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1. Full Text Chemistry of Mixed Melanogenesis—Pivotal Roles of Dopaquinone
by Ito, Shosuke and Wakamatsu, Kazumasa
Photochemistry and Photobiology, ISSN 0031-8655, 05/2008, Volume 84, Issue 3, pp. 582 - 592
Melanins can be classified into two major groups—insoluble brown to black pigments termed eumelanin and alkali‐soluble yellow to reddish‐brown pigments termed... 
BIOPHYSICS | PULSE-RADIOLYSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TYROSINASE-RELATED PROTEIN | DHICA OXIDASE ACTIVITY | MELANOMA-CELLS | METAL-IONS | CHEMICAL CHARACTERIZATION | RED HAIR | CULTURED HUMAN MELANOCYTES | HAIR FOLLICULAR MELANOCYTES | DOPACHROME TAUTOMERASE | Dihydroxyphenylalanine - chemistry | Animals | Signal Transduction | Humans | Dihydroxyphenylalanine - analogs & derivatives | Benzoquinones - chemistry | Kinetics | Dihydroxyphenylalanine - physiology | Melanins - biosynthesis | Polymerization | Pigments | Ultraviolet radiation | Chemistry | Skin
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2. Full Text Tyrosinase‐catalyzed oxidation of rhododendrol produces 2‐methylchromane‐6,7‐dione, the putative ultimate toxic metabolite: implications for melanocyte toxicity
by Ito, Shosuke and Ojika, Makoto and Yamashita, Toshiharu and Wakamatsu, Kazumasa
Pigment Cell & Melanoma Research, ISSN 1755-1471, 09/2014, Volume 27, Issue 5, pp. 744 - 753
RS ‐4‐(4‐Hydroxyphenyl)‐2‐butanol (rhododendrol, RD ) was used as a skin‐whitening agent until it was reported to induce leukoderma in July 2013. To explore... 
sulfhydryl group | whitening agent: tyrosinase | rhododendrol | melanocyte toxicity | Whitening agent: tyrosinase | Melanocyte toxicity | Sulfhydryl group | Rhododendrol | ORTHO-QUINONE | CELLS | 4-S-CYSTEAMINYLPHENOL | MECHANISM | N-PROPIONYL-4-S-CYSTEAMINYLPHENOL | MELANOGENESIS | CELL BIOLOGY | DERMATOLOGY | MUSHROOM TYROSINASE | ONCOLOGY | HYDROXYTYROSOL | SUBSTRATE | CHEMISTRY | Quinones - chemistry | Free Radicals | Glutathione - metabolism | Humans | Superoxides - chemistry | Skin Lightening Preparations - chemistry | Catechols - chemistry | Chromatography, High Pressure Liquid | Monophenol Monooxygenase - toxicity | Spectrophotometry, Ultraviolet | Monophenol Monooxygenase - metabolism | Benzopyrans - chemistry | Skin Lightening Preparations - metabolism | Melanocytes - cytology | Melanocytes - drug effects | Skin Lightening Preparations - toxicity | Oxygen - chemistry | Water - chemistry | Cytosol - metabolism | Butanols - adverse effects | Catalysis | Agaricales - enzymology | Butanols - chemistry | Monophenol Monooxygenase - chemistry | Cellular proteins | Cysteine | Catechin | Thiols | Metabolites | Quinone | Oxidation-reduction reaction | Superoxide | Skin | Chemical properties | Protein binding | Toxicity | Oxidation | Index Medicus
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3. Full Text Drug-Loaded Nanoparticles Targeted to the Colon With Polysaccharide Hydrogel Reduce Colitis in a Mouse Model
by Laroui, Hamed and Dalmasso, Guillaume and Nguyen, Hang Thi Thu and Yan, Yutao and Sitaraman, Shanthi V and Merlin, Didier
Gastroenterology, ISSN 0016-5085, 2010, Volume 138, Issue 3, pp. 843 - 853.e2
Background & Aims One of the challenges to treating inflammatory bowel disease (IBD) is to target the site of inflammation. We engineered nanoparticles (NPs)... 
Gastroenterology and Hepatology | KPV-Loaded Nanoparticle | Polysaccharide Hydrogel | Colitis | Colon Targeting | CAPSULES | ULCERATIVE-COLITIS | CHITOSAN | 5-AMINOSALICYLIC ACID | DELIVERY | IN-VITRO | INFLAMMATORY-BOWEL-DISEASE | THERAPY | PH | GASTROENTEROLOGY & HEPATOLOGY | CYTOTOXICITY | Dextran Sulfate | Intestinal Mucosa - metabolism | Hydrogels | Humans | Colon - drug effects | Gastrointestinal Agents - administration & dosage | Colitis - pathology | Anti-Inflammatory Agents - metabolism | Gastrointestinal Agents - chemistry | Intestinal Mucosa - drug effects | Drug Carriers | Dose-Response Relationship, Drug | Nanoparticles | Time Factors | Melanocyte-Stimulating Hormones - chemistry | Colitis - chemically induced | Drug Compounding | Polysaccharides - chemistry | Anti-Inflammatory Agents - administration & dosage | Female | Glucuronic Acid - chemistry | Disease Models, Animal | Caco-2 Cells | Peptide Fragments - metabolism | Administration, Oral | Colon - pathology | Melanocyte-Stimulating Hormones - administration & dosage | Melanocyte-Stimulating Hormones - metabolism | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Solubility | Hexuronic Acids - chemistry | Chemistry, Pharmaceutical | Colon - metabolism | Peptide Fragments - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Chitosan - chemistry | Alginates - chemistry | Mice | Colitis - prevention & control | Gastrointestinal Agents - metabolism | Dextran | Analysis | Sodium sulfate | Gastrointestinal diseases | Fluorescein | Polyvinyl alcohol | Serum albumin | Mitogens
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4. The melanotropins
: chemistry, physiology, and mechanisms of action
by Eberle, A. (Alex)
1988, ISBN 3805546785, xix, 556
MSH | Metabolism | Physiological effect | Analysis | MSH (Hormone)
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5. Full Text Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis
by Xiao, Bo and Xu, Zhigang and Viennois, Emilie and Zhang, Zhan and Zhang, Mingzhen and Zhang, Yuchen and Han, Moon Kwon and Kang, Yuejun and Merlin, Didier
Molecular Therapy, ISSN 1525-0016, 07/2017, Volume 25, Issue 7, pp. 1628 - 1640
Overcoming adverse effects and selectively delivering drug to target cells are two major challenges in the treatment of ulcerative colitis (UC).... 
tripeptide KPV | targeted delivery | nanoparticle | ulcerative colitis | oral administration | MEDICINE, RESEARCH & EXPERIMENTAL | DRUG-DELIVERY | INTESTINAL INFLAMMATION | INFLAMMATORY-BOWEL-DISEASE | T-CELL RESPONSES | POLYMERIC NANOPARTICLES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | REDUCE COLITIS | GENETICS & HEREDITY | COMBINATION CHEMOTHERAPY | LOADED NANOPARTICLES | PLGA NANOPARTICLES | COLONIC-MUCOSA | Tumor Necrosis Factor-alpha - metabolism | Epithelial Cells - metabolism | Nanoparticles - chemistry | Epithelial Cells - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Melanocyte-Stimulating Hormones - pharmacology | Male | Peptide Fragments - pharmacology | Molecular Targeted Therapy | Anti-Inflammatory Agents - metabolism | Drug Carriers | Melanocyte-Stimulating Hormones - chemistry | Drug Compounding | Colitis, Ulcerative - drug therapy | Glucuronic Acid - chemistry | Gene Expression | Peptide Fragments - metabolism | Macrophages - pathology | Administration, Oral | Anti-Inflammatory Agents - pharmacology | Colitis, Ulcerative - metabolism | Melanocyte-Stimulating Hormones - metabolism | Hyaluronic Acid - chemistry | Epithelial Cells - pathology | Colitis, Ulcerative - pathology | Hexuronic Acids - chemistry | Static Electricity | Sodium Dodecyl Sulfate | Particle Size | Macrophages - metabolism | Peptide Fragments - chemistry | Animals | Anti-Inflammatory Agents - chemistry | Chitosan - chemistry | Colitis, Ulcerative - chemically induced | Alginates - chemistry | Macrophages - drug effects | RAW 264.7 Cells | Mice | Nanoparticles - administration & dosage | Hydrogels - chemistry | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Drug delivery systems | Inflammatory bowel diseases | Particle size | Hydrogels | Epithelial cells | Alginic acid | Mucosa | Proline | Research | Macrophages | Nanoparticles | Intestine | Colon | Statistical analysis | Oral administration | Inflammation | Permeability | Tumor necrosis factor-α | Inflammatory bowel disease | Microscopy | Lysine | Valine | Zeta potential | Morphology | Chitosan | Hyaluronic acid | Ulcerative colitis | Original
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6. Full Text Current challenges in understanding melanogenesis: Bridging chemistry, biological control, morphology, and function
by Simon, John D and Peles, Dana and Wakamatsu, Kazumasa and Ito, Shosuke
Pigment Cell and Melanoma Research, ISSN 1755-1471, 10/2009, Volume 22, Issue 5, pp. 563 - 579
P>Melanin is a natural pigment produced within organelles, melanosomes, located in melanocytes. Biological functions of melanosomes are often attributed to the... 
Casing model | Melanogenesis | Melanosome | Pheomelanin | Eumelanin | Melanin | ALKALINE HYDROGEN-PEROXIDE | pheomelanin | CHEMICAL-CHARACTERIZATION | melanosome | melanin | melanogenesis | casing model | DHICA OXIDASE ACTIVITY | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID | RED HAIR | CULTURED HUMAN MELANOCYTES | CELL BIOLOGY | DERMATOLOGY | ONCOLOGY | OXIDATIVE POLYMERIZATION | MELANOMA-CELLS | HUMAN HAIR | METAL-IONS | eumelanin | Melanins - chemistry | Humans | Cysteinyldopa - chemistry | Dihydroxyphenylalanine - analogs & derivatives | Melanocytes - metabolism | Benzoquinones - chemistry | Melanins - metabolism | Melanosomes - chemistry | Dihydroxyphenylalanine - chemistry | Dihydroxyphenylalanine - metabolism | Iris - ultrastructure | Benzothiazoles - chemistry | Molecular Structure | Benzothiazoles - metabolism | Melanosomes - metabolism | Benzoquinones - metabolism | Cysteinyldopa - metabolism | Iris - chemistry | Animal pigments | Biological control | Chemical properties | Pests | Free radicals (Chemistry) | Dyes and dyeing
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7. Full Text Direct subphthalocyanine conjugation to bombesin: Vs. indirect conjugation to its lipidic nanocarrier
by Bernhard, Yann and Gigot, Elodie and Goncalves, Victor and Moreau, Mathieu and Sok, Nicolas and Richard, Philippe and Decréau, Richard A
Organic and Biomolecular Chemistry, ISSN 1477-0520, 2016, Volume 14, Issue 19, pp. 4511 - 4518
Bombesin (BBN) was covalently bound to graftable subphthalocyanine (SubPc) or to a cholesterol derivative, a component of a liposome that encapsulates... 
FLUORESCENT | ACTIVATION | PHOTODYNAMIC THERAPY | EFFICACY | PHTHALOCYANINE | CHEMISTRY, ORGANIC | MELANOMA-CELLS | MELANOCYTES | Nanostructures - chemistry | Liposomes - chemistry | Alkynes - chemistry | Bombesin - chemistry | Azides - chemistry | Indoles - chemistry | Organic chemistry | Chemical Sciences
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8. Full Text Pheomelanin‐induced oxidative stress: bright and dark chemistry bridging red hair phenotype and melanoma
by Napolitano, Alessandra and Panzella, Lucia and Monfrecola, Giuseppe and d'Ischia, Marco
Pigment Cell & Melanoma Research, ISSN 1755-1471, 09/2014, Volume 27, Issue 5, pp. 721 - 733
The complex interplay of genetic and epigenetic factors linking sun exposure to melanoma in the red hair phenotype hinges on the peculiar physical and chemical... 
melanoma | red hair | pheomelanin | glutathione | oxidative stress | reactive oxygen species | Oxidative stress | Reactive oxygen species | Pheomelanin | Melanoma | Glutathione | Red hair | INDUCED DNA-DAMAGE | ELECTRON-SPIN-RESONANCE | ABSORPTION-SPECTROSCOPY | ULTRAFAST ABSORPTION | OXYGEN PHOTOCONSUMPTION | CULTURED HUMAN MELANOCYTES | DOPACHROME TAUTOMERASE | CELL BIOLOGY | DERMATOLOGY | ONCOLOGY | CHEMICAL-ANALYSIS | TRANSIENT ABSORPTION | ULTRAVIOLET-RADIATION | Melanoma - metabolism | Skin Neoplasms - pathology | Oxidants - chemistry | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Oxidative Stress | Skin Diseases - metabolism | Humans | Receptor, Melanocortin, Type 1 - genetics | Gene Expression Regulation, Neoplastic | Melanins - physiology | Melanoma - pathology | Receptor, Melanocortin, Type 1 - metabolism | Skin Diseases - pathology | Skin Neoplasms - metabolism | Inflammation - metabolism | Phenotype | Animals | Hair Color | Oxygen - chemistry | Skin - pathology | Genetic aspects | Chemical properties | Skin care products | Genotype & phenotype | Index Medicus
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9. Full Text Different levels of skin whitening activity among 3,6-anhydro-L-galactose, agarooligosaccharides, and neoagarooligosaccharides
by Kim, Ji Hye and Yun, Eun Ju and Yu, Sora and Kim, Kyoung Heon and Kang, Nam Joo
Marine Drugs, ISSN 1660-3397, 10/2017, Volume 15, Issue 10, p. 321
3,6-Anhydro-l-galactose (AHG), a major monomeric constituent of red macroalgae (Rhodophyta), was recently reported to possess skin whitening activity.... 
α-melanocyte-stimulating hormone | Skin whitening | Melanogenesis | 3,6-anhydro-L-galactose | Neoagarooligosaccharides | Agarooligosaccharides | CHEMISTRY, MEDICINAL | NEOAGAROBIOSE | melanogenesis | SACCHAROPHAGUS-DEGRADANS 2-40 | BETA-AGARASE | HUMAN MELANOCYTES | IN-VITRO | TYROSINASE ACTIVITY | PURIFICATION | skin whitening | MELANIN PIGMENTATION | alpha-melanocyte-stimulating hormone | AGAROSE | agarooligosaccharides | 3,6-anhydro-l-galactose | neoagarooligosaccharides | Galactose - pharmacology | Humans | Melanocytes | Structure-Activity Relationship | Melanins - biosynthesis | Oligosaccharides - pharmacology | Galactose - analogs & derivatives | Oligosaccharides - chemistry | Glycoside Hydrolases - chemistry | Disaccharidases - chemistry | Epidermis - drug effects | Rhodophyta - chemistry | Skin Lightening Preparations - chemistry | Galactosides - chemistry | Skin Lightening Preparations - pharmacology | Skin Pigmentation - drug effects | Galactose - chemistry | Galactosides - pharmacology | Animals | Sepharose - chemistry | Epidermis - physiology | Cell Line, Tumor | Epidermal Cells | Cell Proliferation - drug effects | Mice | Seaweed - chemistry | Cell proliferation | Physiological effects | Hydrolase | Toxicity | Algae | Melanoma | Polymerization | Agar | Cytotoxicity | Chemical reactions | Inflammation | Oligosaccharides | Proliferation | Agarose | Cells | Antioxidants | Agarase | Skin | Galactose | Sugars | 3,6-anhydro | l-galactose">">l-galactose
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10. Full Text Improved synthesis and biological evaluation of chelator-modified α-MSH analogs prepared by copper-free click chemistry
by Baumhover, Nicholas J and Martin, Molly E and Parameswarappa, Sharavathi G and Kloepping, Kyle C and O’Dorisio, M. Sue and Pigge, F. Christopher and Schultz, Michael K
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2011, Volume 21, Issue 19, pp. 5757 - 5761
Radionuclide chelators (DOTA, NOTA) functionalized with a monofluorocyclooctyne group were prepared. These materials reacted rapidly and in high yield with a... 
Molecular imaging | Copper free click chemistry | PRRT | Gallium-68 | Copper-64 | Melanocyte stimulating hormone | Radionuclide therapy | Peptide synthesis | Cyclooctyne | PET | TARGETING PROPERTIES | CHEMISTRY, MEDICINAL | HORMONE PEPTIDE ANALOGS | CHEMISTRY, ORGANIC | GROWING APPLICATIONS | THERAPY | DERIVATIVES | LINKER | Radiopharmaceuticals - chemistry | alpha-MSH - chemistry | Drug Stability | Humans | Chelating Agents - chemistry | Click Chemistry - methods | Gallium Radioisotopes - chemistry | Radiopharmaceuticals - chemical synthesis | alpha-MSH - metabolism | Azides | Radiopharmaceuticals - metabolism | Animals | Heterocyclic Compounds - chemistry | Heterocyclic Compounds, 1-Ring - chemistry | Sensitivity and Specificity | Cell Line, Tumor | Protein Binding | Mice | Chelating Agents - chemical synthesis | Copper | Copper Radioisotopes - chemistry | Drug Evaluation, Preclinical | alpha-MSH - analogs & derivatives | gallium-68 | cyclooctyne | radionuclide therapy | melanocyte stimulating hormone | copper-64 | molecular imaging | peptide synthesis | copper free click chemistry
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11. Full Text Black Pepper and Health Claims: A Comprehensive Treatise
by Butt, Masood Sadiq and Pasha, Imran and Sultan, Muhammad Tauseef and Randhawa, Muhammad Atif and Saeed, Farhan and Ahmed, Waqas
Critical Reviews in Food Science and Nutrition, ISSN 1040-8398, 01/2013, Volume 53, Issue 9, pp. 875 - 886
For millennia, spices have been an integral part of human diets and commerce. Recently, the widespread recognition of diet-health linkages bolsters their... 
functional properties | Spices | piperine | black pepper | nutraceutical | INDUCED LUNG CARCINOGENESIS | RADICAL SCAVENGING ACTIVITIES | PIPER-NIGRUM L | LIPID-PEROXIDATION | ESSENTIAL OILS | HIGH-FAT DIET | FOOD SCIENCE & TECHNOLOGY | VITRO ANTIOXIDANT ACTIVITY | IN-VITRO | NUTRITION & DIETETICS | CHEMOPREVENTIVE EFFICACY | MELANOCYTE PROLIFERATION | Plant Extracts - chemistry | Polyunsaturated Alkamides - chemistry | Oils, Volatile - analysis | Oils, Volatile - chemistry | Piper nigrum - chemistry | Humans | Benzodioxoles - analysis | Dietary Supplements - analysis | Piperidines - analysis | Plant Extracts - analysis | Anti-Inflammatory Agents - analysis | Food, Organic | Anti-Infective Agents - chemistry | Alkaloids - analysis | Benzodioxoles - chemistry | Phytochemicals - chemistry | Piperidines - chemistry | Phytochemicals - analysis | Polyunsaturated Alkamides - analysis | Animals | Anti-Inflammatory Agents - chemistry | Diet | Anti-Infective Agents - analysis | Antioxidants - administration & dosage | Alkaloids - chemistry | Active control | Antioxidants | Nutrition | Ingredients | Mathematical models | Foods | Peppers
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