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Nature Cell Biology, ISSN 1465-7392, 01/2002, Volume 4, Issue 1, pp. 1 - 10
Transcriptional activity of p53, a central regulatory switch in a network controlling cell proliferation and apoptosis, is modulated by protein stability and... 
TRANSCRIPTION FACTORS | NUCLEAR-BODIES | PREMATURE SENESCENCE | PROMYELOCYTIC LEUKEMIA | DNA-DAMAGE | TUMOR-SUPPRESSOR | POTENTIAL MEDIATOR | CREB BINDING-PROTEIN | SERINE/THREONINE KINASE | P53-REGULATED GENE-EXPRESSION | CELL BIOLOGY | Apoptosis - radiation effects | Humans | Transcriptional Activation | Apoptosis - genetics | Neoplasm Proteins - metabolism | Tumor Suppressor Protein p53 - genetics | Carrier Proteins - radiation effects | Cell Nucleus - metabolism | Protein Isoforms - metabolism | Ultraviolet Rays | Protein-Serine-Threonine Kinases - radiation effects | Trans-Activators - genetics | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Genes, Tumor Suppressor | Protein-Serine-Threonine Kinases - metabolism | Cell Division - genetics | Oligonucleotides, Antisense | CREB-Binding Protein | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Transcription Factors - genetics | Cell Nucleus - ultrastructure | Enzyme Activation - radiation effects | Transcription Factors - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cell Nucleus - genetics | Protein Binding | Trans-Activators - metabolism | Mice | Promyelocytic Leukemia Protein | Tumor Suppressor Proteins | Protein Isoforms - genetics | Post-translational modification | Physiological aspects | Research | Tumor proteins | Protein kinases | Protein-protein interactions | Index Medicus
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 7/2018, Volume 75, Issue 14, pp. 2663 - 2680
Primary cilia are sensory organelles that coordinate multiple cellular signaling pathways, including Hedgehog (HH), Wingless/Int (WNT) and Transforming Growth... 
Biomedicine, general | Biochemistry, general | TSC | LC3b | Primary cilia | TGF-β signaling | WNT5a | Hedgehog signaling | Autophagy | Cell Biology | Life Sciences | Life Sciences, general | mTOR | GLI1 EXPRESSION | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | PROTEIN-COUPLED RECEPTORS | CELL-SIZE | CELL BIOLOGY | TSC1-TSC2 COMPLEX | TGF-beta signaling | GROWTH-FACTOR-BETA | MEDIATORS | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cells, Cultured | Gene Expression Regulation | Hedgehog Proteins - metabolism | Smoothened Receptor - metabolism | Smoothened Receptor - genetics | Cilia - metabolism | Mice, Knockout | Zinc Finger Protein Gli2 - metabolism | Animals | Tuberous Sclerosis Complex 2 Protein | Hedgehog Proteins - genetics | RNA Interference | Embryo, Mammalian - cytology | Tumor Suppressor Proteins - genetics | Tuberous Sclerosis Complex 1 Protein | Zinc Finger Protein Gli2 - genetics | Fibroblasts - metabolism | Tuberous sclerosis | Bone morphogenetic proteins | Protein biosynthesis | Molecular genetics | Transforming growth factors | TOR protein | Tuberous sclerosis 2 protein | Phosphorylation | Wnt protein | Transforming growth factor | Hamartin | Kinases | TSC1 protein | Sclerosis | Proteins | Signal transduction | Smad2 protein | Fibroblasts | Elongation | Cilia | Phenotypes | Rapamycin | Embryo fibroblasts | Organelles | Embryos | TSC2 protein | Signaling | Protein synthesis | Hedgehog protein | Dismantling | Index Medicus | Original
Journal Article
Journal of Cell Science, ISSN 0021-9533, 02/2010, Volume 123, Issue 4, pp. 619 - 626
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 07/2007, Volume 116, Issue 5, pp. 535 - 544
Background - The role of endothelial nitric oxide synthase (eNOS) in ischemic preconditioning ( PC) and cardioprotection is poorly understood. We addressed... 
Myocardial infarction | Occlusion | Ischemia | Stress | MYOCARDIUM | stress | CARDIAC & CARDIOVASCULAR SYSTEMS | CYCLOOXYGENASE-2 | MECHANISM | MEDIATOR | myocardial infarction | STAT3 | CONSCIOUS RABBITS | ischemia | EPSILON | INFARCTION | GENE | occlusion | PERIPHERAL VASCULAR DISEASE | MICE | HEMATOLOGY | Nitric Oxide Synthase Type II - physiology | Cyclooxygenase 2 - biosynthesis | STAT3 Transcription Factor - physiology | MAP Kinase Kinase Kinase 2 - physiology | Protein Processing, Post-Translational - drug effects | Time Factors | Cyclooxygenase 2 - genetics | Mice, Mutant Strains | Myocardial Infarction - pathology | Enzyme Induction - drug effects | Triazenes - pharmacology | Nitric Oxide Donors - therapeutic use | Hypertension - genetics | Nitric Oxide Donors - pharmacology | Phosphorylation - drug effects | Triazenes - therapeutic use | MAP Kinase Kinase Kinase 1 - physiology | STAT1 Transcription Factor - physiology | Specific Pathogen-Free Organisms | Mitogen-Activated Protein Kinase 1 - physiology | Mice, Inbred C57BL | Nitric Oxide Synthase Type II - deficiency | Nitric Oxide Synthase Type III | Adaptation, Physiological - physiology | Nitric Oxide - physiology | Stress, Physiological - physiopathology | DNA - metabolism | Enzyme Activation - drug effects | Mitogen-Activated Protein Kinase 3 - physiology | Myocardial Reperfusion Injury - physiopathology | Mice, Knockout | DNA - genetics | Animals | Nitric Oxide Synthase Type II - genetics | Signal Transduction - drug effects | Ischemic Preconditioning, Myocardial | Hypertension - complications | Signal Transduction - physiology | Mice | Protein Kinase C-epsilon - physiology | Myocardial Reperfusion Injury - prevention & control | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Periodontology, ISSN 0022-3492, 01/2015, Volume 86, Issue 1, pp. 62 - 71
Journal Article
Journal Article
Cell Cycle, ISSN 1538-4101, 01/2015, Volume 14, Issue 2, pp. 219 - 231
In response to genotoxic stress, cells protect their genome integrity by activation of a conserved DNA damage response (DDR) pathway that coordinates DNA... 
mitosis | Polo like kinase 1 | DNA damage response | phosphorylation | 53BP1 | Phosphorylation | Mitosis | H2AX | MDC1 | RNA interference | Polo-like kinase 1 | RIF1 | p53 binding protein 1 | NCS - neocarzinostatin | Rap1-interacting factor 1 homolog | histone variant H2AX | RNF8 | BRCA1 | Cdk | PTIP | CELL BIOLOGY | cyclin dependent kinase | REPAIR PROTEINS | DDR | RNAi | Plk1 | NZ - nocodazole | PAX transactivation activation domain-interacting protein | DOUBLE-STRAND BREAKS | ataxia telangiectasia mutated kinase | CELL-CYCLE PROGRESSION | REPLICATION STRESS | MAMMALIAN-CELLS | RING finger protein 8 | RNF168 | CHECKPOINT RECOVERY | breast cancer type 1 susceptibility protein | mediator of DNA damage checkpoint protein 1 | IR - ionizing radiation | ATM | RING finger protein 168 | UBIQUITIN MARK | DEPENDENT DEGRADATION | Gamma Rays | Humans | Intracellular Signaling Peptides and Proteins - metabolism | CDC2 Protein Kinase - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Ubiquitination | RNA Interference | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Kinetochores - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Intracellular Signaling Peptides and Proteins - chemistry | DNA Repair | Cell Line, Tumor | HeLa Cells | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1 | DNA Damage - radiation effects | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2007, Volume 405, Issue 2, pp. 307 - 317
Mutations in the LRRK2 (leucine-rich repeat kinase-2) gene cause late-onset PD (Parkinson's disease). LRRK2 contains leucine-rich repeats, a GTPase domain, a... 
Kinase substrate tracking and elucidation screening (KESTREL screening) | Ezrin/radixin/moesin family of proteins (ERM proteins) | Protein kinase | Leucine-rich repeat kinase 2 (LRRK2) | Mass spectrometry (MS) | Parkinson's disease (PD) | SITE | GENE LRRK2 | DOMAIN | ERM PROTEINS | ezrin/radixin/moesin family of proteins (ERM proteins) | F-ACTIN BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | leucine-rich repeat kinase 2 (LRRK2) | protein kinase | kinase substrate tracking and elucidation screening (KESTREL screening) | IN-VITRO | EZRIN | MUTATIONS | ASSOCIATION | mass spectrometry (MS) | Amino Acid Sequence | Humans | Protein-Serine-Threonine Kinases - genetics | Rats | Parkinson Disease - genetics | Threonine - metabolism | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Animals | Cytoskeletal Proteins - metabolism | Membrane Proteins - metabolism | Microfilament Proteins - metabolism | Parkinson Disease - metabolism | Protein-Serine-Threonine Kinases - metabolism | Index Medicus | LRRKtide, RLGRDKYKTLRQIRQ | BUBR1, Bub (budding uninhibited by benomyl)-related 1 | ezrin | GbpC, cGMP-binding protein C | moesin family of proteins (ERM proteins) | CRMP2, collapsin response mediator protein 2 | WD40, Trp-Asp 40 | MALDI-TOF, matrix-assisted laser-desorption ionization–time-of-flight | NCBI, National Center for Biotechnology Information | radixin | TSSK1, testis-specific serine kinase 1 | LRRK2, leucine-rich repeat kinase 2 | RIPK, Rho-interacting protein kinase | GST, glutathione S-transferase | LDS, lithium dodecyl sulfate | ROCK-II, Rho-associated kinase-2 | ERM, ezrin | PD, Parkinson's disease | MBP, myelin basic protein | moesin | COR, C-terminal of Roc (Ras of complex) | FERM, four-point-one | KESTREL, kinase substrate tracking and elucidation
Journal Article
Nature, ISSN 0028-0836, 03/2013, Volume 495, Issue 7442, pp. 524 - 528
Macrophages consist of at least two subgroups, M1 and M2 (refs 1-3). Whereas M1 macrophages are proinflammatory and have a central role in host defence against... 
GLUCOSE-HOMEOSTASIS | OBESITY | TRIBBLES HOMOLOG | INSULIN-RESISTANCE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MYELOID LEUKEMOGENESIS | POLARIZATION | ASSOCIATION | ALTERNATIVE ACTIVATION | ADIPOSE-TISSUE | Neutrophils - cytology | Protein-Serine-Threonine Kinases - deficiency | CCAAT-Enhancer-Binding Protein-alpha - metabolism | Eosinophils - metabolism | Hypertriglyceridemia - genetics | Cell Count | Ubiquitin - metabolism | Adipose Tissue - cytology | Diet, High-Fat - adverse effects | Male | Intracellular Signaling Peptides and Proteins - metabolism | Lung - cytology | Intracellular Signaling Peptides and Proteins - deficiency | Adipose Tissue - metabolism | Inflammation Mediators - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Female | Cell Differentiation | Cytokines - genetics | Intracellular Signaling Peptides and Proteins - genetics | Neutrophils - metabolism | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Macrophages - classification | Bone Marrow Cells - cytology | Adipose Tissue - pathology | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Cell Cycle Proteins - deficiency | Lipodystrophy - metabolism | Spleen - cytology | Macrophages - cytology | Organ Specificity | Lipolysis | Hypertriglyceridemia - chemically induced | Macrophages - metabolism | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Insulin Resistance - genetics | Lipodystrophy - pathology | Lipodystrophy - chemically induced | Mice | Protein-Serine-Threonine Kinases - chemistry | Eosinophils - cytology | Bone Marrow Cells - metabolism | Proteins | Care and treatment | Metabolic diseases | Cellular signal transduction | Research | Macrophages | Properties | Identification and classification | Testing | Studies | Spleen | Heart attacks | Transplants & implants | Bone marrow | Binding sites | Metabolic disorders | Defects | Index Medicus
Journal Article