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1. Full Text Design and Development of Spray-Dried Microsystems to Improve Technological and Functional Properties of Bioactive Compounds from Hazelnut Shells
by Esposito, Tiziana and Mencherini, Teresa and Del Gaudio, Pasquale and Auriemma, Giulia and Franceschelli, Silvia and Picerno, Patrizia and Aquino, Rita P and Sansone, Francesca
Molecules (Basel, Switzerland), ISSN 1420-3049, 03/2020, Volume 25, Issue 6, p. 1273
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Plant Extracts - chemistry | Antioxidants - chemistry | Humans | Cellulose - chemistry | Lecithins - chemistry | Melanocytes - drug effects | Melanocytes - pathology | Inhibitory Concentration 50 | Anticarcinogenic Agents - pharmacology | Anticarcinogenic Agents - isolation & purification | Cellulose - analogs & derivatives | Powders | Fruit - chemistry | Drug Stability | Waste Products - analysis | Antineoplastic Agents, Phytogenic - chemistry | Antioxidants - pharmacology | Spray Drying | Pectins - chemistry | Proline - chemistry | Anticarcinogenic Agents - chemistry | Antioxidants - isolation & purification | Cell Line, Tumor | Corylus - chemistry | HeLa Cells | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Viscosity | Lecithin | Proline | Amino acids | Caspase-3 | Antioxidants | Bioactive compounds | Polymers | Food | Functional foods & nutraceuticals | Ethanol | Hazelnuts | Melanoma | Ingredients | Solubility | Spray drying | Shells | Pectin | Industrial applications | Bioavailability | Tumor cell lines | Cervix | L-Proline | Smell | Plant extracts | Hydroxyethyl celluloses | Phytochemicals | Morphology | Cervical cancer | Apoptosis | Drying | Pharmaceuticals | Index Medicus | improvement of the chemopreventive effect | long-term stability | multicomponent-based matrix | hazelnut shells by-product extract | spray-dried microsystems
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2. Full Text Drug-Loaded Nanoparticles Targeted to the Colon With Polysaccharide Hydrogel Reduce Colitis in a Mouse Model
by Laroui, Hamed and Dalmasso, Guillaume and Nguyen, Hang Thi Thu and Yan, Yutao and Sitaraman, Shanthi V and Merlin, Didier
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2010, Volume 138, Issue 3, pp. 843 - 853.e2
Gastroenterology and Hepatology | KPV-Loaded Nanoparticle | Polysaccharide Hydrogel | Colitis | Colon Targeting | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Dextran Sulfate | Intestinal Mucosa - metabolism | Hydrogels | Humans | Colon - drug effects | Gastrointestinal Agents - administration & dosage | Colitis - pathology | Anti-Inflammatory Agents - metabolism | Gastrointestinal Agents - chemistry | Intestinal Mucosa - drug effects | Drug Carriers | Dose-Response Relationship, Drug | Nanoparticles | Time Factors | Melanocyte-Stimulating Hormones - chemistry | Colitis - chemically induced | Drug Compounding | Polysaccharides - chemistry | Anti-Inflammatory Agents - administration & dosage | Female | Glucuronic Acid - chemistry | Disease Models, Animal | Caco-2 Cells | Peptide Fragments - metabolism | Administration, Oral | Colon - pathology | Melanocyte-Stimulating Hormones - administration & dosage | Melanocyte-Stimulating Hormones - metabolism | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Solubility | Hexuronic Acids - chemistry | Chemistry, Pharmaceutical | Colon - metabolism | Peptide Fragments - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Chitosan - chemistry | Alginates - chemistry | Mice | Colitis - prevention & control | Gastrointestinal Agents - metabolism | Dextran | Analysis | Sodium sulfate | Gastrointestinal diseases | Fluorescein | Polyvinyl alcohol | Serum albumin | Mitogens | Index Medicus | Abridged Index Medicus
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3. Full Text Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis
by Xiao, Bo and Xu, Zhigang and Viennois, Emilie and Zhang, Yuchen and Zhang, Zhan and Zhang, Mingzhen and Han, Moon Kwon and Kang, Yuejun and Merlin, Didier
Molecular therapy, ISSN 1525-0016, 07/2017, Volume 25, Issue 7, pp. 1628 - 1640
tripeptide KPV | targeted delivery | nanoparticle | ulcerative colitis | oral administration | Tumor Necrosis Factor-alpha - metabolism | Epithelial Cells - metabolism | Nanoparticles - chemistry | Epithelial Cells - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Melanocyte-Stimulating Hormones - pharmacology | Male | Peptide Fragments - pharmacology | Molecular Targeted Therapy | Anti-Inflammatory Agents - metabolism | Drug Carriers | Melanocyte-Stimulating Hormones - chemistry | Drug Compounding | Colitis, Ulcerative - drug therapy | Glucuronic Acid - chemistry | Gene Expression | Peptide Fragments - metabolism | Macrophages - pathology | Administration, Oral | Anti-Inflammatory Agents - pharmacology | Colitis, Ulcerative - metabolism | Melanocyte-Stimulating Hormones - metabolism | Hyaluronic Acid - chemistry | Epithelial Cells - pathology | Colitis, Ulcerative - pathology | Hexuronic Acids - chemistry | Static Electricity | Sodium Dodecyl Sulfate | Particle Size | Macrophages - metabolism | Peptide Fragments - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Chitosan - chemistry | Colitis, Ulcerative - chemically induced | Alginates - chemistry | Macrophages - drug effects | RAW 264.7 Cells | Mice | Nanoparticles - administration & dosage | Hydrogels - chemistry | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Drug delivery systems | Inflammatory bowel diseases | Particle size | Hydrogels | Epithelial cells | Alginic acid | Mucosa | Proline | Research | Macrophages | Nanoparticles | Intestine | Colon | Statistical analysis | Oral administration | Inflammation | Permeability | Tumor necrosis factor-α | Inflammatory bowel disease | Microscopy | Lysine | Valine | Zeta potential | Morphology | Chitosan | Hyaluronic acid | Ulcerative colitis | Index Medicus | Original
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4. Full Text Different levels of skin whitening activity among 3,6-anhydro-L-galactose, agarooligosaccharides, and neoagarooligosaccharides
by Kim, Ji Hye and Yun, Eun Ju and Yu, Sora and Kim, Kyoung Heon and Kang, Nam Joo
Marine drugs, ISSN 1660-3397, 10/2017, Volume 15, Issue 10, p. 321
α-melanocyte-stimulating hormone | Skin whitening | Melanogenesis | 3,6-anhydro-L-galactose | Neoagarooligosaccharides | Agarooligosaccharides | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Galactose - pharmacology | Humans | Melanocytes | Structure-Activity Relationship | Melanins - biosynthesis | Oligosaccharides - pharmacology | Galactose - analogs & derivatives | Oligosaccharides - chemistry | Glycoside Hydrolases - chemistry | Disaccharidases - chemistry | Epidermis - drug effects | Rhodophyta - chemistry | Skin Lightening Preparations - chemistry | Galactosides - chemistry | Skin Lightening Preparations - pharmacology | Skin Pigmentation - drug effects | Galactose - chemistry | Galactosides - pharmacology | Animals | Sepharose - chemistry | Epidermis - physiology | Cell Line, Tumor | Epidermal Cells | Cell Proliferation - drug effects | Mice | Seaweed - chemistry | Cell proliferation | Physiological effects | Hydrolase | Toxicity | Algae | Melanoma | Polymerization | Agar | Cytotoxicity | Chemical reactions | Inflammation | Oligosaccharides | Proliferation | Agarose | Cells | Antioxidants | Agarase | Skin | Galactose | Sugars | Index Medicus | 3,6-anhydro | l-galactose">">l-galactose | skin whitening | melanogenesis | agarooligosaccharides | neoagarooligosaccharides
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5. Full Text Current challenges in understanding melanogenesis: bridging chemistry, biological control, morphology, and function
by Simon, John D and Peles, Dana and Wakamatsu, Kazumasa and Ito, Shosuke
Pigment cell and melanoma research, ISSN 1755-1471, 10/2009, Volume 22, Issue 5, pp. 563 - 579
melanogenesis | pheomelanin | casing model | melanosome | melanin | eumelanin | Casing model | Melanogenesis | Melanosome | Pheomelanin | Eumelanin | Melanin | Oncology | Life Sciences & Biomedicine | Dermatology | Science & Technology | Cell Biology | Melanins - chemistry | Humans | Cysteinyldopa - chemistry | Dihydroxyphenylalanine - analogs & derivatives | Melanocytes - metabolism | Benzoquinones - chemistry | Melanins - metabolism | Melanosomes - chemistry | Dihydroxyphenylalanine - chemistry | Dihydroxyphenylalanine - metabolism | Iris - ultrastructure | Benzothiazoles - chemistry | Molecular Structure | Benzothiazoles - metabolism | Melanosomes - metabolism | Benzoquinones - metabolism | Cysteinyldopa - metabolism | Iris - chemistry | Animal pigments | Biological control | Chemical properties | Pests | Free radicals (Chemistry) | Dyes and dyeing | Index Medicus
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6. Full Text Tyrosinase‐catalyzed oxidation of rhododendrol produces 2‐methylchromane‐6,7‐dione, the putative ultimate toxic metabolite: implications for melanocyte toxicity
by Ito, Shosuke and Ojika, Makoto and Yamashita, Toshiharu and Wakamatsu, Kazumasa
Pigment cell and melanoma research, ISSN 1755-1471, 09/2014, Volume 27, Issue 5, pp. 744 - 753
sulfhydryl group | whitening agent: tyrosinase | rhododendrol | melanocyte toxicity | Whitening agent: tyrosinase | Melanocyte toxicity | Sulfhydryl group | Rhododendrol | Oncology | Life Sciences & Biomedicine | Dermatology | Science & Technology | Cell Biology | Quinones - chemistry | Free Radicals | Glutathione - metabolism | Humans | Superoxides - chemistry | Skin Lightening Preparations - chemistry | Catechols - chemistry | Chromatography, High Pressure Liquid | Monophenol Monooxygenase - toxicity | Spectrophotometry, Ultraviolet | Monophenol Monooxygenase - metabolism | Benzopyrans - chemistry | Skin Lightening Preparations - metabolism | Melanocytes - cytology | Melanocytes - drug effects | Skin Lightening Preparations - toxicity | Oxygen - chemistry | Water - chemistry | Cytosol - metabolism | Butanols - adverse effects | Catalysis | Agaricales - enzymology | Butanols - chemistry | Monophenol Monooxygenase - chemistry | Cellular proteins | Cysteine | Catechin | Thiols | Metabolites | Quinone | Oxidation-reduction reaction | Superoxide | Skin | Chemical properties | Protein binding | Toxicity | Oxidation | Index Medicus
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7. Synthetic peptide drugs for targeting skin cancer: Malignant melanoma and melanotic lesions
by Eberle, Alex N and Rout, Bhimsen and Bigliardi-Qi, Mei and Bigliardi, Paul L
Current medicinal chemistry, ISSN 0929-8673, 2017, Volume 24, Issue 17, pp. 1797 - 1826
Melanocyte-stimulating hormone (MSH) | Photodynamic therapy | Melanin-binding peptide | Melanocortin-1 receptor (MC1R) | Malignant melanoma | Metastasis | Photosensitizer | Radiometal | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Photosensitizing Agents - chemical synthesis | Skin Neoplasms - pathology | Photosensitizing Agents - chemistry | Radiopharmaceuticals - chemistry | Skin Neoplasms - drug therapy | Peptides - chemistry | Photosensitizing Agents - therapeutic use | Humans | Melanocyte-Stimulating Hormones - metabolism | Chelating Agents - chemistry | Melanoma - radiotherapy | Radiopharmaceuticals - chemical synthesis | Skin Neoplasms - metabolism | Animals | Peptides - chemical synthesis | Metals - chemistry | Melanocyte-Stimulating Hormones - chemistry | Melanoma - drug therapy | Peptides - therapeutic use | Radiopharmaceuticals - therapeutic use | Lactams - chemistry | Drugs | Melanocyte-stimulating hormone | Peptides | Melanoma | Organs | Feasibility studies | Radioisotopes | Melanocortin | Melanocytes | Light emitting diodes | Drug delivery | C-Terminus | Lead compounds | Neuroendocrine system | Skin cancer | Metastases | Skin | Synthetic peptides | Chelating agents | a-Melanocyte-stimulating hormone | Lesions | Melanin | Tumors
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8. Full Text Provitamin supramolecular polymer micelle with pH responsiveness to control release, bioavailability enhancement and potentiation of cytotoxic efficacy
by Mejías, Francisco J. R and Gutiérrez, M. Teresa and Durán, Alexandra G and Molinillo, José M.G and Valdivia, Manuel M and Macías, Francisco A
Colloids and surfaces, B, Biointerfaces, ISSN 0927-7765, 01/2019, Volume 173, pp. 85 - 93
Encapsulation | Cytotoxicity bioassay | Supramolecular polymer micelle | Core/shell nanoparticles | β-Carotene | Physical Sciences | Chemistry | Materials Science | Life Sciences & Biomedicine | Technology | Materials Science, Biomaterials | Biophysics | Chemistry, Physical | Science & Technology | Poloxamer - chemistry | Cell Survival - drug effects | Antioxidants - chemistry | Nanoparticles - chemistry | Drug Compounding - methods | Humans | Nanoparticles - ultrastructure | Solubility | Biological Availability | Antioxidants - pharmacology | beta Carotene - chemistry | Cytotoxins - pharmacology | Rotaxanes - chemistry | Lecithins - chemistry | Melanocytes - drug effects | Melanocytes - pathology | Micelles | Cyclodextrins - chemistry | Cytotoxins - chemistry | beta Carotene - pharmacology | Cell Line, Tumor | Delayed-Action Preparations | Hydrogen-Ion Concentration | Product enhancement | Lecithin | Melanoma | Nuclear magne