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The Journal of clinical investigation, ISSN 0021-9738, 2011, Volume 121, Issue 6, pp. 2350 - 2360
Journal Article
Journal of clinical oncology, ISSN 1527-7755, 2012, Volume 30, Issue 21, pp. 2691 - 2697
Monoclonal antibodies directed against the immune checkpoint protein cytotoxic T-lymphocyte antigen-4 (CTLA-4; CD152)-ipilimumab and tremelimumab-have been... 
REGRESSION | METASTATIC MELANOMA | LYMPHOCYTE-ASSOCIATED ANTIGEN-4 | EFFICACY | ONCOLOGY | PHASE-II | MONOCLONAL-ANTIBODY | CTLA-4 | PATIENT | CANCER-IMMUNOTHERAPY | BLOCKADE | Stevens-Johnson Syndrome - immunology | Peripheral Nervous System Diseases - chemically induced | Skin Neoplasms - drug therapy | Humans | Ipilimumab | Antibodies, Monoclonal - adverse effects | Scleritis - chemically induced | Antineoplastic Agents - administration & dosage | Liver - immunology | Liver - drug effects | Antineoplastic Agents - adverse effects | Diarrhea - immunology | Pancreatitis - immunology | Scleritis - immunology | Mucous Membrane - drug effects | Colitis - immunology | Peripheral Nervous System Diseases - immunology | Antibodies, Monoclonal - immunology | Drug Eruptions - immunology | Skin - immunology | Melanoma - metabolism | Skin Neoplasms - pathology | Skin Neoplasms - immunology | Antineoplastic Agents - immunology | CTLA-4 Antigen - drug effects | Lymphatic Diseases - immunology | Antibodies, Monoclonal - pharmacokinetics | CTLA-4 Antigen - immunology | Pancreatitis - chemically induced | Melanoma - secondary | Chemical and Drug Induced Liver Injury - immunology | Pituitary Gland - immunology | Skin Neoplasms - metabolism | Lymphatic Diseases - chemically induced | Mucous Membrane - immunology | Antibodies, Monoclonal - administration & dosage | Melanoma - immunology | Uveitis - immunology | Melanoma - drug therapy | Uveitis - chemically induced | Pituitary Gland - drug effects | Skin - drug effects | Index Medicus
Journal Article
The Journal of immunology (1950), ISSN 1550-6606, 2018, Volume 200, Issue 7, pp. 2263 - 2279
Journal Article
Cancer research (Chicago, Ill.), ISSN 0008-5472, 06/2010, Volume 70, Issue 11, pp. 4335 - 4345
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 50, pp. 15408 - 15413
Spontaneous CD8 T-cell responses occur in growing tumors but are usually poorly effective. Understanding the molecular and cellular mechanisms that drive these... 
Antitumor immunity | STING | Type I IFNs | Tumor endothelial cells | CD8 T cells | type I IFNs | DENDRITIC CELLS | RECOGNITION | MULTIDISCIPLINARY SCIENCES | SENSOR | antitumor immunity | I INTERFERON | 2ND-MESSENGER | tumor endothelial cells | RESPONSES | INTRACELLULAR DNA | MELANOMA | IMMUNOGENIC TUMORS | IPILIMUMAB | Dose-Response Relationship, Immunologic | Dendritic Cells - immunology | Immunity | Neoplasms - therapy | Melanoma, Experimental - immunology | Injections, Intralesional | Interferon Type I - metabolism | Dendritic Cells - drug effects | Membrane Proteins - metabolism | Disease Models, Animal | Receptor, Interferon alpha-beta - metabolism | Nucleotides, Cyclic - pharmacology | Antigens, Neoplasm - immunology | Endothelial Cells - metabolism | Mice, Inbred C57BL | Melanoma, Experimental - pathology | Lymphocytes, Tumor-Infiltrating - drug effects | Melanoma - pathology | CTLA-4 Antigen - immunology | Animals | Signal Transduction - drug effects | Melanoma - immunology | Neoplasms - immunology | Cell Proliferation - drug effects | Nucleotides, Cyclic - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Endothelial Cells - drug effects | Lymphocytes, Tumor-Infiltrating - immunology | Growth | Cancer cells | Physiological aspects | Genetic aspects | T cells | Health aspects | Tumors | Endothelium | Biological Sciences
Journal Article
Journal Article
Journal Article
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2013, Volume 38, Issue 2, pp. 275 - 284
Epidermal growth factor receptor (EGFR) is known to be critically involved in tissue development and homeostasis as well as in the pathogenesis of cancer. Here... 
CETUXIMAB | RESPONSES | TOLERANCE | MAST-CELLS | DISEASE | MODEL | IMMUNOLOGY | CARCINOMA | EXPRESSION | METASTATIC COLORECTAL-CANCER | EGF RECEPTOR | Forkhead Transcription Factors - immunology | Cell Communication - immunology | Receptor, Epidermal Growth Factor - genetics | T-Lymphocytes, Regulatory - metabolism | Humans | Colitis - pathology | Homeodomain Proteins - immunology | Amphiregulin | Glycoproteins - pharmacology | T-Lymphocytes, Regulatory - immunology | Signal Transduction - immunology | Melanoma, Experimental - immunology | EGF Family of Proteins | Colitis - chemically induced | Peptide Fragments - immunology | Mast Cells - metabolism | Colitis - immunology | Glycoproteins - genetics | Mast Cells - immunology | Receptor, Epidermal Growth Factor - immunology | Peptide Fragments - administration & dosage | Glycoproteins - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - genetics | Melanoma, Experimental - pathology | Antibodies, Neutralizing - pharmacology | Membrane Proteins - immunology | Mice, Transgenic | Forkhead Transcription Factors - genetics | Mast Cells - drug effects | Homeodomain Proteins - genetics | Gene Expression Regulation - drug effects | Membrane Proteins - administration & dosage | Glycoproteins - immunology | T-Lymphocytes, Regulatory - drug effects | Animals | Melanoma, Experimental - genetics | Signal Transduction - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Lymphocyte Activation - drug effects | Colitis - metabolism | Mice | Intercellular Signaling Peptides and Proteins - immunology | Epidermal growth factor | Universities and colleges | T cells | Analysis | Vaccination | Cells | Flow cytometry | Cytokines | Cloning | Melanoma | Kinases | Experiments | Cancer therapies | Rodents | Bone marrow | Software | Tumors | Cancer
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2003, Volume 100, Issue 14, pp. 8372 - 8377
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical immunoregulatory molecule (expressed on activated T cells and a subset of regulatory T... 
T lymphocytes | Autoimmunity | Antigens | Biological Sciences | Lungs | Lymphocytes | Vaccination | Immunotherapy | Melanoma | Biopsies | Tumors | IMMUNIZATION | ACTIVATION | INHIBITION | DENDRITIC CELLS | 4 CTLA-4 | MULTIDISCIPLINARY SCIENCES | COMBINATION IMMUNOTHERAPY | CD28 | CELL-CYCLE PROGRESSION | EXPRESSION | VACCINES | Peptides | Humans | Middle Aged | Neoplasm Proteins - immunology | Hepatitis, Autoimmune - etiology | Antibodies, Monoclonal - therapeutic use | Male | Antigens, Neoplasm - administration & dosage | gp100 Melanoma Antigen | Neoplasm Metastasis | Injections, Subcutaneous | Peptide Fragments - immunology | Autoimmune Diseases - pathology | Antibodies, Monoclonal - immunology | Antigens, Neoplasm - immunology | Lymphocyte Activation | Hepatitis, Autoimmune - immunology | Neoplasm Proteins - chemistry | Antigens, Differentiation - physiology | CTLA-4 Antigen | Dermatitis - etiology | Antigens, CD | Antigens, Differentiation - immunology | T-Lymphocyte Subsets - immunology | Antibodies, Neoplasm - therapeutic use | Injections, Intravenous | Dermatitis - immunology | Membrane Glycoproteins - chemistry | Antibodies, Monoclonal - adverse effects | Salvage Therapy | Colitis - pathology | Autoimmune Diseases - etiology | Hepatitis, Autoimmune - pathology | Immune Tolerance - immunology | Adult | Female | Membrane Glycoproteins - immunology | Colitis - immunology | T-Lymphocytes, Cytotoxic - immunology | Antibodies, Neoplasm - immunology | HLA-A2 Antigen - immunology | Peptide Fragments - administration & dosage | Vitiligo - immunology | Autoimmune Diseases - immunology | Vitiligo - etiology | Dermatitis - pathology | Colitis - etiology | Vitiligo - pathology | Melanoma - immunology | Melanoma - therapy | Antibodies, Neoplasm - adverse effects | Cancer regression | Physiological aspects | T cells
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2010, Volume 207, Issue 8, pp. 1791 - 1804
Studies of T cell responses to tumors have focused on the draining lymph node (LN) as the site of activation. We examined the tumor mass as a potential site of... 
MEDICINE, RESEARCH & EXPERIMENTAL | NODE ADDRESSIN | INDOLEAMINE 2,3-DIOXYGENASE | CO-STIMULATION | IMMUNE DYSFUNCTION | MATURE DENDRITIC CELLS | LYMPHOTOXIN-ALPHA | ANTIGEN CROSS-PRESENTATION | IMMUNOLOGY | CANCER | SPHINGOSINE 1-PHOSPHATE | SELF-TOLERANCE | CD8-Positive T-Lymphocytes - cytology | Cell Proliferation | Ovalbumin - immunology | Carcinoma, Lewis Lung - immunology | Interferon-gamma - metabolism | Cell Movement - immunology | Lymphocyte Activation - immunology | Peptide Fragments - immunology | Hyaluronan Receptors - metabolism | CD8-Positive T-Lymphocytes - metabolism | Lymph Nodes - drug effects | Receptors, Antigen, T-Cell - immunology | CD11a Antigen - metabolism | Propylene Glycols - pharmacology | Antigen Presentation - genetics | Mice, Transgenic | Lymph Nodes - immunology | Antigen Presentation - immunology | Lymph Nodes - cytology | Mice, Knockout | Sphingosine - pharmacology | Cell Differentiation - immunology | Cell Movement - drug effects | Sphingosine - analogs & derivatives | Neoplasms - immunology | Carcinoma, Lewis Lung - pathology | Mice | Receptors, Antigen, T-Cell - genetics | CD8-Positive T-Lymphocytes - immunology | beta 2-Microglobulin - genetics | T-Lymphocyte Subsets - immunology | Lymph Nodes - pathology | T-Lymphocyte Subsets - cytology | Granzymes - metabolism | Adoptive Transfer | Melanoma, Experimental - immunology | Neoplasms - genetics | Immunosuppressive Agents - pharmacology | Lysosome-Associated Membrane Glycoproteins - metabolism | Mice, Inbred C57BL | Fingolimod Hydrochloride | DNA-Binding Proteins - genetics | Antigen-Presenting Cells - immunology | Animals | Carcinoma, Lewis Lung - genetics | Integrin alpha4 - metabolism | Monophenol Monooxygenase - immunology | T-Lymphocyte Subsets - metabolism | Neoplasms - pathology
Journal Article
Cell reports (Cambridge), ISSN 2211-1247, 2012, Volume 1, Issue 3, pp. 191 - 199
Journal Article