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1. Full Text Regulation of the p53 response and its relationship to cancer
by Meek, David W
Biochemical Journal, ISSN 0264-6021, 08/2015, Volume 469, Issue 3, pp. 325 - 346
p53 has been studied intensively as a major tumour suppressor that detects oncogenic events in cancer cells and eliminates them through senescence (a permanent... 
Post-translational modification | MDM2 | Tumour suppressor | Signalling | p53 | MDM2 E3 LIGASE | tumour suppressor | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CYCLE ARREST | POSTTRANSLATIONAL MODIFICATIONS | post-translational modification | ONCOGENE-INDUCED SENESCENCE | IN-VIVO | MUTANT P53 | TUMOR-SUPPRESSOR PROTEIN | DNA-DAMAGE-RESPONSE | NF-KAPPA-B | ACTIVATES P53 | signalling | Neoplasms - metabolism | Proto-Oncogene Proteins c-mdm2 - genetics | Animals | Neoplasms - genetics | Humans | Tumor Suppressor Protein p53 - metabolism | Proto-Oncogene Proteins c-mdm2 - metabolism | Tumor Suppressor Protein p53 - genetics
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2. Full Text Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication
by Klusmann, Ina and Wohlberedt, Kai and Magerhans, Anna and Teloni, Federico and Korbel, Jan O and Altmeyer, Matthias and Dobbelstein, Matthias and Dobbelstein, Matthias
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2018, Volume 115, Issue 48, pp. E11311 - E11320
The p53-Mdm2 system is key to tumor suppression. We have recently reported that p53 as well as Mdm2 are capable of supporting DNA replication fork progression.... 
Ubiquitin | Mdm2 | Histone | RNF2 | P53 | COMPLEX | STABILITY | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | R-LOOPS | ubiquitin | DAMAGE | FORKS | p53 | CONFLICTS | REPAIR | DEGRADATION | histone | STRESS | Chromatin - metabolism | Proto-Oncogene Proteins c-mdm2 - genetics | Tumor Suppressor Proteins - metabolism | Polycomb Repressive Complex 1 - metabolism | Humans | DNA Replication | DNA - metabolism | Proto-Oncogene Proteins c-mdm2 - chemistry | Ubiquitin Thiolesterase - genetics | RNA - genetics | DNA - genetics | Polycomb Repressive Complex 1 - genetics | Ubiquitination | Histones - genetics | Tumor Suppressor Proteins - genetics | Cell Line, Tumor | Protein Domains | Ubiquitin Thiolesterase - metabolism | Histones - metabolism | Chromatin - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | RNA - metabolism | Chromatin | MDM2 protein | Hybrids | Transcription elongation | p53 Protein | Ribonuclease H | Ribonucleic acid--RNA | Kinases | DNA biosynthesis | Polycomb group proteins | Depletion | Replication | Deoxyribonucleic acid--DNA | Ubiquitin-protein ligase | Elongation | Biological Sciences | PNAS Plus
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3. Full Text Regulation of the Mdm2–p53 pathway by the ubiquitin E3 ligase MARCH7
by Zhao, Kailiang and Yang, Yang and Zhang, Guang and Wang, Chenfeng and Wang, Decai and Wu, Mian and Mei, Yide
EMBO reports, ISSN 1469-221X, 02/2018, Volume 19, Issue 2, pp. 305 - 319
The tumor suppressor p53 plays a prominent role in the protection against cancer. The activity of p53 is mainly controlled by the ubiquitin E3 ligase Mdm2,... 
Mdm2 | MARCH7 | ubiquitination | p53 | TARGETING MDM2 | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | CELL BIOLOGY | MDM2-DEFICIENT MICE | INHIBITORY-FACTOR LIF | P53 ACTIVATION | ACUTE LYMPHOBLASTIC-LEUKEMIA | EMBRYONIC LETHALITY | GENE AMPLIFICATION | STABILIZES MDM2 | Proto-Oncogene Proteins c-mdm2 - genetics | HCT116 Cells | Humans | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Male | Tumor Suppressor Protein p53 - genetics | Animals | DNA Damage - physiology | Mice, Nude | HEK293 Cells | DNA Damage - genetics | Protein Binding | Mice | Ubiquitination - physiology | Ubiquitin-Protein Ligases - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Ubiquitination - genetics | Cell proliferation | Ubiquitin | MDM2 protein | Stabilization | p53 Protein | DNA damage | Degradation | Cell growth | Proteasomes | Tumor suppressor genes | Tumorigenesis | Ubiquitin-protein ligase | Deoxyribonucleic acid--DNA | Apoptosis | Cancer | Post-translational Modifications, Proteolysis & Proteomics
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4. Full Text Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1
by Sun, Xiao‐Xin and Challagundla, Kishore B and Dai, Mu‐Shui
The EMBO Journal, ISSN 0261-4189, 02/2012, Volume 31, Issue 3, pp. 576 - 592
The ubiquitin (Ub)–proteasome system plays a pivotal role in the regulation of p53 protein stability and activity. p53 is ubiquitinated and destabilized by... 
Otub1 | MDM2 | deubiquitinating enzyme | ubiquitination | p53 | MDM2 GENE AMPLIFICATION | UBIQUITIN-PROTEIN LIGASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR EXPORT | RIBOSOMAL STRESS | CELL BIOLOGY | ONCOPROTEIN MDM2 | MDM2-DEFICIENT MICE | AUTOREGULATORY FEEDBACK LOOP | MECHANISTIC INSIGHTS | EMBRYONIC LETHALITY | TUMOR-SUPPRESSOR | Biocatalysis | Cell Proliferation | Humans | Tumor Suppressor Protein p53 - metabolism | Proto-Oncogene Proteins c-mdm2 - physiology | DNA Primers | Gene Knockdown Techniques | Tumor Suppressor Protein p53 - physiology | Transcription, Genetic - physiology | Cysteine Endopeptidases - metabolism | Base Sequence | Cysteine Endopeptidases - genetics | Cell Line, Tumor | Protein Binding | DNA Damage | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proteins | Enzymes | Signal transduction | Cellular biology
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5. Full Text Signaling to p53: Ribosomal Proteins Find Their Way
by Zhang, Yanping and Lu, Hua
Cancer Cell, ISSN 1535-6108, 2009, Volume 16, Issue 5, pp. 369 - 377
Inherently disparate cell growth and division, which are intimately coupled through a delicate network of intracellular and extracellular signaling, require... 
CELLCYCLE | ONCOPROTEIN MDM2 | ONCOLOGY | IN-VIVO | DIAMOND-BLACKFAN ANEMIA | C-MYC | EMBRYONIC LETHALITY | NON-ONCOGENE ADDICTION | CELL-CYCLE | ACTIVATES P53 | UBIQUITIN LIGASE ACTIVITY | ZINC-FINGER DOMAIN | CELL BIOLOGY | Proto-Oncogene Proteins c-mdm2 - genetics | Ubiquitination | Animals | Signal Transduction | Ribosomal Proteins - genetics | Humans | Tumor Suppressor Protein p53 - metabolism | Cell Cycle - physiology | Proto-Oncogene Proteins c-mdm2 - metabolism | Tumor Suppressor Protein p53 - genetics | Ribosomal Proteins - metabolism | Ubiquitin | Biosynthesis | Ribosomal proteins | Tumor proteins | Protein binding | RPL5 | Ribosome biogenesis | RPL23 | RPL11 | MDM2 | nucleolus | cancer | zinc finger | p53
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6. Full Text Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
by Chen, D and Zhang, Z and Li, M and Wang, W and Li, Y and Rayburn, E.R and Hill, D.L and Wang, H and Zhang, R
Oncogene, ISSN 0950-9232, 08/2007, Volume 26, Issue 35, pp. 5029 - 5037
As a major negative regulator of p53, the MDM2 oncogene plays an important role in carcinogenesis and tumor progression. MDM2 promotes p53 proteasomal... 
Protein degradation | Ubiquitination | RPS7 | MDM2 | Tumor suppressor | p53 | Proteasome | proteasome | TUMOR SUPPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | tumor suppressor | RIBOSOME BIOGENESIS | NEGATIVE REGULATOR | CELL BIOLOGY | ONCOPROTEIN MDM2 | INHIBITION | ONCOLOGY | ubiquitination | PATHWAY | PROSTATE-CANCER | GENETICS & HEREDITY | DEGRADATION | IN-VIVO ACTIVITIES | protein degradation | Ribosomal Proteins - chemistry | Proto-Oncogene Proteins c-mdm2 - genetics | Gene Library | Ribosomal Proteins - genetics | Humans | Tumor Suppressor Protein p53 - metabolism | Male | Proto-Oncogene Proteins c-mdm2 - chemistry | Prostate - metabolism | Tumor Suppressor Protein p53 - genetics | Ribosomal Proteins - metabolism | Two-Hybrid System Techniques | Cell Line, Tumor | Tumor Suppressor Protein p53 - chemistry | Proto-Oncogene Proteins c-mdm2 - metabolism | Apoptosis | Tumor suppressor genes | Genetic aspects | Research | Ribosomal proteins | Ubiquitin-proteasome system | Proteolysis | Proteins | Oncology | Genes | Binding sites | Cancer
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7. Full Text Targeted Inactivation of Mdm2 RING Finger E3 Ubiquitin Ligase Activity in the Mouse Reveals Mechanistic Insights into p53 Regulation
by Itahana, Koji and Itahana, Yoko and Mao, Hua and Jin, Aiwen and Clegg, Hilary V and Lindström, Mikael S and Bhat, Krishna P and Godfrey, Virginia L and Evan, Gerard I and Zhang, Yanping
Cancer Cell, ISSN 1535-6108, 10/2007, Volume 12, Issue 4, pp. 355 - 366
It is believed that Mdm2 suppresses p53 in two ways: transcriptional inhibition by direct binding, and degradation via its E3 ligase activity. To study these... 
CELLCYCLE | ONCOPROTEIN MDM2 | DOMAIN | ACTIVATION | PROTEIN | AMPLIFICATION | REPRESSION | ONCOLOGY | NUCLEOLAR-LOCALIZATION | IN-VIVO | DEGRADATION | CELL-PROLIFERATION | Gamma Rays | Fibroblasts - enzymology | Proto-Oncogene Proteins c-mdm2 - genetics | Embryo, Mammalian | Transcription, Genetic - radiation effects | Proto-Oncogene Proteins c-mdm2 - chemistry | Tumor Suppressor Protein p53 - genetics | Proto-Oncogene Proteins c-mdm2 - metabolism | Fibroblasts - metabolism | Protein Structure, Tertiary | Mutagenesis, Site-Directed | Down-Regulation | Mice, Inbred C57BL | Cells, Cultured | Proto-Oncogene Proteins c-mdm2 - deficiency | Tumor Suppressor Protein p53 - metabolism | Genotype | Tumor Suppressor Protein p53 - deficiency | Gestational Age | Mice, Knockout | Homozygote | Phenotype | Animals | Gene Expression Regulation, Developmental - radiation effects | Fibroblasts - radiation effects | Mice | DNA Damage | Mutation | Proteasome Endopeptidase Complex - metabolism | Amino Acid Substitution
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8. Full Text The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor
by Manfredi, James J
Genes and Development, ISSN 0890-9369, 08/2010, Volume 24, Issue 15, pp. 1580 - 1589
Mdm2 has been well characterized as a negative regulator of the tumor suppressor p53. Recent studies have shown that Mdm2 is activated in response to a variety... 
Mdm2 | Ubiquitination | Tumorigenesis | Tumor suppressor | Oncogene | p53 | RING-FINGER DOMAIN | DNA-DAMAGE | RIBOSOMAL-PROTEIN L26 | tumor suppressor | CELL-CYCLE ARREST | DEVELOPMENTAL BIOLOGY | oncogene | HUMAN ONCOPROTEIN MDM2 | CELL BIOLOGY | MESSENGER-RNA | ubiquitination | IN-VIVO | GENETICS & HEREDITY | EMBRYONIC LETHALITY | SINGLE NUCLEOTIDE POLYMORPHISM | tumorigenesis | ACTIVATES P53 | Proto-Oncogene Proteins c-mdm2 - genetics | Cell Proliferation | Humans | Gene Expression Regulation, Neoplastic | Tumor Suppressor Protein p53 - metabolism | Tumor Suppressor Protein p53 - genetics | Animals | Cell Differentiation | Epithelial Cells - cytology | Genes, Tumor Suppressor | Proto-Oncogene Proteins c-mdm2 - metabolism | Oncogenes | Apoptosis | Tumor suppressor genes | Research | Genetic regulation | Ubiquitin-proteasome system | Analysis | Review
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9. Full Text Mdm2-mediated ubiquitylation: p53 and beyond
by Marine, J.-C and Lozano, G
Cell Death and Differentiation, ISSN 1350-9047, 01/2010, Volume 17, Issue 1, pp. 93 - 102
The really interesting genes (RING)-finger-containing oncoprotein, Mdm2, is a promising drug target for cancer therapy. A key Mdm2 function is to promote... 
MDM2 | cancer therapy | ubiquitylation | p53 | SOFT-TISSUE SARCOMAS | PROTEASOMAL DEGRADATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | NUCLEAR EXPORT | UBIQUITIN LIGASE ACTIVITY | CELL BIOLOGY | P53-MDM2 FEEDBACK LOOP | LI-FRAUMENI-SYNDROME | P53-DEPENDENT MANNER | IN-VIVO | RING DOMAIN | Neoplasms - therapy | Proto-Oncogene Proteins c-mdm2 - genetics | Ubiquitination | Feedback | Humans | Tumor Suppressor Protein p53 - metabolism | Proto-Oncogene Proteins c-mdm2 - physiology | Proto-Oncogene Proteins c-mdm2 - metabolism | Tumor Suppressor Protein p53 - genetics
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10. Full Text The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches
by Joerger, Andreas C and Fersht, Alan R
Annual Review of Biochemistry, ISSN 0066-4154, 6/2016, Volume 85, Issue 1, pp. 375 - 404
Inactivation of the transcription factor p53, through either direct mutation or aberrations in one of its many regulatory pathways, is a hallmark of virtually... 
cancer therapy | signaling pathways | protein evolution | drug design | p53 family | small-molecule stabilizers | Protein evolution | Signaling pathways | Drug design | Small-molecule stabilizers | P53 family | Cancer therapy | DNA-BINDING DOMAIN | TRANSIENT PROTEIN STATES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-CYCLE ARREST | TUMOR-SUPPRESSOR P53 | CORE-DOMAIN | STRUCTURAL BASIS | SMALL-MOLECULE INHIBITORS | MUTANT P53 | TETRAMERIZATION DOMAIN | TRANSACTIVATION DOMAIN | Neoplasms - metabolism | Proto-Oncogene Proteins c-mdm2 - genetics | Antineoplastic Agents, Alkylating - chemical synthesis | Humans | Protein Multimerization | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins - chemistry | Molecular Targeted Therapy | Proto-Oncogene Proteins c-mdm2 - chemistry | Tumor Suppressor Protein p53 - genetics | Neoplasms - genetics | Tumor Suppressor Protein p53 - agonists | Drug Design | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Protein Structure, Secondary | Signal Transduction | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | Nuclear Proteins - chemistry | Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Animals | Nuclear Proteins - antagonists & inhibitors | Molecular Docking Simulation | Tumor Suppressor Protein p53 - chemistry | Mutation | Neoplasms - pathology | Transcription factors | Care and treatment | Health aspects | Methods | Cancer
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