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1. Full Text The p53 Pathway: Origins, Inactivation in Cancer, and Emerging Therapeutic Approaches
by Joerger, Andreas C and Fersht, Alan R
Annual review of biochemistry, ISSN 0066-4154, 6/2016, Volume 85, Issue 1, pp. 375 - 404
cancer therapy | signaling pathways | protein evolution | drug design | p53 family | small-molecule stabilizers | Protein evolution | Signaling pathways | Drug design | Small-molecule stabilizers | P53 family | Cancer therapy | Neoplasms - metabolism | Proto-Oncogene Proteins c-mdm2 - genetics | Antineoplastic Agents, Alkylating - chemical synthesis | Humans | Protein Multimerization | Gene Expression Regulation, Neoplastic | Proto-Oncogene Proteins - chemistry | Molecular Targeted Therapy | Proto-Oncogene Proteins c-mdm2 - chemistry | Tumor Suppressor Protein p53 - genetics | Neoplasms - genetics | Tumor Suppressor Protein p53 - agonists | Drug Design | Nuclear Proteins - genetics | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Protein Structure, Secondary | Signal Transduction | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | Nuclear Proteins - chemistry | Neoplasms - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Animals | Nuclear Proteins - antagonists & inhibitors | Molecular Docking Simulation | Tumor Suppressor Protein p53 - chemistry | Mutation | Neoplasms - pathology | Transcription factors | Care and treatment | Health aspects | Methods | Cancer | Medical screening | Tumors | Index Medicus
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2. Full Text MDM2/X inhibitors under clinical evaluation: Perspectives for the management of hematological malignancies and pediatric cancer
by Tisato, Veronica and Voltan, Rebecca and Gonelli, Arianna and Secchiero, Paola and Zauli, Giorgio
Journal of hematology and oncology, ISSN 1756-8722, 07/2017, Volume 10, Issue 1, pp. 133 - 133
MDM2 | Pediatric tumors | Clinical studies | Leukemia | MDMX | Pharmacological inhibitor | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Proto-Oncogene Proteins c-mdm2 - genetics | Protein Interaction Maps - drug effects | para-Aminobenzoates - pharmacology | Humans | Spiro Compounds - therapeutic use | Antineoplastic Agents - therapeutic use | Hematologic Neoplasms - pathology | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Imidazolines - therapeutic use | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Nuclear Proteins - genetics | Child | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Hematologic Neoplasms - metabolism | Molecular Targeted Therapy - methods | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Suppressor Protein p53 - metabolism | Imidazolines - pharmacology | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Animals | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | para-Aminobenzoates - therapeutic use | Hematologic Neoplasms - drug therapy | Indoles - therapeutic use | Hematologic Neoplasms - genetics | Spiro Compounds - pharmacology | Pediatrics | Medical research | Clinical trials | Medicine, Experimental | Development and progression | Tumor proteins | Cancer | Cell proliferation | MDM2 protein | Animal models | Medical innovations | p53 Protein | Genomics | Multiple myeloma | Genomes | Lymphoma | Proteins | Side effects | Chemotherapy | Cell cycle | Mutation | Chromosomes | Regulatory proteins | Tumors | Index Medicus
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3. Full Text Mdm2-mediated ubiquitylation: p53 and beyond
by Marine, J.-C and Lozano, G
Cell death and differentiation, ISSN 1350-9047, 01/2010, Volume 17, Issue 1, pp. 93 - 102
MDM2 | cancer therapy | ubiquitylation | p53 | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - therapy | Proto-Oncogene Proteins c-mdm2 - genetics | Ubiquitination | Feedback | Humans | Tumor Suppressor Protein p53 - metabolism | Proto-Oncogene Proteins c-mdm2 - physiology | Proto-Oncogene Proteins c-mdm2 - metabolism | Tumor Suppressor Protein p53 - genetics | Index Medicus
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