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1. Full Text Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes
by Robert M. Waterhouse and Evgenia V. Kriventseva and Stephan Meister and Zhiyong Xi and Kanwal S. Alvarez and Lyric C. Bartholomay and Carolina Barillas-Mury and Guowu Bian and Stephanie Blandin and Bruce M. Christensen and Yuemei Dong and Haobo Jiang and Michael R. Kanost and Anastasios C. Koutsos and Elena A. Levashina and Jianyong Li and Petros Ligoxygakis and Robert M. MacCallum and George F. Mayhew and Antonio Mendes and Kristin Michel and Mike A. Osta and Susan Paskewitz and Sang Woon Shin and Dina Vlachou and Lihui Wang and Weiqi Wei and Liangbiao Zheng and Zhen Zou and David W. Severson and Alexander S. Raikhel and Fotis C. Kafatos and George Dimopoulos and Evgeny M. Zdobnov and George K. Christophides
Science, ISSN 0036-8075, 6/2007, Volume 316, Issue 5832, pp. 1738 - 1743
Mosquitoes are vectors of parasitic and viral diseases of immense importance for public health. The acquisition of the genome sequence of the yellow fever and... 
Receptors | Divergent evolution | Evolution | Reports | Genomes | Tolls | Melanization | Insect vectors | Immunity | Insect genetics | Mosquitos | ANTIVIRAL RESPONSE | MELANIZATION | PHAGOCYTOSIS | ACTIVATION | SERINE PROTEASES | DROSOPHILA-MELANOGASTER | MULTIDISCIPLINARY SCIENCES | SEPHADEX BEADS | PLASMODIUM | ANOPHELES-GAMBIAE | AEDES-AEGYPTI | Carrier Proteins - physiology | Genes, Insect | Multigene Family | Drosophila melanogaster - immunology | Insect Proteins - physiology | Signal Transduction | Species Specificity | Anopheles - genetics | Antimicrobial Cationic Peptides - physiology | Immunity, Innate - genetics | Insect Proteins - genetics | Insect Vectors - immunology | Aedes - immunology | Aedes - genetics | Drosophila melanogaster - genetics | Melanins - metabolism | Carrier Proteins - genetics | Animals | Insect Vectors - genetics | Malaria - transmission | Anopheles - immunology | Evolution, Molecular | Physiological aspects | Mosquitoes | Genetic aspects | Adaptation (Biology) | Health aspects | Immune system | Disease transmission | Immunology | Evolutionary biology | Insects | Genomics | Public health
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2. Full Text Phenotypic Plasticity through Transcriptional Regulation of the Evolutionary Hotspot Gene tan in Drosophila melanogaster
by Gibert, Jean-Michel and Mouchel-Vielh, Emmanuèle and De Castro, Sandra and Peronnet, Frédérique
PLoS Genetics, ISSN 1553-7390, 08/2016, Volume 12, Issue 8, p. e1006218
Phenotypic plasticity is the ability of a given genotype to produce different phenotypes in response to distinct environmental conditions. Phenotypic... 
DEVELOPMENTAL PLASTICITY | ELEMENTS | CHROMATIN | H3K4 | HOMEOTIC GENE | TRITHORAX | GENETICS & HEREDITY | PATTERNS | REACTION NORMS | EXPRESSION | PIGMENTATION | Promoter Regions, Genetic | Histone-Lysine N-Methyltransferase - genetics | Temperature | Drosophila melanogaster - physiology | Gene Expression Regulation | Genotype | DNA-Binding Proteins - genetics | Drosophila melanogaster - genetics | Gene-Environment Interaction | Chromosomal Proteins, Non-Histone - genetics | Drosophila Proteins - biosynthesis | Melanins - biosynthesis | Selection, Genetic - genetics | Phenotype | Animals | Pigmentation - genetics | Female | Drosophila Proteins - genetics | Chromatin - genetics | Drosophila | Phenotypic plasticity | Genetic aspects | Research | Genetic transcription | Genetic regulation | Natural history | Genotype & phenotype | Insects | Body temperature | Morphology | DNA methylation | Evolution | Standard deviation | Gene expression | Females | Experiments | Abdomen | Life Sciences | Animal genetics | Genetics | Biochemistry, Molecular Biology | Genomics
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3. Full Text Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease
by Lubbe, S.J and Escott-Price, V and Brice, A and Gasser, T and Pittman, A.M and Bras, J and Hardy, J and Heutink, P and Wood, N.M and Singleton, A.B and Grosset, D.G and Carroll, C.B and Law, M.H and Demenais, F and Iles, M.M and Bishop, D.T and Newton-Bishop, J and Williams, N.M and Morris, H.R and Melanoma Meta-Anal Consortium and Int Parkinson's Dis Genomics and International Parkinson's Disease Genomics Consortium and Melanoma Meta-Analysis Consortium
Neurobiology of Aging, ISSN 0197-4580, 2016, Volume 48, pp. 222.e1 - 222.e7
Abstract A shared genetic susceptibility between cutaneous malignant melanoma (CMM) and Parkinson's disease (PD) has been suggested. We investigated this by... 
Neurology | Internal Medicine | Parkinson's | Shared genetic background | Cutaneous malignant melanoma | Pigmentation | Tyrosinase | METAANALYSIS | RISK | SUBSTANTIA-NIGRA | CANCER | NEUROSCIENCES | GERIATRICS & GERONTOLOGY | NEUROMELANIN | NEURONS | MUTATIONS | SEQUENCING DATA | ASSOCIATION | DCC Receptor | Genetic Predisposition to Disease - genetics | Genetic Association Studies | Oxidoreductases - genetics | Humans | Dopamine - biosynthesis | Monophenol Monooxygenase | Genotype | Risk | Parkinson Disease - genetics | Ubiquitin Thiolesterase - genetics | Melanins - biosynthesis | Membrane Glycoproteins - genetics | Pigmentation - genetics | Melanoma - genetics | Skin Neoplasms - genetics | Tumor Suppressor Proteins - genetics | Genetic Variation - genetics | Receptor, ErbB-4 - genetics | Cohort Studies | Receptors, Cell Surface - genetics | Enzymes | Medical colleges | Neurosciences | Parkinson's disease | Analysis | Genes | Melanoma | Genetic research | Disease susceptibility | Tumor proteins | Medical research | Medicine, Experimental | Genetic Report Abstract
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4. Full Text Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up
by Liu, F and Visser, Mijke and Duffy, David and Hysi, Pirro and Jacobs, Leonie and Lao Grueso, Oscar and Zhong, Kaiyin and Walsh, Susan and Chaitanya, Lakshmi and Wollstein, Aneas and Zhu, Gu and Montgomery, Grant and Henders, Anjali and Mangino, Massimo and Glass, Daniel and Bataille, Veronique and Sturm, Richard A and Rivadeneira Ramirez, Fernando and Hofman, Albert and IJcken, Wilfred and Uitterlinden, Ané and Palstra, Robert-Jan and Spector, Timothy and Martin, Nicholas and Nijsten, Tamar and Kayser, Manfred
Human Genetics, ISSN 0340-6717, 08/2015, Volume 134, Issue 8, pp. 823 - 835
textabstractIn the International Visible Trait Genetics (VisiGen) Consortium, we investigated the genetics of human skin color by combining a series of... 
Human Genetics | Gene Function | Molecular Medicine | Biomedicine | Metabolic Diseases | HAIR | GLUTATHIONE | TYROSINASE | GENETICS & HEREDITY | EPIDERMAL MELANIN UNIT | HUMANS | MELANOGENESIS | MALIGNANT-MELANOMA | HUMAN PIGMENTATION | EYE COLOR | MELANOCYTES | Antigens, Neoplasm - genetics | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Guanine Nucleotide Exchange Factors - genetics | Follow-Up Studies | Chromosomes, Human - genetics | Humans | Middle Aged | Interferon Regulatory Factors - genetics | Male | United Kingdom | Genetic Loci | Skin Pigmentation - genetics | Membrane Transport Proteins - genetics | Agouti Signaling Protein - genetics | Female | Polymorphism, Single Nucleotide | Europeans | Laws, regulations and rules | Genes | Genomics | Genetic research | Genomes | Genetic aspects | Skin | Research | Single nucleotide polymorphisms | Gene expression | Original Investigation
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5. Full Text Association of the OCA2 polymorphism His615Arg with melanin content in East Asian populations: Further evidence of convergent evolution of skin pigmentation
by Edwards, Melissa and Bigham, Abigail and Tan, Jinze and Li, Shilin and Gozdzik, Agnes and Ross, Kendra and Jin, Li and Parra, Esteban J
PLoS Genetics, ISSN 1553-7390, 03/2010, Volume 6, Issue 3, p. e1000867
The last decade has witnessed important advances in our understanding of the genetics of pigmentation in European populations, but very little is known about... 
HERC2 | POSITIVE SELECTION | GENE | SIGNATURES | GENETICS & HEREDITY | HUMANS | SIGNALING-PROTEIN ASIP | EYE COLOR | CANDIDATE LOCI | SINGLE NUCLEOTIDE POLYMORPHISMS | MELANOCYTES | Gene Frequency - genetics | Humans | Asian Continental Ancestry Group - genetics | Selection, Genetic | Histidine - genetics | Genotype | Linear Models | Melanins - metabolism | Skin Pigmentation - genetics | Biological Evolution | Canada | Haplotypes - genetics | Ethnic Groups - genetics | Membrane Transport Proteins - genetics | Arginine - genetics | Polymorphism, Single Nucleotide - genetics | Amino Acid Substitution - genetics | Allelomorphism | Single nucleotide polymorphisms | Research | Properties | Identification and classification | Melanin | Melanism (Evolutionary adaptation) | Studies | Haplotypes | Genealogy | Genomics | Genomes | Gene expression
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6. Full Text Insights into the Genetic Architecture of Early Stage Age-Related Macular Degeneration: A Genome-Wide Association Study Meta-Analysis
by Holliday, Elizabeth and Smith, G.D and Cornes, Belinda and Buitendijk, Gabrielle and Jensen, Richard and Sim, Xueling and Aspelund, Thor and Aung, Tin and Baird, Paul and Boerwinkle, Eric and Cheng, Ching-Yu and Duijn, Cornelia and Eiriksdottir, Gudny and Gudnason, Vilmundur and Harris, Tamara and Hewit, Alex and Inouye, Michael and Jonasson, Fridbert and Klein, Barbara and Launer, Lenore and Li, Xiaohui and Liew, Gerald and Lumley, Thomas and McElduff, Patrick and McKnight, Barbara and Mitchell, Paul and Psaty, Bruce and Rochtchina, Elena and Rotter, Jerome and Scott, Rodney and Tay, Wan-Ting and Taylor, Kent and Teo, Yik Ying and Uitterlinden, Ané and Viswanathan, Anand and Xie, Sophia and Vingerling, Hans and Klaver, Caroline and Tai, Shyong and Siscovick, David and Klein, Ronald and Cotch, Mary Frances and Wong, Tien Yin and Attia, John and Wang, Jie Jin and Wellcome Trust Case Control Consor and Wellcome Trust Case Control Consortium 2
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, p. e53830
Genetic factors explain a majority of risk variance for age-related macular degeneration (AMD). While genome-wide association studies (GWAS) for late AMD... 
SKIN PIGMENTATION | EYE | POPULATION | IDENTIFIES 3 | VARIANTS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | RISK | PROGRESSION | APOLIPOPROTEIN-E | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Risk Factors | Zinc Finger Protein Gli3 | Genotype | Nerve Tissue Proteins - genetics | Proteins - genetics | Macular Degeneration - genetics | Apolipoproteins E - genetics | Polymorphism, Single Nucleotide | Complement Factor H - genetics | Kruppel-Like Transcription Factors - genetics | Macular degeneration | Physiological aspects | Genomes | DNA binding proteins | Analysis | Genomics | Biometrics | Heart | Regulators | Demography | Laboratories | Risk | Cardiovascular disease | Retina | Systematic review | Biosynthesis | Epidemiology | Consortia | Genetic effects | Signal transduction | Complement factor H | Pathways | Apolipoprotein E | Genetics | Genetic factors | Zinc finger proteins | Public health | Age | Medical research | Architecture | Inflammation | Apolipoproteins | Loci | Age related diseases | Biological activity | Zinc | Medicine | Pathology | Regeneration | Signaling | Hospitals | Hedgehog protein | Alzheimers disease | Tyrosinase | Melanin
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7. Full Text Molecular and Evolutionary History of Melanism in North American Gray Wolves
by Tovi M. Anderson and Bridgett M. vonHoldt and Sophie I. Candille and Marco Musiani and Claudia Greco and Daniel R. Stahler and Douglas W. Smith and Badri Padhukasahasram and Ettore Randi and Jennifer A. Leonard and Carlos D. Bustamante and Elaine A. Ostrander and Hua Tang and Robert K. Wayne and Gregory S. Barsh and Teknisk-naturvetenskapliga vetenskapsområdet and Evolutionsbiologi and Biologiska sektionen and Uppsala universitet and Institutionen för evolutionsbiologi and Institutionen för ekologi och genetik
Science, ISSN 0036-8075, 3/2009, Volume 323, Issue 5919, pp. 1339 - 1343
Morphological diversity within closely related species is an essential aspect of evolution and adaptation. Mutations in the Melanocortin 1 receptor (Mc1r) gene... 
Haplotypes | Wolves | Boreal forests | Dogs | Alleles | Genetic loci | Evolution | Reports | Melanosis | Chromosomes | Genetic mutation | GENETIC-BASIS | MULTIDISCIPLINARY SCIENCES | SEQUENCE | PATTERNS | HAPLOTYPE STRUCTURE | DIFFERENTIATION | COAT COLOR | GENOME | DOMESTIC DOGS | MICROSATELLITE LOCI | INTROGRESSION | Sequence Deletion | beta-Defensins - genetics | Gene Flow | Hair Color - genetics | Receptor, Melanocortin, Type 1 - genetics | Selection, Genetic | Wolves - genetics | Molecular Sequence Data | Phylogeny | Melanins - metabolism | Linkage Disequilibrium | Biological Evolution | Phenotype | Animals | Coyotes - genetics | Pigmentation - genetics | Agouti Signaling Protein - genetics | Ecosystem | Polymorphism, Single Nucleotide | Dogs - genetics | Mutation | Gene mutations | Causes of | Genetic aspects | Research | Peptide hormones | Melanism (Evolutionary adaptation) | Skin | Evolutionary biology | Population genetics | Color | Biological Sciences | Biology | Biologi | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
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8. Full Text Mutations in POFUT1, Encoding Protein O-fucosyltransferase 1, Cause Generalized Dowling-Degos Disease
by Li, Ming and Li, Chengrang and Li, Chunqi and Cheng, Ruhong and Liang, Jianying and Yan, Heng and Zhang, Hui and Yang, Lijia and Jiao, Qingqing and Lu, Zhiyong and He, Jianhui and Ji, Jin and Shen, Zhu and Hao, Fei and Yu, Hong and Yao, Zhirong
The American Journal of Human Genetics, ISSN 0002-9297, 06/2013, Volume 92, Issue 6, pp. 895 - 903
Dowling-Degos disease (DDD), or reticular pigmented anomaly of the flexures, is a type of rare autosomal-dominant genodermatosis characterized by reticular... 
DYSCHROMATOSIS UNIVERSALIS HEREDITARIA | HOMEOSTASIS | ALAGILLE-SYNDROME | GENE | GENETICS & HEREDITY | NOTCH2 CAUSE | PHENOTYPE | DISORDER | RECEPTORS | AORTIC-VALVE DISEASE | MELANOBLASTS | Skin Diseases, Papulosquamous - genetics | Humans | Middle Aged | Skin Diseases, Papulosquamous - pathology | Mutation, Missense | Gene Knockdown Techniques | Melanins - biosynthesis | Skin Diseases, Genetic - genetics | HEK293 Cells | Hyperpigmentation - pathology | Female | Genetic Linkage | Fucosyltransferases - genetics | Gene Expression | Genetic Predisposition to Disease | Genome-Wide Association Study | Zebrafish Proteins - biosynthesis | Skin Diseases, Genetic - pathology | Zebrafish | Chromosome Mapping | Hyperpigmentation - genetics | Melanins - genetics | Sequence Analysis, DNA | Animals | Pedigree | Polymorphism, Single Nucleotide | Zebrafish Proteins - genetics | Chromosomes, Human, Pair 20 - genetics
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9. Full Text SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans
by Rebecca L. Lamason and Manzoor-Ali P. K. Mohideen and Jason R. Mest and Andrew C. Wong and Heather L. Norton and Michele C. Aros and Michael J. Jurynec and Xianyun Mao and Vanessa R. Humphreville and Jasper E. Humbert and Soniya Sinha and Jessica L. Moore and Pudur Jagadeeswaran and Wei Zhao and Gang Ning and Izabela Makalowska and Paul M. McKeigue and David O'Donnell and Rick Kittles and Esteban J. Parra and Nancy J. Mangini and David J. Grunwald and Mark D. Shriver and Victor A. Canfield and Keith C. Cheng
Science, ISSN 0036-8075, 12/2005, Volume 310, Issue 5755, pp. 1782 - 1786
Lighter variations of pigmentation in humans are associated with diminished number, size, and density of melanosomes, the pigmented organelles of melanocytes.... 
Larvae | Melanophores | Calcium | Melanosomes | Humans | Alleles | Pigmentation | Embryos | Genetic mutation | Melanin | Research Article | PROTEIN | GENE | MULTIDISCIPLINARY SCIENCES | SKIN COLOR | AFRICAN-AMERICANS | MUTATIONS | INDUCTION | HUMAN MELANOCYTES | MAP | HERMANSKY-PUDLAK-SYNDROME | MELANOSOMES | Haplotypes | Melanosomes - ultrastructure | Calcium - metabolism | Antiporters - chemistry | Genes | Asian Continental Ancestry Group - genetics | Molecular Sequence Data | Zebrafish - embryology | Melanosomes - chemistry | Multifactorial Inheritance | Skin Pigmentation - genetics | Genetic Variation | Melanins - analysis | Alanine - genetics | Pigment Epithelium of Eye - chemistry | Threonine - genetics | Antiporters - genetics | Pigment Epithelium of Eye - ultrastructure | Ion Transport | African Continental Ancestry Group - genetics | Amino Acid Sequence | European Continental Ancestry Group - genetics | Zebrafish Proteins - chemistry | Gene Frequency | Selection, Genetic | African Americans - genetics | Zebrafish - genetics | Zebrafish Proteins - physiology | Biological Evolution | Animals | Zebrafish - metabolism | Heterozygote | Mice | Polymorphism, Single Nucleotide | Mutation | Zebrafish Proteins - genetics | Antiporters - physiology | Genetic research | Color of animals | Research | Analysis | Pigments | Fish | Polymorphism
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10. Full Text Loci associated with skin pigmentation identified in African populations
by Crawford, Nicholas G and Kelly, Derek E and Hansen, Matthew E. B and Beltrame, Marcia H and Fan, Shaohua and Bowman, Shanna L and Jewett, Ethan and Ranciaro, Alessia and Thompson, Simon and Lo, Yancy and Pfeifer, Susanne P and Jensen, Jeffrey D and Campbell, Michael C and Beggs, William and Hormozdiari, Farhad and Mpoloka, Sununguko Wata and Mokone, Gaonyadiwe George and Nyambo, Thomas and Meskel, Dawit Wolde and Belay, Gurja and Haut, Jake and Rothschild, Harriet and Zon, Leonard and Zhou, Yi and Kovacs, Michael A and Xu, Mai and Zhang, Tongwu and Bishop, Kevin and Sinclair, Jason and Rivas, Cecilia and Elliot, Eugene and Choi, Jiyeon and Li, Shengchao A and Hicks, Belynda and Burgess, Shawn and Abnet, Christian and Watkins-Chow, Dawn E and Oceana, Elena and Song, Yun S and Eskin, Eleazar and Brown, Kevin M and Marks, Michael S and Loftus, Stacie K and Pavan, William J and Yeager, Meredith and Chanock, Stephen and Tishkoff, Sarah A and NISC Comparative Sequencing Progra and NISC Comparative Sequencing Program
Science, ISSN 0036-8075, 11/2017, Volume 358, Issue 6365, pp. 887 - 887
Despite the wide range of skin pigmentation in humans, little is known about its genetic basis in global populations. Examining ethnically diverse African... 
ZEBRAFISH | POSITIVE SELECTION | OCULOCUTANEOUS ALBINISM | COLOR | MULTIDISCIPLINARY SCIENCES | P GENE-MUTATIONS | SEQUENCE | DNA-BINDING PROTEIN-1 | INFERENCE | GENOME-WIDE ASSOCIATION | HISTORY | Africa, Eastern | Genome-Wide Association Study | Gene Flow | Membrane Proteins - genetics | Humans | Melanocytes - metabolism | Genetic Loci | Melanins - genetics | DNA-Binding Proteins - genetics | Melanins - metabolism | Melanins - biosynthesis | Radiation Exposure | Skin Pigmentation - genetics | Animals | Ethnic Groups - genetics | Ultraviolet Rays | Antiporters - genetics | Mice | Polymorphism, Single Nucleotide | African Continental Ancestry Group - genetics | Genome, Human | Evolution, Molecular | Suppression, Genetic | Alternative splicing | Correlation | Populations | Transcription | Migration | Dark adaptation | Biological evolution | Genes | Positive selection | DNA damage | Population studies | Melanocytes | Genomes | Regulatory sequences | Biology | Population genetics | DNA repair | Human populations | Proteins | Vitamin D | Light | Evolution | Genetics | Deoxyribonucleic acid--DNA | Splicing | Phenotypic variations | Adaptiveness | Color | Zebrafish | Gene expression | Pigmentation | Genetic variance | Gene flow | Equatorial regions | Alleles | Skin | Mutation | Gene mapping | Lysosomal protein | Melanin
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