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Journal Article
Experimental neurology, ISSN 0014-4886, 2009, Volume 219, Issue 1, pp. 146 - 155
Cancer pain significantly affects the quality of cancer patients, and current treatments for this pain are limited. C-Jun N-terminal kinase (JNK) has been... 
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Melanoma - complications | Skin Neoplasms - drug therapy | Analgesics, Opioid - pharmacology | Melanoma - enzymology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Peripheral Nervous System Diseases - physiopathology | Skin Neoplasms - enzymology | Pain - enzymology | Pain - drug therapy | Pain - etiology | Sensory Receptor Cells - metabolism | Disease Models, Animal | Peripheral Nervous System Diseases - etiology | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Morphine - pharmacology | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Peripheral Nervous System Diseases - enzymology | Activating Transcription Factor 3 - metabolism | Enzyme Inhibitors - therapeutic use | Peptides - pharmacology | Skin Neoplasms - complications | Animals | Sensory Receptor Cells - cytology | Sensory Receptor Cells - drug effects | Hyperalgesia - drug therapy | Melanoma - drug therapy | Cell Line, Tumor | Hyperalgesia - etiology | Cell Proliferation - drug effects | Mice | Pain Measurement | Hyperalgesia - enzymology | Peptides - therapeutic use | Allergy | Care and treatment | Pain | Peptides | Growth | Analysis | Melanoma | Fluorescence | Cancer pain | Allergic reaction | Skin cancer | Cancer | Index Medicus
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 06/2011, Volume 333, Issue 6039, pp. 233 - 238
Journal Article
Nature (London), ISSN 1476-4687, 07/2017, Volume 547, Issue 7664, pp. 453 - 457
Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness(1-4). A... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Prostatic Neoplasms - metabolism | Cadherins - metabolism | Humans | Mesoderm - drug effects | Melanoma - enzymology | Male | Lipid Peroxides - metabolism | Zinc Finger E-box-Binding Homeobox 1 - genetics | Neoplasms - genetics | Mesoderm - enzymology | Cell Death | Epithelial-Mesenchymal Transition | Lipid Peroxidation - drug effects | Cell Transdifferentiation | Prostatic Neoplasms - drug therapy | Melanoma - metabolism | Glutathione Peroxidase - metabolism | Prostatic Neoplasms - pathology | Reproducibility of Results | Neoplasms - enzymology | Melanoma - pathology | Iron - metabolism | Neoplasms - drug therapy | Cell Lineage | Drug Resistance, Neoplasm - genetics | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Proteomics | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Mesoderm - metabolism | Neoplasms - pathology | Mesoderm - pathology | Peroxidase | Research | Chemical properties | Chemical synthesis | Analysis | Cancer cells | Therapy | Biotechnology | Carcinoma | Mesenchyme | Genes | Lipid peroxidation | Lipids | Iron | Genomes | Phospholipids | Kinases | Cancer therapies | Proteins | Organoids | Dissipation | Peroxides | Lipid metabolism | Glutathione | Transfer RNA | Peroxidation | Glutathione peroxidase | Enzymes | Mortality | Melanoma | Selenocysteine | Tumor cell lines | Metabolism | Substrates | Cell death | Lipoxygenase | Prostate cancer | Prostate | Tumors | Apoptosis | Cancer | Index Medicus
Journal Article
Journal Article
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 05/2008, Volume 26, Issue 13, pp. 2139 - 2146
To assess the tolerability, pharmacokinetics (PKs), and pharmacodynamics (PDs) of the mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor AZD6244... 
ras Proteins - genetics | Phosphorylation | Proto-Oncogene Proteins p21(ras) | Humans | Middle Aged | Melanoma - enzymology | Male | Antineoplastic Agents - administration & dosage | Extracellular Signal-Regulated MAP Kinases - metabolism | Protein Kinase Inhibitors - adverse effects | Dose-Response Relationship, Drug | Benzimidazoles - administration & dosage | Neoplasms - genetics | Antineoplastic Agents - adverse effects | DNA Mutational Analysis | Melanoma - genetics | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Benzimidazoles - adverse effects | Protein Kinase Inhibitors - pharmacokinetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Leukocytes, Mononuclear - drug effects | Drug Administration Schedule | Administration, Oral | Benzimidazoles - pharmacokinetics | Neoplasms - enzymology | MAP Kinase Kinase 1 - metabolism | Proto-Oncogene Proteins - genetics | Treatment Outcome | MAP Kinase Kinase 2 - metabolism | Melanoma - pathology | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Maximum Tolerated Dose | Ki-67 Antigen - analysis | MAP Kinase Kinase 2 - antagonists & inhibitors | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Leukocytes, Mononuclear - enzymology | Aged | Cell Proliferation - drug effects | Mutation | Neoplasm Staging | Neoplasms - pathology | Index Medicus
Journal Article
Cancer cell, ISSN 1535-6108, 03/2008, Volume 13, Issue 3, pp. 193 - 205
Tumor vasculature is derived from sprouting of local vessels (angiogenesis) and bone marrow (BM)-derived circulating cells (vasculogenesis). By using a model... 
CELLCYCLE | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Myeloid Cells - enzymology | Bone Marrow Cells - enzymology | Neoplasms, Experimental - enzymology | Antineoplastic Agents - therapeutic use | Monocytes - immunology | Subcutaneous Tissue - surgery | Neovascularization, Pathologic - pathology | Neoplasms, Experimental - pathology | Neovascularization, Pathologic - enzymology | Protease Inhibitors - pharmacology | Matrix Metalloproteinase 9 - metabolism | Monocytes - transplantation | Melanoma, Experimental | Stem Cells - enzymology | Time Factors | Matrix Metalloproteinase 9 - genetics | Myeloid Cells - immunology | Bone Marrow Cells - immunology | Bone Marrow Transplantation | Diphosphonates - therapeutic use | Bone Marrow Cells - drug effects | Myeloid Cells - drug effects | Neovascularization, Pathologic - prevention & control | Antineoplastic Agents - pharmacology | Imidazoles - therapeutic use | Protease Inhibitors - therapeutic use | Signal Transduction | Mice, Inbred C57BL | Imidazoles - pharmacology | Matrix Metalloproteinase 9 - deficiency | Neoplasms, Experimental - radiotherapy | Mice, Inbred C3H | Mice, Knockout | Monocytes - drug effects | Monocytes - enzymology | Subcutaneous Tissue - radiation effects | Animals | Subcutaneous Tissue - blood supply | Matrix Metalloproteinase Inhibitors | Myeloid Cells - transplantation | Mice | CD11b Antigen - metabolism | Endothelial Cells - enzymology | Neoplasms, Experimental - drug therapy | Diphosphonates - pharmacology | Neoplasms, Experimental - blood supply | Neovascularization | Nuclear radiation | Analysis | Tumors | Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 12/2008, Volume 457, Issue 7229, pp. 599 - 602
Journal Article