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1. Full Text Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1-targeted therapy in lung cancer patients
by Kamphorst, Alice O and Pillai, Rathi N and Yang, Shu and Nasti, Tahseen H and Akondy, Rama S and Wieland, Andreas and Sica, Gabriel L and Yu, Ke and Koenig, Lydia and Patel, Nikita T and Behera, Madhusmita and Wu, Hong and McCausland, Megan and Chen, Zhengjia and Zhang, Chao and Khuri, Fadlo R and Owonikoko, Taofeek K and Ahmed, Rafi and Ramalingam, Suresh S
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 19, pp. 4993 - 4998
Exhausted T cells in chronic infections and cancer have sustained expression of the inhibitory receptor programmed cell death 1 (PD-1). Therapies that block... 
Checkpoint inhibition | T-cell exhaustion | Cancer immunotherapy | PD-1 | CD8 T cells | checkpoint inhibition | MULTIDISCIPLINARY SCIENCES | ANTIBODY | CHECKPOINT BLOCKADE | UNTREATED MELANOMA | RESPONSES | cancer immunotherapy | RESISTANCE | INFECTION | NIVOLUMAB | IPILIMUMAB | EXHAUSTION | LYMPHOCYTES | Flow cytometry | Care and treatment | Usage | Lung cancer | Immunotherapy | Research | T cells | CD27 antigen | Cell proliferation | Therapy | Bcl-2 protein | PD-1 protein | CD8 antigen | Medical services | Effector cells | Lymphocytes T | CD28 antigen | Blood | Molecules | CTLA-4 protein | Cell activation | Immunology | Lymphocytes | CD38 antigen | Peripheral blood | Bioindicators | Non-small cell lung carcinoma | T cell receptors | Patients | Cell death | ICOS protein | Bcl protein | Biomarkers | Histocompatibility antigen HLA | Apoptosis | Tumors | Cancer | Index Medicus | Biological Sciences
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2. Full Text Plasma markers for identifying patients with metastatic melanoma
by Kluger, Harriet M and Hoyt, Kathleen and Bacchiocchi, Antonella and Mayer, Tina and Kirsch, Jonathan and Kluger, Yuval and Sznol, Mario and Ariyan, Stephan and Molinaro, Annette and Halaban, Ruth
Clinical Cancer Research, ISSN 1078-0432, 04/2011, Volume 17, Issue 8, pp. 2417 - 2425
Purpose: With the rising incidence of melanoma, more patients are undergoing surveillance for disease recurrence. Our purpose was to study levels of proteins... 
CELLS | OSTEOPONTIN | ONCOLOGY | RECOMMENDATIONS | MACROPHAGE INHIBITORY CYTOKINE-1 | CUTANEOUS MELANOMA | SERUM-LEVELS | SURVEILLANCE | FOLLOW-UP | MALIGNANT-MELANOMA | CANCER | Enzyme-Linked Immunosorbent Assay - methods | L-Lactate Dehydrogenase - metabolism | Melanoma - blood | Prognosis | Humans | Middle Aged | Male | Neoplasm Metastasis | S100 Proteins - blood | Sensitivity and Specificity | Female | Intercellular Adhesion Molecule-1 - blood | Nerve Growth Factors - blood | Neoplasm Recurrence, Local - blood | Tissue Inhibitor of Metalloproteinase-1 - blood | Cell Adhesion Molecules - blood | Reproducibility of Results | S100 Calcium Binding Protein beta Subunit | Extracellular Matrix Proteins - blood | Glycoproteins - blood | Neoplasm Recurrence, Local - diagnosis | Melanoma - pathology | Biomarkers, Tumor - blood | Antigens, CD - blood | Growth Differentiation Factor 15 - blood | Neoplasm Proteins - blood | Aged | Melanoma - surgery | Neoplasm Staging | Index Medicus
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3. Full Text Peripheral Blood Biomarkers Associated with Clinical Outcome in Non–Small Cell Lung Cancer Patients Treated with Nivolumab
by Tanizaki, Junko and Haratani, Koji and Hayashi, Hidetoshi and Chiba, Yasutaka and Nakamura, Yasushi and Yonesaka, Kimio and Kudo, Keita and Kaneda, Hiroyasu and Hasegawa, Yoshikazu and Tanaka, Kaoru and Takeda, Masayuki and Ito, Akihiko and Nakagawa, Kazuhiko
Journal of Thoracic Oncology, ISSN 1556-0864, 01/2018, Volume 13, Issue 1, pp. 97 - 105
The aim of this study was to identify baseline peripheral blood biomarkers associated with clinical outcome in patients with NSCLC treated with nivolumab.... 
Prognostic factor | Non–small cell lung cancer | Peripheral blood biomarker | Predictive factor | Nivolumab | SURVIVAL | METASTATIC MELANOMA PATIENTS | EOSINOPHILS | NEUTROPHILS | TUMORS | DOCETAXEL | ONCOLOGY | RESPIRATORY SYSTEM | Non-small cell lung cancer | TO-LYMPHOCYTE RATIO | EXPERIENCE | STAGE-IV | IPILIMUMAB | Carcinoma, Squamous Cell - blood | Leukocytes - pathology | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Prognosis | Follow-Up Studies | Carcinoma, Squamous Cell - pathology | Humans | Antibodies, Monoclonal - therapeutic use | Lung Neoplasms - pathology | Male | Antineoplastic Agents - therapeutic use | Female | Retrospective Studies | Neutrophils - pathology | Carcinoma, Non-Small-Cell Lung - pathology | Adenocarcinoma - blood | Survival Rate | Adenocarcinoma - drug therapy | Lymphocytes - pathology | Carcinoma, Squamous Cell - drug therapy | Carcinoma, Non-Small-Cell Lung - blood | Aged | Lung Neoplasms - blood | Carcinoma, Non-Small-Cell Lung - drug therapy | Index Medicus
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4. Full Text Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice
by Pereira, Ethel R and Kedrin, Dmitriy and Seano, Giorgio and Gautier, Olivia and Meijer, Eelco F.J and Jones, Dennis and Chin, Shan-Min and Kitahara, Shuji and Bouta, Echoe M and Chang, Jonathan and Beech, Elizabeth and Jeong, Han-Sin and Carroll, Michael C and Taghian, Alphonse G and Padera, Timothy P
Science, ISSN 0036-8075, 03/2018, Volume 359, Issue 6382, pp. 1403 - 1407
Lymph node metastases in cancer patients are associated with tumor aggressiveness, poorer prognoses, and the recommendation for systemic therapy. Whether... 
BREAST-CANCER | SURVIVAL | SURGERY | IRRADIATION | MULTIDISCIPLINARY SCIENCES | SENTINEL-NODE | PREMENOPAUSAL WOMEN | RADIOTHERAPY | AXILLARY DISSECTION | CARCINOMA | MAMMARY | Lung - pathology | Lymph Nodes - pathology | Neoplasm Seeding | Blood Vessels - pathology | Mice, Inbred C57BL | Cell Tracking - methods | Cytosol - chemistry | Carcinoma, Squamous Cell | Luminescent Proteins - analysis | Animals | Melanoma, Experimental | Lymphatic Metastasis - pathology | Neoplastic Cells, Circulating | Cell Line, Tumor | Female | Mice | Mice, Inbred BALB C | Cell Movement | Lymphatic metastasis | Blood vessels | Physiological aspects | Development and progression | Cancer cells | Animal models | Lymphatic system | Squamous cell carcinoma | Carcinoma | Tumor cells | Lung | Melanoma | Organs | Metastasis | Patients | Blood | Lymph nodes | Metastases | Blood circulation | Biopsy | Mastectomy | Mammary gland | Cancer | Lymph | Index Medicus
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5. Full Text Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
by Gros, Alena and Parkhurst, Maria R and Tran, Eric and Pasetto, Anna and Robbins, Paul F and Ilyas, Sadia and Prickett, Todd D and Gartner, Jared J and Crystal, Jessica S and Roberts, Ilana M and Trebska-Mcgowan, Kasia and Wunderlich, John R and Yang, James C and Rosenberg, Steven A
Nature Medicine, ISSN 1078-8956, 04/2016, Volume 22, Issue 4, pp. 433 - 438
Detection of lymphocytes that target tumor-specific mutant neoantigens-derived from products encoded by mutated genes in the tumor-is mostly limited to... 
MEDICINE, RESEARCH & EXPERIMENTAL | RNA | PD-1 BLOCKADE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR | ANTIGENS | CANCER-IMMUNOTHERAPY | CELL BIOLOGY | UNTREATED MELANOMA | METASTATIC MELANOMA | REACTIVE T-CELLS | ENHANCED ANTITUMOR-ACTIVITY | IPILIMUMAB | Melanoma - blood | Prospective Studies | Humans | Middle Aged | Male | Programmed Cell Death 1 Receptor - blood | Lymphocytes - immunology | Melanoma - genetics | Immunotherapy | Antigens, Neoplasm - blood | Adult | Female | Receptors, Antigen, T-Cell - immunology | Antigens, Neoplasm - genetics | Antigens, Neoplasm - immunology | Lymphocytes - pathology | Lymphocytes, Tumor-Infiltrating - pathology | Melanoma - immunology | Cell Line, Tumor | Aged | Receptors, Antigen, T-Cell - genetics | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Melanoma - therapy | Programmed Cell Death 1 Receptor - genetics | Lymphocytes, Tumor-Infiltrating - immunology | Ligands (Biochemistry) | Melanoma | Development and progression | Genetic aspects | Properties | Gene expression | Health aspects | Lymphocytes | Index Medicus
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6. Full Text Vitamin D Status and Skin Cancer Risk Independent of Time Outdoors: 11-Year Prospective Study in an Australian Community
by van der Pols, Jolieke C and Russell, Anne and Bauer, Ulrike and Neale, Rachel E and Kimlin, Michael G and Green, Adèle C
Journal of Investigative Dermatology, ISSN 0022-202X, 03/2013, Volume 133, Issue 3, pp. 637 - 641
Vitamin D may have anti–skin cancer effects, but population-based evidence is lacking. We therefore assessed associations between vitamin D status and skin... 
SUPPLEMENTATION | MELANOMA | REGULAR SUNSCREEN USE | BASAL-CELL CARCINOMA | PREVENTION | RANDOMIZED CONTROLLED-TRIAL | NONMELANOMA | ASSOCIATION | DERMATOLOGY | Melanoma - blood | Melanoma - epidemiology | Carcinoma, Squamous Cell - blood | Prospective Studies | Follow-Up Studies | Carcinoma, Squamous Cell - epidemiology | Humans | Middle Aged | Risk Factors | Male | Carcinoma, Basal Cell - epidemiology | Skin Neoplasms - blood | Skin Neoplasms - epidemiology | Australia - epidemiology | Incidence | Vitamin D - blood | Biomarkers, Tumor - blood | Regression Analysis | Sunlight - adverse effects | Carcinoma, Basal Cell - blood | Female | Vitamin D - analogs & derivatives | Longitudinal Studies | Index Medicus
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7. Full Text Merkel cell polyomavirus-specific CD8+and CD4+ T-cell responses identified in Merkel cell carcinomas and blood
by Iyer, Jayasri G and Afanasiev, Olga K and McClurkan, Christopher and Paulson, Kelly and Nagase, Kotaro and Jing, Lichen and Marshak, Joshua O and Dong, Lichun and Carter, Joseph and Lai, Ivy and Farrar, Erik and Byrd, David and Galloway, Denise and Yee, Cassian and Koelle, David M and Nghiem, Paul
Clinical Cancer Research, ISSN 1078-0432, 11/2011, Volume 17, Issue 21, pp. 6671 - 6680
Purpose: Merkel cell polyomavirus (MCPyV) is prevalent in the general population, integrates into most Merkel cell carcinomas (MCC), and encodes oncoproteins... 
METASTATIC MELANOMA | IMMUNE-RESPONSE | PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY | ONCOLOGY | GENITAL HERPES | JC VIRUS | PERIPHERAL-BLOOD | INFECTION | VACCINIA VIRUS | EXPRESSION | ANTIGEN | Polyomavirus Infections - immunology | Epitope Mapping | Tumor Virus Infections - virology | Antigens, Viral, Tumor - immunology | Humans | Cercopithecus aethiops | Polyomavirus Infections - blood | Skin Neoplasms - blood | CD4-Positive T-Lymphocytes - immunology | Carcinoma, Merkel Cell - immunology | Tumor Virus Infections - immunology | Tumor Virus Infections - blood | Epitopes, T-Lymphocyte - immunology | HLA-A24 Antigen - immunology | Skin Neoplasms - immunology | Peptides - immunology | Merkel cell polyomavirus - immunology | Animals | Polyomavirus Infections - virology | Interferon-gamma - immunology | Skin Neoplasms - virology | Carcinoma, Merkel Cell - blood | Carcinoma, Merkel Cell - virology | CD8-Positive T-Lymphocytes - immunology | COS Cells | Interferon-gamma - biosynthesis | Lymphocytes, Tumor-Infiltrating - immunology | Index Medicus
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8. Full Text Blood monocytes sample MelanA/MART1 antigen for long‐lasting cross‐presentation to CD8+ T cells after differentiation into dendritic cells
by Faure, Florence and Jouve, Mabel and Lebhar‐Peguillet, Isabelle and Sadaka, Charlotte and Sepulveda, Fernando and Lantz, Olivier and Berre, Stefano and Gaudin, Raphael and Sánchez‐Ramón, Silvia and Amigorena, Sebastian
International Journal of Cancer, ISSN 0020-7136, 01/2018, Volume 142, Issue 1, pp. 133 - 144
Human blood monocytes are very potent to take up antigens. Like macrophages in tissue, they efficiently degrade exogenous protein and are less efficient than... 
monocytes | melanoma | CD8+ T cells | cross‐presentation | antigen storage | cross-presentation | CD8+T cells | LYMPH-NODES | BONE-MARROW | MELANOMA PATIENTS | TUMOR-DERIVED EXOSOMES | CANCER | MOLECULES | TRANSPORT | MEMORY | ONCOLOGY | INFECTION | EXHAUSTION | MART-1 Antigen - immunology | Cell Differentiation - immunology | Cross-Priming - immunology | Melanoma - immunology | Monocytes - cytology | Dendritic Cells - immunology | Humans | Dendritic Cells - cytology | Monocytes - immunology | Antigen Presentation - immunology | CD8-Positive T-Lymphocytes - immunology | Antigens | Peptides | Dendritic cells | Melanoma | Metastasis | T cells | Macrophages | CD8 antigen | Lysosomes | Lymphocytes T | CD14 antigen | Blood | Lymph nodes | Metastases | Lymphocytes | Compartments | Immunotherapy | Sampling | Antigen presentation | Immune response | T cell receptors | Patients | Immune systems | Monocytes | Antigen-presenting cells | Antigen (tumor-associated) | Differentiation | Cell migration | Cancer | Index Medicus
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9. Full Text Baseline peripheral blood biomarkers associated with clinical outcome of advanced melanoma patients treated with ipilimumab
by Martens, Alexander and Wistuba-Hamprecht, Kilian and Foppen, Marnix Geukes and Yuan, Jianda and Postow, Michael A and Wong, Phillip and Romano, Emanuela and Khammari, Amir and Dreno, Brigitte and Capone, Mariaelena and Ascierto, Paolo A and Di Giacomo, Anna Maria and Maio, Michele and Schilling, Bastian and Sucker, Antje and Schadendorf, Dirk and Hassel, Jessica C and Eigentler, Thomas K and Martus, Peter and Wolchok, Jedd D and Blank, Christian and Pawelec, Graham and Garbe, Claus and Weide, Benjamin
Clinical Cancer Research, ISSN 1078-0432, 06/2016, Volume 22, Issue 12, pp. 2908 - 2918
Purpose: To identify baseline peripheral blood biomarkers associated with clinical outcome following ipilimumab treatment in advanced melanoma patients.... 
SURVIVAL | METASTATIC MELANOMA | CTLA-4 BLOCKADE | ONCOLOGY | LYMPHOCYTE COUNT | EXPANDED ACCESS PROGRAM | EXPERIENCE | SUPPRESSOR-CELLS | CANCER | T-CELLS | PROGNOSTIC MODEL | Skin Neoplasms - pathology | Skin Neoplasms - drug therapy | Humans | Male | Treatment Outcome | Ipilimumab - adverse effects | Melanoma - pathology | Biomarkers, Tumor - blood | Antineoplastic Agents, Immunological - adverse effects | Antineoplastic Agents, Immunological - therapeutic use | L-Lactate Dehydrogenase - blood | Skin Neoplasms - mortality | Ipilimumab - therapeutic use | Melanoma - drug therapy | Myeloid-Derived Suppressor Cells - cytology | T-Lymphocytes, Regulatory - cytology | Lymphocyte Count | Female | Aged | Erythrocyte Count | Melanoma - mortality | Index Medicus | Life Sciences | Cancer | MDSCs | LDH | Tregs | Melanoma | ipilimumab | biomarker | T cells | prognosis
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10. Full Text Identification of a New Subset of Myeloid Suppressor Cells in Peripheral Blood of Melanoma Patients With Modulation by a Granulocyte-Macrophage Colony-Stimulation Factor–Based Antitumor Vaccine
by Paola Filipazzi and Roberta Valenti and Veronica Huber and Lorenzo Pilla and Paola Canese and Manuela Iero and Chiara Castelli and Luigi Mariani and Giorgio Parmiani and Licia Rivoltini
Journal of Clinical Oncology, ISSN 0732-183X, 06/2007, Volume 25, Issue 18, pp. 2546 - 2553
Purpose Phenotypic and functional features of myeloid suppressor cells ( MSC), which are known to serve as critical regulators of antitumor T-cell responses in... 
TUMOR-INFILTRATING LYMPHOCYTES | PROGENITOR CELLS | RESPONSES | GROWTH-FACTOR-BETA | CANCER-PATIENTS | DENDRITIC CELLS | ONCOLOGY | IMMUNE SUPPRESSION | GM-CSF | MECHANISMS | T-CELLS | Enzyme-Linked Immunosorbent Assay | Humans | Male | Treatment Outcome | Melanoma - pathology | Heat-Shock Proteins - immunology | T-Lymphocytes, Regulatory - immunology | Cancer Vaccines - immunology | Neoplasm Metastasis | Phenotype | Flow Cytometry | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Melanoma - prevention & control | Melanoma - immunology | Myeloid Cells - immunology | Adult | Female | HLA-DR Antigens - immunology | Index Medicus
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11. Full Text Phase 1/2 study of immunotherapy with dendritic cells pulsed with autologous tumor lysate in patients with refractory bone and soft tissue sarcoma
by Miwa, Shinji and Nishida, Hideji and Tanzawa, Yoshikazu and Takeuchi, Akihiko and Hayashi, Katsuhiro and Yamamoto, Norio and Mizukoshi, Eishiro and Nakamoto, Yasunari and Kaneko, Shuichi and Tsuchiya, Hiroyuki
Cancer, ISSN 0008-543X, 05/2017, Volume 123, Issue 9, pp. 1576 - 1584
In a phase 1/2 trial of immunotherapy using dendritic cells pulsed with autologous tumor lysate and OK‐432, dendritic cell–based immunotherapy activates the... 
clinical trial | tumor lysate | dendritic cells | sarcoma | immunotherapy | CANCER PATIENTS | STAGE IV MELANOMA | CLINICAL-TRIAL | VACCINATION | SUPPORTIVE CARE | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | STREPTOCOCCAL PREPARATION OK-432 | REGULATORY T-CELLS | GENERATION | RELAPSED OSTEOSARCOMA | Interleukin-4 | Immunotherapy - methods | Dendritic Cells | Bone Neoplasms - therapy | Humans | Middle Aged | Male | Leukocytes, Mononuclear | Sarcoma - blood | Sarcoma - therapy | Young Adult | Interleukin-12 - blood | Picibanil | Chondrosarcoma - blood | Adult | Female | Histiocytoma, Malignant Fibrous - therapy | Bone Neoplasms - blood | Child | Osteosarcoma - blood | Soft Tissue Neoplasms - therapy | Leiomyosarcoma - blood | Sarcoma, Clear Cell - blood | Sarcoma, Synovial - therapy | Soft Tissue Neoplasms - blood | Antineoplastic Agents | Treatment Outcome | Chondrosarcoma - therapy | Tumor Necrosis Factor-alpha | Leiomyosarcoma - therapy | Disease-Free Survival | Sarcoma, Synovial - blood | Adolescent | Aged | Histiocytoma, Malignant Fibrous - blood | Sarcoma, Clear Cell - therapy | Granulocyte-Macrophage Colony-Stimulating Factor | Osteosarcoma - therapy | Interferon-gamma - blood | Cancer patients | Usage | Dendritic cells | Immunotherapy | Research | Tumor lysis syndrome | Diagnosis | Health aspects | Therapy | Toxicity | Interleukin | Medical services | Leukocytes (mononuclear) | Macrophages | Metastases | Interleukin 4 | Immunology | Peripheral blood mononuclear cells | Colony-stimulating factor | Cell survival | Immune response | Sarcoma | Granulocyte-macrophage colony-stimulating factor | Soft tissue sarcoma | Interleukin 12 | T cell receptors | Injection | Patients | Side effects | Interferon | Bone | Cancer | Index Medicus | Abridged Index Medicus
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12. Full Text In vivo measurements of blood vessels’ distribution in non‐melanoma skin cancer by dynamic optical coherence tomography — a new quantitative measure?
by Sigsgaard, V and Themstrup, L and Theut Riis, P and Olsen, J and Jemec, G. B
Skin Research and Technology, ISSN 0909-752X, 02/2018, Volume 24, Issue 1, pp. 123 - 128
Background: Skin biopsies only provide point-in-time data making longitudinal studies difficult. Using Dynamic optical coherence tomography (D-OCT) in vivo,... 
non‐melanoma skin caner | OCT | NMSC | dynamic optical coherence tomography | D-OCT | non-melanoma skin caner | MICROVASCULATURE | BASAL-CELL CARCINOMA | MORPHOLOGY | ACTINIC KERATOSIS | DERMATOLOGY | Measurement | Tomography | Squamous cell carcinoma | Melanoma | Skin cancer | Invasiveness | Blood vessels | Blood | Optical Coherence Tomography | Correlation analysis | Skin diseases | Skin | Longitudinal studies | In vivo methods and tests | Qualitative analysis | Microvasculature | Lesions | Cancer | Tumors | Keratosis | Index Medicus
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13. Full Text Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients
by Siravegna, Giulia and Mussolin, Benedetta and Buscarino, Michela and Corti, Giorgio and Cassingena, Andrea and Crisafulli, Giovanni and Ponzetti, Agostino and Cremolini, Chiara and Amatu, Alessio and Lauricella, Calogero and Lamba, Simona and Hobor, Sebastijan and Avallone, Antonio and Valtorta, Emanuele and Rospo, Giuseppe and Medico, Enzo and