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Science, ISSN 0036-8075, 7/2009, Volume 325, Issue 5937, pp. 207 - 210
μ-Opioid receptor (MOR) agonists represent the gold standard for the treatment of severe pain but may paradoxically also enhance pain sensitivity, that is,... 
Receptors | Neurons | N methyl D aspartate receptors | Long term potentiation | Agonists | Reports | Pipettes | Synapses | Unmyelinated nerve fibers | Opioid analgesics | Posterior horn | PROTEIN-KINASE-C | SPINAL MORPHINE | ACTIVATION | PAIN | INDUCED HYPERALGESIA | MULTIDISCIPLINARY SCIENCES | NEURONS | MORPHINE-WITHDRAWAL | CELLULAR MECHANISMS | ANTINOCICEPTIVE TOLERANCE | DEPENDENCE | Hyperalgesia - chemically induced | Posterior Horn Cells - drug effects | Calcium - metabolism | Enkephalin, Ala-MePhe-Gly- - administration & dosage | Evoked Potentials | Receptors, N-Methyl-D-Aspartate - metabolism | Analgesics, Opioid - pharmacology | Enkephalin, Ala-MePhe-Gly- - adverse effects | Male | Receptors, Opioid, mu - agonists | Analgesics, Opioid - adverse effects | Long-Term Potentiation - drug effects | Piperidines - pharmacology | Synapses - drug effects | Piperidines - administration & dosage | Nerve Fibers, Unmyelinated - physiology | Signal Transduction | Enkephalin, Ala-MePhe-Gly- - pharmacology | Synapses - physiology | Rats | Rats, Sprague-Dawley | Patch-Clamp Techniques | Animals | Analgesics, Opioid - administration & dosage | Piperidines - adverse effects | Posterior Horn Cells - physiology | Substance Withdrawal Syndrome - physiopathology | GTP-Binding Proteins - metabolism | Drug withdrawal symptoms | Opioids | Development and progression | Neural transmission | Observations | Properties | Health aspects | Signal transduction | Neurosciences | Pharmacology | Binding sites | Pain management | Index Medicus
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 09/2016, Volume 92, pp. 173 - 182
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2010, Volume 649, Issue 1, pp. 336 - 341
Pruritus is a common adverse effect of opioid treatment. However, the mechanism by which pruritus is induced by opioid administration is unclear. In this... 
Naloxone methiodide | Peripheral opioid receptor | Loperamide | Itch | DAMGO | SYSTEM | INDUCED PRURITUS | ACTIVATION | MORPHINE | DELTA | NALOXONE | RESPONSES | KAPPA | PHARMACOLOGY & PHARMACY | SKIN | Analgesics, Opioid - antagonists & inhibitors | Analgesics, Opioid - toxicity | Opioid-Related Disorders - drug therapy | Loperamide - toxicity | Enkephalin, Ala-MePhe-Gly- - administration & dosage | Antipruritics - therapeutic use | Analgesics, Opioid - pharmacology | Male | Receptors, Opioid, mu - agonists | Antipruritics - pharmacology | Dose-Response Relationship, Drug | Loperamide - antagonists & inhibitors | Pruritus - drug therapy | Behavior, Animal - drug effects | Receptors, Opioid, delta - antagonists & inhibitors | Enkephalin, Ala-MePhe-Gly- - antagonists & inhibitors | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - toxicity | Enkephalin, D-Penicillamine (2,5)- - toxicity | Pruritus - chemically induced | Injections, Intradermal | Receptors, Opioid, kappa - antagonists & inhibitors | Loperamide - administration & dosage | Enkephalin, Ala-MePhe-Gly- - pharmacology | Quaternary Ammonium Compounds - therapeutic use | Receptors, Opioid, kappa - agonists | Loperamide - pharmacology | Antipruritics - administration & dosage | Naloxone - therapeutic use | Receptors, Opioid, mu - antagonists & inhibitors | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology | Mice, Inbred ICR | Naloxone - analogs & derivatives | Animals | Analgesics, Opioid - administration & dosage | Enkephalin, Ala-MePhe-Gly- - toxicity | Naloxone - pharmacology | Quaternary Ammonium Compounds - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - pharmacology | Mice | Naloxone - administration & dosage | Receptors, Opioid, delta - agonists | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - therapeutic use | Skin - drug effects | Quaternary Ammonium Compounds - pharmacology | Receptors, Opioid, mu - physiology | Pruritus | Acetic acid
Journal Article
Journal Article
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, ISSN 0363-6119, 07/2008, Volume 295, Issue 1, pp. 243 - 251
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 1/2016, Volume 33, Issue 1, pp. 177 - 185
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 05/2013, Volume 10, Issue 5, pp. 1533 - 1541
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e104420
The analgesic effect of delta-opioid receptor (DOR) ligands in neuropathic pain is not diminished in contrast to other opioid receptor ligands, which lose... 
PERIPHERAL-NERVE INJURY | ROOT GANGLION NEURONS | MORPHINE-TOLERANCE | MULTIDISCIPLINARY SCIENCES | ATTENUATES MECHANICAL ALLODYNIA | SPINAL-CORD | PROINFLAMMATORY CYTOKINES | KNOCKOUT MICE | HETEROLOGOUS DESENSITIZATION | CHRONIC INFLAMMATION | CHEMOKINE RECEPTORS | Microglia - cytology | Receptors, Opioid, delta - metabolism | Microglia - metabolism | Microglia - drug effects | Rats, Wistar | Enkephalin, Ala-MePhe-Gly- - administration & dosage | Cells, Cultured | Analgesics, Opioid - therapeutic use | Male | Neuralgia - drug therapy | Gene Expression Regulation - drug effects | Anti-Bacterial Agents - therapeutic use | Animals | Enkephalin, Ala-MePhe-Gly- - therapeutic use | Analgesics, Opioid - administration & dosage | Minocycline - therapeutic use | Receptors, Opioid, delta - genetics | Minocycline - administration & dosage | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - administration & dosage | Anti-Bacterial Agents - administration & dosage | Morphine - administration & dosage | Receptors, Opioid, delta - agonists | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - therapeutic use | Morphine - therapeutic use | Cell culture | Spinal cord | Immunocytochemistry | Opioid receptors (type mu) | Morphine | Activation | Neuropathy | Spinal cord injury | Drug development | Experiments | Western blotting | Proteins | Receptors | Pain | Dorsal root ganglia | Analgesics | Rodents | Opioid receptors (type kappa) | Down-regulation | Microglial cells | Minocycline | Trends | Injuries | Pain perception | Cytokines | Narcotics | Rats | Inflammation | Pharmacology | Ganglia | Opioid receptors (type delta) | Studies | Analgesia | Deltorphin II | Enkephalins | Ligands | Laboratory animals | Sciatic nerve | Chemokines
Journal Article