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Molecular Cell, ISSN 1097-2765, 06/2015, Volume 58, Issue 6, pp. 977 - 988
Target of Rapamycin (TOR) plays central roles in the regulation of eukaryote growth as the hub of two essential multiprotein complexes: TORC1, which is... 
BINDING PARTNER | GROWTH-CONTROL | PROTEINS SLM1 | KINASE YPK1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PLECKSTRIN HOMOLOGY DOMAIN | ELECTRON-MICROSCOPY | SINGLE-PARTICLE ANALYSIS | ACTIN CYTOSKELETON | SACCHAROMYCES-CEREVISIAE | MASS-SPECTROMETRY | CELL BIOLOGY | Cell Cycle - genetics | TOR Serine-Threonine Kinases - metabolism | Saccharomyces cerevisiae - genetics | Multiprotein Complexes - genetics | Saccharomyces cerevisiae - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Mechanistic Target of Rapamycin Complex 2 | Cell Cycle Proteins - chemistry | Saccharomyces cerevisiae - metabolism | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Biocatalysis - drug effects | Antifungal Agents - metabolism | Cell Cycle Proteins - genetics | Carrier Proteins - chemistry | Antifungal Agents - pharmacology | Protein Structure, Tertiary | Saccharomyces cerevisiae Proteins - ultrastructure | Cell Cycle Proteins - metabolism | Phosphatidylinositol 3-Kinases - chemistry | Binding Sites - genetics | Saccharomyces cerevisiae Proteins - genetics | Sirolimus - metabolism | Microscopy, Electron | Sirolimus - pharmacology | Blotting, Western | Phosphatidylinositol 3-Kinases - genetics | Carrier Proteins - genetics | Drug Resistance - genetics | Multiprotein Complexes - chemistry | Carrier Proteins - metabolism | TOR Serine-Threonine Kinases - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Mutation | Cell Cycle - drug effects | Mass Spectrometry - methods | Saccharomyces cerevisiae Proteins - chemistry | Physiological aspects | Crosslinked polymers | Rapamycin | Molecular biology | Electron microscopy | Mass spectrometry | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 02/2014, Volume 129, Issue 8, pp. 864 - 874
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 11/2013, Volume 128, Issue 19, pp. 2132 - 2144
BACKGROUND—The mechanistic target of rapamycin (mTOR) comprises 2 structurally distinct multiprotein complexes, mTOR complexes 1 and 2 (mTORC1 and mTORC2).... 
RICTOR protein, human | AKT1S1 protein, human | TOR serine-threonine kinases | RICH AKT SUBSTRATE | MAMMALIAN TARGET | SURVIVAL | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | CANCER | AKT1S1 protein | RICTOR protein | MTOR | INHIBITION | PRAS40 | CARDIAC-HYPERTROPHY | DISEASE | PERIPHERAL VASCULAR DISEASE | human | Myocardial Ischemia - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Male | Multiprotein Complexes - genetics | Mechanistic Target of Rapamycin Complex 2 | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - antagonists & inhibitors | TOR Serine-Threonine Kinases - antagonists & inhibitors | Multiprotein Complexes - metabolism | TOR Serine-Threonine Kinases - genetics | Myocardial Infarction - pathology | Rapamycin-Insensitive Companion of mTOR Protein | Recombinant Proteins - metabolism | Myocytes, Cardiac - cytology | Mice, Inbred C57BL | Recombinant Proteins - genetics | Myocardial Infarction - metabolism | Mice, Knockout | Myocardial Ischemia - pathology | Animals | Carrier Proteins - metabolism | Signal Transduction - drug effects | Myocytes, Cardiac - physiology | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Mice | Apoptosis - physiology | Primary Cell Culture | Adaptor Proteins, Signal Transducing - metabolism | Naphthyridines - pharmacology | Prevention | Usage | Ischemia | Rapamycin | Drug therapy | Health aspects | Heart diseases | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 31, pp. 12043 - 12053
Target of rapamycin complex 2 (TORC2) is a widely conserved serine/threonine protein kinase. In the yeast Saccharomyces cerevisiae, TORC2 is essential, playing... 
Prk1 family | FLIPPASES | CYTOSKELETON | signal transduction | BUDDING YEAST | aminophospholipid flippase | BIOCHEMISTRY & MOLECULAR BIOLOGY | Ark1 | REGULATES ACTIN POLARIZATION | target of rapamycin (TOR) | PLASMA-MEMBRANE | Fpk1 | Pan1 | actin | membrane function | SERINE/THREONINE KINASE PRK1P | CELL-GROWTH CONTROL | SIGNALING PATHWAY | endocytosis | PHOSPHOLIPID TRANSLOCATION | in vitro kinase assay | TOR2 | Protein Kinases - metabolism | Sphingolipids - biosynthesis | Protein Kinases - genetics | Saccharomyces cerevisiae - genetics | Saccharomyces cerevisiae - drug effects | Saccharomyces cerevisiae - ultrastructure | Saccharomyces cerevisiae - metabolism | Actin Cytoskeleton - drug effects | Cell Membrane - metabolism | Endocytosis - genetics | Microfilament Proteins - metabolism | Phosphorylation - drug effects | Mechanistic Target of Rapamycin Complex 2 - antagonists & inhibitors | Mechanistic Target of Rapamycin Complex 2 - genetics | Microfilament Proteins - genetics | Cell Membrane - drug effects | Gene Expression Regulation, Fungal | Actin Cytoskeleton - metabolism | Signal Transduction | Endocytosis - drug effects | Cell Membrane - ultrastructure | Saccharomyces cerevisiae Proteins - genetics | Glycogen Synthase Kinase 3 - metabolism | Serine - metabolism | Mechanistic Target of Rapamycin Complex 2 - metabolism | Glycerol - metabolism | Glycogen Synthase Kinase 3 - genetics | Saccharomyces cerevisiae Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | Actin Cytoskeleton - ultrastructure | Index Medicus
Journal Article
The Journal of Physiology, ISSN 0022-3751, 07/2017, Volume 595, Issue 14, pp. 4845 - 4855
Journal Article
Journal Article
The Journal of Pathology, ISSN 0022-3417, 08/2017, Volume 242, Issue 4, pp. 488 - 499
Mammalian target of rapamycin (mTOR) signalling controls many essential cellular functions. However, the role of Rictor/mTOR complex 2 (mTORC2) in regulating... 
Rictor/mTORC2 | macrophage | kidney fibrosis | PHOSPHORYLATION | INJURY | PROLIFERATION | PATHOLOGY | RENAL FIBROSIS | FIBROBLAST ACTIVATION | REPAIR | ONCOLOGY | PATHWAY | DISEASE | MTOR COMPLEX | POLARIZATION | Carrier Proteins - physiology | Macrophage Activation - physiology | Kidney - pathology | Mice, Inbred C57BL | Cells, Cultured | Male | Mechanistic Target of Rapamycin Complex 2 | Cell Movement - physiology | Multiprotein Complexes - physiology | Kidney - metabolism | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Up-Regulation - physiology | Fibrosis | Cell Polarity - physiology | Signal Transduction - physiology | TOR Serine-Threonine Kinases - physiology | Cytokines - biosynthesis | Disease Models, Animal | Rapamycin-Insensitive Companion of mTOR Protein | Chronic kidney failure | Macrophages | Growth factors | Analysis | TOR protein | Polarization | Protein kinase C | Platelet-derived growth factor | Leukocyte migration | Interleukin | AKT protein | Activation | Kinases | Cell adhesion & migration | Connective tissues | Signal transduction | Interleukin 4 | Cell activation | Reperfusion | Ischemia | Clonal deletion | Deletion | Bone marrow | Inhibition | Ureter | Conditioning | Vascular endothelial growth factor | Kidneys | Cytokines | Connective tissue growth factor | Rapamycin | Inflammation | Mammals | Patients | Ablation | Signaling | Protein kinase | Mice | Kidney diseases | Cell migration | Kidney transplantation | Index Medicus
Journal Article
Journal Article
Journal Article