Cell Survival - drug effects | Echocardiography | Matrix Metalloproteinase 2 - metabolism | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Rats | Myocardial Infarction - metabolism | Blotting, Western | Mice, Knockout | Collagen - metabolism | Matrix Metalloproteinase 2 - genetics | Animals | Quantum Dots | Fibroblasts - drug effects | Mice | Collagenases - secretion | Matrix Metalloproteinase 1 - metabolism | Mesenchymal Stem Cell Transplantation | Heart Ventricles - drug effects | Index Medicus
Journal Article