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BMC Cancer, ISSN 1471-2407, 01/2009, Volume 9, Issue 1, pp. 20 - 20
Background: The metastatic disease rather than the primary tumor itself is responsible for death in most solid tumors, including breast cancer. The role of... 
KAZAL MOTIFS | MATRIX METALLOPROTEINASES | LUNG-CANCER | IN-VITRO | CYSTEINE-RICH PROTEIN | ONCOLOGY | RT-PCR | EXTRACELLULAR-MATRIX | PROGNOSTIC-SIGNIFICANCE | CARCINOMA | RNA EXPRESSION | Matrix Metalloproteinases - genetics | Tissue Inhibitor of Metalloproteinase-1 - biosynthesis | Humans | Membrane Glycoproteins - biosynthesis | GPI-Linked Proteins | Tissue Inhibitor of Metalloproteinase-2 - genetics | Breast Neoplasms - metabolism | Tissue Inhibitor of Metalloproteinases - genetics | Matrix Metalloproteinase 14 - biosynthesis | RNA, Messenger - biosynthesis | Breast Neoplasms - enzymology | Neoplasm Metastasis | Matrix Metalloproteinase 9 - genetics | Tissue Inhibitor of Metalloproteinase-2 - biosynthesis | Matrix Metalloproteinase 2 - biosynthesis | Tissue Inhibitor of Metalloproteinases - biosynthesis | Matrix Metalloproteinases - biosynthesis | Matrix Metalloproteinase 9 - biosynthesis | Neoplasm Invasiveness | RNA, Messenger - genetics | Reverse Transcriptase Polymerase Chain Reaction | Membrane Glycoproteins - genetics | Matrix Metalloproteinase 2 - genetics | Tissue Inhibitor of Metalloproteinase-1 - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Matrix Metalloproteinase 14 - genetics | Cell Line, Tumor | Care and treatment | Prognosis | Enzyme inhibitors | Proteases | Breast cancer | Genetic aspects | Dosage and administration | Research | Gene expression | Health aspects
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 04/2007, Volume 27, Issue 4, pp. 697 - 709
Matrix metalloproteinases (MMPs) disrupt the blood—brain barrier (BBB) during reperfusion. Occludin and claudins are recently described tight junction proteins... 
Blood-brain barrier opening | Claudin-5 | Matrix metalloproteinases | Rat | Middle cerebral artery occlusion | Occludin | ACTIVATION | rat | PERMEABILITY | REPERFUSION | PROTEOLYSIS | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | occludin | STRANDS | TYROSINE PHOSPHATASE INHIBITION | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | MATRIX-METALLOPROTEINASE-9 | HEMATOLOGY | matrix metalloproteinases | blood-brain barrier opening | middle cerebral artery occlusion | claudin-5 | Enzyme Activators - pharmacology | Immunohistochemistry | Cerebral Veins - metabolism | Sucrose | Brain Ischemia - metabolism | Male | Cerebral Arteries - drug effects | Protease Inhibitors - pharmacology | RNA, Messenger - biosynthesis | Gelatinases - metabolism | Membrane Proteins - metabolism | Matrix Metalloproteinases - biosynthesis | Tight Junctions - drug effects | Rats, Inbred SHR | Tight Junctions - metabolism | Astrocytes - drug effects | Furin - biosynthesis | Cerebral Veins - drug effects | Reperfusion Injury - pathology | Endothelial Cells - metabolism | Matrix Metalloproteinase 2 - metabolism | Rats | Infarction, Middle Cerebral Artery - pathology | Reverse Transcriptase Polymerase Chain Reaction | Blood-Brain Barrier - drug effects | Blotting, Western | Nerve Tissue Proteins - metabolism | Animals | Evans Blue | Cerebral Arteries - metabolism | Brain Ischemia - drug therapy | Matrix Metalloproteinase Inhibitors | Matrix Metalloproteinases - physiology | Astrocytes - metabolism | Endothelial Cells - drug effects
Journal Article
The Journal of Immunology, ISSN 0022-1767, 03/2003, Volume 170, Issue 6, pp. 3369 - 3376
IL-8, a member of the chemokine family, has been shown to play an important role in tumor growth, angiogenesis, and metastasis. The objective of this study was... 
CARCINOMA-CELLS | C-X-C | BCL-X | HUMAN-MELANOMA CELLS | NON-HODGKINS-LYMPHOMA | MALIGNANT-MELANOMA | IMMUNOLOGY | TUMOR-GROWTH | HUMAN INTERLEUKIN-8 | EXPRESSION | CANCER | Endothelium, Vascular - cytology | Matrix Metalloproteinases - genetics | Receptors, Interleukin-8A - biosynthesis | Humans | Receptors, Interleukin-8A - genetics | Cell Survival - genetics | Apoptosis - genetics | Interleukin-8 - physiology | Endothelium, Vascular - enzymology | Cell Movement - genetics | Capillaries - physiology | Cell Movement - immunology | RNA, Messenger - biosynthesis | Cell Division - immunology | Matrix Metalloproteinase 9 - genetics | Interleukin-8 - metabolism | Matrix Metalloproteinase 2 - biosynthesis | Endothelium, Vascular - immunology | Matrix Metalloproteinases - biosynthesis | Cell Division - genetics | Receptors, Interleukin-8B - physiology | Recombinant Proteins - metabolism | Cell Line | Matrix Metalloproteinase 9 - biosynthesis | Neovascularization, Physiologic - genetics | Up-Regulation - genetics | Recombinant Proteins - pharmacology | Cell Survival - immunology | Neovascularization, Physiologic - immunology | Down-Regulation - genetics | Matrix Metalloproteinase 2 - genetics | Apoptosis - immunology | Receptors, Interleukin-8B - biosynthesis | Up-Regulation - immunology | Down-Regulation - immunology | Endothelium, Vascular - metabolism | Receptors, Interleukin-8B - genetics | Receptors, Interleukin-8A - physiology
Journal Article
Experimental Neurology, ISSN 0014-4886, 2010, Volume 226, Issue 1, pp. 183 - 190
Blood–brain barrier (BBB) breakdown after stroke is linked to the up-regulation of metalloproteinases (MMPs) and inflammation. This study examines the effects... 
Permanent middle cerebral artery occlusion | Tumor necrosis factor-alpha | Cytokines | Ischemia | Tight junction proteins | Inflammatory response | Progesterone | Metalloproteinases | Allopregnanolone | Blood–brain barrier | Blood-brain barrier | MIDDLE CEREBRAL-ARTERY | FUNCTIONAL DEFICITS | MALE RATS | EXPERIMENTAL STROKE | GENE KNOCK-OUT | NEUROSCIENCES | INFARCT VOLUME | PLASMINOGEN-ACTIVATOR | NEUROPROTECTIVE FACTOR | MEDIATED DISRUPTION | CENTRAL-NERVOUS-SYSTEM | Immunohistochemistry | Male | Occludin | Brain Ischemia - enzymology | Stroke - pathology | Ligation | Progesterone - pharmacology | Matrix Metalloproteinase 2 - biosynthesis | Matrix Metalloproteinases - biosynthesis | Matrix Metalloproteinase 9 - biosynthesis | Brain Edema - pathology | Rats | Claudin-5 | Middle Cerebral Artery - pathology | Stroke - drug therapy | Infarction, Middle Cerebral Artery - pathology | Permeability | Blood-Brain Barrier - drug effects | Rats, Sprague-Dawley | Blotting, Western | Membrane Proteins - biosynthesis | Animals | Blood-Brain Barrier - enzymology | Pregnanolone - pharmacology | Brain Ischemia - pathology | Interleukin-6 - biosynthesis | Tumor Necrosis Factor-alpha - biosynthesis | Proteins | Analysis | blood-brain barrier | tumor necrosis factor-alpha | progesterone | inflammatory response | metalloproteinases | tight junction proteins | allopregnanolone | cytokines | permanent middle cerebral artery occlusion | ischemia
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 10/2013, Volume 272, Issue 1, pp. 180 - 190
Journal Article
Gut, ISSN 0017-5749, 06/2009, Volume 58, Issue 6, pp. 777 - 789
Background and Aims: In addition to its crucial role in dampening tissue-damaging immune responses in the gut, transforming growth factor beta (TGF beta) is a... 
MIGRATION | CELLS | INFLAMMATORY-BOWEL-DISEASE | COLLAGEN | GUT INFLAMMATION | TISSUE INHIBITOR | STROMELYSIN-1 | INTESTINAL MYOFIBROBLASTS | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | FIBROBLASTS | Intestinal Mucosa - metabolism | Humans | Middle Aged | Crohn Disease - metabolism | Matrix Metalloproteinase 12 - genetics | Smad3 Protein - metabolism | Case-Control Studies | Young Adult | Smad3 Protein - genetics | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Transforming Growth Factor beta - analysis | Tissue Inhibitor of Metalloproteinase-1 - analysis | Cellular Senescence | Reverse Transcriptase Polymerase Chain Reaction - methods | Smad2 Protein - genetics | Adult | Fibroblasts - metabolism | Matrix Metalloproteinases - biosynthesis | Blotting, Western - methods | Colon - pathology | Cells, Cultured | Smad2 Protein - metabolism | Matrix Metalloproteinase 3 - metabolism | Matrix Metalloproteinases - analysis | Matrix Metalloproteinase 12 - metabolism | Matrix Metalloproteinase 3 - analysis | Transforming Growth Factor beta - genetics | Crohn Disease - pathology | Fibrosis | Signal Transduction - physiology | Aged | Smad3 Protein - analysis | Matrix Metalloproteinase 3 - genetics | Smad2 Protein - analysis | Transforming Growth Factor beta - metabolism | Apoptosis | Intestinal Mucosa - pathology | Matrix Metalloproteinase 12 - analysis
Journal Article
Journal Article