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Journal Article
STEM CELLS, ISSN 1066-5099, 02/2013, Volume 31, Issue 2, pp. 372 - 383
Hematopoietic stem and progenitor cells (HSPCs), which continuously maintain all mature blood cells, are regulated within the marrow microenvironment. We... 
Bone marrow | Irradiation | Prostaglandin E2 | Hematopoietic stem cells | Apoptosis | PROGENITOR CELLS | OSTEOBLASTIC MC3T3-E1 CELLS | WHOLE-BODY IRRADIATION | DUODENAL-ULCER | 16,16-DIMETHYL PROSTAGLANDIN-E2 | MACROPHAGES | BONE-MARROW | CELL & TISSUE ENGINEERING | CELL BIOLOGY | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CYCLOOXYGENASE-2 EXPRESSION | HEMATOLOGY | EXPOSURE | MEGAKARYOCYTE MATURATION | Whole-Body Irradiation | Gene Expression - drug effects | Apoptosis - drug effects | Apoptosis - radiation effects | Radiation Injuries, Experimental - immunology | Hematopoietic Stem Cells - pathology | Male | Actins - immunology | Actins - genetics | Cellular Microenvironment - radiation effects | Cyclooxygenase 2 - genetics | Radiation Injuries, Experimental - drug therapy | Radiation-Protective Agents - pharmacology | Bone Marrow Cells - drug effects | Macrophages - radiation effects | Cyclooxygenase 2 - immunology | Hematopoietic Stem Cells - radiation effects | Cell Differentiation - radiation effects | Hematopoietic Stem Cells - drug effects | Cell Survival - drug effects | Dinoprostone - pharmacology | Macrophages - pathology | Bone Marrow Cells - pathology | Mice, Transgenic | Bone Marrow Cells - radiation effects | Radiation Injuries, Experimental - pathology | Cell Survival - radiation effects | Gene Expression - radiation effects | Animals | Cell Differentiation - drug effects | Dinoprostone - analogs & derivatives | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | Cellular Microenvironment - drug effects | Cell Proliferation - radiation effects | Medical colleges | Nuclear radiation | Analysis | Prostaglandins E | Information management | Macrophages | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 07/2013, Volume 122, Issue 3, pp. 376 - 385
Journal Article
PLoS Medicine, ISSN 1549-1277, 2006, Volume 3, Issue 7, pp. 1140 - 1151
The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid... 
Recombinant Fusion Proteins - adverse effects | Humans | Myeloproliferative Disorders - pathology | Mutation, Missense | Primary Myelofibrosis - pathology | Receptors, Cytokine - physiology | Janus Kinases - physiology | Bone Marrow Transplantation | Hematopoiesis - physiology | Myeloid Cells - drug effects | Transcription, Genetic | Colony-Forming Units Assay | Phosphorylation - drug effects | mRNA Cleavage and Polyadenylation Factors - genetics | Hematologic Neoplasms - physiopathology | Disease Models, Animal | Cells, Cultured - drug effects | Bone Marrow Cells - pathology | Hematopoiesis - genetics | Signal Transduction - genetics | Thrombocytosis - etiology | Sequence Analysis, DNA | Cell Division - drug effects | mRNA Cleavage and Polyadenylation Factors - physiology | Receptor, Platelet-Derived Growth Factor alpha - physiology | Hematologic Neoplasms - drug therapy | Mice | Mice, Inbred BALB C | Myeloid Cells - pathology | Protein Processing, Post-Translational - genetics | Myeloproliferative Disorders - genetics | Oncogene Proteins, Fusion - physiology | STAT Transcription Factors - physiology | Protein Processing, Post-Translational - drug effects | Cells, Cultured - pathology | Bone Marrow Cells - drug effects | Spleen - pathology | Thrombocytosis - pathology | Gene Expression Regulation | Janus Kinases - antagonists & inhibitors | Point Mutation | Megakaryocytes - pathology | Primary Myelofibrosis - genetics | Animals | Oncogene Proteins, Fusion - genetics | Protein Kinase Inhibitors - therapeutic use | Receptor, Platelet-Derived Growth Factor alpha - genetics | Myeloproliferative Disorders - etiology | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Genetic Vectors | Megakaryocytes - drug effects | Cytokines - pharmacology | Amino Acid Substitution | Thrombocytosis - genetics | Genetic aspects | Myelofibrosis | Research | Index Medicus | Hematology | Gene Therapy | Genomics | Genetics | Oncology | Cancer Biology | Hematology (including Blood Transfusion)
Journal Article
Blood, ISSN 0006-4971, 07/2014, Volume 124, Issue 2, pp. 277 - 286
Megakaryocyte (MK) development in the bone marrow progresses spatially from the endosteal niche, which promotes MK progenitor proliferation, to the sinusoidal... 
PROGENITOR CELLS | PLATELET-RELEASE | CHEMOKINE RECEPTOR CXCR4 | DIPROTIN-A | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | C-MPL LIGAND | HEMATOLOGY | PROPLATELET FORMATION | DIPEPTIDYL PEPTIDASE-IV | MARROW VASCULAR NICHE | Chemokine CXCL12 - physiology | Stem Cell Niche - radiation effects | Bone Marrow Cells - physiology | Cell Movement - genetics | Thrombopoiesis - genetics | Cell Differentiation - genetics | Megakaryocyte Progenitor Cells - radiation effects | Bone Marrow Cells - drug effects | Female | Megakaryocytes - cytology | Megakaryocytes - radiation effects | Thrombopoiesis - drug effects | Stem Cell Niche - genetics | Chemokine CXCL12 - administration & dosage | Megakaryocyte Progenitor Cells - cytology | Radiation Injuries, Experimental - genetics | Cell Differentiation - radiation effects | Megakaryocyte Progenitor Cells - drug effects | Bone Marrow Cells - cytology | Megakaryocyte Progenitor Cells - physiology | Mice, Inbred C57BL | Cells, Cultured | Megakaryocytes - physiology | Receptors, CXCR4 - administration & dosage | Bone Marrow Cells - radiation effects | Radiation Injuries, Experimental - pathology | Cell Movement - radiation effects | Receptors, CXCR4 - metabolism | Cell Movement - drug effects | Thrombopoiesis - radiation effects | Animals | Cell Differentiation - drug effects | Mice | Stem Cell Niche - drug effects | Megakaryocytes - drug effects | Index Medicus | Abridged Index Medicus | Platelets and Thrombopoiesis
Journal Article
Blood, ISSN 0006-4971, 08/2017, Volume 130, Issue 9, pp. 1132 - 1143
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2015, Volume 112, Issue 31, pp. 9638 - 9643
Journal Article
BLOOD, ISSN 0006-4971, 06/2012, Volume 119, Issue 24, pp. 5850 - 5858
Mature megakaryocytes depend on the function of Bcl-x(L), a member of the Bcl-2 family of prosurvival proteins, to proceed safely through the process of... 
IDIOPATHIC THROMBOCYTOPENIC PURPURA | BLOOD-PLATELETS | BCL-2 | APOPTOSIS | HEMATOPOIETIC STEM-CELLS | BONE-MARROW | IN-VIVO | PLATELET SENESCENCE | INHIBITOR | HEMATOLOGY | FAMILY | Blood Platelets - pathology | Embryo, Mammalian - drug effects | Organ Specificity - drug effects | Piperazines - administration & dosage | Liver - pathology | Cell Count | Fetus - metabolism | Fetus - pathology | Liver - embryology | Dose-Response Relationship, Drug | Lymphatic Vessels - drug effects | Proto-Oncogene Proteins c-bcl-2 - metabolism | Biphenyl Compounds - pharmacology | Liver - drug effects | Nitrophenols - pharmacology | Gene Deletion | Cell Death - drug effects | Blood Platelets - drug effects | Megakaryocytes - metabolism | Thrombopoiesis - drug effects | Cell Survival - drug effects | Embryo, Mammalian - pathology | Liver - metabolism | Mice, Inbred C57BL | Megakaryocytes - ultrastructure | Cell Size | Nitrophenols - administration & dosage | Sulfonamides - pharmacology | Piperazines - pharmacology | Blood Cell Count | Proto-Oncogene Proteins c-bcl-2 - deficiency | Fetus - drug effects | Megakaryocytes - pathology | Animals | Blood Platelets - metabolism | Lymphatic Vessels - pathology | Myeloid Cell Leukemia Sequence 1 Protein | Alleles | Biphenyl Compounds - administration & dosage | Mice | Megakaryocytes - drug effects | bcl-X Protein - metabolism | Hemorrhage - pathology | Sulfonamides - administration & dosage | Index Medicus | Abridged Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2015, Volume 21, Issue 1, pp. 123 - 133
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 584 - 596
We report a knockin mouse myeloproliferative neoplasm (MPN) model resembling human polycythemia vera (PV). The MPN is serially transplantable and we... 
CELLCYCLE | POLYCYTHEMIA-VERA | ACTIVATING MUTATION | ONCOLOGY | IN-VIVO | TYROSINE KINASE JAK2 | CONDITIONAL EXPRESSION | MYELODYSPLASTIC-SYNDROMES | ESSENTIAL THROMBOCYTHEMIA | VERA-LIKE DISEASE | CHRONIC MYELOMONOCYTIC LEUKEMIA | CHRONIC MYELOID-LEUKEMIA | Erythropoietin - pharmacology | Gene Expression - genetics | Cell Count | Humans | Hematocrit | Hematopoietic Stem Cells - pathology | Polycythemia Vera - genetics | Gene Expression Profiling | Myeloproliferative Disorders - pathology | Spleen - drug effects | Antigens, CD - metabolism | Bone Marrow Transplantation | Megakaryocyte-Erythroid Progenitor Cells - transplantation | Polycythemia Vera - pathology | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Megakaryocyte-Erythroid Progenitor Cells - metabolism | Hematopoietic Stem Cell Transplantation | Mice, Transgenic | Myeloid Progenitor Cells - pathology | Megakaryocyte-Erythroid Progenitor Cells - drug effects | Sulfonamides - pharmacology | Megakaryocyte Progenitor Cells - metabolism | Erythroid Precursor Cells - pathology | Survival Analysis | Erythroid Precursor Cells - metabolism | Mice | Megakaryocyte Progenitor Cells - pathology | Myeloproliferative Disorders - genetics | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Cell Differentiation - genetics | Janus Kinase 2 - metabolism | Bone Marrow Cells - drug effects | Spleen - pathology | Hematopoietic Stem Cells - drug effects | Myeloid Progenitor Cells - metabolism | Mice, Inbred C57BL | Janus Kinase 2 - genetics | Hematopoietic Stem Cells - metabolism | Myeloproliferative Disorders - drug therapy | Animals | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Bone Marrow - pathology | Heterozygote | Protein Kinase Inhibitors - pharmacology | Amino Acid Substitution | Megakaryocyte-Erythroid Progenitor Cells - pathology | Physiological aspects | Medical colleges | Analysis | Hematopoietic stem cells | Tumors | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2017, Volume 16, Issue 9, pp. 1877 - 1886
Journal Article
Leukemia, ISSN 0887-6924, 09/2013, Volume 27, Issue 9, pp. 1882 - 1890
The majority of patients with BCR-ABL1-negative myeloproliferative neoplasms (MPN) harbor mutations in JAK2 or MPL, which lead to constitutive activation of... 
MPL | myelofibrosis | PI3K | JAK2 | POLYCYTHEMIA-VERA | EFFICACY | PRIMARY MYELOFIBROSIS | JAK2V617F | MURINE MODEL | ACTIVATING MUTATION | ONCOLOGY | TYROSINE KINASE JAK2 | INHIBITOR | HEMATOLOGY | PHASE-I | EXPRESSION | Liver - pathology | Apoptosis - drug effects | Heterocyclic Compounds, 3-Ring - pharmacology | Neoplastic Stem Cells - drug effects | Humans | Myeloproliferative Disorders - pathology | Spleen - drug effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Myeloproliferative Disorders - genetics | Neoplastic Stem Cells - metabolism | Bone Marrow - metabolism | Myeloproliferative Disorders - metabolism | Female | Phosphorylation - drug effects | Megakaryocytes - metabolism | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Cell Line | Liver - metabolism | Janus Kinase 2 - genetics | Myeloproliferative Disorders - drug therapy | Fusion Proteins, bcr-abl - deficiency | Animals | Signal Transduction - drug effects | Spleen - metabolism | Cell Cycle Checkpoints - drug effects | Protein Kinase Inhibitors - therapeutic use | Bone Marrow - pathology | Heterocyclic Compounds, 3-Ring - therapeutic use | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Mutation | Megakaryocytes - drug effects | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Antimitotic agents | Complications and side effects | Physiological aspects | Dosage and administration | Genetic aspects | Research | Antineoplastic agents | Drug therapy | Protein kinases | Myeloproliferative disorders | Index Medicus | Myelofibrosis
Journal Article