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The American Journal of Human Genetics, ISSN 0002-9297, 10/2017, Volume 101, Issue 4, pp. 552 - 563
The Sonic Hedgehog (SHH) pathway is a key signaling pathway orchestrating embryonic development, mainly of the CNS and limbs. In vertebrates, SHH signaling is... 
polymicrogyria | developmental defects | hypomorphic variants | congenital ataxia | ciliopathies | SUFU | Joubert syndrome | Sonic Hedgehog | molar tooth sign | GLI3 | SHH | SIGNALING PATHWAY | GENETICS & HEREDITY | PLANAR CELL POLARITY | CEREBELLAR DEVELOPMENT | GLI PROTEINS | MUTATIONS | KIF7 | MEDULLOBLASTOMA | PHENOTYPIC SPECTRUM | PRIMARY CILIA | Abnormalities, Multiple - pathology | Skin - metabolism | Humans | Zinc Finger Protein Gli3 | Hedgehog Proteins - metabolism | Male | Bone Diseases, Developmental - genetics | Mutation, Missense | Cerebellum - abnormalities | Bone Diseases, Developmental - pathology | Gene Expression Regulation, Developmental | Kruppel-Like Transcription Factors - metabolism | Kidney Diseases, Cystic - genetics | Craniofacial Abnormalities - pathology | Female | Child | Abnormalities, Multiple - genetics | Craniofacial Abnormalities - genetics | Repressor Proteins - metabolism | Skin - pathology | Fibroblasts - metabolism | Repressor Proteins - chemistry | Signal Transduction | Cells, Cultured | Repressor Proteins - genetics | Eye Abnormalities - genetics | Fibroblasts - pathology | Genes, Recessive | Sequence Analysis, DNA | Cerebellum - pathology | Kidney Diseases, Cystic - pathology | Nerve Tissue Proteins - metabolism | Eye Abnormalities - pathology | Retina - abnormalities | Retina - pathology | Cohort Studies | Embryonic development | Usage | Gene mutations | Analysis | Nucleotide sequencing | Research | Diagnosis | Children | Health aspects | DNA sequencing | Index Medicus
Journal Article
Neurochirurgie, ISSN 0028-3770, 2018
Medulloblastomas, embryonal neuroepithelial tumors developed in the cerebellum or brain stem, are mainly observed in childhood. The treatment of WHO-Grade IV... 
Histopathology | Medulloblastoma | Molecular biology | WHO classification
Journal Article
Modern Pathology, ISSN 0893-3952, 10/2011, Volume 24, Issue 10, pp. 1320 - 1326
Journal Article
Cancer Cell, ISSN 1535-6108, 05/2012, Volume 21, Issue 5, pp. 601 - 613
The proto-oncogene is mis-expressed in various types of human brain tumors. To clarify how developmental and regional differences influence transformation, we... 
PROGENITORS | SOX9 EXPRESSION | ONCOLOGY | SONIC HEDGEHOG | MOUSE MODEL | EMBRYONIC LETHALITY | PROLIFERATION | GENERATION | MUTATIONS | PEDIATRIC MEDULLOBLASTOMA | ASTROCYTES | CELL BIOLOGY | Oncogene Proteins - genetics | Cell Proliferation | Humans | Zinc Finger Protein Gli2 | Brain Stem - metabolism | Hedgehog Proteins - metabolism | Time Factors | Cell Transformation, Neoplastic - genetics | Glioma - pathology | Medulloblastoma - pathology | Cell Differentiation | N-Myc Proto-Oncogene Protein | Cerebellar Neoplasms - pathology | Prosencephalon - metabolism | Cerebellar Neoplasms - metabolism | Biomarkers - metabolism | Neuroectodermal Tumors, Primitive - metabolism | SOX9 Transcription Factor - metabolism | Transduction, Genetic | Signal Transduction | Oncogene Proteins - metabolism | Brain Neoplasms - genetics | Mice, Transgenic | Medulloblastoma - metabolism | Gestational Age | Cell Lineage | Mice, Nude | Brain Stem - embryology | Mice | Mutation | Brain Neoplasms - pathology | Brain Neoplasms - metabolism | Glioma - metabolism | Cerebellum - embryology | Hedgehog Proteins - genetics | Kruppel-Like Transcription Factors - metabolism | Female | Nuclear Proteins - genetics | Spheroids, Cellular | Proto-Oncogene Proteins - metabolism | Cerebellum - metabolism | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Cell Transformation, Neoplastic - metabolism | Neural Stem Cells - pathology | Animals | Cell Transformation, Neoplastic - pathology | Prosencephalon - embryology | Neural Stem Cells - metabolism | SOX9 Transcription Factor - genetics | Neuroectodermal Tumors, Primitive - pathology | Gliomas | Children's hospitals | Oncology, Experimental | Brain tumors | Stem cells | Transplantation | Universities and colleges | Research | Statistics | Tumors | Cancer | Index Medicus | N-MYC | glioma | SOX9 | medulloblastoma | neural stem cells | GFAP | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
World Neurosurgery, ISSN 1878-8750, 12/2018, Volume 120, pp. 214 - 233
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, pp. e108861 - e108861
Human cytomegalovirus (HCMV) has been indicated being a significant oncomodulator. Recent reports have suggested that an antiviral treatment alters the outcome... 
B-CELL LYMPHOMA | ANTIGEN RETRIEVAL | GLIOBLASTOMA-MULTIFORME | GLIOMA | MULTIDISCIPLINARY SCIENCES | THERAPEUTIC TARGET | TISSUE MICROARRAYS | INFECTION | EXPRESSION | ASSOCIATION | IMMUNOHISTOCHEMISTRY | Immunohistochemistry | Humans | Meningioma - virology | Middle Aged | Brain Neoplasms - pathology | Male | Young Adult | Neoplasm Grading | Phosphoproteins - analysis | Medulloblastoma - pathology | Aged, 80 and over | Adult | Female | Lymphoma - pathology | Medulloblastoma - virology | Cytomegalovirus - isolation & purification | Cytomegalovirus - metabolism | Glioblastoma - virology | Viral Matrix Proteins - analysis | Meningioma - pathology | Glioblastoma - pathology | Adolescent | Aged | Brain Neoplasms - virology | Cohort Studies | Lymphoma - virology | Infection | Antiviral agents | Brain | Gliomas | Brain tumors | Cytomegalovirus infections | Lymphomas | Health aspects | Tegument | Brain cancer | Glioblastoma | Clinical trials | Antibodies | Labelling | Oncology | Viruses | Infections | Neurosurgery | Proteins | Immunology | Neurodegeneration | Degeneration | Telomerase | Deoxyribonucleic acid--DNA | Antigens | Cytomegalovirus | Research & development--R&D | Cloning | Cores | Pathology | Brain research | Lymphocytes B | Medical prognosis | Pp65 protein | Protein expression | Sampling methods | Immunoreactivity | Tumors | B-cell lymphoma | Index Medicus | Clinical Medicine | Medical and Health Sciences | Cancer and Oncology | Klinisk medicin | Medicin och hälsovetenskap | Cancer och onkologi | Research & development | Deoxyribonucleic acid | R&D | DNA
Journal Article
American Journal of Neuroradiology, ISSN 0195-6108, 02/2013, Volume 34, Issue 2, pp. 446 - 450
PT promises to reduce side effects in children with brain tumors by sparing normal tissue compared with 3D conformal or intensity-modulated radiation therapy.... 
GLIOMA | HIGH-DOSE METHOTREXATE | NEUROIMAGING | LESIONS | CLINICAL NEUROLOGY | FEATURES | PSEUDOPROGRESSION | IRRADIATION | NERVOUS-SYSTEM TUMORS | SKULL BASE TUMORS | RADIOTHERAPY | MEDULLOBLASTOMA | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Chemoradiotherapy - adverse effects | Follow-Up Studies | Humans | Proton Therapy - adverse effects | Brain Neoplasms - pathology | Child, Preschool | Gadolinium | Infant | Male | Medulloblastoma - therapy | Rhabdoid Tumor - pathology | Ependymoma - therapy | Rhabdoid Tumor - epidemiology | Cerebellar Neoplasms - epidemiology | Carcinoma - epidemiology | Medulloblastoma - pathology | Neuroectodermal Tumors, Primitive - epidemiology | Ependymoma - pathology | Female | Teratoma - therapy | Cerebellar Neoplasms - pathology | Carcinoma - pathology | Ependymoma - epidemiology | Chemoradiotherapy - methods | Teratoma - epidemiology | Risk Factors | Choroid Plexus Neoplasms - pathology | Neuroectodermal Tumors, Primitive - therapy | Radiation Dosage | Choroid Plexus Neoplasms - epidemiology | Medulloblastoma - epidemiology | Choroid Plexus Neoplasms - therapy | Rhabdoid Tumor - therapy | Magnetic Resonance Imaging | Teratoma - pathology | Brain Neoplasms - therapy | Diffusion Magnetic Resonance Imaging | Carcinoma - therapy | Cerebellar Neoplasms - therapy | Proton Therapy - methods | Brain Neoplasms - epidemiology | Neuroectodermal Tumors, Primitive - pathology | Index Medicus
Journal Article
Cancer, ISSN 0008-543X, 10/2017, Volume 123, Issue 20, pp. 4048 - 4056
Socioeconomic factors affect the use of proton radiotherapy in children. Whether this disparity is related to differences in the referral patterns, the... 
radiotherapy | socioeconomic factors | protons | photons | malignancy | pediatrics | UNITED-STATES | MASTECTOMY | STAGE BREAST-CANCER | DISTANCE | EPENDYMOMA | RACIAL DISPARITIES | ONCOLOGY | PROSTATE-CANCER | PHOTON RADIOTHERAPY | DATA-BASE | CLINICAL-OUTCOMES | Radiotherapy - utilization | United States | Humans | Brain Neoplasms - pathology | Child, Preschool | Rhabdomyosarcoma - pathology | Infant | Male | Educational Status | Bone Neoplasms - pathology | Socioeconomic Factors | Insurance, Health - statistics & numerical data | Young Adult | Neoplasm Metastasis | Rhabdomyosarcoma - radiotherapy | Medulloblastoma - radiotherapy | Medulloblastoma - pathology | Ependymoma - pathology | Female | Neoplasms - radiotherapy | Cerebellar Neoplasms - pathology | Brain Neoplasms - radiotherapy | Medicaid | Odds Ratio | Child | Infant, Newborn | Proton Therapy - utilization | Income - statistics & numerical data | Medically Uninsured | Logistic Models | Head and Neck Neoplasms - pathology | Head and Neck Neoplasms - radiotherapy | Managed Care Programs | Travel | Bone Neoplasms - radiotherapy | Adolescent | Neoplasms - pathology | Cerebellar Neoplasms - radiotherapy | Ependymoma - radiotherapy | Usage | Children | Radiotherapy | Social economics | Health aspects | Analysis | Health care | Pediatrics | Populations | Socio-economic aspects | Radiation | Rhabdomyosarcoma | Economic factors | Social factors | Malignancy | Radiation therapy | Regression analysis | Tissues | Cancer therapies | Patients | Socioeconomics | Metastases | Confidence intervals | Government programs | Socioeconomic factors | Medulloblastoma | Background radiation | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Acta neuropathologica, ISSN 0001-6322, 2012, Volume 124, Issue 6, pp. 875 - 881
Journal Article