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1. Full Text Hydrogen Peroxide Inducible DNA Cross-Linking Agents: Targeted Anticancer Prodrugs
by Kuang, Yunyan and Balakrishnan, Kumudha and Gandhi, Varsha and Peng, Xiaohua
Journal of the American Chemical Society, ISSN 0002-7863, 12/2011, Volume 133, Issue 48, pp. 19278 - 19281
The major concern for anticancer chemotherapeutic agents is the host toxicity. The development of anticancer prodrugs targeting the unique biochemical... 
NUCLEOTIDE | OXYGEN | REPAIR | QUINONE METHIDES | SUBSTITUENTS | DUPLEX | STRESS | CANCER | CHEMISTRY, MULTIDISCIPLINARY | LIVING CELLS | PROBES | Reactive Oxygen Species - metabolism | Humans | Antineoplastic Agents, Alkylating - pharmacology | Mechlorethamine - chemistry | Intercalating Agents - pharmacology | Prodrugs - chemistry | DNA - metabolism | Intercalating Agents - chemistry | Mechlorethamine - pharmacology | Prodrugs - metabolism | Hydrogen Peroxide - metabolism | Neoplasms - drug therapy | Intercalating Agents - metabolism | Mechlorethamine - metabolism | Drug Design | Cell Line, Tumor | Antineoplastic Agents, Alkylating - chemistry | Prodrugs - pharmacology | Antineoplastic Agents, Alkylating - metabolism | Antimitotic agents | Composition | Hydrogen peroxide | Analysis | Cancer cells | Physiological aspects | Research | Chemical properties | Antineoplastic agents | Alkylation | Pharmaceutical chemistry | Binding sites (Biochemistry) | Index Medicus | H2O2-activation | arylboronate and arylboronic acid | Interstrand crosslink | anticancer prodrug | ROS-targeting
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2. Extrahelical cytosine bases in DNA duplexes containing d[GCC] sub(n) times d[GCC] sub(n) repeats: detection by a mechlorethamine crosslinking reaction
by Rojsitthisak, P and Romero, RM and Haworth, IS
Nucleic Acids Research, ISSN 0305-1048, 11/2001, Volume 29, Issue 22, pp. 4716 - 4723
The cytosine-cytosine (C-C) pair is one of the least stable DNA mismatch pairs. The bases of the C-C mismatch are only weakly hydrogen bonded, and previous... 
mechlorethamine
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3. Full Text The efficacy and tolerability of adriamycin, bleomycin, vinblastine, dacarbazine and Stanford V in older Hodgkin lymphoma patients: a comprehensive analysis from the North American intergroup trial E2496
by Evens, Andrew M and Hong, Fangxin and Gordon, Leo I and Fisher, Richard I and Bartlett, Nancy L and Connors, Joseph M and Gascoyne, Randy D and Wagner, Henry and Gospodarowicz, Mary and Cheson, Bruce D and Stiff, Patrick J and Advani, Ranjana and Miller, Thomas P and Hoppe, Richard T and Kahl, Brad S and Horning, Sandra J
British Journal of Haematology, ISSN 0007-1048, 04/2013, Volume 161, Issue 1, pp. 76 - 86
Summary There is a lack of contemporary prospective data examining the adriamycin, bleomycin, vinblastine, dacarbazine (ABVD) and Stanford V (SV; doxorubicin,... 
bleomycin lung toxicity | treatment‐related toxicity | elderly | Hodgkin lymphoma | Bleomycin lung toxicity | Treatment-related toxicity | Elderly | DISEASE PATIENTS | POPULATION | PROGNOSIS | LONG-TERM SURVIVAL | INTENSITY | TOXICITY | treatment-related toxicity | CHEMOTHERAPY | OUTCOMES | HEMATOLOGY | ELDERLY-PATIENTS | EPSTEIN-BARR-VIRUS | Lung Diseases - chemically induced | Dacarbazine - adverse effects | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Age Factors | Hodgkin Disease - pathology | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Mechlorethamine - adverse effects | Male | Vinblastine - administration & dosage | Vinblastine - adverse effects | Aged, 80 and over | Hodgkin Disease - drug therapy | Vincristine - administration & dosage | Female | Doxorubicin - administration & dosage | Hematologic Diseases - chemically induced | Dacarbazine - administration & dosage | Prednisone - administration & dosage | Etoposide - adverse effects | Prednisone - adverse effects | Etoposide - administration & dosage | Treatment Outcome | Bleomycin - administration & dosage | Bleomycin - adverse effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Survival Analysis | Vincristine - adverse effects | Aged | Mechlorethamine - administration & dosage | Neoplasm Staging | Doxorubicin - adverse effects | Index Medicus | Mechlorethamine | Vinblastine | Toxicity | Lung | Mortality | Clinical trials | Etoposide | Data processing | Prednisone | Doxorubicin | Survival | Vincristine | Dacarbazine | Chemotherapy | Bleomycin | Age | Hodgkin's disease
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4. Full Text Topical nitrogen mustard therapy in patients with mycosis fungoides or parapsoriasis
by Lindahl, L.M and Fenger‐Gron, M and Iversen, L
Journal of the European Academy of Dermatology and Venereology, ISSN 0926-9959, 02/2013, Volume 27, Issue 2, pp. 163 - 168
Background  Topical nitrogen mustard is a chemotherapeutic agent used in treatment of mycosis fungoides (MF). Objective  To evaluate the response and side... 
DIAGNOSIS | MANAGEMENT | STAGE | EORTC | T-CELL LYMPHOMA | EXPERIENCE | SEZARY-SYNDROME | MECHLORETHAMINE | CHEMOTHERAPY | RADIATION-THERAPY | DERMATOLOGY | Recurrence | Humans | Middle Aged | Mechlorethamine - adverse effects | Male | Treatment Outcome | Mechlorethamine - therapeutic use | Disease Progression | Mycosis Fungoides - drug therapy | Parapsoriasis - drug therapy | Aged, 80 and over | Adult | Female | Aged | Mechlorethamine - administration & dosage | Retrospective Studies | Administration, Topical | Mycosis fungoides | Mycoses | Care and treatment | Chemotherapy | Cancer
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5. Full Text Synthesis and analysis of activity of a potential anti-melanoma prodrug with a hydrazine linker
by Frąckowiak-Wojtasek, Bożena and Gąsowska-Bajger, Beata and Mazurek, Magdalena and Raniszewska, Agnieszka and Logghe, Marieke and Smolarczyk, Ryszard and Cichoń, Tomasz and Szala, Stanisław and Wojtasek, Hubert
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2014, Volume 71, pp. 98 - 104
A potential anti-melanoma prodrug containing a phenolic activator, a hydrazine linker, and a nitrogen mustard effector – (... 
Anti-melanoma prodrug | Hydrazine | Nitrogen mustard | Tyrosinase | CHEMISTRY, MEDICINAL | THERAPY MDEPT | MELANOGENESIS | MALIGNANT-MELANOMA | INDIRECT OXIDATION | TARGETED TREATMENT | MUSHROOM TYROSINASE | DOPAMINE | CANDIDATES | Hydrazines - pharmacology | Melanoma, Experimental - drug therapy | Mechlorethamine - chemistry | Prodrugs - chemistry | Mechlorethamine - chemical synthesis | Hydrazines - metabolism | Mechlorethamine - pharmacology | Prodrugs - metabolism | Monophenol Monooxygenase - metabolism | Hydrazines - chemistry | Hydrazines - chemical synthesis | Animals | Mechlorethamine - metabolism | Cyclization | Cell Line, Tumor | Prodrugs - chemical synthesis | Mice | Prodrugs - pharmacology | Enzymes | Nitrogen | Analysis | Quinone | Melanoma
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6. Necrotic leg ulcers after topical application of chlormethine
by Gary, C and Gautier, V and Lazareth, I and Bagot, M and Asgari, R and Priollet, P
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, ISSN 0151-9638, 03/2019, Volume 146, Issue 3, pp. 226 - 231
Background. - Topical chlormethine has been widely used in the early stages of mycosis fungoides for many years. Cutaneous reactions (skin irritation and itch)... 
Leg ulcer | 5-FLUOROURACIL | Chlormethine | Side effects | Mechlorethamine | CREAM | MECHLORETHAMINE THERAPY | Mycosis fungoides | MYCOSIS-FUNGOIDES | DERMATOLOGY
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7. Full Text Randomized Phase III Trial of ABVD Versus Stanford V With or Without Radiation Therapy in Locally Extensive and Advanced-Stage Hodgkin Lymphoma: An Intergroup Study Coordinated by the Eastern Cooperative Oncology Group (E2496)
by Leo I. Gordon and Fangxin Hong and Richard I. Fisher and Nancy L. Bartlett and Joseph M. Connors and Randy D. Gascoyne and Henry Wagner and Patrick J. Stiff and Bruce D. Cheson and Mary Gospodarowicz and Ranjana Advani and Brad S. Kahl and Jonathan W. Friedberg and Kristie A. Blum and Thomas M. Habermann and Joseph M. Tuscano and Richard T. Hoppe and Sandra J. Horning
Journal of Clinical Oncology, ISSN 0732-183X, 02/2013, Volume 31, Issue 6, pp. 684 - 691
Purpose Although ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) has been established as the standard of care in patients with advanced Hodgkin... 
CONSOLIDATION | ONCOLOGY | MOPP | ITALIANO LINFOMI | DISEASE | INVOLVED-FIELD RADIOTHERAPY | RISK | CHEMOTHERAPY | Dacarbazine - adverse effects | Hodgkin Disease - pathology | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Mechlorethamine - adverse effects | Male | Vinblastine - administration & dosage | Young Adult | Hodgkin Disease - radiotherapy | Vinblastine - adverse effects | Aged, 80 and over | Hodgkin Disease - drug therapy | Vincristine - administration & dosage | Adult | Female | Neutropenia - chemically induced | Doxorubicin - administration & dosage | Dacarbazine - administration & dosage | Prednisone - administration & dosage | Etoposide - adverse effects | Prednisone - adverse effects | Etoposide - administration & dosage | Treatment Outcome | Combined Modality Therapy | Bleomycin - administration & dosage | Bleomycin - adverse effects | Remission Induction | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Adolescent | Survival Analysis | Vincristine - adverse effects | Aged | Mechlorethamine - administration & dosage | Neoplasm Staging | Doxorubicin - adverse effects | Original Reports | Hema14 | Hema13 | Hema12 | Radn
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8. Molecular Dynamics Simulation of Metallothionein-Drug Complexes
by Szilagyi, Z and Fenselau, C
Drug Metabolism and Disposition, ISSN 0090-9556, 02/2000, Volume 28, Issue 2, pp. 174 - 179
The intermolecular interactions of metallothionein with nitrogen mustard drugs were studied by molecular dynamics simulations. Previous laboratory experiments... 
mechlorethamine
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9. Full Text Topical Chemotherapy in Cutaneous T-cell Lymphoma: Positive Results of a Randomized, Controlled, Multicenter Trial Testing the Efficacy and Safety of a Novel Mechlorethamine, 0.02%, Gel in Mycosis Fungoides
by Lessin, Stuart R and Duvic, Madeleine and Guitart, Joan and Pandya, Amit G and Strober, Bruce E and Olsen, Elise A and Hull, Christopher M and Knobler, Elizabeth H and Rook, Alain H and Kim, Ellen J and Naylor, Mark F and Adelson, David M and Kimball, Alexa B and Wood, Gary S and Sundram, Uma and Wu, Hong and Kim, Youn H
JAMA Dermatology, ISSN 2168-6068, 01/2013, Volume 149, Issue 1, pp. 25 - 32
OBJECTIVE To evaluate the efficacy and safety of a novel mechlorethamine hydrochloride, 0.02%, gel in mycosis fungoides. DESIGN Randomized, controlled,... 
THERAPY | MANAGEMENT | PHASE-III | DISEASE | NITROGEN-MUSTARD | EXPERIENCE | SEZARY-SYNDROME | HYDROCHLORIDE | DERMATOLOGY | Single-Blind Method | Skin Neoplasms - drug therapy | Humans | Middle Aged | Mechlorethamine - adverse effects | Male | Administration, Cutaneous | Antineoplastic Agents, Alkylating - administration & dosage | Mechlorethamine - therapeutic use | Young Adult | Mycosis Fungoides - pathology | Time Factors | Aged, 80 and over | Adult | Female | Ointments | Severity of Illness Index | Skin Neoplasms - pathology | Gels | Treatment Outcome | Mycosis Fungoides - drug therapy | Antineoplastic Agents, Alkylating - therapeutic use | Adolescent | Aged | Mechlorethamine - administration & dosage | Antineoplastic Agents, Alkylating - adverse effects | Neoplasm Staging | Drugs | Dose-response relationship (Biochemistry) | Cutaneous T cell lymphoma | Usage | Care and treatment | Nitrogen mustards | Patient outcomes | Mycosis fungoides | Product/Service Evaluations | Chemotherapy | Dosage and administration | Drug therapy | Cancer
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10. Full Text Stability of the nitrogen mustard mechlorethamine in novel formulations for dermatological use
by Ritschel, Wolfgang A and Ye, Wei and Buhse, Lucinda and Reepmeyer, John C
International Journal of Pharmaceutics, ISSN 0378-5173, 2008, Volume 362, Issue 1, pp. 67 - 73
Long term stability measurements were made for the nitrogen mustard mechlorethamine HCl at a concentration of 0.02% in six topical formulations: Aquaphor... 
Aquaphor | Mechlorethamine | Stability | Nitrogen mustard | Dermal delivery | Transcutol | Aquaphor (R) | RAT | INVITRO | INTRACUTANEOUS DEPOT | MYCOSIS-FUNGOIDES | DELIVERY | PERFORMANCE LIQUID-CHROMATOGRAPHY | OINTMENT-BASED MECHLORETHAMINE | GRISEOFULVIN | Transcutol (R) | PHARMACOLOGY & PHARMACY | SKIN | ACCUMULATION | Drug Stability | Humans | Antineoplastic Agents, Alkylating - pharmacology | Mechlorethamine - chemistry | Administration, Cutaneous | Antineoplastic Agents, Alkylating - administration & dosage | Lymphoma, T-Cell, Cutaneous - drug therapy | Mechlorethamine - therapeutic use | Mechlorethamine - pharmacology | Drug Delivery Systems | Antineoplastic Agents, Alkylating - therapeutic use | Drug Compounding | Mechlorethamine - administration & dosage | Antineoplastic Agents, Alkylating - chemistry | Ointments | Nitrogen mustards | Soil fertility | Toluene | Analysis | Index Medicus
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11. Full Text Mechanistic study of IR-780 dye as a potential tumor targeting and drug delivery agent
by Zhang, Erlong and Luo, Shenglin and Tan, Xu and Shi, Chunmeng
Biomaterials, ISSN 0142-9612, 2013, Volume 35, Issue 2, pp. 771 - 778
Abstract IR-780 iodide, a near-infrared fluorescent heptamethine dye, has been recently characterized to exhibit preferential accumulation property in the... 
Advanced Basic Science | Dentistry | Glycolysis | OATP1B3 | Plasma membrane potential | Nitrogen mustard | IR-780 iodide | MATERIALS SCIENCE, BIOMATERIALS | FLUOROPHORES | MITOCHONDRIAL | TRANSPORTERS | ENGINEERING, BIOMEDICAL | ALKYLATION | NITROGEN-MUSTARD | OATP1 B3 | TOXICITY | ACCUMULATION | INHIBITORS | Fluorescent Dyes - pharmacokinetics | Iodides - pharmacokinetics | Neoplasm Transplantation | Humans | Mechlorethamine - chemistry | Iodides - chemistry | Drug Carriers - chemistry | Organic Anion Transporters - metabolism | Endocytosis | Flow Cytometry | Membrane Potential, Mitochondrial | ATP-Binding Cassette Transporters - metabolism | Cell Membrane - metabolism | Fluorescent Dyes - chemistry | Mice, Inbred C57BL | Rats | Rats, Sprague-Dawley | Microscopy, Confocal | Animals | Cell Line, Tumor | Indoles - pharmacokinetics | Drug Carriers - pharmacokinetics | Mice | Mechlorethamine - pharmacokinetics | Indoles - chemistry | Drugs | Glucose metabolism | Drug delivery systems | Mitochondrial DNA | Drug therapy | Tumors | Vehicles
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12. Full Text Photo-triggered fluorescent theranostic prodrugs as DNA alkylating agents for mechlorethamine release and spatiotemporal monitoring
by Cao, Yanting and Pan, Rong and Xuan, Weimin and Wei, Yongyi and Liu, Kejian and Zhou, Jiahong and Wang, Wei
Organic and Biomolecular Chemistry, ISSN 1477-0520, 06/2015, Volume 13, Issue 24, pp. 6742 - 6748
We describe a new theranostic strategy for selective delivery and spatiotemporal monitoring of mechlorethamine, a DNA alkylating agent. A photo-responsive... 
CROSS-LINKING AGENTS | DESIGN | REDUCTION | DRUG-DELIVERY | QUINONE METHIDES | CHEMISTRY, ORGANIC | MODEL | HYPOXIA | Prodrugs - administration & dosage | Cell Line | Fluorescent Dyes - chemistry | Humans | Coumarins - administration & dosage | Antineoplastic Agents, Alkylating - pharmacology | Coumarins - chemistry | Delayed-Action Preparations - chemistry | Mechlorethamine - chemistry | Prodrugs - chemistry | Antineoplastic Agents, Alkylating - administration & dosage | Mechlorethamine - pharmacology | Neoplasms - drug therapy | Coumarins - pharmacology | DNA - chemistry | Theranostic Nanomedicine - methods | Ultraviolet Rays | Fluorescent Dyes - pharmacology | Mechlorethamine - administration & dosage | HeLa Cells | Antineoplastic Agents, Alkylating - chemistry | Fluorescent Dyes - administration & dosage | Prodrugs - pharmacology
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13. Full Text Design, synthesis and biological evaluation of novel sesquiterpene mustards as potential anticancer agents
by Xu, Yuan-Zhen and Gu, Xue-Yan and Peng, Shou-Jiao and Fang, Jian-Guo and Zhang, Ying-Mei and Huang, De-Jun and Chen, Jian-Jun and Gao, Kun
European Journal of Medicinal Chemistry, ISSN 0223-5234, 04/2015, Volume 94, pp. 284 - 297
Several novel series of sesquiterpene mustards ( s) bearing nitrogen mustard and glutathione (GSH)-reactive α-methylene-γ-butyrolactone groups were... 
Sesquiterpene | Costunolide | Anticancer | DNA cross-linking | Nitrogen mustard | Dehydrocostuslactone | MULTIPLE-MYELOMA | APOPTOSIS | CHEMISTRY, MEDICINAL | BUTHIONINE SULFOXIMINE | CANCER-CELL-LINES | TUMOR-CELLS | NATURAL HERBICIDE MODELS | MELPHALAN CYTOTOXICITY | ALKYLATING-AGENTS | CHRONIC LYMPHOCYTIC-LEUKEMIA | GLUTATHIONE DEPLETION | Cell Survival - drug effects | Sesquiterpenes - chemistry | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Mechlorethamine - chemistry | Sesquiterpenes - chemical synthesis | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Mechlorethamine - chemical synthesis | Mechlorethamine - pharmacology | Hep G2 Cells | Dose-Response Relationship, Drug | Drug Design | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | HeLa Cells | Sesquiterpenes - pharmacology | Cell Cycle - drug effects | Drug Screening Assays, Antitumor | Antimitotic agents | Care and treatment | Antineoplastic agents | Analysis | Biological monitoring | Cancer
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14. Full Text Design and synthesis of novel quinazoline nitrogen mustard derivatives as potential therapeutic agents for cancer
by Li, Shilei and Wang, Xiao and He, Yong and Zhao, Mingxia and Chen, Yurong and Xu, Jingli and Feng, Man and Chang, Jin and Ning, Hongyu and Qi, Chuanmin
European Journal of Medicinal Chemistry, ISSN 0223-5234, 09/2013, Volume 67, pp. 293 - 301
Thirteen novel quinazoline nitrogen mustard derivatives were designed, synthesized and evaluated for their anticancer activities in vitro and in vivo.... 
Quinazoline | Anticancer | Nitrogen mustard | Cell cycle | Apoptosis | Xenograft model | MULTIPLE-MYELOMA | CELLS | CHEMISTRY, MEDICINAL | SOLID TUMORS | CYCLOPHOSPHAMIDE | TRIAL | PHARMACOKINETICS | ALKYLATING-AGENTS | CHRONIC LYMPHOCYTIC-LEUKEMIA | D-GLUCOSYLISOPHOSPHORAMIDE MUSTARD | MELPHALAN | Quinazolines - chemical synthesis | Cell Line | Cell Survival - drug effects | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Mechlorethamine - chemistry | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Mechlorethamine - chemical synthesis | Mechlorethamine - pharmacology | Hep G2 Cells | Dose-Response Relationship, Drug | MCF-7 Cells | Drug Design | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Cell Cycle - drug effects | Quinazolines - pharmacology | Quinazolines - chemistry | Drug Screening Assays, Antitumor | Drug therapy | Health aspects | Analysis | Cancer
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15. Synthesis and In Vitro antiproliferative activity of Thiazole-Based nitrogen mustards: The hydrogen bonding interaction between model systems and nucleobases
by Łączkowski, Krzysztof Z and Misiura, Konrad and Świtalska, Marta and Wietrzyk, Joanna and Baranowska-Łączkowska, Angelika and Fernández, Berta and Paneth, Agata and Plech, Tomasz
Anti-Cancer Agents in Medicinal Chemistry, ISSN 1871-5206, 03/2014, Volume 14, Issue 9, pp. 1271 - 1281
Synthesis, characterization and investigation of antiproliferative activity of eight thiazole-based nitrogen mustard against human cancer cells lines (MV4-11,... 
Antiproliferative activity | Thiazole | Nitrogen mustard | DFT calculations | Interaction energy | Nucleobases | DNA TOPOISOMERASE | CHEMISTRY, MEDICINAL | MOLECULAR-ORBITAL METHODS | nitrogen mustard | 2,4-DISUBSTITUTED THIAZOLES | interaction energy | DIRECTED ALKYLATING-AGENTS | ONCOLOGY | nucleobases | ANTIMICROBIAL ACTIVITIES | ELECTRIC PROPERTIES | thiazole | CHRONIC LYMPHOCYTIC-LEUKEMIA | ANILINE MUSTARDS | GAUSSIAN-BASIS SETS | POLARIZED BASIS-SETS | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | BALB 3T3 Cells | Mechlorethamine - chemistry | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Mechlorethamine - chemical synthesis | Mechlorethamine - pharmacology | Nucleotides - chemistry | Quantum Theory | Animals | Hydrogen Bonding | Thiazoles - chemical synthesis | Cell Line, Tumor | Thiazoles - chemistry | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Mice | Molecular Docking Simulation | Thiazoles - pharmacology | Drug Screening Assays, Antitumor
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16. Full Text ‘Is nitrogen mustard contamination responsible for the reported MT‐45 toxicity?’ Reply from the authors
by Helander, A and Bradley, M and Lapins, J and all authors
British Journal of Dermatology, ISSN 0007-0963, 08/2017, Volume 177, Issue 2, pp. 595 - 595
DERMATOLOGY | Mechlorethamine - toxicity | Piperazines | Toxicity | Contamination | Index Medicus
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17. Full Text Synthesis and antitumor activity of formononetin nitrogen mustard derivatives
by Ren, Jie and Xu, Hua-Jin and Cheng, Hong and Xin, Wen-Qun and Chen, Xin and Hu, Kun
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2012, Volume 54, pp. 175 - 187
A series of formononetin nitrogen mustard derivatives were synthesized and evaluated for their cytotoxicity against five cancer cell lines (SH-SY5Y, HCT-116,... 
Cytotoxicity | Synthesis | Formononetin | Nitrogen mustard | Cell cycle | Apoptosis | CELLS | CHEMISTRY, MEDICINAL | DNA | CROSS-LINKING | ROOTS | MELPHALAN | Chemistry Techniques, Synthetic | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Isoflavones - chemistry | Mechlorethamine - chemistry | Antineoplastic Agents - chemistry | Mechlorethamine - chemical synthesis | Mechlorethamine - pharmacology | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Inhibitory Concentration 50 | Antineoplastic Agents - pharmacology | Melphalan
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18. Full Text Synthesis and biological studies of the thiols-triggered anticancer prodrug for a more effective cancer therapy
by Xu, Yuanzhen and Chen, Jianjun and Li, Ya and Peng, Shoujiao and Gu, Xueyan and Sun, Meng and Gao, Kun and Fang, Jianguo
Organic and Biomolecular Chemistry, ISSN 1477-0520, 03/2015, Volume 13, Issue 9, pp. 2634 - 2639
A novel anticancer prodrug compound 1, which was designed to be triggered by thick and release the chemotherapeutic agent mechlorethamine, was successfully... 
DNA CROSS-LINKING | DESIGN | COMPLEX | SELECTIVE ANTITUMOR AGENTS | CYCLOPHOSPHAMIDE | QUATERNARY-SALTS | CHEMISTRY, ORGANIC | CHRONIC LYMPHOCYTIC-LEUKEMIA | BIOREDUCTIVE PRODRUGS | PROBE | CARCINOMA | Sulfhydryl Compounds - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Mechlorethamine - chemistry | Prodrugs - chemistry | Structure-Activity Relationship | Sulfhydryl Compounds - chemical synthesis | Antineoplastic Agents - chemistry | Mechlorethamine - chemical synthesis | Mechlorethamine - pharmacology | Dose-Response Relationship, Drug | Cell Line, Tumor | Prodrugs - chemical synthesis | Sulfhydryl Compounds - chemistry | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Prodrugs - pharmacology | Drug Screening Assays, Antitumor
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