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International journal of molecular sciences, ISSN 1661-6596, 09/2018, Volume 19, Issue 9, p. 2667
Melanin, the pigment produced by specialized cells, melanocytes, is responsible for skin and hair color. Skin pigmentation is an important protective mechanism... 
Pheomelanin | Paracrine factors | DNA repair | Eumelanin | Melanocortin 1 receptor | Photoprotection | Human melanocytes | melanocortin 1 receptor | pheomelanin | OXIDATIVE STRESS | HUMAN SKIN | ALPHA-MELANOTROPIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | photoprotection | AGOUTI SIGNALING PROTEIN | FIBROBLAST-GROWTH-FACTOR | CHEMISTRY, MULTIDISCIPLINARY | CULTURED HUMAN MELANOCYTES | MINIMAL ACTIVE SEQUENCE | MELANOCYTE-STIMULATING HORMONE | human melanocytes | ULTRAVIOLET-RADIATION | paracrine factors | eumelanin | Melanoma - etiology | alpha-MSH - pharmacology | Humans | DNA Repair - radiation effects | Melanocytes - metabolism | Receptor, Melanocortin, Type 1 - metabolism | Melanins - metabolism | Melanocytes - radiation effects | Skin Neoplasms - prevention & control | Melanoma - prevention & control | Melanocytes - cytology | Melanocytes - drug effects | Melanoma - genetics | Skin Pigmentation - radiation effects | DNA Damage - drug effects | Melanoma - metabolism | DNA Repair - drug effects | alpha-MSH - chemistry | Melanins - genetics | Ultraviolet Rays - adverse effects | Skin Neoplasms - metabolism | Skin Pigmentation - drug effects | Animals | Skin Neoplasms - genetics | Sunscreening Agents - chemistry | Skin Neoplasms - etiology | Sunscreening Agents - pharmacology | DNA Damage - radiation effects | Color sensitivity | U.V. radiation | DNA damage | Color | Melanoma | Melanocortin | Paracrine signalling | Melanocytes | Environmental factors | Pigmentation | Skin cancer | Ultraviolet radiation | Etiology | a-Melanocyte-stimulating hormone | Repair | Radiation damage | Impact damage | Deoxyribonucleic acid--DNA | Melanin | Cancer | Oxidative stress | Mitochondrial DNA | Enzymes | Biological assays | Gene expression | Mutation
Journal Article
Pigment cell research, ISSN 0906-9305, 1988
Journal
Journal of Cellular Biochemistry, ISSN 0730-2312, 09/2018, Volume 119, Issue 9, pp. 7643 - 7656
Journal Article
PloS one, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, p. e0144757
The melanocortin 1 receptor gene (MC1R) expressed in melanocytes is a major determinant of skin pigmentation. It encodes a Gs protein-coupled receptor... 
MELANOMA | MC1R | PROTEIN | GENE | MULTIDISCIPLINARY SCIENCES | DIMERIZATION | HUMAN MELANOCYTES | RED HAIR | EXPRESSION | SKIN-CANCER | PIGMENTATION | alpha-MSH - pharmacology | Humans | Mutant Chimeric Proteins - genetics | Protein Multimerization | Melanocytes - metabolism | Tubulin - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Melanocortin, Type 1 - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | alpha-MSH - metabolism | Melanocytes - radiation effects | RNA Splicing | Tubulin - metabolism | Protein Isoforms - metabolism | Ultraviolet Rays | Melanocytes - cytology | Melanocytes - drug effects | Mutant Chimeric Proteins - metabolism | HEK293 Cells | Cyclic AMP - metabolism | Signal Transduction | Receptor, Melanocortin, Type 1 - genetics | Gene Expression Regulation | Protein Transport | Protein Isoforms - genetics | Care and treatment | Intermedin | Research | Tubulins | Risk factors | Melanoma | Alternative splicing | Poly(A) | Immunoprecipitation | Genes | Amino acids | Melanocytes | Biochemistry | Helices | Kinases | Guanine nucleotide-binding protein | Proteins | Endocytosis | Immunology | Tubulin | Cell cycle | a-Melanocyte-stimulating hormone | Chimeras | Cytokines | Splicing | Dermatology | U.V. radiation | Tanning | Extracellular signal-regulated kinase | Melanocortin | Pigmentation | Medicine | Signaling | Ultraviolet radiation | Sunburn & sun tanning | Isoforms | Skin | Regulation | Aberration | Molecular biology | Binding sites
Journal Article
Journal of investigative dermatology, ISSN 0022-202X, 09/2012, Volume 132, Issue 9, pp. 2255 - 2262
The melanocortin 1 receptor (MC1R), a Gs protein–coupled receptor, has an important role in human pigmentation. We investigated the regulation of expression... 
MELANOMA | COUPLED-RECEPTOR KINASES | DESENSITIZATION | DNA-DAMAGE | RISK | MUTATIONS | ULTRAVIOLET-RADIATION | RED HAIR | EXPRESSION | CULTURED HUMAN MELANOCYTES | DERMATOLOGY | Tetradecanoylphorbol Acetate - pharmacology | alpha-MSH - pharmacology | Humans | Receptor, Melanocortin, Type 1 - antagonists & inhibitors | Tetradecanoylphorbol Acetate - analogs & derivatives | Melanocytes - metabolism | Melanocytes - radiation effects | Monophenol Monooxygenase - metabolism | G-Protein-Coupled Receptor Kinases - biosynthesis | Ultraviolet Rays | Melanocytes - drug effects | Protein Kinase C - metabolism | Skin Pigmentation - radiation effects | Skin Pigmentation - physiology | Agouti Signaling Protein - pharmacology | Colforsin - pharmacology | Receptor, Melanocortin, Type 1 - biosynthesis | Cells, Cultured | Adenylyl Cyclases - metabolism | Skin Pigmentation - drug effects | beta-Arrestin 1 | beta-Arrestins | beta-Defensins - pharmacology | Arrestins - biosynthesis | Melanocortins - pharmacology | Receptor, Melanocortin, Type 1 - agonists | Enzymes | Protein kinase C | U.V. radiation | alpha -Melanocyte-stimulating hormone | 12-O-Tetradecanoylphorbol-13-acetate | Cyclic AMP | MC1R gene | Melanocytes | Antagonists | Monophenol monooxygenase | Pigmentation | Membrane proteins | Adenylate cyclase | beta -Arrestin | Defensins | double prime G protein-coupled receptor kinase | Forskolin | Recycling | Genotypes
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 549, Issue 7672, pp. 399 - 403
Journal Article
Journal Article